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Q00788 (V2R_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vasopressin V2 receptor

Short name=V2R
Alternative name(s):
AVPR V2
Antidiuretic hormone receptor
Renal-type arginine vasopressin receptor
Gene names
Name:Avpr2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in renal water reabsorption By similarity. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Kidney.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement PubMed 15452133. Source: RGD

I-kappaB kinase/NF-kappaB signaling

Inferred from electronic annotation. Source: Ensembl

interferon-gamma production

Inferred from electronic annotation. Source: Ensembl

negative regulation of renal sodium excretion

Inferred from mutant phenotype PubMed 18596120. Source: RGD

negative regulation of urine volume

Inferred from mutant phenotype PubMed 18057218. Source: RGD

positive regulation of blood pressure

Inferred from mutant phenotype PubMed 12072411. Source: RGD

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 18787031. Source: RGD

positive regulation of gene expression

Inferred from mutant phenotype PubMed 16352747. Source: UniProtKB

positive regulation of systemic arterial blood pressure

Inferred from mutant phenotype PubMed 18957383. Source: RGD

response to cytokine

Inferred from electronic annotation. Source: Ensembl

telencephalon development

Inferred from expression pattern PubMed 11021977. Source: RGD

   Cellular_componentintegral component of membrane

Traceable author statement PubMed 15452133. Source: RGD

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpeptide hormone binding

Traceable author statement PubMed 11882591. Source: RGD

vasopressin receptor activity

Inferred from mutant phenotype PubMed 18971210. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371Vasopressin V2 receptor
PRO_0000070211

Regions

Topological domain1 – 3838Extracellular Potential
Transmembrane39 – 6325Helical; Name=1; Potential
Topological domain64 – 7714Cytoplasmic Potential
Transmembrane78 – 9821Helical; Name=2; Potential
Topological domain99 – 11315Extracellular Potential
Transmembrane114 – 13522Helical; Name=3; Potential
Topological domain136 – 15924Cytoplasmic Potential
Transmembrane160 – 18021Helical; Name=4; Potential
Topological domain181 – 20020Extracellular Potential
Transmembrane201 – 22020Helical; Name=5; Potential
Topological domain221 – 27151Cytoplasmic Potential
Transmembrane272 – 29322Helical; Name=6; Potential
Topological domain294 – 30815Extracellular Potential
Transmembrane309 – 32820Helical; Name=7; Potential
Topological domain329 – 37143Cytoplasmic Potential

Amino acid modifications

Lipidation3411S-palmitoyl cysteine By similarity
Lipidation3421S-palmitoyl cysteine By similarity
Glycosylation221N-linked (GlcNAc...) Potential
Glycosylation1851N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict246 – 2549RRRRGRRTG → TPQRAPDR in CAA77989. Ref.1

Secondary structure

......... 371
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q00788 [UniParc].

Last modified February 1, 1994. Version 2.
Checksum: 480636F298087D3C

FASTA37140,749
        10         20         30         40         50         60 
MLLVSTVSAV PGLFSPPSSP SNSSQEELLD DRDPLLVRAE LALLSTIFVA VALSNGLVLG 

        70         80         90        100        110        120 
ALIRRGRRGR WAPMHVFISH LCLADLAVAL FQVLPQLAWD ATDRFHGPDA LCRAVKYLQM 

       130        140        150        160        170        180 
VGMYASSYMI LAMTLDRHRA ICRPMLAYRH GGGARWNRPV LVAWAFSLLL SLPQLFIFAQ 

       190        200        210        220        230        240 
RDVGNGSGVF DCWARFAEPW GLRAYVTWIA LMVFVAPALG IAACQVLIFR EIHASLVPGP 

       250        260        270        280        290        300 
SERAGRRRRG RRTGSPSEGA HVSAAMAKTV RMTLVIVIVY VLCWAPFFLV QLWAAWDPEA 

       310        320        330        340        350        360 
PLERPPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCAQRHTTHS LGPQDESCAT 

       370 
ASSSLMKDTP S 

« Hide

References

[1]"Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus."
Lolait S.J., O'Carroll A.-M., McBride O.W., Konig M., Morel A., Brownstein M.J.
Nature 357:336-339(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar Kyoto.
Tissue: Kidney.
[2]"Molecular analysis of vasopressin receptors in the rat nephron. Evidence for alternative splicing of the V2 receptor."
Firsov D., Mandon B., Morel A., Merot J., le Maout S., Bellanger A.C., de Rouffignac C., Elalouf J.-M., Buhler J.M.
Pflugers Arch. 429:79-89(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION TO 246-254.
Strain: Sprague-Dawley.
Tissue: Kidney.
[3]"Rat vasopressin 2 receptor gene DNA sequence."
Terry R., Mullins D.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z11932 mRNA. Translation: CAA77989.1.
Z22758 Genomic DNA. Translation: CAA80439.1.
AY338195 mRNA. Translation: AAQ01565.1.
PIRS44045.
RefSeqNP_062009.1. NM_019136.1.
XP_006229611.1. XM_006229549.1.
UniGeneRn.209041.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2JX4NMR-A226-271[»]
ProteinModelPortalQ00788.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000053179.

Chemistry

BindingDBQ00788.
ChEMBLCHEMBL3766.
GuidetoPHARMACOLOGY368.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ00788.

Proteomic databases

PaxDbQ00788.
PRIDEQ00788.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000056342; ENSRNOP00000053179; ENSRNOG00000037270.
GeneID25108.
KEGGrno:25108.

Organism-specific databases

CTD554.
RGD2186. Avpr2.

Phylogenomic databases

eggNOGNOG299951.
GeneTreeENSGT00660000095384.
HOGENOMHOG000237331.
HOVERGENHBG105710.
InParanoidQ00788.
KOK04228.
OMAGGARWNR.
OrthoDBEOG7Z69CP.
PhylomeDBQ00788.
TreeFamTF106499.

Gene expression databases

GenevestigatorQ00788.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ00788.
NextBio605447.
PROQ00788.

Entry information

Entry nameV2R_RAT
AccessionPrimary (citable) accession number: Q00788
Secondary accession number(s): Q53ZC4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries