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Protein

Pregnancy-specific beta-1-glycoprotein 6

Gene

PSG6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • female pregnancy Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 6
Short name:
PS-beta-G-6
Short name:
PSBG-6
Short name:
Pregnancy-specific glycoprotein 6
Alternative name(s):
Pregnancy-specific beta-1-glycoprotein 10
Short name:
PS-beta-G-10
Short name:
PSBG-10
Short name:
Pregnancy-specific glycoprotein 10
Pregnancy-specific beta-1-glycoprotein 12
Short name:
PS-beta-G-12
Short name:
PSBG-12
Short name:
Pregnancy-specific glycoprotein 12
Gene namesi
Name:PSG6
Synonyms:CGM3, PSG10, PSG12, PSGGB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9523. PSG6.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33868.

Polymorphism and mutation databases

BioMutaiPSG6.
DMDMi1709853.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence analysisAdd
BLAST
Chaini35 – 435401Pregnancy-specific beta-1-glycoprotein 6PRO_0000014913Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence analysis
Disulfide bondi168 ↔ 216Curated
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence analysis
Disulfide bondi261 ↔ 309Curated
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence analysis
Disulfide bondi353 ↔ 393Curated
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ00889.
PeptideAtlasiQ00889.
PRIDEiQ00889.

PTM databases

PhosphoSiteiQ00889.

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiENSG00000170848.
CleanExiHS_PSG6.
ExpressionAtlasiQ00889. baseline and differential.
GenevisibleiQ00889. HS.

Organism-specific databases

HPAiHPA046327.

Interactioni

Protein-protein interaction databases

BioGridi111650. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ00889.
SMRiQ00889. Positions 33-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 143109Ig-like V-typeAdd
BLAST
Domaini148 – 23386Ig-like C2-type 1Add
BLAST
Domaini241 – 32686Ig-like C2-type 2Add
BLAST
Domaini334 – 40572Ig-like C2-type 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi126 – 1283Cell attachment siteSequence analysis

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ00889.
KOiK06500.
OMAiTINGMFL.
OrthoDBiEOG091G0AMM.
PhylomeDBiQ00889.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q00889-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLSAPPCT QHITWKGLLL TASLLNFWNL PTTAQVIIEA KPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGYIWYKG QMTDLYHYIT SYVVHGQIIY GPAYSGRETV
110 120 130 140 150
YSNASLLIQN VTQEDAGSYT LHIIKRGDGT GGVTGYFTVT LYSETPKPSI
160 170 180 190 200
SSSNLNPREV MEAVRLICDP ETPDASYLWL LNGQNLPMTH RLQLSKTNRT
210 220 230 240 250
LYLFGVTKYI AGPYECEIRN PVSASRSDPV TLNLLPKLPM PYITINNLNP
260 270 280 290 300
REKKDVLAFT CEPKSRNYTY IWWLNGQSLP VSPRVKRPIE NRILILPSVT
310 320 330 340 350
RNETGPYQCE IRDRYGGIRS NPVTLNVLYG PDLPRIYPSF TYYRSGENLD
360 370 380 390 400
LSCFADSNPP AEYSWTINGK FQLSGQKLFI PQITTNHSGL YACSVRNSAT
410 420 430
GKEISKSMIV KVSETASPQV TYAGPNTWFQ EILLL
Length:435
Mass (Da):48,814
Last modified:October 1, 1996 - v1
Checksum:iD94D4B0884327C60
GO
Isoform 2 (identifier: Q00889-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     414-435: ETASPQVTYAGPNTWFQEILLL → GPCHGNQTESH

Show »
Length:424
Mass (Da):47,501
Checksum:i6ECB345E53CCDEA4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411K → Q in CAA34957 (PubMed:2271648).Curated
Sequence conflicti148 – 1481P → R in CAA34957 (PubMed:2271648).Curated
Sequence conflicti220 – 2212NP → RG in CAA34957 (PubMed:2271648).Curated
Sequence conflicti339 – 3391S → Y in CAA34957 (PubMed:2271648).Curated
Sequence conflicti364 – 3641S → F in AAA36512 (PubMed:2346748).Curated
Sequence conflicti364 – 3641S → F in CAA34957 (PubMed:2271648).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851H → D.2 Publications
Corresponds to variant rs3198831 [ dbSNP | Ensembl ].
VAR_049922
Natural varianti155 – 1551L → F.
Corresponds to variant rs1058674 [ dbSNP | Ensembl ].
VAR_011723
Natural varianti161 – 1611M → T.
Corresponds to variant rs1058679 [ dbSNP | Ensembl ].
VAR_049923
Natural varianti165 – 1651R → L.
Corresponds to variant rs1058680 [ dbSNP | Ensembl ].
VAR_011724
Natural varianti167 – 1671I → T.
Corresponds to variant rs1065505 [ dbSNP | Ensembl ].
VAR_011725
Natural varianti180 – 1801L → W.
Corresponds to variant rs1065507 [ dbSNP | Ensembl ].
VAR_011726
Natural varianti181 – 1811L → M.
Corresponds to variant rs1065508 [ dbSNP | Ensembl ].
VAR_011727
Natural varianti185 – 1851N → S.
Corresponds to variant rs1065509 [ dbSNP | Ensembl ].
VAR_011728
Natural varianti188 – 1881M → R.
Corresponds to variant rs59587483 [ dbSNP | Ensembl ].
VAR_061324
Natural varianti191 – 1911R → S.
Corresponds to variant rs1058688 [ dbSNP | Ensembl ].
VAR_011729
Natural varianti196 – 1961K → E.
Corresponds to variant rs1065511 [ dbSNP | Ensembl ].
VAR_011730
Natural varianti253 – 2531K → N.
Corresponds to variant rs1065513 [ dbSNP | Ensembl ].
VAR_011731
Natural varianti257 – 2571L → S.
Corresponds to variant rs1058710 [ dbSNP | Ensembl ].
VAR_011732
Natural varianti258 – 2581A → T.
Corresponds to variant rs1065515 [ dbSNP | Ensembl ].
VAR_011733
Natural varianti404 – 4041I → S.
Corresponds to variant rs1065525 [ dbSNP | Ensembl ].
VAR_011735

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei414 – 43522ETASP…EILLL → GPCHGNQTESH in isoform 2. 3 PublicationsVSP_039344Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33666 mRNA. Translation: AAA60206.1.
M31125 mRNA. Translation: AAA36512.1.
X17098 mRNA. Translation: CAA34957.1.
AC005260 Genomic DNA. Translation: AAC25619.1.
AC005260 Genomic DNA. Translation: AAC25620.1.
BC020652 mRNA. Translation: AAH20652.1.
M32621, M32620 Genomic DNA. Translation: AAA60201.1.
AH007627 Genomic DNA. Translation: AAD28501.1.
AH002953 Genomic DNA. Translation: AAA60202.1.
CCDSiCCDS12613.1. [Q00889-1]
CCDS33038.1. [Q00889-2]
PIRiD33258.
RefSeqiNP_001027020.1. NM_001031850.3. [Q00889-2]
NP_002773.1. NM_002782.4. [Q00889-1]
UniGeneiHs.646353.

Genome annotation databases

EnsembliENST00000187910; ENSP00000187910; ENSG00000170848. [Q00889-2]
ENST00000292125; ENSP00000292125; ENSG00000170848. [Q00889-1]
GeneIDi5675.
KEGGihsa:5675.
UCSCiuc002ovg.3. human. [Q00889-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33666 mRNA. Translation: AAA60206.1.
M31125 mRNA. Translation: AAA36512.1.
X17098 mRNA. Translation: CAA34957.1.
AC005260 Genomic DNA. Translation: AAC25619.1.
AC005260 Genomic DNA. Translation: AAC25620.1.
BC020652 mRNA. Translation: AAH20652.1.
M32621, M32620 Genomic DNA. Translation: AAA60201.1.
AH007627 Genomic DNA. Translation: AAD28501.1.
AH002953 Genomic DNA. Translation: AAA60202.1.
CCDSiCCDS12613.1. [Q00889-1]
CCDS33038.1. [Q00889-2]
PIRiD33258.
RefSeqiNP_001027020.1. NM_001031850.3. [Q00889-2]
NP_002773.1. NM_002782.4. [Q00889-1]
UniGeneiHs.646353.

3D structure databases

ProteinModelPortaliQ00889.
SMRiQ00889. Positions 33-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111650. 1 interaction.

PTM databases

PhosphoSiteiQ00889.

Polymorphism and mutation databases

BioMutaiPSG6.
DMDMi1709853.

Proteomic databases

PaxDbiQ00889.
PeptideAtlasiQ00889.
PRIDEiQ00889.

Protocols and materials databases

DNASUi5675.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000187910; ENSP00000187910; ENSG00000170848. [Q00889-2]
ENST00000292125; ENSP00000292125; ENSG00000170848. [Q00889-1]
GeneIDi5675.
KEGGihsa:5675.
UCSCiuc002ovg.3. human. [Q00889-1]

Organism-specific databases

CTDi5675.
GeneCardsiPSG6.
HGNCiHGNC:9523. PSG6.
HPAiHPA046327.
MIMi176395. gene.
176399. gene.
neXtProtiNX_Q00889.
PharmGKBiPA33868.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ00889.
KOiK06500.
OMAiTINGMFL.
OrthoDBiEOG091G0AMM.
PhylomeDBiQ00889.
TreeFamiTF336859.

Miscellaneous databases

ChiTaRSiPSG6. human.
GeneWikiiPSG6.
GenomeRNAii5675.
PROiQ00889.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170848.
CleanExiHS_PSG6.
ExpressionAtlasiQ00889. baseline and differential.
GenevisibleiQ00889. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSG6_HUMAN
AccessioniPrimary (citable) accession number: Q00889
Secondary accession number(s): O75244
, Q15224, Q15235, Q549K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.