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Protein

Alpha-1-antitrypsin 1-3

Gene

Serpina1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of serine proteases. Can inhibit trypsin and chymotrypsin; relatively ineffective against elastase.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei377 – 3782Reactive bondBy similarity

GO - Molecular functioni

GO - Biological processi

  • response to cytokine Source: MGI
  • response to peptide hormone Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-antitrypsin 1-3
Alternative name(s):
Alpha-1 protease inhibitor 3
Alpha-1 protease inhibitor 6
Alpha-1-antitrypsin 1-6
Serine protease inhibitor 1-3
Serine protease inhibitor 1-6
Serine protease inhibitor A1c
Short name:
Serpin A1c
Gene namesi
Name:Serpina1c
Synonyms:Dom3, Dom6, Spi1-3, Spi1-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:891969. Serpina1c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 412388Alpha-1-antitrypsin 1-3PRO_0000032390Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis
Glycosylationi265 – 2651N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ00896.
PaxDbiQ00896.
PeptideAtlasiQ00896.
PRIDEiQ00896.

2D gel databases

REPRODUCTION-2DPAGEQ00896.

PTM databases

iPTMnetiQ00896.
PhosphoSiteiQ00896.

Expressioni

Gene expression databases

BgeeiENSMUSG00000079015.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ00896. 1 interaction.
MINTiMINT-1854752.
STRINGi10090.ENSMUSP00000073695.

Structurei

3D structure databases

ProteinModelPortaliQ00896.
SMRiQ00896. Positions 42-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni368 – 38720RCLAdd
BLAST

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina1-related genes may determine target protease specificity.By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiQ00896.
KOiK03984.
PhylomeDBiQ00896.
TreeFamiTF343201.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPSISWGLL LLAGLCCLVP SFLAEDVQET DTSQKDQSPA SHEIATNLGD
60 70 80 90 100
FAISLYRELV HQSNTSNIFF SPVSIATAFA MLSLGSKGDT HTQILEGLQF
110 120 130 140 150
NLTQTSEADI HKSFQHLLQT LNRPDSELQL STGNGLFVNN DLKLVEKFLE
160 170 180 190 200
EAKNHYQAEV FSVNFAESEE AKKVINDFVE KGTQGKIVEA VKKLDQDTVF
210 220 230 240 250
ALANYILFKG KWKKPFDPEN TEEAEFHVDE STTVKVPMMT LSGMLDVHHC
260 270 280 290 300
STLSSWVLLM DYAGNATAVF LLPDDGKMQH LEQTLSKELI SKFLLNRRRR
310 320 330 340 350
LAQIHFPRLS ISGEYNLKTL MSPLGITRIF NNGADLSGIT EENAPLKLSQ
360 370 380 390 400
AVHKAVLTID ETGTEAAAVT VLLAVPYSMP PILRFDHPFL FIIFEEHTQS
410
PLFVGKVVDP TH
Length:412
Mass (Da):45,823
Last modified:September 2, 2008 - v2
Checksum:iFFA3BF10ABC1B8AE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → HASGDLELADAWV in AAH10988 (PubMed:15489334).Curated
Sequence conflicti188 – 1881V → A in AAC28868 (PubMed:1946354).Curated
Sequence conflicti188 – 1881V → A in AAH10988 (PubMed:15489334).Curated
Sequence conflicti296 – 2983NRR → KRP in AAC28868 (PubMed:1946354).Curated
Sequence conflicti359 – 3591I → M in AAC28868 (PubMed:1946354).Curated
Sequence conflicti369 – 3691V → A in AAC28868 (PubMed:1946354).Curated
Sequence conflicti383 – 3831L → V in AAC28868 (PubMed:1946354).Curated
Sequence conflicti412 – 4121H → HK in AAC28868 (PubMed:1946354).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75720 mRNA. Translation: AAC28868.1.
BC009818 mRNA. Translation: AAH09818.1.
BC010984 mRNA. Translation: AAH10984.1.
BC010988 mRNA. Translation: AAH10988.1.
BC011041 mRNA. Translation: AAH11041.1.
BC015266 mRNA. Translation: AAH15266.1.
BC021325 mRNA. Translation: AAH21325.1.
BC021780 mRNA. Translation: AAH21780.1.
BC024108 mRNA. Translation: AAH24108.1.
BC031707 mRNA. Translation: AAH31707.1.
X00945 Genomic DNA. Translation: CAA25457.1.
PIRiI49472.
RefSeqiNP_033271.1. NM_009245.2.
UniGeneiMm.439692.
Mm.439694.

Genome annotation databases

GeneIDi20702.
KEGGimmu:20702.
UCSCiuc007owk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75720 mRNA. Translation: AAC28868.1.
BC009818 mRNA. Translation: AAH09818.1.
BC010984 mRNA. Translation: AAH10984.1.
BC010988 mRNA. Translation: AAH10988.1.
BC011041 mRNA. Translation: AAH11041.1.
BC015266 mRNA. Translation: AAH15266.1.
BC021325 mRNA. Translation: AAH21325.1.
BC021780 mRNA. Translation: AAH21780.1.
BC024108 mRNA. Translation: AAH24108.1.
BC031707 mRNA. Translation: AAH31707.1.
X00945 Genomic DNA. Translation: CAA25457.1.
PIRiI49472.
RefSeqiNP_033271.1. NM_009245.2.
UniGeneiMm.439692.
Mm.439694.

3D structure databases

ProteinModelPortaliQ00896.
SMRiQ00896. Positions 42-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ00896. 1 interaction.
MINTiMINT-1854752.
STRINGi10090.ENSMUSP00000073695.

Protein family/group databases

MEROPSiI04.001.

PTM databases

iPTMnetiQ00896.
PhosphoSiteiQ00896.

2D gel databases

REPRODUCTION-2DPAGEQ00896.

Proteomic databases

MaxQBiQ00896.
PaxDbiQ00896.
PeptideAtlasiQ00896.
PRIDEiQ00896.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20702.
KEGGimmu:20702.
UCSCiuc007owk.1. mouse.

Organism-specific databases

CTDi20702.
MGIiMGI:891969. Serpina1c.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiQ00896.
KOiK03984.
PhylomeDBiQ00896.
TreeFamiTF343201.

Miscellaneous databases

PROiQ00896.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079015.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA1AT3_MOUSE
AccessioniPrimary (citable) accession number: Q00896
Secondary accession number(s): P81105
, Q91V74, Q91WH5, Q91XC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 2, 2008
Last modified: September 7, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Murine alpha-1-antitrypsin is represented by a cluster of up to 6 individual Serpina1-related genes. The precise complement of Serpina1-related genes present varies according to the strain of the animal.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.