ID   PSG4_HUMAN              Reviewed;         419 AA.
AC   Q00888; E7EX79; Q13047; Q13048; Q15234; Q15240; Q9UQ76;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 3.
DT   27-MAR-2024, entry version 207.
DE   RecName: Full=Pregnancy-specific beta-1-glycoprotein 4;
DE            Short=PS-beta-G-4;
DE            Short=PSBG-4;
DE            Short=Pregnancy-specific glycoprotein 4;
DE   AltName: Full=Pregnancy-specific beta-1-glycoprotein 9;
DE            Short=PS-beta-G-9;
DE            Short=PSBG-9;
DE            Short=Pregnancy-specific glycoprotein 9;
DE   Flags: Precursor;
GN   Name=PSG4; Synonyms=CGM4, PSG9;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), AND VARIANT HIS-11.
RX   PubMed=1690992; DOI=10.1016/0006-291x(90)92103-7;
RA   Thompson J., Koumari R., Wagner K., Barnert S., Schleussner C., Schrewe H.,
RA   Zimmermann W., Mueller G., Schempp W., Zaninetta D., Ammaturo D.,
RA   Hardman N.;
RT   "The human pregnancy-specific glycoprotein genes are tightly linked on the
RT   long arm of chromosome 19 and are coordinately expressed.";
RL   Biochem. Biophys. Res. Commun. 167:848-859(1990).
RN   [2]
RP   ERRATUM OF PUBMED:1690992.
RX   PubMed=2346490;
RA   Thompson J., Koumari R., Wagner K., Barnert S., Schleussner C., Schrewe H.,
RA   Zimmermann W., Mueller G., Schempp W., Zaninetta D., Ammaturo D.,
RA   Hardman N.;
RL   Biochem. Biophys. Res. Commun. 168:1325-1325(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS HIS-11; VAL-75 AND
RP   GLU-267.
RC   TISSUE=Bone marrow;
RX   PubMed=2271648; DOI=10.1021/bi00496a009;
RA   Barnett T.R., Pickle W. II, Elting J.J.;
RT   "Characterization of two new members of the pregnancy-specific beta 1-
RT   glycoprotein family from the myeloid cell line KG-1 and suggestion of two
RT   distinct classes of transcription unit.";
RL   Biochemistry 29:10213-10218(1990).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS HIS-11; VAL-75 AND
RP   GLU-267.
RX   PubMed=1922019; DOI=10.1007/bf00230182;
RA   Chan W.Y., Zheng Q.X., McMahon J., Tease L.A.;
RT   "Characterization of new members of the pregnancy-specific beta 1-
RT   glycoprotein family.";
RL   Mol. Cell. Biochem. 106:161-170(1991).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANTS HIS-11; VAL-75
RP   AND GLU-267.
RC   TISSUE=Fetal liver;
RX   PubMed=7794280; DOI=10.1006/bbrc.1995.1862;
RA   Teglund S., Zhou G.Q., Hammarstroem S.;
RT   "Characterization of cDNA encoding novel pregnancy-specific glycoprotein
RT   variants.";
RL   Biochem. Biophys. Res. Commun. 211:656-664(1995).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 210-419 (ISOFORM 1), AND VARIANT GLU-267.
RC   TISSUE=Fetal liver;
RX   PubMed=2783133; DOI=10.1016/0006-291x(89)91105-4;
RA   Zimmermann W.A., Weiss M., Thompson J.A.;
RT   "cDNA cloning demonstrates the expression of pregnancy-specific
RT   glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family,
RT   in fetal liver.";
RL   Biochem. Biophys. Res. Commun. 163:1197-1209(1989).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-143.
RX   PubMed=3180995; DOI=10.1089/dna.1.1988.7.545;
RA   Chan W.-Y., Borjigin J., Zheng Q.-X., Shupert W.L.;
RT   "Characterization of cDNA encoding human pregnancy-specific beta 1-
RT   glycoprotein from placenta and extraplacental tissues and their comparison
RT   with carcinoembryonic antigen.";
RL   DNA 7:545-555(1988).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-43.
RA   Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.;
RT   "Characterization of upstream promotor region, exon 1 and exon 2 of the PSG
RT   gene family.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q00888-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q00888-2; Sequence=VSP_007875, VSP_040131;
CC       Name=3;
CC         IsoId=Q00888-3; Sequence=VSP_055025;
CC   -!- DEVELOPMENTAL STAGE: PSBG are produced in high quantity during
CC       pregnancy.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA60208.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
CC       Sequence=M32625; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; M32622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M32623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M32624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M32625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M32626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M32627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; X17097; CAA34956.1; -; mRNA.
DR   EMBL; M94891; AAA60195.1; -; mRNA.
DR   EMBL; U18468; AAA75294.1; -; mRNA.
DR   EMBL; U18469; AAA75295.1; -; mRNA.
DR   EMBL; AC005392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M33665; AAA60208.1; ALT_SEQ; mRNA.
DR   EMBL; AH007625; AAD28499.1; -; Genomic_DNA.
DR   CCDS; CCDS33039.1; -. [Q00888-2]
DR   CCDS; CCDS46093.1; -. [Q00888-1]
DR   CCDS; CCDS62695.1; -. [Q00888-3]
DR   PIR; A36109; A36109.
DR   PIR; B54312; B54312.
DR   PIR; C33258; C33258.
DR   PIR; JC4124; JC4124.
DR   RefSeq; NP_002771.2; NM_002780.4. [Q00888-1]
DR   RefSeq; NP_998798.1; NM_213633.2. [Q00888-2]
DR   AlphaFoldDB; Q00888; -.
DR   SMR; Q00888; -.
DR   BioGRID; 111647; 6.
DR   IntAct; Q00888; 5.
DR   STRING; 9606.ENSP00000384770; -.
DR   GlyCosmos; Q00888; 6 sites, No reported glycans.
DR   GlyGen; Q00888; 6 sites.
DR   iPTMnet; Q00888; -.
DR   PhosphoSitePlus; Q00888; -.
DR   BioMuta; PSG4; -.
DR   DMDM; 313104197; -.
DR   jPOST; Q00888; -.
DR   MassIVE; Q00888; -.
DR   MaxQB; Q00888; -.
DR   PaxDb; 9606-ENSP00000384770; -.
DR   PeptideAtlas; Q00888; -.
DR   ProteomicsDB; 19001; -.
DR   ProteomicsDB; 57880; -. [Q00888-1]
DR   ProteomicsDB; 57881; -. [Q00888-2]
DR   Antibodypedia; 35053; 103 antibodies from 21 providers.
DR   DNASU; 5672; -.
DR   Ensembl; ENST00000244295.13; ENSP00000244295.8; ENSG00000243137.8. [Q00888-2]
DR   Ensembl; ENST00000405312.8; ENSP00000384770.3; ENSG00000243137.8. [Q00888-1]
DR   Ensembl; ENST00000433626.6; ENSP00000387864.2; ENSG00000243137.8. [Q00888-3]
DR   GeneID; 5672; -.
DR   KEGG; hsa:5672; -.
DR   MANE-Select; ENST00000405312.8; ENSP00000384770.3; NM_002780.5; NP_002771.2.
DR   UCSC; uc002ovy.4; human. [Q00888-1]
DR   AGR; HGNC:9521; -.
DR   CTD; 5672; -.
DR   DisGeNET; 5672; -.
DR   GeneCards; PSG4; -.
DR   HGNC; HGNC:9521; PSG4.
DR   HPA; ENSG00000243137; Group enriched (parathyroid gland, placenta).
DR   MIM; 176393; gene.
DR   neXtProt; NX_Q00888; -.
DR   OpenTargets; ENSG00000243137; -.
DR   PharmGKB; PA33866; -.
DR   VEuPathDB; HostDB:ENSG00000243137; -.
DR   eggNOG; ENOG502RXPD; Eukaryota.
DR   GeneTree; ENSGT01100000263479; -.
DR   InParanoid; Q00888; -.
DR   OMA; LEIWIMG; -.
DR   OrthoDB; 3033616at2759; -.
DR   PhylomeDB; Q00888; -.
DR   TreeFam; TF336859; -.
DR   PathwayCommons; Q00888; -.
DR   Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR   SignaLink; Q00888; -.
DR   BioGRID-ORCS; 5672; 20 hits in 1091 CRISPR screens.
DR   ChiTaRS; PSG4; human.
DR   GeneWiki; PSG4; -.
DR   GenomeRNAi; 5672; -.
DR   Pharos; Q00888; Tbio.
DR   PRO; PR:Q00888; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q00888; Protein.
DR   Bgee; ENSG00000243137; Expressed in placenta and 93 other cell types or tissues.
DR   ExpressionAtlas; Q00888; baseline and differential.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:1990782; F:protein tyrosine kinase binding; IBA:GO_Central.
DR   GO; GO:0007565; P:female pregnancy; TAS:UniProtKB.
DR   GO; GO:0002682; P:regulation of immune system process; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd20948; IgC2_CEACAM5-like; 1.
DR   CDD; cd05740; IgI_hCEACAM_2_4_6_like; 2.
DR   CDD; cd05774; IgV_CEACAM_D1; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR44427; CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19; 1.
DR   PANTHER; PTHR44427:SF17; PREGNANCY-SPECIFIC BETA-1-GLYCOPROTEIN 4-RELATED; 1.
DR   Pfam; PF13895; Ig_2; 1.
DR   Pfam; PF13927; Ig_3; 2.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 3.
DR   SUPFAM; SSF48726; Immunoglobulin; 4.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   Genevisible; Q00888; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000255"
FT   CHAIN           35..419
FT                   /note="Pregnancy-specific beta-1-glycoprotein 4"
FT                   /id="PRO_0000014911"
FT   DOMAIN          35..144
FT                   /note="Ig-like V-type"
FT   DOMAIN          147..234
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          237..327
FT                   /note="Ig-like C2-type 2"
FT   DOMAIN          332..410
FT                   /note="Ig-like C2-type 3"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        111
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        199
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        268
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        299
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        303
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        169..217
FT                   /evidence="ECO:0000305"
FT   DISULFID        262..310
FT                   /evidence="ECO:0000305"
FT   DISULFID        354..394
FT                   /evidence="ECO:0000305"
FT   VAR_SEQ         144..236
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_055025"
FT   VAR_SEQ         237..329
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:7794280"
FT                   /id="VSP_007875"
FT   VAR_SEQ         330
FT                   /note="Y -> H (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:7794280"
FT                   /id="VSP_040131"
FT   VARIANT         11
FT                   /note="Q -> H (in dbSNP:rs11883278)"
FT                   /evidence="ECO:0000269|PubMed:1690992,
FT                   ECO:0000269|PubMed:1922019, ECO:0000269|PubMed:2271648,
FT                   ECO:0000269|PubMed:7794280"
FT                   /id="VAR_060362"
FT   VARIANT         75
FT                   /note="L -> V (in dbSNP:rs3170216)"
FT                   /evidence="ECO:0000269|PubMed:1922019,
FT                   ECO:0000269|PubMed:2271648, ECO:0000269|PubMed:7794280"
FT                   /id="VAR_016040"
FT   VARIANT         177
FT                   /note="S -> R (in dbSNP:rs73548061)"
FT                   /id="VAR_060363"
FT   VARIANT         240
FT                   /note="S -> P (in dbSNP:rs3859474)"
FT                   /id="VAR_056073"
FT   VARIANT         267
FT                   /note="K -> E (in dbSNP:rs1058718)"
FT                   /evidence="ECO:0000269|PubMed:1922019,
FT                   ECO:0000269|PubMed:2271648, ECO:0000269|PubMed:2783133,
FT                   ECO:0000269|PubMed:7794280"
FT                   /id="VAR_060364"
FT   VARIANT         286
FT                   /note="V -> A (in dbSNP:rs2355442)"
FT                   /id="VAR_056074"
FT   CONFLICT        12
FT                   /note="R -> L (in Ref. 1; M32622, 3; CAA34956, 4; AAA60195
FT                   and 5; AAA75294/AAA75295)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        18
FT                   /note="V -> L (in Ref. 4; AAA60195)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        175
FT                   /note="A -> P (in Ref. 1; M32624)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        352
FT                   /note="L -> F (in Ref. 3; CAA34956)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        356
FT                   /note="A -> G (in Ref. 3; CAA34956)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   419 AA;  47113 MW;  576BFB4CBA502CC2 CRC64;
     MGPLSAPPCT QRITWKGVLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ
     NLAGYIWYKG QMTYLYHYIT SYVVDGQRII YGPAYSGRER VYSNASLLIQ NVTQEDAGSY
     TLHIIKRRDG TGGVTGHFTF TLHLETPKPS ISSSNLNPRE AMEAVILTCD PATPAASYQW
     WMNGQSLPMT HRLQLSKTNR TLFIFGVTKY IAGPYECEIR NPVSASRSDP VTLNLLPKLS
     KPYITINNLN PRENKDVLTF TCEPKSKNYT YIWWLNGQSL PVSPRVKRPI ENRILILPNV
     TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPSIYPS FTYYRSGENL YLSCFAESNP
     RAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA TGKESSKSIT VKVSDWILP
//