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Q00871

- CTRB1_LITVA

UniProt

Q00871 - CTRB1_LITVA

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Protein
Chymotrypsin BI
Gene
N/A
Organism
Litopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Serine protease with chymotryptic and collagenolytic activities.

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Charge relay system By similarity
Active sitei132 – 1321Charge relay system By similarity
Active sitei223 – 2231Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. collagen catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Collagen degradation

Protein family/group databases

MEROPSiS01.122.

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin BI (EC:3.4.21.1)
OrganismiLitopenaeus vannamei (Whiteleg shrimp) (Penaeus vannamei)
Taxonomic identifieri6689 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaDendrobranchiataPenaeoideaPenaeidaeLitopenaeus

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed prediction
Add
BLAST
Propeptidei16 – 4530Activation peptide
PRO_0000027650Add
BLAST
Chaini46 – 271226Chymotrypsin BI
PRO_0000027651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 87 By similarity
Disulfide bondi196 ↔ 209 By similarity
Disulfide bondi219 ↔ 245 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ00871.
SMRiQ00871. Positions 46-271.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 268223Peptidase S1
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00871-1 [UniParc]FASTAAdd to Basket

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MIGKLSLLLV CVAVASGNPA AGKPWHWKSP KPLVDPRIHV NATPRIVGGV    50
EATPHSWPHQ AALFIDDMYF CGGSLISSEW VLTAAHCMDG AGFVEVVLGA 100
HNIRQNEASQ VSITSTDFFT HENWNSWLLT NDIALIRLPS PVSLNSNIKT 150
VKLPSSDVSV GTTVTPTGWG RPSDSASGIS DVLRQVNVPV MTNADCDSVY 200
GIVGDGVVCI DGTGGKSTCN GDSGGPLNLN GMTYGITSFG SSAGCEKGYP 250
AAFTRVYYYL DWIQQKTGVT P 271
Length:271
Mass (Da):28,685
Last modified:February 1, 1994 - v1
Checksum:i0967398D5401E5B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66415 mRNA. Translation: CAA47046.1.
PIRiS29239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66415 mRNA. Translation: CAA47046.1 .
PIRi S29239.

3D structure databases

ProteinModelPortali Q00871.
SMRi Q00871. Positions 46-271.
ModBasei Search...

Protein family/group databases

MEROPSi S01.122.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a cDNA that encodes a serine protease with chymotryptic and collagenolytic activities in the hepatopancreas of the shrimp Penaeus vanameii (Crustacea, Decapoda)."
    Sellos D., van Wormhoudt A.
    FEBS Lett. 309:219-224(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hepatopancreas.
  2. "Purification, biochemical characterization and N-terminal sequence of a serine-protease with chymotrypsic and collagenolytic activities in a tropical shrimp, Penaeus vannamei (Crustacea, Decapoda)."
    van Wormhoudt A., le Chevalier P., Sellos D.
    Comp. Biochem. Physiol. 103B:675-680(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 46-65, CHARACTERIZATION.
    Tissue: Hepatopancreas.

Entry informationi

Entry nameiCTRB1_LITVA
AccessioniPrimary (citable) accession number: Q00871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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