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Protein

Alpha-1-antitrypsin 1-3

Gene

Serpina1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of serine proteases. Can inhibit trypsin and chymotrypsin; relatively ineffective against elastase.2 Publications

Miscellaneous

Murine alpha-1-antitrypsin is represented by a cluster of up to 6 individual Serpina1-related genes. The precise complement of Serpina1-related genes present varies according to the strain of the animal.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei377 – 378Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

  • response to cytokine Source: MGI
  • response to peptide hormone Source: MGI

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-antitrypsin 1-3
Alternative name(s):
Alpha-1 protease inhibitor 3
Alpha-1 protease inhibitor 6
Alpha-1-antitrypsin 1-6
Serine protease inhibitor 1-3
Serine protease inhibitor 1-6
Serine protease inhibitor A1c
Short name:
Serpin A1c
Gene namesi
Name:Serpina1c
Synonyms:Dom3, Dom6, Spi1-3, Spi1-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:891969. Serpina1c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000003239025 – 412Alpha-1-antitrypsin 1-3Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ00896.
PaxDbiQ00896.
PeptideAtlasiQ00896.
PRIDEiQ00896.

2D gel databases

REPRODUCTION-2DPAGEiQ00896.

PTM databases

iPTMnetiQ00896.
PhosphoSitePlusiQ00896.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ00896. 1 interactor.
MINTiMINT-1854752.
STRINGi10090.ENSMUSP00000073695.

Structurei

3D structure databases

ProteinModelPortaliQ00896.
SMRiQ00896.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni368 – 387RCLAdd BLAST20

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity). Variability within the reactive center loop (RCL) sequences of Serpina1-related genes may determine target protease specificity.By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOGENOMiHOG000238521.
HOVERGENiHBG005957.
InParanoidiQ00896.
KOiK03984.
PhylomeDBiQ00896.
TreeFamiTF343201.

Family and domain databases

InterProiView protein in InterPro
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiView protein in Pfam
PF00079. Serpin. 1 hit.
SMARTiView protein in SMART
SM00093. SERPIN. 1 hit.
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiView protein in PROSITE
PS00284. SERPIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00896-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPSISWGLL LLAGLCCLVP SFLAEDVQET DTSQKDQSPA SHEIATNLGD
60 70 80 90 100
FAISLYRELV HQSNTSNIFF SPVSIATAFA MLSLGSKGDT HTQILEGLQF
110 120 130 140 150
NLTQTSEADI HKSFQHLLQT LNRPDSELQL STGNGLFVNN DLKLVEKFLE
160 170 180 190 200
EAKNHYQAEV FSVNFAESEE AKKVINDFVE KGTQGKIVEA VKKLDQDTVF
210 220 230 240 250
ALANYILFKG KWKKPFDPEN TEEAEFHVDE STTVKVPMMT LSGMLDVHHC
260 270 280 290 300
STLSSWVLLM DYAGNATAVF LLPDDGKMQH LEQTLSKELI SKFLLNRRRR
310 320 330 340 350
LAQIHFPRLS ISGEYNLKTL MSPLGITRIF NNGADLSGIT EENAPLKLSQ
360 370 380 390 400
AVHKAVLTID ETGTEAAAVT VLLAVPYSMP PILRFDHPFL FIIFEEHTQS
410
PLFVGKVVDP TH
Length:412
Mass (Da):45,823
Last modified:September 2, 2008 - v2
Checksum:iFFA3BF10ABC1B8AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → HASGDLELADAWV in AAH10988 (PubMed:15489334).Curated1
Sequence conflicti188V → A in AAC28868 (PubMed:1946354).Curated1
Sequence conflicti188V → A in AAH10988 (PubMed:15489334).Curated1
Sequence conflicti296 – 298NRR → KRP in AAC28868 (PubMed:1946354).Curated3
Sequence conflicti359I → M in AAC28868 (PubMed:1946354).Curated1
Sequence conflicti369V → A in AAC28868 (PubMed:1946354).Curated1
Sequence conflicti383L → V in AAC28868 (PubMed:1946354).Curated1
Sequence conflicti412H → HK in AAC28868 (PubMed:1946354).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75720 mRNA. Translation: AAC28868.1.
BC009818 mRNA. Translation: AAH09818.1.
BC010984 mRNA. Translation: AAH10984.1.
BC010988 mRNA. Translation: AAH10988.1.
BC011041 mRNA. Translation: AAH11041.1.
BC015266 mRNA. Translation: AAH15266.1.
BC021325 mRNA. Translation: AAH21325.1.
BC021780 mRNA. Translation: AAH21780.1.
BC024108 mRNA. Translation: AAH24108.1.
BC031707 mRNA. Translation: AAH31707.1.
X00945 Genomic DNA. Translation: CAA25457.1.
PIRiI49472.
RefSeqiNP_033271.1. NM_009245.2.
UniGeneiMm.439692.
Mm.439694.

Genome annotation databases

GeneIDi20702.
KEGGimmu:20702.
UCSCiuc007owk.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiA1AT3_MOUSE
AccessioniPrimary (citable) accession number: Q00896
Secondary accession number(s): P81105
, Q91V74, Q91WH5, Q91XC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 2, 2008
Last modified: September 27, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families