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Protein

Pregnancy-specific beta-1-glycoprotein 4

Gene

PSG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • female pregnancy Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 4
Short name:
PS-beta-G-4
Short name:
PSBG-4
Short name:
Pregnancy-specific glycoprotein 4
Alternative name(s):
Pregnancy-specific beta-1-glycoprotein 9
Short name:
PS-beta-G-9
Short name:
PSBG-9
Short name:
Pregnancy-specific glycoprotein 9
Gene namesi
Name:PSG4
Synonyms:CGM4, PSG9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9521. PSG4.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000243137.
PharmGKBiPA33866.

Polymorphism and mutation databases

DMDMi313104197.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001491135 – 419Pregnancy-specific beta-1-glycoprotein 4Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi169 ↔ 217Curated
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi262 ↔ 310Curated
Glycosylationi268N-linked (GlcNAc...)Sequence analysis1
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi354 ↔ 394Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ00888.
MaxQBiQ00888.
PaxDbiQ00888.
PeptideAtlasiQ00888.
PRIDEiQ00888.

PTM databases

iPTMnetiQ00888.
PhosphoSitePlusiQ00888.

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiENSG00000243137.
CleanExiHS_PSG9.
ExpressionAtlasiQ00888. baseline and differential.
GenevisibleiQ00888. HS.

Organism-specific databases

HPAiHPA046327.

Interactioni

Protein-protein interaction databases

BioGridi111647. 4 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ00888.
SMRiQ00888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-typeAdd BLAST110
Domaini147 – 234Ig-like C2-type 1Add BLAST88
Domaini237 – 327Ig-like C2-type 2Add BLAST91
Domaini332 – 410Ig-like C2-type 3Add BLAST79

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ00888.
KOiK06500.
OMAiVSDWILP.
OrthoDBiEOG091G0AMM.
PhylomeDBiQ00888.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q00888-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLSAPPCT QRITWKGVLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLAGYIWYKG QMTYLYHYIT SYVVDGQRII YGPAYSGRER
110 120 130 140 150
VYSNASLLIQ NVTQEDAGSY TLHIIKRRDG TGGVTGHFTF TLHLETPKPS
160 170 180 190 200
ISSSNLNPRE AMEAVILTCD PATPAASYQW WMNGQSLPMT HRLQLSKTNR
210 220 230 240 250
TLFIFGVTKY IAGPYECEIR NPVSASRSDP VTLNLLPKLS KPYITINNLN
260 270 280 290 300
PRENKDVLTF TCEPKSKNYT YIWWLNGQSL PVSPRVKRPI ENRILILPNV
310 320 330 340 350
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPSIYPS FTYYRSGENL
360 370 380 390 400
YLSCFAESNP RAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA
410
TGKESSKSIT VKVSDWILP
Length:419
Mass (Da):47,113
Last modified:November 30, 2010 - v3
Checksum:i576BFB4CBA502CC2
GO
Isoform 2 (identifier: Q00888-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-329: Missing.
     330-330: Y → H

Show »
Length:326
Mass (Da):36,277
Checksum:i6182CE9AC921FB54
GO
Isoform 3 (identifier: Q00888-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-236: Missing.

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:326
Mass (Da):36,793
Checksum:i286D5D59B2F24DFC
GO

Sequence cautioni

The sequence AAA60208 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence M32625 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12R → L in M32622 (PubMed:1690992).Curated1
Sequence conflicti12R → L in CAA34956 (PubMed:2271648).Curated1
Sequence conflicti12R → L in AAA60195 (PubMed:1922019).Curated1
Sequence conflicti12R → L in AAA75294 (PubMed:7794280).Curated1
Sequence conflicti12R → L in AAA75295 (PubMed:7794280).Curated1
Sequence conflicti18V → L in AAA60195 (PubMed:1922019).Curated1
Sequence conflicti175A → P in M32624 (PubMed:1690992).Curated1
Sequence conflicti352L → F in CAA34956 (PubMed:2271648).Curated1
Sequence conflicti356A → G in CAA34956 (PubMed:2271648).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06036211Q → H.4 PublicationsCorresponds to variant rs11883278dbSNPEnsembl.1
Natural variantiVAR_01604075L → V.3 PublicationsCorresponds to variant rs3170216dbSNPEnsembl.1
Natural variantiVAR_060363177S → R.Corresponds to variant rs73548061dbSNPEnsembl.1
Natural variantiVAR_056073240S → P.Corresponds to variant rs3859474dbSNPEnsembl.1
Natural variantiVAR_060364267K → E.4 PublicationsCorresponds to variant rs1058718dbSNPEnsembl.1
Natural variantiVAR_056074286V → A.Corresponds to variant rs2355442dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055025144 – 236Missing in isoform 3. CuratedAdd BLAST93
Alternative sequenceiVSP_007875237 – 329Missing in isoform 2. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_040131330Y → H in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32622 Genomic DNA. No translation available.
M32623 Genomic DNA. No translation available.
M32624 Genomic DNA. No translation available.
M32625 Genomic DNA. No translation available.
M32626 Genomic DNA. No translation available.
M32627 Genomic DNA. No translation available.
X17097 mRNA. Translation: CAA34956.1.
M94891 mRNA. Translation: AAA60195.1.
U18468 mRNA. Translation: AAA75294.1.
U18469 mRNA. Translation: AAA75295.1.
AC005392 Genomic DNA. No translation available.
M33665 mRNA. Translation: AAA60208.1. Sequence problems.
AH007625 Genomic DNA. Translation: AAD28499.1.
CCDSiCCDS33039.1. [Q00888-2]
CCDS46093.1. [Q00888-1]
CCDS62695.1. [Q00888-3]
PIRiA36109.
B54312.
C33258.
JC4124.
RefSeqiNP_002771.2. NM_002780.4. [Q00888-1]
NP_998798.1. NM_213633.2. [Q00888-2]
UniGeneiHs.711363.

Genome annotation databases

EnsembliENST00000244295; ENSP00000244295; ENSG00000243137. [Q00888-2]
ENST00000405312; ENSP00000384770; ENSG00000243137. [Q00888-1]
ENST00000433626; ENSP00000387864; ENSG00000243137. [Q00888-3]
GeneIDi5672.
KEGGihsa:5672.
UCSCiuc002ovy.4. human. [Q00888-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32622 Genomic DNA. No translation available.
M32623 Genomic DNA. No translation available.
M32624 Genomic DNA. No translation available.
M32625 Genomic DNA. No translation available.
M32626 Genomic DNA. No translation available.
M32627 Genomic DNA. No translation available.
X17097 mRNA. Translation: CAA34956.1.
M94891 mRNA. Translation: AAA60195.1.
U18468 mRNA. Translation: AAA75294.1.
U18469 mRNA. Translation: AAA75295.1.
AC005392 Genomic DNA. No translation available.
M33665 mRNA. Translation: AAA60208.1. Sequence problems.
AH007625 Genomic DNA. Translation: AAD28499.1.
CCDSiCCDS33039.1. [Q00888-2]
CCDS46093.1. [Q00888-1]
CCDS62695.1. [Q00888-3]
PIRiA36109.
B54312.
C33258.
JC4124.
RefSeqiNP_002771.2. NM_002780.4. [Q00888-1]
NP_998798.1. NM_213633.2. [Q00888-2]
UniGeneiHs.711363.

3D structure databases

ProteinModelPortaliQ00888.
SMRiQ00888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111647. 4 interactors.

PTM databases

iPTMnetiQ00888.
PhosphoSitePlusiQ00888.

Polymorphism and mutation databases

DMDMi313104197.

Proteomic databases

EPDiQ00888.
MaxQBiQ00888.
PaxDbiQ00888.
PeptideAtlasiQ00888.
PRIDEiQ00888.

Protocols and materials databases

DNASUi5672.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244295; ENSP00000244295; ENSG00000243137. [Q00888-2]
ENST00000405312; ENSP00000384770; ENSG00000243137. [Q00888-1]
ENST00000433626; ENSP00000387864; ENSG00000243137. [Q00888-3]
GeneIDi5672.
KEGGihsa:5672.
UCSCiuc002ovy.4. human. [Q00888-1]

Organism-specific databases

CTDi5672.
GeneCardsiPSG4.
H-InvDBHIX0137523.
HGNCiHGNC:9521. PSG4.
HPAiHPA046327.
MIMi176393. gene.
neXtProtiNX_Q00888.
OpenTargetsiENSG00000243137.
PharmGKBiPA33866.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ00888.
KOiK06500.
OMAiVSDWILP.
OrthoDBiEOG091G0AMM.
PhylomeDBiQ00888.
TreeFamiTF336859.

Miscellaneous databases

GeneWikiiPSG4.
GenomeRNAii5672.
PROiQ00888.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000243137.
CleanExiHS_PSG9.
ExpressionAtlasiQ00888. baseline and differential.
GenevisibleiQ00888. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSG4_HUMAN
AccessioniPrimary (citable) accession number: Q00888
Secondary accession number(s): E7EX79
, Q13047, Q13048, Q15234, Q15240, Q9UQ76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 159 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.