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Protein

Mite group 2 allergen Der f 2

Gene

DERF2

Organism
Dermatophagoides farinae (American house dust mite)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Mite group 2 allergen Der f 2
Alternative name(s):
Allergen Der f II
Allergen: Der f 2
Gene namesi
Name:DERF2
OrganismiDermatophagoides farinae (American house dust mite)
Taxonomic identifieri6954 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei1108. Der f 2.0103.
1294. Der f 2.0101.
1295. Der f 2.0102.
302. Der f 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000001986018 – 146Mite group 2 allergen Der f 2Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 1361 Publication
Disulfide bondi38 ↔ 441 Publication
Disulfide bondi90 ↔ 951 Publication

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 28Combined sources6
Beta strandi30 – 35Combined sources6
Beta strandi36 – 38Combined sources3
Beta strandi40 – 43Combined sources4
Beta strandi44 – 47Combined sources4
Beta strandi50 – 59Combined sources10
Beta strandi68 – 75Combined sources8
Beta strandi78 – 80Combined sources3
Beta strandi83 – 85Combined sources3
Helixi89 – 91Combined sources3
Turni92 – 94Combined sources3
Beta strandi95 – 97Combined sources3
Beta strandi102 – 110Combined sources9
Beta strandi121 – 129Combined sources9
Beta strandi132 – 139Combined sources8
Beta strandi142 – 145Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AHKNMR-A18-146[»]
1AHMNMR-A18-146[»]
1WRFNMR-A18-146[»]
1XWVX-ray1.83A/B18-146[»]
2F08X-ray2.20A/B/C/D18-146[»]
ProteinModelPortaliQ00855.
SMRiQ00855.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00855.

Family & Domainsi

Sequence similaritiesi

Belongs to the NPC2 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.40.770. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR003172. ML_dom.
[Graphical view]
PfamiPF02221. E1_DerP2_DerF2. 1 hit.
[Graphical view]
SMARTiSM00737. ML. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISKILCLSL LVAAVVADQV DVKDCANNEI KKVMVDGCHG SDPCIIHRGK
60 70 80 90 100
PFTLEALFDA NQNTKTAKIE IKASLDGLEI DVPGIDTNAC HFMKCPLVKG
110 120 130 140
QQYDIKYTWN VPKIAPKSEN VVVTVKLIGD NGVLACAIAT HGKIRD
Length:146
Mass (Da):15,802
Last modified:October 1, 1993 - v1
Checksum:iFA118206CD88534A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5 – 8ILCL → GTMV in AAB30829 (PubMed:8198452).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti93M → V in clone 1. 1
Natural varianti105I → A in clone 11. 1
Natural varianti128I → V in clone 11. 1
Natural varianti142G → A in clone 11. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10447 mRNA. Translation: BAA01239.1.
D10448 mRNA. Translation: BAA01240.1.
D10449 mRNA. Translation: BAA01241.1.
S70378 mRNA. Translation: AAB30829.1.
PIRiJU0394.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10447 mRNA. Translation: BAA01239.1.
D10448 mRNA. Translation: BAA01240.1.
D10449 mRNA. Translation: BAA01241.1.
S70378 mRNA. Translation: AAB30829.1.
PIRiJU0394.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AHKNMR-A18-146[»]
1AHMNMR-A18-146[»]
1WRFNMR-A18-146[»]
1XWVX-ray1.83A/B18-146[»]
2F08X-ray2.20A/B/C/D18-146[»]
ProteinModelPortaliQ00855.
SMRiQ00855.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1108. Der f 2.0103.
1294. Der f 2.0101.
1295. Der f 2.0102.
302. Der f 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ00855.

Family and domain databases

Gene3Di2.60.40.770. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR003172. ML_dom.
[Graphical view]
PfamiPF02221. E1_DerP2_DerF2. 1 hit.
[Graphical view]
SMARTiSM00737. ML. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALL2_DERFA
AccessioniPrimary (citable) accession number: Q00855
Secondary accession number(s): P39672, Q26359
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The sequence shown here is from clone 2. The N-terminal sequence (AA 1-8) from clone 1 and 11 are not yet known.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.