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Protein

Pregnancy-specific beta-1-glycoprotein 4

Gene

PSG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • female pregnancy Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 4
Short name:
PS-beta-G-4
Short name:
PSBG-4
Short name:
Pregnancy-specific glycoprotein 4
Alternative name(s):
Pregnancy-specific beta-1-glycoprotein 9
Short name:
PS-beta-G-9
Short name:
PSBG-9
Short name:
Pregnancy-specific glycoprotein 9
Gene namesi
Name:PSG4
Synonyms:CGM4, PSG9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9521. PSG4.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33866.

Polymorphism and mutation databases

DMDMi313104197.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 419385Pregnancy-specific beta-1-glycoprotein 4PRO_0000014911Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi169 ↔ 217Curated
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi262 ↔ 310Curated
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi354 ↔ 394Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ00888.
PRIDEiQ00888.

PTM databases

PhosphoSiteiQ00888.

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiQ00888.
CleanExiHS_PSG9.
ExpressionAtlasiQ00888. baseline and differential.
GenevisibleiQ00888. HS.

Organism-specific databases

HPAiHPA046327.

Interactioni

Protein-protein interaction databases

BioGridi111647. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ00888.
SMRiQ00888. Positions 34-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 144110Ig-like V-typeAdd
BLAST
Domaini147 – 23488Ig-like C2-type 1Add
BLAST
Domaini237 – 32791Ig-like C2-type 2Add
BLAST
Domaini332 – 41079Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG145000.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ00888.
KOiK06500.
OMAiVSDWILP.
OrthoDBiEOG79CZ37.
PhylomeDBiQ00888.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q00888-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLSAPPCT QRITWKGVLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLAGYIWYKG QMTYLYHYIT SYVVDGQRII YGPAYSGRER
110 120 130 140 150
VYSNASLLIQ NVTQEDAGSY TLHIIKRRDG TGGVTGHFTF TLHLETPKPS
160 170 180 190 200
ISSSNLNPRE AMEAVILTCD PATPAASYQW WMNGQSLPMT HRLQLSKTNR
210 220 230 240 250
TLFIFGVTKY IAGPYECEIR NPVSASRSDP VTLNLLPKLS KPYITINNLN
260 270 280 290 300
PRENKDVLTF TCEPKSKNYT YIWWLNGQSL PVSPRVKRPI ENRILILPNV
310 320 330 340 350
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPSIYPS FTYYRSGENL
360 370 380 390 400
YLSCFAESNP RAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA
410
TGKESSKSIT VKVSDWILP
Length:419
Mass (Da):47,113
Last modified:November 30, 2010 - v3
Checksum:i576BFB4CBA502CC2
GO
Isoform 2 (identifier: Q00888-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-329: Missing.
     330-330: Y → H

Show »
Length:326
Mass (Da):36,277
Checksum:i6182CE9AC921FB54
GO
Isoform 3 (identifier: Q00888-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-236: Missing.

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:326
Mass (Da):36,793
Checksum:i286D5D59B2F24DFC
GO

Sequence cautioni

The sequence AAA60208.1 differs from that shown.Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence M32625 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121R → L in M32622 (PubMed:1690992).Curated
Sequence conflicti12 – 121R → L in CAA34956 (PubMed:2271648).Curated
Sequence conflicti12 – 121R → L in AAA60195 (PubMed:1922019).Curated
Sequence conflicti12 – 121R → L in AAA75294 (PubMed:7794280).Curated
Sequence conflicti12 – 121R → L in AAA75295 (PubMed:7794280).Curated
Sequence conflicti18 – 181V → L in AAA60195 (PubMed:1922019).Curated
Sequence conflicti175 – 1751A → P in M32624 (PubMed:1690992).Curated
Sequence conflicti352 – 3521L → F in CAA34956 (PubMed:2271648).Curated
Sequence conflicti356 – 3561A → G in CAA34956 (PubMed:2271648).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111Q → H.4 Publications
Corresponds to variant rs11883278 [ dbSNP | Ensembl ].
VAR_060362
Natural varianti75 – 751L → V.3 Publications
Corresponds to variant rs3170216 [ dbSNP | Ensembl ].
VAR_016040
Natural varianti177 – 1771S → R.
Corresponds to variant rs73548061 [ dbSNP | Ensembl ].
VAR_060363
Natural varianti240 – 2401S → P.
Corresponds to variant rs3859474 [ dbSNP | Ensembl ].
VAR_056073
Natural varianti267 – 2671K → E.4 Publications
Corresponds to variant rs1058718 [ dbSNP | Ensembl ].
VAR_060364
Natural varianti286 – 2861V → A.
Corresponds to variant rs2355442 [ dbSNP | Ensembl ].
VAR_056074

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei144 – 23693Missing in isoform 3. CuratedVSP_055025Add
BLAST
Alternative sequencei237 – 32993Missing in isoform 2. 1 PublicationVSP_007875Add
BLAST
Alternative sequencei330 – 3301Y → H in isoform 2. 1 PublicationVSP_040131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32622 Genomic DNA. No translation available.
M32623 Genomic DNA. No translation available.
M32624 Genomic DNA. No translation available.
M32625 Genomic DNA. No translation available.
M32626 Genomic DNA. No translation available.
M32627 Genomic DNA. No translation available.
X17097 mRNA. Translation: CAA34956.1.
M94891 mRNA. Translation: AAA60195.1.
U18468 mRNA. Translation: AAA75294.1.
U18469 mRNA. Translation: AAA75295.1.
AC005392 Genomic DNA. No translation available.
M33665 mRNA. Translation: AAA60208.1. Sequence problems.
AH007625 Genomic DNA. Translation: AAD28499.1.
CCDSiCCDS33039.1. [Q00888-2]
CCDS46093.1. [Q00888-1]
CCDS62695.1. [Q00888-3]
PIRiA36109.
B54312.
C33258.
JC4124.
RefSeqiNP_002771.2. NM_002780.4. [Q00888-1]
NP_998798.1. NM_213633.2. [Q00888-2]
UniGeneiHs.711363.

Genome annotation databases

EnsembliENST00000244295; ENSP00000244295; ENSG00000243137. [Q00888-2]
ENST00000405312; ENSP00000384770; ENSG00000243137. [Q00888-1]
ENST00000433626; ENSP00000387864; ENSG00000243137. [Q00888-3]
GeneIDi5672.
KEGGihsa:5672.
UCSCiuc002ovy.4. human. [Q00888-1]
uc002ovz.4. human. [Q00888-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32622 Genomic DNA. No translation available.
M32623 Genomic DNA. No translation available.
M32624 Genomic DNA. No translation available.
M32625 Genomic DNA. No translation available.
M32626 Genomic DNA. No translation available.
M32627 Genomic DNA. No translation available.
X17097 mRNA. Translation: CAA34956.1.
M94891 mRNA. Translation: AAA60195.1.
U18468 mRNA. Translation: AAA75294.1.
U18469 mRNA. Translation: AAA75295.1.
AC005392 Genomic DNA. No translation available.
M33665 mRNA. Translation: AAA60208.1. Sequence problems.
AH007625 Genomic DNA. Translation: AAD28499.1.
CCDSiCCDS33039.1. [Q00888-2]
CCDS46093.1. [Q00888-1]
CCDS62695.1. [Q00888-3]
PIRiA36109.
B54312.
C33258.
JC4124.
RefSeqiNP_002771.2. NM_002780.4. [Q00888-1]
NP_998798.1. NM_213633.2. [Q00888-2]
UniGeneiHs.711363.

3D structure databases

ProteinModelPortaliQ00888.
SMRiQ00888. Positions 34-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111647. 2 interactions.

PTM databases

PhosphoSiteiQ00888.

Polymorphism and mutation databases

DMDMi313104197.

Proteomic databases

PaxDbiQ00888.
PRIDEiQ00888.

Protocols and materials databases

DNASUi5672.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244295; ENSP00000244295; ENSG00000243137. [Q00888-2]
ENST00000405312; ENSP00000384770; ENSG00000243137. [Q00888-1]
ENST00000433626; ENSP00000387864; ENSG00000243137. [Q00888-3]
GeneIDi5672.
KEGGihsa:5672.
UCSCiuc002ovy.4. human. [Q00888-1]
uc002ovz.4. human. [Q00888-2]

Organism-specific databases

CTDi5672.
GeneCardsiGC19M043696.
H-InvDBHIX0137523.
HGNCiHGNC:9521. PSG4.
HPAiHPA046327.
MIMi176393. gene.
neXtProtiNX_Q00888.
PharmGKBiPA33866.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG145000.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ00888.
KOiK06500.
OMAiVSDWILP.
OrthoDBiEOG79CZ37.
PhylomeDBiQ00888.
TreeFamiTF336859.

Miscellaneous databases

GeneWikiiPSG4.
GenomeRNAii5672.
NextBioi22028.
PROiQ00888.
SOURCEiSearch...

Gene expression databases

BgeeiQ00888.
CleanExiHS_PSG9.
ExpressionAtlasiQ00888. baseline and differential.
GenevisibleiQ00888. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed."
    Thompson J., Koumari R., Wagner K., Barnert S., Schleussner C., Schrewe H., Zimmermann W., Mueller G., Schempp W., Zaninetta D., Ammaturo D., Hardman N.
    Biochem. Biophys. Res. Commun. 167:848-859(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT HIS-11.
  2. "Characterization of two new members of the pregnancy-specific beta 1-glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit."
    Barnett T.R., Pickle W. II, Elting J.J.
    Biochemistry 29:10213-10218(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS HIS-11; VAL-75 AND GLU-267.
    Tissue: Bone marrow.
  3. "Characterization of new members of the pregnancy-specific beta 1-glycoprotein family."
    Chan W.Y., Zheng Q.X., McMahon J., Tease L.A.
    Mol. Cell. Biochem. 106:161-170(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS HIS-11; VAL-75 AND GLU-267.
  4. "Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants."
    Teglund S., Zhou G.Q., Hammarstroem S.
    Biochem. Biophys. Res. Commun. 211:656-664(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS HIS-11; VAL-75 AND GLU-267.
    Tissue: Fetal liver.
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver."
    Zimmermann W.A., Weiss M., Thompson J.A.
    Biochem. Biophys. Res. Commun. 163:1197-1209(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 210-419 (ISOFORM 1), VARIANT GLU-267.
    Tissue: Fetal liver.
  7. "Characterization of cDNA encoding human pregnancy-specific beta 1-glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen."
    Chan W.-Y., Borjigin J., Zheng Q.-X., Shupert W.L.
    DNA 7:545-555(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-143.
  8. "Characterization of upstream promotor region, exon 1 and exon 2 of the PSG gene family."
    Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-43.

Entry informationi

Entry nameiPSG4_HUMAN
AccessioniPrimary (citable) accession number: Q00888
Secondary accession number(s): E7EX79
, Q13047, Q13048, Q15234, Q15240, Q9UQ76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: June 24, 2015
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.