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Q00859

- MAPK_FUSSO

UniProt

Q00859 - MAPK_FUSSO

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Protein

Mitogen-activated protein kinase

Gene

MAPK

Organism
Fusarium solani subsp. pisi (Nectria haematococca)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Responds to activation by environmental stress by phosphorylating downstream targets.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521ATPPROSITE-ProRule annotation
Active sitei147 – 1471Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 379ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.24. 2361.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase (EC:2.7.11.24)
Alternative name(s):
FsMAPK
Gene namesi
Name:MAPK
OrganismiFusarium solani subsp. pisi (Nectria haematococca)
Taxonomic identifieri70791 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Mitogen-activated protein kinasePRO_0000186335Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831PhosphothreonineBy similarity
Modified residuei185 – 1851PhosphotyrosineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ00859.

Structurei

3D structure databases

ProteinModelPortaliQ00859.
SMRiQ00859. Positions 13-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 311289Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi183 – 1853TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00859-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRSNPPNPT GSRKISFNVS EQYDIQDVVG EGAYGVVCSA IHKPSGQKVA
60 70 80 90 100
IKKITPFDHS MFCLRTLREM KLLRYFNHEN IISILDIQKP RNYESFNEVY
110 120 130 140 150
LIQELMETDM HRAIRTQDLS DDHCQYFIYQ TLRALKAMHS ANVLHRDLKP
160 170 180 190 200
SNLLLNANCD LKVCDFGLAR SAASQEDNSG FMTEYVATRW YRAPEIMLTF
210 220 230 240 250
KEYTKAIDVW SVGCILAEML SGKPLFPGKD YHHQLTLILD VLGTPTMEDY
260 270 280 290 300
YGIKSRRARE YIRSLPFKKK VPFRTLFPKT SDLALDLLEK LLAFNPVKRI
310 320 330 340 350
TVEEALKHPY LEPYHDPEDE PTAPPIPEEF FDFDKHKDNL SKEQLKQLIY

QEIMR
Length:355
Mass (Da):41,221
Last modified:November 1, 1996 - v1
Checksum:iD692EF98EF76C0CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52963 mRNA. Translation: AAB72017.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52963 mRNA. Translation: AAB72017.1 .

3D structure databases

ProteinModelPortali Q00859.
SMRi Q00859. Positions 13-354.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q00859.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.11.24. 2361.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of cDNA encoding a mitogen-activated protein kinase from a phytopathogenic filamentous fungus."
    Li D., Rogers L., Kolattukudy P.E.
    Gene 195:161-166(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: T-8.

Entry informationi

Entry nameiMAPK_FUSSO
AccessioniPrimary (citable) accession number: Q00859
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3