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Q00788

- V2R_RAT

UniProt

Q00788 - V2R_RAT

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Protein

Vasopressin V2 receptor

Gene

Avpr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in renal water reabsorption (By similarity). Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.By similarity

GO - Molecular functioni

  1. peptide hormone binding Source: RGD
  2. vasopressin receptor activity Source: RGD

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: RGD
  2. I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  3. interferon-gamma production Source: Ensembl
  4. negative regulation of renal sodium excretion Source: RGD
  5. negative regulation of urine volume Source: RGD
  6. positive regulation of blood pressure Source: RGD
  7. positive regulation of cell proliferation Source: RGD
  8. positive regulation of gene expression Source: UniProtKB
  9. positive regulation of systemic arterial blood pressure Source: RGD
  10. response to cytokine Source: Ensembl
  11. telencephalon development Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V2 receptor
Short name:
V2R
Alternative name(s):
AVPR V2
Antidiuretic hormone receptor
Renal-type arginine vasopressin receptor
Gene namesi
Name:Avpr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi2186. Avpr2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: RGD
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Vasopressin V2 receptorPRO_0000070211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
Lipidationi341 – 3411S-palmitoyl cysteineBy similarity
Lipidationi342 – 3421S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ00788.
PRIDEiQ00788.

PTM databases

PhosphoSiteiQ00788.

Expressioni

Tissue specificityi

Kidney.

Gene expression databases

GenevestigatoriQ00788.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053179.

Structurei

Secondary structure

1
371
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi226 – 23611
Helixi238 – 2425
Turni243 – 2475
Turni251 – 2533
Helixi254 – 27118

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JX4NMR-A226-271[»]
ProteinModelPortaliQ00788.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00788.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
BLAST
Topological domaini64 – 7714CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini99 – 11315ExtracellularSequence AnalysisAdd
BLAST
Topological domaini136 – 15924CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini181 – 20020ExtracellularSequence AnalysisAdd
BLAST
Topological domaini221 – 27151CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini294 – 30815ExtracellularSequence AnalysisAdd
BLAST
Topological domaini329 – 37143CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 6325Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei78 – 9821Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei114 – 13522Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei160 – 18021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei201 – 22020Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei272 – 29322Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei309 – 32820Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiQ00788.
KOiK04228.
OMAiGGARWNR.
OrthoDBiEOG7Z69CP.
PhylomeDBiQ00788.
TreeFamiTF106499.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00788 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLVSTVSAV PGLFSPPSSP SNSSQEELLD DRDPLLVRAE LALLSTIFVA
60 70 80 90 100
VALSNGLVLG ALIRRGRRGR WAPMHVFISH LCLADLAVAL FQVLPQLAWD
110 120 130 140 150
ATDRFHGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAYRH
160 170 180 190 200
GGGARWNRPV LVAWAFSLLL SLPQLFIFAQ RDVGNGSGVF DCWARFAEPW
210 220 230 240 250
GLRAYVTWIA LMVFVAPALG IAACQVLIFR EIHASLVPGP SERAGRRRRG
260 270 280 290 300
RRTGSPSEGA HVSAAMAKTV RMTLVIVIVY VLCWAPFFLV QLWAAWDPEA
310 320 330 340 350
PLERPPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCAQRHTTHS
360 370
LGPQDESCAT ASSSLMKDTP S
Length:371
Mass (Da):40,749
Last modified:February 1, 1994 - v2
Checksum:i480636F298087D3C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti246 – 2549RRRRGRRTG → TPQRAPDR in CAA77989. (PubMed:1534150)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z11932 mRNA. Translation: CAA77989.1.
Z22758 Genomic DNA. Translation: CAA80439.1.
AY338195 mRNA. Translation: AAQ01565.1.
PIRiS44045.
RefSeqiNP_062009.1. NM_019136.1.
XP_006229611.1. XM_006229549.2.
UniGeneiRn.209041.

Genome annotation databases

EnsembliENSRNOT00000056342; ENSRNOP00000053179; ENSRNOG00000037270.
GeneIDi25108.
KEGGirno:25108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z11932 mRNA. Translation: CAA77989.1 .
Z22758 Genomic DNA. Translation: CAA80439.1 .
AY338195 mRNA. Translation: AAQ01565.1 .
PIRi S44045.
RefSeqi NP_062009.1. NM_019136.1.
XP_006229611.1. XM_006229549.2.
UniGenei Rn.209041.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2JX4 NMR - A 226-271 [» ]
ProteinModelPortali Q00788.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000053179.

Chemistry

BindingDBi Q00788.
ChEMBLi CHEMBL3766.
GuidetoPHARMACOLOGYi 368.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q00788.

Proteomic databases

PaxDbi Q00788.
PRIDEi Q00788.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000056342 ; ENSRNOP00000053179 ; ENSRNOG00000037270 .
GeneIDi 25108.
KEGGi rno:25108.

Organism-specific databases

CTDi 554.
RGDi 2186. Avpr2.

Phylogenomic databases

eggNOGi NOG299951.
GeneTreei ENSGT00760000119156.
HOGENOMi HOG000237331.
HOVERGENi HBG105710.
InParanoidi Q00788.
KOi K04228.
OMAi GGARWNR.
OrthoDBi EOG7Z69CP.
PhylomeDBi Q00788.
TreeFami TF106499.

Miscellaneous databases

EvolutionaryTracei Q00788.
NextBioi 605447.
PROi Q00788.

Gene expression databases

Genevestigatori Q00788.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus."
    Lolait S.J., O'Carroll A.-M., McBride O.W., Konig M., Morel A., Brownstein M.J.
    Nature 357:336-339(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar Kyoto.
    Tissue: Kidney.
  2. "Molecular analysis of vasopressin receptors in the rat nephron. Evidence for alternative splicing of the V2 receptor."
    Firsov D., Mandon B., Morel A., Merot J., le Maout S., Bellanger A.C., de Rouffignac C., Elalouf J.-M., Buhler J.M.
    Pflugers Arch. 429:79-89(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SEQUENCE REVISION TO 246-254.
    Strain: Sprague-Dawley.
    Tissue: Kidney.
  3. "Rat vasopressin 2 receptor gene DNA sequence."
    Terry R., Mullins D.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiV2R_RAT
AccessioniPrimary (citable) accession number: Q00788
Secondary accession number(s): Q53ZC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3