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Q007T0 (SDHB_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

EC=1.3.5.1
Alternative name(s):
Iron-sulfur subunit of complex II
Short name=Ip
Gene names
Name:SDHB
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster.

Binds 1 3Fe-4S cluster.

Binds 1 4Fe-4S cluster.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Ref.3

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2828Mitochondrion
Chain29 – 280252Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
PRO_0000343799

Regions

Domain40 – 131922Fe-2S ferredoxin-type
Domain176 – 206314Fe-4S ferredoxin-type

Sites

Metal binding931Iron-sulfur 1 (2Fe-2S)
Metal binding981Iron-sulfur 1 (2Fe-2S)
Metal binding1011Iron-sulfur 1 (2Fe-2S)
Metal binding1131Iron-sulfur 1 (2Fe-2S)
Metal binding1861Iron-sulfur 2 (4Fe-4S)
Metal binding1891Iron-sulfur 2 (4Fe-4S)
Metal binding1921Iron-sulfur 2 (4Fe-4S)
Metal binding1961Iron-sulfur 3 (3Fe-4S)
Metal binding2431Iron-sulfur 3 (3Fe-4S)
Metal binding2491Iron-sulfur 3 (3Fe-4S)
Metal binding2531Iron-sulfur 2 (4Fe-4S)
Binding site2011Ubiquinone; shared with DHSD

Amino acid modifications

Modified residue511N6-acetyllysine By similarity
Modified residue551N6-acetyllysine By similarity

Secondary structure

.............................................. 280
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q007T0 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 096B11189EF1ED59

FASTA28031,586
        10         20         30         40         50         60 
MAAVVAVSLK RWFPATTLGG ACLQACRGAQ TAAATAPRIK KFAIYRWDPD KTGDKPHMQT 

        70         80         90        100        110        120 
YEIDLNNCGP MVLDALIKIK NEIDSTLTFR RSCREGICGS CAMNINGGNT LACTRRIDTN 

       130        140        150        160        170        180 
LDKVSKIYPL PHMYVIKDLV PDLSNFYAQY KSIEPYLKKK DESQEGKQQY LQSIEEREKL 

       190        200        210        220        230        240 
DGLYECILCA CCSTSCPSYW WNGDKYLGPA VLMQAYRWMI DSRDDFTEER LAKLQDPFSL 

       250        260        270        280 
YRCHTIMNCT GTCPKGLNPG KAIAEIKKMM ATYKEKKASA 

« Hide

References

« Hide 'large scale' references
[1]Liu G.Y.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Housekeeping genes for phylogenetic analysis of eutherian relationships."
Kullberg M., Nilsson M.A., Arnason U., Harley E.H., Janke A.
Mol. Biol. Evol. 23:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-264.
Tissue: Liver.
[3]"Crystal structure of mitochondrial respiratory membrane protein complex II."
Sun F., Huo X., Zhai Y., Wang A., Xu J., Su D., Bartlam M., Rao Z.
Cell 121:1043-1057(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 29-279 IN COMPLEX WITH IRON-SULFUR CLUSTERS AND UBIQUINONE, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ915498 mRNA. Translation: ABJ09403.1.
DQ403018 mRNA. Translation: ABD77151.1.
RefSeqNP_001098423.1. NM_001104953.1.
UniGeneSsc.55804.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZOYX-ray2.40B29-279[»]
1ZP0X-ray3.50B29-279[»]
3ABVX-ray3.24B29-280[»]
3AE1X-ray3.14B29-280[»]
3AE2X-ray3.10B29-280[»]
3AE3X-ray3.35B29-280[»]
3AE4X-ray2.91B29-280[»]
3AE5X-ray3.41B29-280[»]
3AE6X-ray3.40B29-280[»]
3AE7X-ray3.62B29-280[»]
3AE8X-ray3.40B29-280[»]
3AE9X-ray3.31B29-280[»]
3AEAX-ray3.39B29-280[»]
3AEBX-ray3.00B29-280[»]
3AECX-ray3.61B29-280[»]
3AEDX-ray3.52B29-280[»]
3AEEX-ray3.22B29-280[»]
3AEFX-ray2.80B29-280[»]
3AEGX-ray3.27B29-280[»]
3SFDX-ray2.61B29-279[»]
3SFEX-ray2.81B29-279[»]
ProteinModelPortalQ007T0.
SMRQ007T0. Positions 37-275.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ007T0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID414412.
KEGGssc:414412.

Organism-specific databases

CTD6390.

Phylogenomic databases

HOVERGENHBG005483.
KOK00235.

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ007T0.

Entry information

Entry nameSDHB_PIG
AccessionPrimary (citable) accession number: Q007T0
Secondary accession number(s): Q0QEX6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: November 14, 2006
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways