Vasopressin V2 receptor - Rattus norvegicus (Rat)

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Q00788 (V2R_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 108. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Vasopressin V2 receptor
Short name=V2R

Alternative name(s):
AVPR V2
Antidiuretic hormone receptor
Renal-type arginine vasopressin receptor

Gene names

Name:

Avpr2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in renal water reabsorption By similarity. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Kidney.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: Compara interferon-gamma production Inferred from electronic annotation. Source: Compara negative regulation of renal sodium excretion Inferred from mutant phenotype PubMed 18596120. Source: RGD negative regulation of urine volume Inferred from mutant phenotype PubMed 18057218. Source: RGD positive regulation of cell proliferation Inferred from mutant phenotype PubMed 18787031. Source: RGD positive regulation of gene expression Inferred from mutant phenotype PubMed 16352747. Source: UniProtKB positive regulation of systemic arterial blood pressure Inferred from mutant phenotype PubMed 18957383. Source: RGD response to cytokine stimulus Inferred from electronic annotation. Source: Compara telencephalon development Inferred from expression pattern PubMed 11021977. Source: RGD
Cellular_component	integral to membrane Traceable author statement PubMed 15452133. Source: RGD plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	peptide hormone binding Traceable author statement PubMed 11882591. Source: RGD vasopressin receptor activity Inferred from mutant phenotype PubMed 18971210. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 371

371

Vasopressin V2 receptor

PRO_0000070211

Regions

Topological domain

1 – 38

Extracellular Potential

Transmembrane

39 – 63

Helical; Name=1; Potential

Topological domain

64 – 77

Cytoplasmic Potential

Transmembrane

78 – 98

Helical; Name=2; Potential

Topological domain

99 – 113

Extracellular Potential

Transmembrane

114 – 135

Helical; Name=3; Potential

Topological domain

136 – 159

Cytoplasmic Potential

Transmembrane

160 – 180

Helical; Name=4; Potential

Topological domain

181 – 200

Extracellular Potential

Transmembrane

201 – 220

Helical; Name=5; Potential

Topological domain

221 – 271

Cytoplasmic Potential

Transmembrane

272 – 293

Helical; Name=6; Potential

Topological domain

294 – 308

Extracellular Potential

Transmembrane

309 – 328

Helical; Name=7; Potential

Topological domain

329 – 371

Cytoplasmic Potential

Amino acid modifications

Lipidation

341

S-palmitoyl cysteine By similarity

Lipidation

342

S-palmitoyl cysteine By similarity

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

185

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

246 – 254

RRRRGRRTG → TPQRAPDR in CAA77989. Ref.1

Secondary structure

371

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q00788 [UniParc].

Last modified February 1, 1994. Version 2.
Checksum: 480636F298087D3C
Show »

FASTA

371

40,749

        10         20         30         40         50         60 
MLLVSTVSAV PGLFSPPSSP SNSSQEELLD DRDPLLVRAE LALLSTIFVA VALSNGLVLG 

        70         80         90        100        110        120 
ALIRRGRRGR WAPMHVFISH LCLADLAVAL FQVLPQLAWD ATDRFHGPDA LCRAVKYLQM 

       130        140        150        160        170        180 
VGMYASSYMI LAMTLDRHRA ICRPMLAYRH GGGARWNRPV LVAWAFSLLL SLPQLFIFAQ 

       190        200        210        220        230        240 
RDVGNGSGVF DCWARFAEPW GLRAYVTWIA LMVFVAPALG IAACQVLIFR EIHASLVPGP 

       250        260        270        280        290        300 
SERAGRRRRG RRTGSPSEGA HVSAAMAKTV RMTLVIVIVY VLCWAPFFLV QLWAAWDPEA 

       310        320        330        340        350        360 
PLERPPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCAQRHTTHS LGPQDESCAT 

       370 
ASSSLMKDTP S

« Hide

References

[1]	"Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus." Lolait S.J., O'Carroll A.-M., McBride O.W., Konig M., Morel A., Brownstein M.J. Nature 357:336-339(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar Kyoto. Tissue: Kidney.
[2]	"Molecular analysis of vasopressin receptors in the rat nephron. Evidence for alternative splicing of the V2 receptor." Firsov D., Mandon B., Morel A., Merot J., le Maout S., Bellanger A.C., de Rouffignac C., Elalouf J.-M., Buhler J.M. Pflugers Arch. 429:79-89(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION TO 246-254. Strain: Sprague-Dawley. Tissue: Kidney.
[3]	"Rat vasopressin 2 receptor gene DNA sequence." Terry R., Mullins D. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z11932 mRNA. Translation: CAA77989.1.
Z22758 Genomic DNA. Translation: CAA80439.1.
AY338195 mRNA. Translation: AAQ01565.1.

IPI

IPI00202371.

PIR

S44045.

RefSeq

NP_062009.1. NM_019136.1.

UniGene

Rn.209041.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2JX4	NMR	-	A	225-271	[»]

ProteinModelPortal

Q00788.

ModBase

Search...

Protein-protein interaction databases

STRING

10116.ENSRNOP00000053179.

Protein family/group databases

GPCRDB

Search...

PTM databases

PhosphoSite

Q00788.

Proteomic databases

PaxDb

Q00788.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSRNOT00000056342; ENSRNOP00000053179; ENSRNOG00000037270.

GeneID

25108.

KEGG

rno:25108.

Organism-specific databases

CTD

554.

RGD

2186. Avpr2.

Phylogenomic databases

eggNOG

NOG299951.

GeneTree

ENSGT00660000095384.

HOGENOM

HOG000237331.

HOVERGEN

HBG105710.

InParanoid

Q00788.

K04228.

OrthoDB

EOG412M60.

Gene expression databases

Genevestigator

Q00788.

GermOnline

ENSRNOG00000037270. Rattus norvegicus.

Family and domain databases

InterPro

IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]

Pfam

PF00001. 7tm_1. 1 hit.
[Graphical view]

PRINTS

PR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.

PROSITE

PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q00788.

ChEMBL

CHEMBL3766.

EvolutionaryTrace

Q00788.

NextBio

605447.

Entry information

Entry name

V2R_RAT

Accession

Primary (citable) accession number: Q00788
Secondary accession number(s): Q53ZC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 108 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents