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Q00888

- PSG4_HUMAN

UniProt

Q00888 - PSG4_HUMAN

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Protein
Pregnancy-specific beta-1-glycoprotein 4
Gene
PSG4, CGM4, PSG9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. female pregnancy Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 4
Short name:
PS-beta-G-4
Short name:
PSBG-4
Short name:
Pregnancy-specific glycoprotein 4
Alternative name(s):
Pregnancy-specific beta-1-glycoprotein 9
Short name:
PS-beta-G-9
Short name:
PSBG-9
Short name:
Pregnancy-specific glycoprotein 9
Gene namesi
Name:PSG4
Synonyms:CGM4, PSG9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:9521. PSG4.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33866.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 Reviewed prediction
Add
BLAST
Chaini35 – 419385Pregnancy-specific beta-1-glycoprotein 4
PRO_0000014911Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi104 – 1041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi111 – 1111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi169 ↔ 217 Inferred
Glycosylationi199 – 1991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi262 ↔ 310 Inferred
Glycosylationi268 – 2681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi299 – 2991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi303 – 3031N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi354 ↔ 394 Inferred

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ00888.
PRIDEiQ00888.

PTM databases

PhosphoSiteiQ00888.

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

ArrayExpressiQ00888.
BgeeiQ00888.
CleanExiHS_PSG9.
GenevestigatoriQ00888.

Organism-specific databases

HPAiHPA046327.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000384770.

Structurei

3D structure databases

ProteinModelPortaliQ00888.
SMRiQ00888. Positions 34-412.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 144110Ig-like V-type
Add
BLAST
Domaini147 – 23488Ig-like C2-type 1
Add
BLAST
Domaini237 – 32791Ig-like C2-type 2
Add
BLAST
Domaini332 – 41079Ig-like C2-type 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG145000.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ00888.
KOiK06500.
OMAiVSDWILP.
OrthoDBiEOG79CZ37.
PhylomeDBiQ00888.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q00888-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGPLSAPPCT QRITWKGVLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD    50
VLLLVHNLPQ NLAGYIWYKG QMTYLYHYIT SYVVDGQRII YGPAYSGRER 100
VYSNASLLIQ NVTQEDAGSY TLHIIKRRDG TGGVTGHFTF TLHLETPKPS 150
ISSSNLNPRE AMEAVILTCD PATPAASYQW WMNGQSLPMT HRLQLSKTNR 200
TLFIFGVTKY IAGPYECEIR NPVSASRSDP VTLNLLPKLS KPYITINNLN 250
PRENKDVLTF TCEPKSKNYT YIWWLNGQSL PVSPRVKRPI ENRILILPNV 300
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPSIYPS FTYYRSGENL 350
YLSCFAESNP RAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA 400
TGKESSKSIT VKVSDWILP 419
Length:419
Mass (Da):47,113
Last modified:November 30, 2010 - v3
Checksum:i576BFB4CBA502CC2
GO
Isoform 2 (identifier: Q00888-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-329: Missing.
     330-330: Y → H

Show »
Length:326
Mass (Da):36,277
Checksum:i6182CE9AC921FB54
GO
Isoform 3 (identifier: Q00888-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-236: Missing.

Note: No experimental confirmation available. Derived from EST data.

Show »
Length:326
Mass (Da):36,793
Checksum:i286D5D59B2F24DFC
GO

Sequence cautioni

The sequence AAA60208.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.
The sequence M32625 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111Q → H.4 Publications
Corresponds to variant rs11883278 [ dbSNP | Ensembl ].
VAR_060362
Natural varianti75 – 751L → V.3 Publications
Corresponds to variant rs3170216 [ dbSNP | Ensembl ].
VAR_016040
Natural varianti177 – 1771S → R.
Corresponds to variant rs73548061 [ dbSNP | Ensembl ].
VAR_060363
Natural varianti240 – 2401S → P.
Corresponds to variant rs3859474 [ dbSNP | Ensembl ].
VAR_056073
Natural varianti267 – 2671K → E.4 Publications
Corresponds to variant rs1058718 [ dbSNP | Ensembl ].
VAR_060364
Natural varianti286 – 2861V → A.
Corresponds to variant rs2355442 [ dbSNP | Ensembl ].
VAR_056074

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei144 – 23693Missing in isoform 3.
VSP_055025Add
BLAST
Alternative sequencei237 – 32993Missing in isoform 2.
VSP_007875Add
BLAST
Alternative sequencei330 – 3301Y → H in isoform 2.
VSP_040131

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121R → L in M32622. 1 Publication
Sequence conflicti12 – 121R → L in CAA34956. 1 Publication
Sequence conflicti12 – 121R → L in AAA60195. 1 Publication
Sequence conflicti12 – 121R → L in AAA75294. 1 Publication
Sequence conflicti12 – 121R → L in AAA75295. 1 Publication
Sequence conflicti18 – 181V → L in AAA60195. 1 Publication
Sequence conflicti175 – 1751A → P in M32624. 1 Publication
Sequence conflicti352 – 3521L → F in CAA34956. 1 Publication
Sequence conflicti356 – 3561A → G in CAA34956. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32622 Genomic DNA. No translation available.
M32623 Genomic DNA. No translation available.
M32624 Genomic DNA. No translation available.
M32625 Genomic DNA. No translation available.
M32626 Genomic DNA. No translation available.
M32627 Genomic DNA. No translation available.
X17097 mRNA. Translation: CAA34956.1.
M94891 mRNA. Translation: AAA60195.1.
U18468 mRNA. Translation: AAA75294.1.
U18469 mRNA. Translation: AAA75295.1.
AC005392 Genomic DNA. No translation available.
M33665 mRNA. Translation: AAA60208.1. Sequence problems.
AH007625 Genomic DNA. Translation: AAD28499.1.
CCDSiCCDS33039.1. [Q00888-2]
CCDS46093.1. [Q00888-1]
PIRiA36109.
B54312.
C33258.
JC4124.
RefSeqiNP_002771.2. NM_002780.4. [Q00888-1]
NP_998798.1. NM_213633.2. [Q00888-2]
UniGeneiHs.711363.

Genome annotation databases

EnsembliENST00000244295; ENSP00000244295; ENSG00000243137. [Q00888-2]
ENST00000405312; ENSP00000384770; ENSG00000243137. [Q00888-1]
ENST00000433626; ENSP00000387864; ENSG00000243137.
GeneIDi5672.
KEGGihsa:5672.
UCSCiuc002ovy.4. human. [Q00888-1]
uc002ovz.4. human. [Q00888-2]

Polymorphism databases

DMDMi313104197.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32622 Genomic DNA. No translation available.
M32623 Genomic DNA. No translation available.
M32624 Genomic DNA. No translation available.
M32625 Genomic DNA. No translation available.
M32626 Genomic DNA. No translation available.
M32627 Genomic DNA. No translation available.
X17097 mRNA. Translation: CAA34956.1 .
M94891 mRNA. Translation: AAA60195.1 .
U18468 mRNA. Translation: AAA75294.1 .
U18469 mRNA. Translation: AAA75295.1 .
AC005392 Genomic DNA. No translation available.
M33665 mRNA. Translation: AAA60208.1 . Sequence problems.
AH007625 Genomic DNA. Translation: AAD28499.1 .
CCDSi CCDS33039.1. [Q00888-2 ]
CCDS46093.1. [Q00888-1 ]
PIRi A36109.
B54312.
C33258.
JC4124.
RefSeqi NP_002771.2. NM_002780.4. [Q00888-1 ]
NP_998798.1. NM_213633.2. [Q00888-2 ]
UniGenei Hs.711363.

3D structure databases

ProteinModelPortali Q00888.
SMRi Q00888. Positions 34-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000384770.

PTM databases

PhosphoSitei Q00888.

Polymorphism databases

DMDMi 313104197.

Proteomic databases

PaxDbi Q00888.
PRIDEi Q00888.

Protocols and materials databases

DNASUi 5672.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000244295 ; ENSP00000244295 ; ENSG00000243137 . [Q00888-2 ]
ENST00000405312 ; ENSP00000384770 ; ENSG00000243137 . [Q00888-1 ]
ENST00000433626 ; ENSP00000387864 ; ENSG00000243137 .
GeneIDi 5672.
KEGGi hsa:5672.
UCSCi uc002ovy.4. human. [Q00888-1 ]
uc002ovz.4. human. [Q00888-2 ]

Organism-specific databases

CTDi 5672.
GeneCardsi GC19M043696.
H-InvDB HIX0137523.
HGNCi HGNC:9521. PSG4.
HPAi HPA046327.
MIMi 176393. gene.
neXtProti NX_Q00888.
PharmGKBi PA33866.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145000.
HOGENOMi HOG000233417.
HOVERGENi HBG007922.
InParanoidi Q00888.
KOi K06500.
OMAi VSDWILP.
OrthoDBi EOG79CZ37.
PhylomeDBi Q00888.
TreeFami TF336859.

Miscellaneous databases

GeneWikii PSG4.
GenomeRNAii 5672.
NextBioi 22028.
PROi Q00888.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q00888.
Bgeei Q00888.
CleanExi HS_PSG9.
Genevestigatori Q00888.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed."
    Thompson J., Koumari R., Wagner K., Barnert S., Schleussner C., Schrewe H., Zimmermann W., Mueller G., Schempp W., Zaninetta D., Ammaturo D., Hardman N.
    Biochem. Biophys. Res. Commun. 167:848-859(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANT HIS-11.
  2. "Characterization of two new members of the pregnancy-specific beta 1-glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit."
    Barnett T.R., Pickle W. II, Elting J.J.
    Biochemistry 29:10213-10218(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS HIS-11; VAL-75 AND GLU-267.
    Tissue: Bone marrow.
  3. "Characterization of new members of the pregnancy-specific beta 1-glycoprotein family."
    Chan W.Y., Zheng Q.X., McMahon J., Tease L.A.
    Mol. Cell. Biochem. 106:161-170(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS HIS-11; VAL-75 AND GLU-267.
  4. "Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants."
    Teglund S., Zhou G.Q., Hammarstroem S.
    Biochem. Biophys. Res. Commun. 211:656-664(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS HIS-11; VAL-75 AND GLU-267.
    Tissue: Fetal liver.
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver."
    Zimmermann W.A., Weiss M., Thompson J.A.
    Biochem. Biophys. Res. Commun. 163:1197-1209(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 210-419 (ISOFORM 1), VARIANT GLU-267.
    Tissue: Fetal liver.
  7. "Characterization of cDNA encoding human pregnancy-specific beta 1-glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen."
    Chan W.-Y., Borjigin J., Zheng Q.-X., Shupert W.L.
    DNA 7:545-555(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-143.
  8. "Characterization of upstream promotor region, exon 1 and exon 2 of the PSG gene family."
    Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-43.

Entry informationi

Entry nameiPSG4_HUMAN
AccessioniPrimary (citable) accession number: Q00888
Secondary accession number(s): E7EX79
, Q13047, Q13048, Q15234, Q15240, Q9UQ76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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