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Q00788

- V2R_RAT

UniProt

Q00788 - V2R_RAT

Protein

Vasopressin V2 receptor

Gene

Avpr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Involved in renal water reabsorption By similarity. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.By similarity

    GO - Molecular functioni

    1. peptide hormone binding Source: RGD
    2. vasopressin receptor activity Source: RGD

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: RGD
    2. I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    3. interferon-gamma production Source: Ensembl
    4. negative regulation of renal sodium excretion Source: RGD
    5. negative regulation of urine volume Source: RGD
    6. positive regulation of blood pressure Source: RGD
    7. positive regulation of cell proliferation Source: RGD
    8. positive regulation of gene expression Source: UniProtKB
    9. positive regulation of systemic arterial blood pressure Source: RGD
    10. response to cytokine Source: Ensembl
    11. telencephalon development Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vasopressin V2 receptor
    Short name:
    V2R
    Alternative name(s):
    AVPR V2
    Antidiuretic hormone receptor
    Renal-type arginine vasopressin receptor
    Gene namesi
    Name:Avpr2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi2186. Avpr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: RGD
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 371371Vasopressin V2 receptorPRO_0000070211Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Lipidationi341 – 3411S-palmitoyl cysteineBy similarity
    Lipidationi342 – 3421S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ00788.
    PRIDEiQ00788.

    PTM databases

    PhosphoSiteiQ00788.

    Expressioni

    Tissue specificityi

    Kidney.

    Gene expression databases

    GenevestigatoriQ00788.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000053179.

    Structurei

    Secondary structure

    1
    371
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi226 – 23611
    Helixi238 – 2425
    Turni243 – 2475
    Turni251 – 2533
    Helixi254 – 27118

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2JX4NMR-A226-271[»]
    ProteinModelPortaliQ00788.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ00788.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini64 – 7714CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini99 – 11315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini136 – 15924CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini181 – 20020ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 27151CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini294 – 30815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini329 – 37143CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 6325Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei114 – 13522Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei201 – 22020Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29322Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei309 – 32820Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299951.
    GeneTreeiENSGT00660000095384.
    HOGENOMiHOG000237331.
    HOVERGENiHBG105710.
    InParanoidiQ00788.
    KOiK04228.
    OMAiGGARWNR.
    OrthoDBiEOG7Z69CP.
    PhylomeDBiQ00788.
    TreeFamiTF106499.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR000161. Vprsn_rcpt_V2.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00898. VASOPRSNV2R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q00788-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLVSTVSAV PGLFSPPSSP SNSSQEELLD DRDPLLVRAE LALLSTIFVA    50
    VALSNGLVLG ALIRRGRRGR WAPMHVFISH LCLADLAVAL FQVLPQLAWD 100
    ATDRFHGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAYRH 150
    GGGARWNRPV LVAWAFSLLL SLPQLFIFAQ RDVGNGSGVF DCWARFAEPW 200
    GLRAYVTWIA LMVFVAPALG IAACQVLIFR EIHASLVPGP SERAGRRRRG 250
    RRTGSPSEGA HVSAAMAKTV RMTLVIVIVY VLCWAPFFLV QLWAAWDPEA 300
    PLERPPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCAQRHTTHS 350
    LGPQDESCAT ASSSLMKDTP S 371
    Length:371
    Mass (Da):40,749
    Last modified:February 1, 1994 - v2
    Checksum:i480636F298087D3C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti246 – 2549RRRRGRRTG → TPQRAPDR in CAA77989. (PubMed:1534150)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11932 mRNA. Translation: CAA77989.1.
    Z22758 Genomic DNA. Translation: CAA80439.1.
    AY338195 mRNA. Translation: AAQ01565.1.
    PIRiS44045.
    RefSeqiNP_062009.1. NM_019136.1.
    XP_006229611.1. XM_006229549.1.
    UniGeneiRn.209041.

    Genome annotation databases

    EnsembliENSRNOT00000056342; ENSRNOP00000053179; ENSRNOG00000037270.
    GeneIDi25108.
    KEGGirno:25108.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z11932 mRNA. Translation: CAA77989.1 .
    Z22758 Genomic DNA. Translation: CAA80439.1 .
    AY338195 mRNA. Translation: AAQ01565.1 .
    PIRi S44045.
    RefSeqi NP_062009.1. NM_019136.1.
    XP_006229611.1. XM_006229549.1.
    UniGenei Rn.209041.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2JX4 NMR - A 226-271 [» ]
    ProteinModelPortali Q00788.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000053179.

    Chemistry

    BindingDBi Q00788.
    ChEMBLi CHEMBL3766.
    GuidetoPHARMACOLOGYi 368.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q00788.

    Proteomic databases

    PaxDbi Q00788.
    PRIDEi Q00788.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000056342 ; ENSRNOP00000053179 ; ENSRNOG00000037270 .
    GeneIDi 25108.
    KEGGi rno:25108.

    Organism-specific databases

    CTDi 554.
    RGDi 2186. Avpr2.

    Phylogenomic databases

    eggNOGi NOG299951.
    GeneTreei ENSGT00660000095384.
    HOGENOMi HOG000237331.
    HOVERGENi HBG105710.
    InParanoidi Q00788.
    KOi K04228.
    OMAi GGARWNR.
    OrthoDBi EOG7Z69CP.
    PhylomeDBi Q00788.
    TreeFami TF106499.

    Miscellaneous databases

    EvolutionaryTracei Q00788.
    NextBioi 605447.
    PROi Q00788.

    Gene expression databases

    Genevestigatori Q00788.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR000161. Vprsn_rcpt_V2.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00898. VASOPRSNV2R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus."
      Lolait S.J., O'Carroll A.-M., McBride O.W., Konig M., Morel A., Brownstein M.J.
      Nature 357:336-339(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar Kyoto.
      Tissue: Kidney.
    2. "Molecular analysis of vasopressin receptors in the rat nephron. Evidence for alternative splicing of the V2 receptor."
      Firsov D., Mandon B., Morel A., Merot J., le Maout S., Bellanger A.C., de Rouffignac C., Elalouf J.-M., Buhler J.M.
      Pflugers Arch. 429:79-89(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION TO 246-254.
      Strain: Sprague-Dawley.
      Tissue: Kidney.
    3. "Rat vasopressin 2 receptor gene DNA sequence."
      Terry R., Mullins D.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiV2R_RAT
    AccessioniPrimary (citable) accession number: Q00788
    Secondary accession number(s): Q53ZC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3