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Protein

Pregnancy-specific beta-1-glycoprotein 9

Gene

PSG9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • female pregnancy Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 9
Short name:
PS-beta-G-9
Short name:
PSBG-9
Short name:
Pregnancy-specific glycoprotein 9
Alternative name(s):
PS34
Pregnancy-specific beta-1 glycoprotein B
Short name:
PS-beta-B
Pregnancy-specific beta-1-glycoprotein 11
Short name:
PS-beta-G-11
Short name:
PSBG-11
Short name:
Pregnancy-specific glycoprotein 11
Pregnancy-specific glycoprotein 7
Short name:
PSG7
Gene namesi
Name:PSG9
Synonyms:PSG11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9526. PSG9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5678.
OpenTargetsiENSG00000183668.
PharmGKBiPA33871.

Polymorphism and mutation databases

BioMutaiPSG9.
DMDMi6093845.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001491635 – 426Pregnancy-specific beta-1-glycoprotein 9Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi169 ↔ 217Curated
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi262 ↔ 310Curated
Glycosylationi268N-linked (GlcNAc...)Sequence analysis1
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi354 ↔ 394Curated
Glycosylationi387N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ00887.
PeptideAtlasiQ00887.
PRIDEiQ00887.

PTM databases

iPTMnetiQ00887.
PhosphoSitePlusiQ00887.

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiENSG00000183668.
CleanExiHS_PSG11.
HS_PSG9.
ExpressionAtlasiQ00887. baseline and differential.
GenevisibleiQ00887. HS.

Organism-specific databases

HPAiHPA046327.

Interactioni

Protein-protein interaction databases

BioGridi111652. 19 interactors.
IntActiQ00887. 5 interactors.
MINTiMINT-1180125.

Structurei

3D structure databases

ProteinModelPortaliQ00887.
SMRiQ00887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-typeAdd BLAST110
Domaini147 – 234Ig-like C2-type 1Add BLAST88
Domaini242 – 326Ig-like C2-type 2Add BLAST85
Domaini335 – 410Ig-like C2-type 3Add BLAST76

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 129Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ00887.
KOiK06500.
OMAiVTECVND.
OrthoDBiEOG091G0AMM.
PhylomeDBiQ00887.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q00887-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLPAPSCT QRITWKGLLL TASLLNFWNP PTTAEVTIEA QPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLPGYFWYKG EMTDLYHYII SYIVDGKIII YGPAYSGRET
110 120 130 140 150
VYSNASLLIQ NVTRKDAGTY TLHIIKRGDE TREEIRHFTF TLYLETPKPY
160 170 180 190 200
ISSSNLNPRE AMEAVRLICD PETLDASYLW WMNGQSLPVT HRLQLSKTNR
210 220 230 240 250
TLYLFGVTKY IAGPYECEIR NPVSASRSDP VTLNLLPKLP IPYITINNLN
260 270 280 290 300
PRENKDVLAF TCEPKSENYT YIWWLNGQSL PVSPGVKRPI ENRILILPSV
310 320 330 340 350
TRNETGPYQC EIRDRYGGLR SNPVILNVLY GPDLPRIYPS FTYYRSGENL
360 370 380 390 400
DLSCFTESNP PAEYFWTING KFQQSGQKLF IPQITRNHSG LYACSVHNSA
410 420
TGKEISKSMT VKVSGPCHGD LTESQS
Length:426
Mass (Da):48,272
Last modified:July 15, 1999 - v2
Checksum:i69F72CF4B608BA39
GO
Isoform 2 (identifier: Q00887-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-330: PKLPIPYITI...SNPVILNVLY → H
     416-426: PCHGDLTESQS → KWIPASLAVG...KKVGRGLYQP

Show »
Length:402
Mass (Da):45,336
Checksum:iF57EC479DC08120E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4L → F in AAA60203 (PubMed:1581354).Curated1
Sequence conflicti49K → Q in AAA63251 (PubMed:1581354).Curated1
Sequence conflicti203Y → C in CAA35612 (PubMed:2322584).Curated1
Sequence conflicti226S → I in AAA60203 (PubMed:1581354).Curated1
Sequence conflicti313R → Q in AAH20759 (PubMed:15489334).Curated1
Sequence conflicti349N → I in AAA63251 (PubMed:1581354).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05941018L → V.Corresponds to variant rs8101191dbSNPEnsembl.1
Natural variantiVAR_058296176A → T.Corresponds to variant rs1058085dbSNPEnsembl.1
Natural variantiVAR_049925325I → T.Corresponds to variant rs1135905dbSNPEnsembl.1
Natural variantiVAR_049926374Q → L.Corresponds to variant rs2074923dbSNPEnsembl.1
Natural variantiVAR_049927397H → R.Corresponds to variant rs2072285dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055602237 – 330PKLPI…LNVLY → H in isoform 2. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_055603416 – 426PCHGDLTESQS → KWIPASLAVGFYVESIWLSE KSQENIFIPSLCPMGTSKSQ ILLLNPPNLSLQTLFSLFFC FLMADLVSGLKKVGRGLYQP in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17610 mRNA. Translation: CAA35612.1.
M34421 mRNA. Translation: AAA52605.1.
M34481 mRNA. Translation: AAA74512.1.
M38046 mRNA. Translation: AAA63251.1.
M94890 mRNA. Translation: AAA60194.1.
M58591 mRNA. Translation: AAA60203.1.
AK313256 mRNA. Translation: BAG36066.1.
AC005392 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57180.1.
CH471126 Genomic DNA. Translation: EAW57183.1.
BC020759 mRNA. Translation: AAH20759.1.
AH007520 Genomic DNA. Translation: AAD21023.1.
M38243 Genomic DNA. Translation: AAA63252.1.
U04325 Genomic DNA. Translation: AAA78266.1.
CCDSiCCDS12618.1. [Q00887-1]
PIRiB35334.
C55181.
S09016.
RefSeqiNP_001288636.1. NM_001301707.1.
NP_001288637.1. NM_001301708.1.
NP_001288638.1. NM_001301709.1.
NP_002775.3. NM_002784.4. [Q00887-1]
XP_005259132.1. XM_005259075.3. [Q00887-2]
UniGeneiHs.502092.

Genome annotation databases

EnsembliENST00000244293; ENSP00000244293; ENSG00000183668. [Q00887-2]
ENST00000270077; ENSP00000270077; ENSG00000183668. [Q00887-1]
GeneIDi5678.
KEGGihsa:5678.
UCSCiuc002owd.5. human. [Q00887-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17610 mRNA. Translation: CAA35612.1.
M34421 mRNA. Translation: AAA52605.1.
M34481 mRNA. Translation: AAA74512.1.
M38046 mRNA. Translation: AAA63251.1.
M94890 mRNA. Translation: AAA60194.1.
M58591 mRNA. Translation: AAA60203.1.
AK313256 mRNA. Translation: BAG36066.1.
AC005392 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57180.1.
CH471126 Genomic DNA. Translation: EAW57183.1.
BC020759 mRNA. Translation: AAH20759.1.
AH007520 Genomic DNA. Translation: AAD21023.1.
M38243 Genomic DNA. Translation: AAA63252.1.
U04325 Genomic DNA. Translation: AAA78266.1.
CCDSiCCDS12618.1. [Q00887-1]
PIRiB35334.
C55181.
S09016.
RefSeqiNP_001288636.1. NM_001301707.1.
NP_001288637.1. NM_001301708.1.
NP_001288638.1. NM_001301709.1.
NP_002775.3. NM_002784.4. [Q00887-1]
XP_005259132.1. XM_005259075.3. [Q00887-2]
UniGeneiHs.502092.

3D structure databases

ProteinModelPortaliQ00887.
SMRiQ00887.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111652. 19 interactors.
IntActiQ00887. 5 interactors.
MINTiMINT-1180125.

PTM databases

iPTMnetiQ00887.
PhosphoSitePlusiQ00887.

Polymorphism and mutation databases

BioMutaiPSG9.
DMDMi6093845.

Proteomic databases

PaxDbiQ00887.
PeptideAtlasiQ00887.
PRIDEiQ00887.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244293; ENSP00000244293; ENSG00000183668. [Q00887-2]
ENST00000270077; ENSP00000270077; ENSG00000183668. [Q00887-1]
GeneIDi5678.
KEGGihsa:5678.
UCSCiuc002owd.5. human. [Q00887-1]

Organism-specific databases

CTDi5678.
DisGeNETi5678.
GeneCardsiPSG9.
HGNCiHGNC:9526. PSG9.
HPAiHPA046327.
MIMi176398. gene.
neXtProtiNX_Q00887.
OpenTargetsiENSG00000183668.
PharmGKBiPA33871.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG1N. Eukaryota.
ENOG410YTW2. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ00887.
KOiK06500.
OMAiVTECVND.
OrthoDBiEOG091G0AMM.
PhylomeDBiQ00887.
TreeFamiTF336859.

Miscellaneous databases

ChiTaRSiPSG9. human.
GeneWikiiPSG9.
GenomeRNAii5678.
PROiQ00887.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183668.
CleanExiHS_PSG11.
HS_PSG9.
ExpressionAtlasiQ00887. baseline and differential.
GenevisibleiQ00887. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSG9_HUMAN
AccessioniPrimary (citable) accession number: Q00887
Secondary accession number(s): B2R869
, Q15227, Q15236, Q15237, Q8WW78, Q9UQ73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1999
Last modified: November 30, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.