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Protein

Pregnancy-specific beta-1-glycoprotein 6

Gene

PSG6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • female pregnancy Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 6
Short name:
PS-beta-G-6
Short name:
PSBG-6
Short name:
Pregnancy-specific glycoprotein 6
Alternative name(s):
Pregnancy-specific beta-1-glycoprotein 10
Short name:
PS-beta-G-10
Short name:
PSBG-10
Short name:
Pregnancy-specific glycoprotein 10
Pregnancy-specific beta-1-glycoprotein 12
Short name:
PS-beta-G-12
Short name:
PSBG-12
Short name:
Pregnancy-specific glycoprotein 12
Gene namesi
Name:PSG6
Synonyms:CGM3, PSG10, PSG12, PSGGB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9523. PSG6.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5675.
OpenTargetsiENSG00000170848.
PharmGKBiPA33868.

Polymorphism and mutation databases

BioMutaiPSG6.
DMDMi1709853.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001491335 – 435Pregnancy-specific beta-1-glycoprotein 6Add BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi168 ↔ 216Curated
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi261 ↔ 309Curated
Glycosylationi267N-linked (GlcNAc...)Sequence analysis1
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi353 ↔ 393Curated
Glycosylationi386N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ00889.
PeptideAtlasiQ00889.
PRIDEiQ00889.

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiENSG00000170848.
CleanExiHS_PSG6.
ExpressionAtlasiQ00889. baseline and differential.
GenevisibleiQ00889. HS.

Organism-specific databases

HPAiHPA046327.

Interactioni

Protein-protein interaction databases

BioGridi111650. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ00889.
SMRiQ00889.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 143Ig-like V-typeAdd BLAST109
Domaini148 – 233Ig-like C2-type 1Add BLAST86
Domaini241 – 326Ig-like C2-type 2Add BLAST86
Domaini334 – 405Ig-like C2-type 3Add BLAST72

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi126 – 128Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ00889.
KOiK06500.
OMAiTINGMFL.
OrthoDBiEOG091G0AMM.
PhylomeDBiQ00889.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q00889-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLSAPPCT QHITWKGLLL TASLLNFWNL PTTAQVIIEA KPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGYIWYKG QMTDLYHYIT SYVVHGQIIY GPAYSGRETV
110 120 130 140 150
YSNASLLIQN VTQEDAGSYT LHIIKRGDGT GGVTGYFTVT LYSETPKPSI
160 170 180 190 200
SSSNLNPREV MEAVRLICDP ETPDASYLWL LNGQNLPMTH RLQLSKTNRT
210 220 230 240 250
LYLFGVTKYI AGPYECEIRN PVSASRSDPV TLNLLPKLPM PYITINNLNP
260 270 280 290 300
REKKDVLAFT CEPKSRNYTY IWWLNGQSLP VSPRVKRPIE NRILILPSVT
310 320 330 340 350
RNETGPYQCE IRDRYGGIRS NPVTLNVLYG PDLPRIYPSF TYYRSGENLD
360 370 380 390 400
LSCFADSNPP AEYSWTINGK FQLSGQKLFI PQITTNHSGL YACSVRNSAT
410 420 430
GKEISKSMIV KVSETASPQV TYAGPNTWFQ EILLL
Length:435
Mass (Da):48,814
Last modified:October 1, 1996 - v1
Checksum:iD94D4B0884327C60
GO
Isoform 2 (identifier: Q00889-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     414-435: ETASPQVTYAGPNTWFQEILLL → GPCHGNQTESH

Show »
Length:424
Mass (Da):47,501
Checksum:i6ECB345E53CCDEA4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41K → Q in CAA34957 (PubMed:2271648).Curated1
Sequence conflicti148P → R in CAA34957 (PubMed:2271648).Curated1
Sequence conflicti220 – 221NP → RG in CAA34957 (PubMed:2271648).Curated2
Sequence conflicti339S → Y in CAA34957 (PubMed:2271648).Curated1
Sequence conflicti364S → F in AAA36512 (PubMed:2346748).Curated1
Sequence conflicti364S → F in CAA34957 (PubMed:2271648).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04992285H → D.2 PublicationsCorresponds to variant rs3198831dbSNPEnsembl.1
Natural variantiVAR_011723155L → F.Corresponds to variant rs1058674dbSNPEnsembl.1
Natural variantiVAR_049923161M → T.Corresponds to variant rs1058679dbSNPEnsembl.1
Natural variantiVAR_011724165R → L.Corresponds to variant rs1058680dbSNPEnsembl.1
Natural variantiVAR_011725167I → T.Corresponds to variant rs1065505dbSNPEnsembl.1
Natural variantiVAR_011726180L → W.Corresponds to variant rs1065507dbSNPEnsembl.1
Natural variantiVAR_011727181L → M.Corresponds to variant rs1065508dbSNPEnsembl.1
Natural variantiVAR_011728185N → S.Corresponds to variant rs1065509dbSNPEnsembl.1
Natural variantiVAR_061324188M → R.Corresponds to variant rs59587483dbSNPEnsembl.1
Natural variantiVAR_011729191R → S.Corresponds to variant rs1058688dbSNPEnsembl.1
Natural variantiVAR_011730196K → E.Corresponds to variant rs1065511dbSNPEnsembl.1
Natural variantiVAR_011731253K → N.Corresponds to variant rs1065513dbSNPEnsembl.1
Natural variantiVAR_011732257L → S.Corresponds to variant rs1058710dbSNPEnsembl.1
Natural variantiVAR_011733258A → T.Corresponds to variant rs1065515dbSNPEnsembl.1
Natural variantiVAR_011735404I → S.Corresponds to variant rs1065525dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039344414 – 435ETASP…EILLL → GPCHGNQTESH in isoform 2. 3 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33666 mRNA. Translation: AAA60206.1.
M31125 mRNA. Translation: AAA36512.1.
X17098 mRNA. Translation: CAA34957.1.
AC005260 Genomic DNA. Translation: AAC25619.1.
AC005260 Genomic DNA. Translation: AAC25620.1.
BC020652 mRNA. Translation: AAH20652.1.
M32621, M32620 Genomic DNA. Translation: AAA60201.1.
AH007627 Genomic DNA. Translation: AAD28501.1.
AH002953 Genomic DNA. Translation: AAA60202.1.
CCDSiCCDS12613.1. [Q00889-1]
CCDS33038.1. [Q00889-2]
PIRiD33258.
RefSeqiNP_001027020.1. NM_001031850.3. [Q00889-2]
NP_002773.1. NM_002782.4. [Q00889-1]
UniGeneiHs.646353.

Genome annotation databases

EnsembliENST00000187910; ENSP00000187910; ENSG00000170848. [Q00889-2]
ENST00000292125; ENSP00000292125; ENSG00000170848. [Q00889-1]
GeneIDi5675.
KEGGihsa:5675.
UCSCiuc002ovg.3. human. [Q00889-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33666 mRNA. Translation: AAA60206.1.
M31125 mRNA. Translation: AAA36512.1.
X17098 mRNA. Translation: CAA34957.1.
AC005260 Genomic DNA. Translation: AAC25619.1.
AC005260 Genomic DNA. Translation: AAC25620.1.
BC020652 mRNA. Translation: AAH20652.1.
M32621, M32620 Genomic DNA. Translation: AAA60201.1.
AH007627 Genomic DNA. Translation: AAD28501.1.
AH002953 Genomic DNA. Translation: AAA60202.1.
CCDSiCCDS12613.1. [Q00889-1]
CCDS33038.1. [Q00889-2]
PIRiD33258.
RefSeqiNP_001027020.1. NM_001031850.3. [Q00889-2]
NP_002773.1. NM_002782.4. [Q00889-1]
UniGeneiHs.646353.

3D structure databases

ProteinModelPortaliQ00889.
SMRiQ00889.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111650. 1 interactor.

Polymorphism and mutation databases

BioMutaiPSG6.
DMDMi1709853.

Proteomic databases

PaxDbiQ00889.
PeptideAtlasiQ00889.
PRIDEiQ00889.

Protocols and materials databases

DNASUi5675.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000187910; ENSP00000187910; ENSG00000170848. [Q00889-2]
ENST00000292125; ENSP00000292125; ENSG00000170848. [Q00889-1]
GeneIDi5675.
KEGGihsa:5675.
UCSCiuc002ovg.3. human. [Q00889-1]

Organism-specific databases

CTDi5675.
DisGeNETi5675.
GeneCardsiPSG6.
HGNCiHGNC:9523. PSG6.
HPAiHPA046327.
MIMi176395. gene.
176399. gene.
neXtProtiNX_Q00889.
OpenTargetsiENSG00000170848.
PharmGKBiPA33868.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ00889.
KOiK06500.
OMAiTINGMFL.
OrthoDBiEOG091G0AMM.
PhylomeDBiQ00889.
TreeFamiTF336859.

Miscellaneous databases

ChiTaRSiPSG6. human.
GeneWikiiPSG6.
GenomeRNAii5675.
PROiQ00889.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170848.
CleanExiHS_PSG6.
ExpressionAtlasiQ00889. baseline and differential.
GenevisibleiQ00889. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSG6_HUMAN
AccessioniPrimary (citable) accession number: Q00889
Secondary accession number(s): O75244
, Q15224, Q15235, Q549K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.