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Protein

Vasopressin V2 receptor

Gene

Avpr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:1534150). Involved in renal water reabsorption (By similarity).By similarity1 Publication

GO - Molecular functioni

  • peptide hormone binding Source: RGD
  • vasopressin receptor activity Source: RGD

GO - Biological processi

  • cellular response to hormone stimulus Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: RGD
  • I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  • interferon-gamma production Source: Ensembl
  • negative regulation of renal sodium excretion Source: RGD
  • negative regulation of urine volume Source: RGD
  • positive regulation of blood pressure Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of systemic arterial blood pressure Source: RGD
  • positive regulation of vasoconstriction Source: GO_Central
  • regulation of systemic arterial blood pressure by vasopressin Source: GO_Central
  • response to cytokine Source: Ensembl
  • response to peptide Source: GO_Central
  • telencephalon development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-388479. Vasopressin-like receptors.
R-RNO-418555. G alpha (s) signalling events.
R-RNO-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-RNO-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V2 receptor
Short name:
V2R
Alternative name(s):
AVPR V2
Antidiuretic hormone receptor
Renal-type arginine vasopressin receptor
Gene namesi
Name:Avpr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi2186. Avpr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 63Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini64 – 77CytoplasmicSequence analysisAdd BLAST14
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 113ExtracellularSequence analysisAdd BLAST15
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 159CytoplasmicSequence analysisAdd BLAST24
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 200ExtracellularSequence analysisAdd BLAST20
Transmembranei201 – 220Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini221 – 271CytoplasmicSequence analysisAdd BLAST51
Transmembranei272 – 293Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini294 – 308ExtracellularSequence analysisAdd BLAST15
Transmembranei309 – 328Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini329 – 371CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

  • integral component of membrane Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3766.
GuidetoPHARMACOLOGYi368.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702111 – 371Vasopressin V2 receptorAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...)Sequence analysis1
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1
Lipidationi341S-palmitoyl cysteineBy similarity1
Lipidationi342S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ00788.
PRIDEiQ00788.

PTM databases

PhosphoSitePlusiQ00788.

Expressioni

Tissue specificityi

Kidney.

Gene expression databases

BgeeiENSRNOG00000037270.
ExpressionAtlasiQ00788. baseline.
GenevisibleiQ00788. RN.

Interactioni

Subunit structurei

Interacts with ARRDC4. Identified in a complex containing at least ARRDC4, V2R and HGS.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053179.

Chemistry databases

BindingDBiQ00788.

Structurei

Secondary structure

1371
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi226 – 236Combined sources11
Helixi238 – 242Combined sources5
Turni243 – 247Combined sources5
Turni251 – 253Combined sources3
Helixi254 – 271Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JX4NMR-A226-271[»]
ProteinModelPortaliQ00788.
SMRiQ00788.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00788.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiQ00788.
KOiK04228.
OMAiGGARWNR.
OrthoDBiEOG091G0DB6.
PhylomeDBiQ00788.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00788-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLVSTVSAV PGLFSPPSSP SNSSQEELLD DRDPLLVRAE LALLSTIFVA
60 70 80 90 100
VALSNGLVLG ALIRRGRRGR WAPMHVFISH LCLADLAVAL FQVLPQLAWD
110 120 130 140 150
ATDRFHGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAYRH
160 170 180 190 200
GGGARWNRPV LVAWAFSLLL SLPQLFIFAQ RDVGNGSGVF DCWARFAEPW
210 220 230 240 250
GLRAYVTWIA LMVFVAPALG IAACQVLIFR EIHASLVPGP SERAGRRRRG
260 270 280 290 300
RRTGSPSEGA HVSAAMAKTV RMTLVIVIVY VLCWAPFFLV QLWAAWDPEA
310 320 330 340 350
PLERPPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCAQRHTTHS
360 370
LGPQDESCAT ASSSLMKDTP S
Length:371
Mass (Da):40,749
Last modified:February 1, 1994 - v2
Checksum:i480636F298087D3C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246 – 254RRRRGRRTG → TPQRAPDR in CAA77989 (PubMed:1534150).Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11932 mRNA. Translation: CAA77989.1.
Z22758 Genomic DNA. Translation: CAA80439.1.
AY338195 mRNA. Translation: AAQ01565.1.
PIRiS44045.
RefSeqiNP_062009.1. NM_019136.1.
XP_006229611.1. XM_006229549.3.
UniGeneiRn.209041.

Genome annotation databases

EnsembliENSRNOT00000091495; ENSRNOP00000071931; ENSRNOG00000059862.
GeneIDi25108.
KEGGirno:25108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11932 mRNA. Translation: CAA77989.1.
Z22758 Genomic DNA. Translation: CAA80439.1.
AY338195 mRNA. Translation: AAQ01565.1.
PIRiS44045.
RefSeqiNP_062009.1. NM_019136.1.
XP_006229611.1. XM_006229549.3.
UniGeneiRn.209041.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JX4NMR-A226-271[»]
ProteinModelPortaliQ00788.
SMRiQ00788.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053179.

Chemistry databases

BindingDBiQ00788.
ChEMBLiCHEMBL3766.
GuidetoPHARMACOLOGYi368.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ00788.

Proteomic databases

PaxDbiQ00788.
PRIDEiQ00788.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000091495; ENSRNOP00000071931; ENSRNOG00000059862.
GeneIDi25108.
KEGGirno:25108.

Organism-specific databases

CTDi554.
RGDi2186. Avpr2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiQ00788.
KOiK04228.
OMAiGGARWNR.
OrthoDBiEOG091G0DB6.
PhylomeDBiQ00788.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiR-RNO-388479. Vasopressin-like receptors.
R-RNO-418555. G alpha (s) signalling events.
R-RNO-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-RNO-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

EvolutionaryTraceiQ00788.
PROiQ00788.

Gene expression databases

BgeeiENSRNOG00000037270.
ExpressionAtlasiQ00788. baseline.
GenevisibleiQ00788. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV2R_RAT
AccessioniPrimary (citable) accession number: Q00788
Secondary accession number(s): Q53ZC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.