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Q00888

- PSG4_HUMAN

UniProt

Q00888 - PSG4_HUMAN

Protein

Pregnancy-specific beta-1-glycoprotein 4

Gene

PSG4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. female pregnancy Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 4
    Short name:
    PS-beta-G-4
    Short name:
    PSBG-4
    Short name:
    Pregnancy-specific glycoprotein 4
    Alternative name(s):
    Pregnancy-specific beta-1-glycoprotein 9
    Short name:
    PS-beta-G-9
    Short name:
    PSBG-9
    Short name:
    Pregnancy-specific glycoprotein 9
    Gene namesi
    Name:PSG4
    Synonyms:CGM4, PSG9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:9521. PSG4.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33866.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 419385Pregnancy-specific beta-1-glycoprotein 4PRO_0000014911Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi169 ↔ 217Curated
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi262 ↔ 310Curated
    Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi354 ↔ 394Curated

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ00888.
    PRIDEiQ00888.

    PTM databases

    PhosphoSiteiQ00888.

    Expressioni

    Developmental stagei

    PSBG are produced in high quantity during pregnancy.

    Gene expression databases

    ArrayExpressiQ00888.
    BgeeiQ00888.
    CleanExiHS_PSG9.
    GenevestigatoriQ00888.

    Organism-specific databases

    HPAiHPA046327.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000384770.

    Structurei

    3D structure databases

    ProteinModelPortaliQ00888.
    SMRiQ00888. Positions 34-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 144110Ig-like V-typeAdd
    BLAST
    Domaini147 – 23488Ig-like C2-type 1Add
    BLAST
    Domaini237 – 32791Ig-like C2-type 2Add
    BLAST
    Domaini332 – 41079Ig-like C2-type 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. CEA family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG145000.
    HOGENOMiHOG000233417.
    HOVERGENiHBG007922.
    InParanoidiQ00888.
    KOiK06500.
    OMAiVSDWILP.
    OrthoDBiEOG79CZ37.
    PhylomeDBiQ00888.
    TreeFamiTF336859.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 3 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q00888-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGPLSAPPCT QRITWKGVLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD    50
    VLLLVHNLPQ NLAGYIWYKG QMTYLYHYIT SYVVDGQRII YGPAYSGRER 100
    VYSNASLLIQ NVTQEDAGSY TLHIIKRRDG TGGVTGHFTF TLHLETPKPS 150
    ISSSNLNPRE AMEAVILTCD PATPAASYQW WMNGQSLPMT HRLQLSKTNR 200
    TLFIFGVTKY IAGPYECEIR NPVSASRSDP VTLNLLPKLS KPYITINNLN 250
    PRENKDVLTF TCEPKSKNYT YIWWLNGQSL PVSPRVKRPI ENRILILPNV 300
    TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPSIYPS FTYYRSGENL 350
    YLSCFAESNP RAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA 400
    TGKESSKSIT VKVSDWILP 419
    Length:419
    Mass (Da):47,113
    Last modified:November 30, 2010 - v3
    Checksum:i576BFB4CBA502CC2
    GO
    Isoform 2 (identifier: Q00888-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         237-329: Missing.
         330-330: Y → H

    Show »
    Length:326
    Mass (Da):36,277
    Checksum:i6182CE9AC921FB54
    GO
    Isoform 3 (identifier: Q00888-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         144-236: Missing.

    Note: No experimental confirmation available. Derived from EST data.

    Show »
    Length:326
    Mass (Da):36,793
    Checksum:i286D5D59B2F24DFC
    GO

    Sequence cautioni

    The sequence AAA60208.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.
    The sequence M32625 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121R → L in M32622. (PubMed:1690992)Curated
    Sequence conflicti12 – 121R → L in CAA34956. (PubMed:2271648)Curated
    Sequence conflicti12 – 121R → L in AAA60195. (PubMed:1922019)Curated
    Sequence conflicti12 – 121R → L in AAA75294. (PubMed:7794280)Curated
    Sequence conflicti12 – 121R → L in AAA75295. (PubMed:7794280)Curated
    Sequence conflicti18 – 181V → L in AAA60195. (PubMed:1922019)Curated
    Sequence conflicti175 – 1751A → P in M32624. (PubMed:1690992)Curated
    Sequence conflicti352 – 3521L → F in CAA34956. (PubMed:2271648)Curated
    Sequence conflicti356 – 3561A → G in CAA34956. (PubMed:2271648)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti11 – 111Q → H.4 Publications
    Corresponds to variant rs11883278 [ dbSNP | Ensembl ].
    VAR_060362
    Natural varianti75 – 751L → V.3 Publications
    Corresponds to variant rs3170216 [ dbSNP | Ensembl ].
    VAR_016040
    Natural varianti177 – 1771S → R.
    Corresponds to variant rs73548061 [ dbSNP | Ensembl ].
    VAR_060363
    Natural varianti240 – 2401S → P.
    Corresponds to variant rs3859474 [ dbSNP | Ensembl ].
    VAR_056073
    Natural varianti267 – 2671K → E.4 Publications
    Corresponds to variant rs1058718 [ dbSNP | Ensembl ].
    VAR_060364
    Natural varianti286 – 2861V → A.
    Corresponds to variant rs2355442 [ dbSNP | Ensembl ].
    VAR_056074

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei144 – 23693Missing in isoform 3. CuratedVSP_055025Add
    BLAST
    Alternative sequencei237 – 32993Missing in isoform 2. 1 PublicationVSP_007875Add
    BLAST
    Alternative sequencei330 – 3301Y → H in isoform 2. 1 PublicationVSP_040131

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32622 Genomic DNA. No translation available.
    M32623 Genomic DNA. No translation available.
    M32624 Genomic DNA. No translation available.
    M32625 Genomic DNA. No translation available.
    M32626 Genomic DNA. No translation available.
    M32627 Genomic DNA. No translation available.
    X17097 mRNA. Translation: CAA34956.1.
    M94891 mRNA. Translation: AAA60195.1.
    U18468 mRNA. Translation: AAA75294.1.
    U18469 mRNA. Translation: AAA75295.1.
    AC005392 Genomic DNA. No translation available.
    M33665 mRNA. Translation: AAA60208.1. Sequence problems.
    AH007625 Genomic DNA. Translation: AAD28499.1.
    CCDSiCCDS33039.1. [Q00888-2]
    CCDS46093.1. [Q00888-1]
    CCDS62695.1. [Q00888-3]
    PIRiA36109.
    B54312.
    C33258.
    JC4124.
    RefSeqiNP_002771.2. NM_002780.4. [Q00888-1]
    NP_998798.1. NM_213633.2. [Q00888-2]
    UniGeneiHs.711363.

    Genome annotation databases

    EnsembliENST00000244295; ENSP00000244295; ENSG00000243137. [Q00888-2]
    ENST00000405312; ENSP00000384770; ENSG00000243137. [Q00888-1]
    ENST00000433626; ENSP00000387864; ENSG00000243137. [Q00888-3]
    GeneIDi5672.
    KEGGihsa:5672.
    UCSCiuc002ovy.4. human. [Q00888-1]
    uc002ovz.4. human. [Q00888-2]

    Polymorphism databases

    DMDMi313104197.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32622 Genomic DNA. No translation available.
    M32623 Genomic DNA. No translation available.
    M32624 Genomic DNA. No translation available.
    M32625 Genomic DNA. No translation available.
    M32626 Genomic DNA. No translation available.
    M32627 Genomic DNA. No translation available.
    X17097 mRNA. Translation: CAA34956.1 .
    M94891 mRNA. Translation: AAA60195.1 .
    U18468 mRNA. Translation: AAA75294.1 .
    U18469 mRNA. Translation: AAA75295.1 .
    AC005392 Genomic DNA. No translation available.
    M33665 mRNA. Translation: AAA60208.1 . Sequence problems.
    AH007625 Genomic DNA. Translation: AAD28499.1 .
    CCDSi CCDS33039.1. [Q00888-2 ]
    CCDS46093.1. [Q00888-1 ]
    CCDS62695.1. [Q00888-3 ]
    PIRi A36109.
    B54312.
    C33258.
    JC4124.
    RefSeqi NP_002771.2. NM_002780.4. [Q00888-1 ]
    NP_998798.1. NM_213633.2. [Q00888-2 ]
    UniGenei Hs.711363.

    3D structure databases

    ProteinModelPortali Q00888.
    SMRi Q00888. Positions 34-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000384770.

    PTM databases

    PhosphoSitei Q00888.

    Polymorphism databases

    DMDMi 313104197.

    Proteomic databases

    PaxDbi Q00888.
    PRIDEi Q00888.

    Protocols and materials databases

    DNASUi 5672.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000244295 ; ENSP00000244295 ; ENSG00000243137 . [Q00888-2 ]
    ENST00000405312 ; ENSP00000384770 ; ENSG00000243137 . [Q00888-1 ]
    ENST00000433626 ; ENSP00000387864 ; ENSG00000243137 . [Q00888-3 ]
    GeneIDi 5672.
    KEGGi hsa:5672.
    UCSCi uc002ovy.4. human. [Q00888-1 ]
    uc002ovz.4. human. [Q00888-2 ]

    Organism-specific databases

    CTDi 5672.
    GeneCardsi GC19M043696.
    H-InvDB HIX0137523.
    HGNCi HGNC:9521. PSG4.
    HPAi HPA046327.
    MIMi 176393. gene.
    neXtProti NX_Q00888.
    PharmGKBi PA33866.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145000.
    HOGENOMi HOG000233417.
    HOVERGENi HBG007922.
    InParanoidi Q00888.
    KOi K06500.
    OMAi VSDWILP.
    OrthoDBi EOG79CZ37.
    PhylomeDBi Q00888.
    TreeFami TF336859.

    Miscellaneous databases

    GeneWikii PSG4.
    GenomeRNAii 5672.
    NextBioi 22028.
    PROi Q00888.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q00888.
    Bgeei Q00888.
    CleanExi HS_PSG9.
    Genevestigatori Q00888.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 3 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed."
      Thompson J., Koumari R., Wagner K., Barnert S., Schleussner C., Schrewe H., Zimmermann W., Mueller G., Schempp W., Zaninetta D., Ammaturo D., Hardman N.
      Biochem. Biophys. Res. Commun. 167:848-859(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT HIS-11.
    2. "Characterization of two new members of the pregnancy-specific beta 1-glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit."
      Barnett T.R., Pickle W. II, Elting J.J.
      Biochemistry 29:10213-10218(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS HIS-11; VAL-75 AND GLU-267.
      Tissue: Bone marrow.
    3. "Characterization of new members of the pregnancy-specific beta 1-glycoprotein family."
      Chan W.Y., Zheng Q.X., McMahon J., Tease L.A.
      Mol. Cell. Biochem. 106:161-170(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS HIS-11; VAL-75 AND GLU-267.
    4. "Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants."
      Teglund S., Zhou G.Q., Hammarstroem S.
      Biochem. Biophys. Res. Commun. 211:656-664(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS HIS-11; VAL-75 AND GLU-267.
      Tissue: Fetal liver.
    5. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver."
      Zimmermann W.A., Weiss M., Thompson J.A.
      Biochem. Biophys. Res. Commun. 163:1197-1209(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 210-419 (ISOFORM 1), VARIANT GLU-267.
      Tissue: Fetal liver.
    7. "Characterization of cDNA encoding human pregnancy-specific beta 1-glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen."
      Chan W.-Y., Borjigin J., Zheng Q.-X., Shupert W.L.
      DNA 7:545-555(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-143.
    8. "Characterization of upstream promotor region, exon 1 and exon 2 of the PSG gene family."
      Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-43.

    Entry informationi

    Entry nameiPSG4_HUMAN
    AccessioniPrimary (citable) accession number: Q00888
    Secondary accession number(s): E7EX79
    , Q13047, Q13048, Q15234, Q15240, Q9UQ76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 142 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3