Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pregnancy-specific beta-1-glycoprotein 9

Gene

PSG9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • female pregnancy Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 9
Short name:
PS-beta-G-9
Short name:
PSBG-9
Short name:
Pregnancy-specific glycoprotein 9
Alternative name(s):
PS34
Pregnancy-specific beta-1 glycoprotein B
Short name:
PS-beta-B
Pregnancy-specific beta-1-glycoprotein 11
Short name:
PS-beta-G-11
Short name:
PSBG-11
Short name:
Pregnancy-specific glycoprotein 11
Pregnancy-specific glycoprotein 7
Short name:
PSG7
Gene namesi
Name:PSG9
Synonyms:PSG11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9526. PSG9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33871.

Polymorphism and mutation databases

BioMutaiPSG9.
DMDMi6093845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence analysisAdd
BLAST
Chaini35 – 426392Pregnancy-specific beta-1-glycoprotein 9PRO_0000014916Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Disulfide bondi169 ↔ 217Curated
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence analysis
Disulfide bondi262 ↔ 310Curated
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence analysis
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence analysis
Disulfide bondi354 ↔ 394Curated
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ00887.
PeptideAtlasiQ00887.
PRIDEiQ00887.

PTM databases

iPTMnetiQ00887.
PhosphoSiteiQ00887.

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiQ00887.
CleanExiHS_PSG11.
HS_PSG9.
ExpressionAtlasiQ00887. baseline and differential.
GenevisibleiQ00887. HS.

Organism-specific databases

HPAiHPA046327.

Interactioni

Protein-protein interaction databases

BioGridi111652. 19 interactions.
IntActiQ00887. 5 interactions.
MINTiMINT-1180125.

Structurei

3D structure databases

ProteinModelPortaliQ00887.
SMRiQ00887. Positions 34-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 144110Ig-like V-typeAdd
BLAST
Domaini147 – 23488Ig-like C2-type 1Add
BLAST
Domaini242 – 32685Ig-like C2-type 2Add
BLAST
Domaini335 – 41076Ig-like C2-type 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi127 – 1293Cell attachment siteSequence analysis

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ00887.
KOiK06500.
OMAiVTECVND.
PhylomeDBiQ00887.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q00887-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLPAPSCT QRITWKGLLL TASLLNFWNP PTTAEVTIEA QPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLPGYFWYKG EMTDLYHYII SYIVDGKIII YGPAYSGRET
110 120 130 140 150
VYSNASLLIQ NVTRKDAGTY TLHIIKRGDE TREEIRHFTF TLYLETPKPY
160 170 180 190 200
ISSSNLNPRE AMEAVRLICD PETLDASYLW WMNGQSLPVT HRLQLSKTNR
210 220 230 240 250
TLYLFGVTKY IAGPYECEIR NPVSASRSDP VTLNLLPKLP IPYITINNLN
260 270 280 290 300
PRENKDVLAF TCEPKSENYT YIWWLNGQSL PVSPGVKRPI ENRILILPSV
310 320 330 340 350
TRNETGPYQC EIRDRYGGLR SNPVILNVLY GPDLPRIYPS FTYYRSGENL
360 370 380 390 400
DLSCFTESNP PAEYFWTING KFQQSGQKLF IPQITRNHSG LYACSVHNSA
410 420
TGKEISKSMT VKVSGPCHGD LTESQS
Length:426
Mass (Da):48,272
Last modified:July 15, 1999 - v2
Checksum:i69F72CF4B608BA39
GO
Isoform 2 (identifier: Q00887-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-330: PKLPIPYITI...SNPVILNVLY → H
     416-426: PCHGDLTESQS → KWIPASLAVG...KKVGRGLYQP

Show »
Length:402
Mass (Da):45,336
Checksum:iF57EC479DC08120E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41L → F in AAA60203 (PubMed:1581354).Curated
Sequence conflicti49 – 491K → Q in AAA63251 (PubMed:1581354).Curated
Sequence conflicti203 – 2031Y → C in CAA35612 (PubMed:2322584).Curated
Sequence conflicti226 – 2261S → I in AAA60203 (PubMed:1581354).Curated
Sequence conflicti313 – 3131R → Q in AAH20759 (PubMed:15489334).Curated
Sequence conflicti349 – 3491N → I in AAA63251 (PubMed:1581354).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181L → V.
Corresponds to variant rs8101191 [ dbSNP | Ensembl ].
VAR_059410
Natural varianti176 – 1761A → T.
Corresponds to variant rs1058085 [ dbSNP | Ensembl ].
VAR_058296
Natural varianti325 – 3251I → T.
Corresponds to variant rs1135905 [ dbSNP | Ensembl ].
VAR_049925
Natural varianti374 – 3741Q → L.
Corresponds to variant rs2074923 [ dbSNP | Ensembl ].
VAR_049926
Natural varianti397 – 3971H → R.
Corresponds to variant rs2072285 [ dbSNP | Ensembl ].
VAR_049927

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei237 – 33094PKLPI…LNVLY → H in isoform 2. 1 PublicationVSP_055602Add
BLAST
Alternative sequencei416 – 42611PCHGDLTESQS → KWIPASLAVGFYVESIWLSE KSQENIFIPSLCPMGTSKSQ ILLLNPPNLSLQTLFSLFFC FLMADLVSGLKKVGRGLYQP in isoform 2. 1 PublicationVSP_055603Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17610 mRNA. Translation: CAA35612.1.
M34421 mRNA. Translation: AAA52605.1.
M34481 mRNA. Translation: AAA74512.1.
M38046 mRNA. Translation: AAA63251.1.
M94890 mRNA. Translation: AAA60194.1.
M58591 mRNA. Translation: AAA60203.1.
AK313256 mRNA. Translation: BAG36066.1.
AC005392 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57180.1.
CH471126 Genomic DNA. Translation: EAW57183.1.
BC020759 mRNA. Translation: AAH20759.1.
AH007520 Genomic DNA. Translation: AAD21023.1.
M38243 Genomic DNA. Translation: AAA63252.1.
U04325 Genomic DNA. Translation: AAA78266.1.
CCDSiCCDS12618.1. [Q00887-1]
PIRiB35334.
C55181.
S09016.
RefSeqiNP_001288636.1. NM_001301707.1.
NP_001288637.1. NM_001301708.1.
NP_001288638.1. NM_001301709.1.
NP_002775.3. NM_002784.4. [Q00887-1]
XP_005259132.1. XM_005259075.3. [Q00887-2]
UniGeneiHs.502092.

Genome annotation databases

EnsembliENST00000244293; ENSP00000244293; ENSG00000183668. [Q00887-2]
ENST00000270077; ENSP00000270077; ENSG00000183668. [Q00887-1]
GeneIDi5678.
KEGGihsa:5678.
UCSCiuc002owd.5. human. [Q00887-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17610 mRNA. Translation: CAA35612.1.
M34421 mRNA. Translation: AAA52605.1.
M34481 mRNA. Translation: AAA74512.1.
M38046 mRNA. Translation: AAA63251.1.
M94890 mRNA. Translation: AAA60194.1.
M58591 mRNA. Translation: AAA60203.1.
AK313256 mRNA. Translation: BAG36066.1.
AC005392 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57180.1.
CH471126 Genomic DNA. Translation: EAW57183.1.
BC020759 mRNA. Translation: AAH20759.1.
AH007520 Genomic DNA. Translation: AAD21023.1.
M38243 Genomic DNA. Translation: AAA63252.1.
U04325 Genomic DNA. Translation: AAA78266.1.
CCDSiCCDS12618.1. [Q00887-1]
PIRiB35334.
C55181.
S09016.
RefSeqiNP_001288636.1. NM_001301707.1.
NP_001288637.1. NM_001301708.1.
NP_001288638.1. NM_001301709.1.
NP_002775.3. NM_002784.4. [Q00887-1]
XP_005259132.1. XM_005259075.3. [Q00887-2]
UniGeneiHs.502092.

3D structure databases

ProteinModelPortaliQ00887.
SMRiQ00887. Positions 34-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111652. 19 interactions.
IntActiQ00887. 5 interactions.
MINTiMINT-1180125.

PTM databases

iPTMnetiQ00887.
PhosphoSiteiQ00887.

Polymorphism and mutation databases

BioMutaiPSG9.
DMDMi6093845.

Proteomic databases

PaxDbiQ00887.
PeptideAtlasiQ00887.
PRIDEiQ00887.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244293; ENSP00000244293; ENSG00000183668. [Q00887-2]
ENST00000270077; ENSP00000270077; ENSG00000183668. [Q00887-1]
GeneIDi5678.
KEGGihsa:5678.
UCSCiuc002owd.5. human. [Q00887-1]

Organism-specific databases

CTDi5678.
GeneCardsiPSG9.
HGNCiHGNC:9526. PSG9.
HPAiHPA046327.
MIMi176398. gene.
neXtProtiNX_Q00887.
PharmGKBiPA33871.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ00887.
KOiK06500.
OMAiVTECVND.
PhylomeDBiQ00887.
TreeFamiTF336859.

Miscellaneous databases

ChiTaRSiPSG9. human.
GeneWikiiPSG9.
GenomeRNAii5678.
PROiQ00887.
SOURCEiSearch...

Gene expression databases

BgeeiQ00887.
CleanExiHS_PSG11.
HS_PSG9.
ExpressionAtlasiQ00887. baseline and differential.
GenevisibleiQ00887. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide and deduced amino acid sequences of a cDNA encoding a new species of pregnancy-specific beta 1-glycoprotein (PS beta G)."
    Arakawa F., Kuroki M., Misumi Y., Matsuo Y., Matsuoka Y.
    Biochim. Biophys. Acta 1048:303-305(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. "Structure, evolution and chromosomal localization of the human pregnancy-specific beta 1 glycoprotein gene family."
    Streydio C., Swillens S., Georges M., Szpirer C., Vassart G.
    Genomics 6:579-592(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "Identification of a new carcinoembryonic antigen (CEA) family member in human fetal liver -- cloning and sequence determination of pregnancy-specific glycoprotein 7."
    Khan W.N., Hammarstroem S.
    Biochem. Biophys. Res. Commun. 168:214-225(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal liver.
  4. "Characterization of new members of the pregnancy-specific beta 1-glycoprotein family."
    Chan W.Y., Zheng Q.X., McMahon J., Tease L.A.
    Mol. Cell. Biochem. 106:161-170(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Placenta.
  5. "cDNA sequence of the pregnancy-specific beta 1-glycoprotein-11s (PSG-11s)."
    Brophy B.K., MacDonald R.E., McLenachan P.A., Mansfield B.C.
    Biochim. Biophys. Acta 1131:119-121(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  7. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  10. "Characterization of upstream promotor region, exon1 and exon2 of the PSG gene family."
    Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 1-143.
  11. Beggs K.T., McLenachan T., Mansfield B.
    Submitted (AUG-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 23-143.
    Tissue: Peripheral blood.
  12. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 416-426.

Entry informationi

Entry nameiPSG9_HUMAN
AccessioniPrimary (citable) accession number: Q00887
Secondary accession number(s): B2R869
, Q15227, Q15236, Q15237, Q8WW78, Q9UQ73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1999
Last modified: July 6, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.