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Q007T0

- SDHB_PIG

UniProt

Q007T0 - SDHB_PIG

Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

SDHB

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.
    Binds 1 3Fe-4S cluster.
    Binds 1 4Fe-4S cluster.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi93 – 931Iron-sulfur 1 (2Fe-2S)
    Metal bindingi98 – 981Iron-sulfur 1 (2Fe-2S)
    Metal bindingi101 – 1011Iron-sulfur 1 (2Fe-2S)
    Metal bindingi113 – 1131Iron-sulfur 1 (2Fe-2S)
    Metal bindingi186 – 1861Iron-sulfur 2 (4Fe-4S)
    Metal bindingi189 – 1891Iron-sulfur 2 (4Fe-4S)
    Metal bindingi192 – 1921Iron-sulfur 2 (4Fe-4S)
    Metal bindingi196 – 1961Iron-sulfur 3 (3Fe-4S)
    Binding sitei201 – 2011Ubiquinone; shared with DHSD1 Publication
    Metal bindingi243 – 2431Iron-sulfur 3 (3Fe-4S)
    Metal bindingi249 – 2491Iron-sulfur 3 (3Fe-4S)
    Metal bindingi253 – 2531Iron-sulfur 2 (4Fe-4S)

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
    2. 3 iron, 4 sulfur cluster binding Source: UniProtKB
    3. 4 iron, 4 sulfur cluster binding Source: UniProtKB
    4. electron carrier activity Source: InterPro
    5. metal ion binding Source: UniProtKB-KW
    6. protein binding Source: UniProtKB
    7. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    8. ubiquinone binding Source: UniProtKB

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Iron-sulfur subunit of complex II
    Short name:
    Ip
    Gene namesi
    Name:SDHB
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB
    2. mitochondrial respiratory chain complex II Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2828MitochondrionAdd
    BLAST
    Chaini29 – 280252Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000343799Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei51 – 511N6-acetyllysineBy similarity
    Modified residuei55 – 551N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ007T0.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.1 Publication

    Structurei

    Secondary structure

    1
    280
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi39 – 468
    Beta strandi51 – 533
    Beta strandi57 – 648
    Helixi65 – 673
    Helixi72 – 8110
    Beta strandi94 – 985
    Beta strandi103 – 1053
    Beta strandi108 – 1103
    Turni112 – 1143
    Beta strandi123 – 1286
    Beta strandi130 – 1323
    Beta strandi133 – 1375
    Helixi144 – 1529
    Turni163 – 1675
    Helixi174 – 1785
    Turni179 – 1857
    Helixi193 – 1953
    Helixi197 – 2026
    Turni203 – 2053
    Helixi208 – 21912
    Helixi227 – 2326
    Beta strandi236 – 2383
    Turni239 – 2424
    Helixi250 – 2523
    Helixi259 – 27012

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ZOYX-ray2.40B29-279[»]
    1ZP0X-ray3.50B29-279[»]
    3ABVX-ray3.24B29-280[»]
    3AE1X-ray3.14B29-280[»]
    3AE2X-ray3.10B29-280[»]
    3AE3X-ray3.35B29-280[»]
    3AE4X-ray2.91B29-280[»]
    3AE5X-ray3.41B29-280[»]
    3AE6X-ray3.40B29-280[»]
    3AE7X-ray3.62B29-280[»]
    3AE8X-ray3.40B29-280[»]
    3AE9X-ray3.31B29-280[»]
    3AEAX-ray3.39B29-280[»]
    3AEBX-ray3.00B29-280[»]
    3AECX-ray3.61B29-280[»]
    3AEDX-ray3.52B29-280[»]
    3AEEX-ray3.22B29-280[»]
    3AEFX-ray2.80B29-280[»]
    3AEGX-ray3.27B29-280[»]
    3SFDX-ray2.61B29-280[»]
    3SFEX-ray2.81B29-280[»]
    ProteinModelPortaliQ007T0.
    SMRiQ007T0. Positions 37-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ007T0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini40 – 131922Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini176 – 206314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG005483.
    KOiK00235.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view]
    PfamiPF13085. Fer2_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR00384. dhsB. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q007T0-1 [UniParc]FASTAAdd to Basket

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    MAAVVAVSLK RWFPATTLGG ACLQACRGAQ TAAATAPRIK KFAIYRWDPD    50
    KTGDKPHMQT YEIDLNNCGP MVLDALIKIK NEIDSTLTFR RSCREGICGS 100
    CAMNINGGNT LACTRRIDTN LDKVSKIYPL PHMYVIKDLV PDLSNFYAQY 150
    KSIEPYLKKK DESQEGKQQY LQSIEEREKL DGLYECILCA CCSTSCPSYW 200
    WNGDKYLGPA VLMQAYRWMI DSRDDFTEER LAKLQDPFSL YRCHTIMNCT 250
    GTCPKGLNPG KAIAEIKKMM ATYKEKKASA 280
    Length:280
    Mass (Da):31,586
    Last modified:November 14, 2006 - v1
    Checksum:i096B11189EF1ED59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ915498 mRNA. Translation: ABJ09403.1.
    DQ403018 mRNA. Translation: ABD77151.1.
    RefSeqiNP_001098423.1. NM_001104953.1.
    UniGeneiSsc.55804.

    Genome annotation databases

    GeneIDi414412.
    KEGGissc:414412.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ915498 mRNA. Translation: ABJ09403.1 .
    DQ403018 mRNA. Translation: ABD77151.1 .
    RefSeqi NP_001098423.1. NM_001104953.1.
    UniGenei Ssc.55804.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ZOY X-ray 2.40 B 29-279 [» ]
    1ZP0 X-ray 3.50 B 29-279 [» ]
    3ABV X-ray 3.24 B 29-280 [» ]
    3AE1 X-ray 3.14 B 29-280 [» ]
    3AE2 X-ray 3.10 B 29-280 [» ]
    3AE3 X-ray 3.35 B 29-280 [» ]
    3AE4 X-ray 2.91 B 29-280 [» ]
    3AE5 X-ray 3.41 B 29-280 [» ]
    3AE6 X-ray 3.40 B 29-280 [» ]
    3AE7 X-ray 3.62 B 29-280 [» ]
    3AE8 X-ray 3.40 B 29-280 [» ]
    3AE9 X-ray 3.31 B 29-280 [» ]
    3AEA X-ray 3.39 B 29-280 [» ]
    3AEB X-ray 3.00 B 29-280 [» ]
    3AEC X-ray 3.61 B 29-280 [» ]
    3AED X-ray 3.52 B 29-280 [» ]
    3AEE X-ray 3.22 B 29-280 [» ]
    3AEF X-ray 2.80 B 29-280 [» ]
    3AEG X-ray 3.27 B 29-280 [» ]
    3SFD X-ray 2.61 B 29-280 [» ]
    3SFE X-ray 2.81 B 29-280 [» ]
    ProteinModelPortali Q007T0.
    SMRi Q007T0. Positions 37-275.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q007T0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 414412.
    KEGGi ssc:414412.

    Organism-specific databases

    CTDi 6390.

    Phylogenomic databases

    HOVERGENi HBG005483.
    KOi K00235.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .

    Miscellaneous databases

    EvolutionaryTracei Q007T0.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view ]
    Pfami PF13085. Fer2_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR00384. dhsB. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Liu G.Y.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Housekeeping genes for phylogenetic analysis of eutherian relationships."
      Kullberg M., Nilsson M.A., Arnason U., Harley E.H., Janke A.
      Mol. Biol. Evol. 23:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-264.
      Tissue: Liver.
    3. "Crystal structure of mitochondrial respiratory membrane protein complex II."
      Sun F., Huo X., Zhai Y., Wang A., Xu J., Su D., Bartlam M., Rao Z.
      Cell 121:1043-1057(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 29-279 IN COMPLEX WITH IRON-SULFUR CLUSTERS AND UBIQUINONE, SUBUNIT.

    Entry informationi

    Entry nameiSDHB_PIG
    AccessioniPrimary (citable) accession number: Q007T0
    Secondary accession number(s): Q0QEX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3