Q00887 (PSG9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pregnancy-specific beta-1-glycoprotein 9
Short name=PS-beta-G-9
Short name=PSBG-9
Short name=Pregnancy-specific glycoprotein 9

Alternative name(s):
PS34
Pregnancy-specific beta-1 glycoprotein B
Short name=PS-beta-B
Pregnancy-specific beta-1-glycoprotein 11
Short name=PS-beta-G-11
Short name=PSBG-11
Short name=Pregnancy-specific glycoprotein 11
Pregnancy-specific glycoprotein 7
Short name=PSG7

Gene names

Name:	PSG9
Synonyms:	PSG11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Developmental stage	PSBG are produced in high quantity during pregnancy.
Sequence similarities	Belongs to the immunoglobulin superfamily. CEA family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	female pregnancy Traceable author statement PubMed 1690992. Source: ProtInc
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 34	34	Potential
	Chain	35 – 426	392	Pregnancy-specific beta-1-glycoprotein 9		PRO_0000014916
Regions
	Domain	35 – 144	110	Ig-like V-type
	Domain	147 – 234	88	Ig-like C2-type 1
	Domain	242 – 326	85	Ig-like C2-type 2
	Domain	335 – 410	76	Ig-like C2-type 3
	Motif	127 – 129	3	Cell attachment site Potential
Amino acid modifications
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Glycosylation	111	1	N-linked (GlcNAc...) Potential
	Glycosylation	199	1	N-linked (GlcNAc...) Potential
	Glycosylation	268	1	N-linked (GlcNAc...) Potential
	Glycosylation	303	1	N-linked (GlcNAc...) Potential
	Glycosylation	387	1	N-linked (GlcNAc...) Potential
	Disulfide bond	169 ↔ 217		Probable
	Disulfide bond	262 ↔ 310		Probable
	Disulfide bond	354 ↔ 394		Probable
Natural variations
	Natural variant	18	1	L → V. Corresponds to variant rs8101191 [ dbSNP | Ensembl ].		VAR_059410
	Natural variant	176	1	A → T. Corresponds to variant rs1058085 [ dbSNP | Ensembl ].		VAR_058296
	Natural variant	325	1	I → T. Corresponds to variant rs1135905 [ dbSNP | Ensembl ].		VAR_049925
	Natural variant	374	1	Q → L. Corresponds to variant rs2074923 [ dbSNP | Ensembl ].		VAR_049926
	Natural variant	397	1	H → R. Corresponds to variant rs2072285 [ dbSNP | Ensembl ].		VAR_049927
Experimental info
	Sequence conflict	4	1	L → F in AAA60203. Ref.4
	Sequence conflict	49	1	K → Q in AAA63251. Ref.4
	Sequence conflict	203	1	Y → C in CAA35612. Ref.1
	Sequence conflict	226	1	S → I in AAA60203. Ref.4
	Sequence conflict	313	1	R → Q in AAH20759. Ref.8
	Sequence conflict	349	1	N → I in AAA63251. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q00887 [UniParc]. Last modified July 15, 1999. Version 2. Checksum: 69F72CF4B608BA39	FASTA	426	48,272
	10 20 30 40 50 60 MGPLPAPSCT QRITWKGLLL TASLLNFWNP PTTAEVTIEA QPPKVSEGKD VLLLVHNLPQ 70 80 90 100 110 120 NLPGYFWYKG EMTDLYHYII SYIVDGKIII YGPAYSGRET VYSNASLLIQ NVTRKDAGTY 130 140 150 160 170 180 TLHIIKRGDE TREEIRHFTF TLYLETPKPY ISSSNLNPRE AMEAVRLICD PETLDASYLW 190 200 210 220 230 240 WMNGQSLPVT HRLQLSKTNR TLYLFGVTKY IAGPYECEIR NPVSASRSDP VTLNLLPKLP 250 260 270 280 290 300 IPYITINNLN PRENKDVLAF TCEPKSENYT YIWWLNGQSL PVSPGVKRPI ENRILILPSV 310 320 330 340 350 360 TRNETGPYQC EIRDRYGGLR SNPVILNVLY GPDLPRIYPS FTYYRSGENL DLSCFTESNP 370 380 390 400 410 420 PAEYFWTING KFQQSGQKLF IPQITRNHSG LYACSVHNSA TGKEISKSMT VKVSGPCHGD LTESQS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide and deduced amino acid sequences of a cDNA encoding a new species of pregnancy-specific beta 1-glycoprotein (PS beta G)." Arakawa F., Kuroki M., Misumi Y., Matsuo Y., Matsuoka Y. Biochim. Biophys. Acta 1048:303-305(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Structure, evolution and chromosomal localization of the human pregnancy-specific beta 1 glycoprotein gene family." Streydio C., Swillens S., Georges M., Szpirer C., Vassart G. Genomics 6:579-592(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[3]	"Identification of a new carcinoembryonic antigen (CEA) family member in human fetal liver -- cloning and sequence determination of pregnancy-specific glycoprotein 7." Khan W.N., Hammarstroem S. Biochem. Biophys. Res. Commun. 168:214-225(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal liver.
[4]	"cDNA sequence of the pregnancy-specific beta 1-glycoprotein-11s (PSG-11s)." Brophy B.K., MacDonald R.E., McLenachan P.A., Mansfield B.C. Biochim. Biophys. Acta 1131:119-121(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[6]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[9]	"Characterization of upstream promotor region, exon1 and exon2 of the PSG gene family." Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-143.
[10]	Beggs K.T., McLenachan T., Mansfield B. Submitted (AUG-1991) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 23-143. Tissue: Peripheral blood.
[11]	"Characterization of the PSG11 gene." McLenachan P.A., Rutherfurd K.J., Beggs K.T., Sims S.E., Mansfield B.C. Genomics 22:356-363(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 416-426.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X17610 mRNA. Translation: CAA35612.1. M34421 mRNA. Translation: AAA52605.1. M34481 mRNA. Translation: AAA74512.1. M38046 mRNA. Translation: AAA63251.1. M58591 mRNA. Translation: AAA60203.1. AK313256 mRNA. Translation: BAG36066.1. AC005392 Genomic DNA. No translation available. CH471126 Genomic DNA. Translation: EAW57180.1. BC020759 mRNA. Translation: AAH20759.1. AH007520 Genomic DNA. Translation: AAD21023.1. M38243 Genomic DNA. Translation: AAA63252.1. U04325 Genomic DNA. Translation: AAA78266.1.
IPI	IPI00293461.
PIR	B35334. C55181. S09016.
RefSeq	NP_002775.3. NM_002784.3.
UniGene	Hs.502092.
3D structure databases
ProteinModelPortal	Q00887.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q00887. 2 interactions.
MINT	MINT-1180125.
STRING	9606.ENSP00000270077.
PTM databases
PhosphoSite	Q00887.
Polymorphism databases
DMDM	6093845.
Proteomic databases
PaxDb	Q00887.
PRIDE	Q00887.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000270077; ENSP00000270077; ENSG00000183668.
GeneID	5678.
KEGG	hsa:5678.
UCSC	uc002owd.4. human.
Organism-specific databases
CTD	5678.
GeneCards	GC19M043757.
HGNC	HGNC:9526. PSG9.
HPA	HPA046327.
MIM	176398. gene.
neXtProt	NX_Q00887.
PharmGKB	PA33871.
GenAtlas	Search...
Phylogenomic databases
eggNOG	KOG4475.
HOGENOM	HOG000233417.
HOVERGEN	HBG007922.
InParanoid	Q00887.
KO	K06500.
OMA	SCTQHIT.
OrthoDB	EOG43FGZR.
PhylomeDB	Q00887.
Gene expression databases
ArrayExpress	Q00887.
Bgee	Q00887.
CleanEx	HS_PSG11. HS_PSG9.
Genevestigator	Q00887.
GermOnline	ENSG00000183668. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 4 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR013106. Ig_V-set. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 2 hits. SM00408. IGc2. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PSG9. human.
GenomeRNAi	5678.
NextBio	22048.
SOURCE	Search...

Entry information

Entry name

PSG9_HUMAN

Accession

Primary (citable) accession number: Q00887
Secondary accession number(s): B2R869 , Q15236, Q15237, Q8WW78, Q9UQ73

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	July 15, 1999
Last modified:	May 1, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.