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Q00888 (PSG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 137. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pregnancy-specific beta-1-glycoprotein 4

Short name=PS-beta-G-4
Short name=PSBG-4
Short name=Pregnancy-specific glycoprotein 4
Alternative name(s):
Pregnancy-specific beta-1-glycoprotein 9
Short name=PS-beta-G-9
Short name=PSBG-9
Short name=Pregnancy-specific glycoprotein 9
Gene names
Name:PSG4
Synonyms:CGM4, PSG9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Developmental stage

PSBG are produced in high quantity during pregnancy.

Sequence similarities

Belongs to the immunoglobulin superfamily. CEA family.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence caution

The sequence AAA60208.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

The sequence M32625 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainImmunoglobulin domain
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfemale pregnancy

Traceable author statement Ref.5. Source: UniProtKB

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q00888-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q00888-2)

The sequence of this isoform differs from the canonical sequence as follows:
     237-329: Missing.
     330-330: Y → H

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 419385Pregnancy-specific beta-1-glycoprotein 4
PRO_0000014911

Regions

Domain35 – 144110Ig-like V-type
Domain147 – 23488Ig-like C2-type 1
Domain237 – 32791Ig-like C2-type 2
Domain332 – 41079Ig-like C2-type 3

Amino acid modifications

Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation2681N-linked (GlcNAc...) Potential
Glycosylation2991N-linked (GlcNAc...) Potential
Glycosylation3031N-linked (GlcNAc...) Potential
Disulfide bond169 ↔ 217 Probable
Disulfide bond262 ↔ 310 Probable
Disulfide bond354 ↔ 394 Probable

Natural variations

Alternative sequence237 – 32993Missing in isoform 2.
VSP_007875
Alternative sequence3301Y → H in isoform 2.
VSP_040131
Natural variant111Q → H. Ref.1 Ref.3 Ref.4 Ref.5
Corresponds to variant rs11883278 [ dbSNP | Ensembl ].
VAR_060362
Natural variant751L → V. Ref.3 Ref.4 Ref.5
Corresponds to variant rs3170216 [ dbSNP | Ensembl ].
VAR_016040
Natural variant1771S → R.
Corresponds to variant rs73548061 [ dbSNP | Ensembl ].
VAR_060363
Natural variant2401S → P.
Corresponds to variant rs3859474 [ dbSNP | Ensembl ].
VAR_056073
Natural variant2671K → E. Ref.3 Ref.4 Ref.5 Ref.7
Corresponds to variant rs1058718 [ dbSNP | Ensembl ].
VAR_060364
Natural variant2861V → A.
Corresponds to variant rs2355442 [ dbSNP | Ensembl ].
VAR_056074

Experimental info

Sequence conflict121R → L in M32622. Ref.1
Sequence conflict121R → L in CAA34956. Ref.3
Sequence conflict121R → L in AAA60195. Ref.4
Sequence conflict121R → L in AAA75294. Ref.5
Sequence conflict121R → L in AAA75295. Ref.5
Sequence conflict181V → L in AAA60195. Ref.4
Sequence conflict1751A → P in M32624. Ref.1
Sequence conflict3521L → F in CAA34956. Ref.3
Sequence conflict3561A → G in CAA34956. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 30, 2010. Version 3.
Checksum: 576BFB4CBA502CC2

FASTA41947,113
        10         20         30         40         50         60 
MGPLSAPPCT QRITWKGVLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ 

        70         80         90        100        110        120 
NLAGYIWYKG QMTYLYHYIT SYVVDGQRII YGPAYSGRER VYSNASLLIQ NVTQEDAGSY 

       130        140        150        160        170        180 
TLHIIKRRDG TGGVTGHFTF TLHLETPKPS ISSSNLNPRE AMEAVILTCD PATPAASYQW 

       190        200        210        220        230        240 
WMNGQSLPMT HRLQLSKTNR TLFIFGVTKY IAGPYECEIR NPVSASRSDP VTLNLLPKLS 

       250        260        270        280        290        300 
KPYITINNLN PRENKDVLTF TCEPKSKNYT YIWWLNGQSL PVSPRVKRPI ENRILILPNV 

       310        320        330        340        350        360 
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPSIYPS FTYYRSGENL YLSCFAESNP 

       370        380        390        400        410 
RAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA TGKESSKSIT VKVSDWILP 

« Hide

Isoform 2 [UniParc].

Checksum: 6182CE9AC921FB54
Show »

FASTA32636,277

References

« Hide 'large scale' references
[1]"The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed."
Thompson J., Koumari R., Wagner K., Barnert S., Schleussner C., Schrewe H., Zimmermann W., Mueller G., Schempp W., Zaninetta D., Ammaturo D., Hardman N.
Biochem. Biophys. Res. Commun. 167:848-859(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT HIS-11.
[2]Erratum
Thompson J., Koumari R., Wagner K., Barnert S., Schleussner C., Schrewe H., Zimmermann W., Mueller G., Schempp W., Zaninetta D., Ammaturo D., Hardman N.
Biochem. Biophys. Res. Commun. 168:1325-1325(1990) [PubMed] [Europe PMC] [Abstract]
[3]"Characterization of two new members of the pregnancy-specific beta 1-glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit."
Barnett T.R., Pickle W. II, Elting J.J.
Biochemistry 29:10213-10218(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS HIS-11; VAL-75 AND GLU-267.
Tissue: Bone marrow.
[4]"Characterization of new members of the pregnancy-specific beta 1-glycoprotein family."
Chan W.Y., Zheng Q.X., McMahon J., Tease L.A.
Mol. Cell. Biochem. 106:161-170(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS HIS-11; VAL-75 AND GLU-267.
[5]"Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants."
Teglund S., Zhou G.Q., Hammarstroem S.
Biochem. Biophys. Res. Commun. 211:656-664(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS HIS-11; VAL-75 AND GLU-267.
Tissue: Fetal liver.
[6]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver."
Zimmermann W.A., Weiss M., Thompson J.A.
Biochem. Biophys. Res. Commun. 163:1197-1209(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 210-419 (ISOFORM 1), VARIANT GLU-267.
Tissue: Fetal liver.
[8]"Characterization of cDNA encoding human pregnancy-specific beta 1-glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen."
Chan W.-Y., Borjigin J., Zheng Q.-X., Shupert W.L.
DNA 7:545-555(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-143.
[9]"Characterization of upstream promotor region, exon 1 and exon 2 of the PSG gene family."
Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-43.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M32622 Genomic DNA. No translation available.
M32623 Genomic DNA. No translation available.
M32624 Genomic DNA. No translation available.
M32625 Genomic DNA. No translation available.
M32626 Genomic DNA. No translation available.
M32627 Genomic DNA. No translation available.
X17097 mRNA. Translation: CAA34956.1.
M94891 mRNA. Translation: AAA60195.1.
U18468 mRNA. Translation: AAA75294.1.
U18469 mRNA. Translation: AAA75295.1.
AC005392 Genomic DNA. No translation available.
M33665 mRNA. Translation: AAA60208.1. Sequence problems.
AH007625 Genomic DNA. Translation: AAD28499.1.
PIRA36109.
B54312.
C33258.
JC4124.
RefSeqNP_002771.2. NM_002780.4.
NP_998798.1. NM_213633.2.
UniGeneHs.711363.

3D structure databases

ProteinModelPortalQ00888.
SMRQ00888. Positions 34-412.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000384770.

PTM databases

PhosphoSiteQ00888.

Polymorphism databases

DMDM313104197.

Proteomic databases

PaxDbQ00888.
PRIDEQ00888.

Protocols and materials databases

DNASU5672.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000244295; ENSP00000244295; ENSG00000243137. [Q00888-2]
ENST00000405312; ENSP00000384770; ENSG00000243137. [Q00888-1]
GeneID5672.
KEGGhsa:5672.
UCSCuc002ovy.4. human. [Q00888-1]
uc002ovz.4. human. [Q00888-2]

Organism-specific databases

CTD5672.
GeneCardsGC19M043696.
H-InvDBHIX0137523.
HGNCHGNC:9521. PSG4.
HPAHPA046327.
MIM176393. gene.
neXtProtNX_Q00888.
PharmGKBPA33866.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG145000.
HOGENOMHOG000233417.
HOVERGENHBG007922.
InParanoidQ00888.
KOK06500.
OMAVSDWILP.
OrthoDBEOG79CZ37.
PhylomeDBQ00888.
TreeFamTF336859.

Gene expression databases

ArrayExpressQ00888.
BgeeQ00888.
CleanExHS_PSG9.
GenevestigatorQ00888.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPSG4.
GenomeRNAi5672.
NextBio22028.
PROQ00888.
SOURCESearch...

Entry information

Entry namePSG4_HUMAN
AccessionPrimary (citable) accession number: Q00888
Secondary accession number(s): Q13047 expand/collapse secondary AC list , Q13048, Q15234, Q15240, Q9UQ76
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM