Reviewed, UniProtKB/Swiss-Prot Q00777 (P5CR3_BACSU)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase 3
      Short name=P5C reductase 3
      Short name=P5CR 3
    EC=1.5.1.2

Gene names

Name:	proG
Synonyms:	ykeA, yzcA
Ordered Locus Names:	BSU12910

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Pyrroline-5-carboxylate reductase 3		PRO_0000187287

Sequences

	Sequence		Length	Mass (Da)
	Q00777-1 [UniParc]. Last modified July 15, 1999. Version 2. Checksum: 3109430A67868638	FASTA	272	30,203
	10 20 30 40 50 60 MEQIGLIGYG SMADMIARQL LKHEQIKENE LFIETRTKGE RLRALMSDYP NVSADPLENW 70 80 90 100 110 120 ANTCQLILIC VPPLHVIETM RRLYPYVNRN THIVSIAAGV PLRLLEAETE AGISRVIPAI 130 140 150 160 170 180 TSEAEAGISL VVHSEALAAE KKERLNELLS VFSRVREIKE SNLDVASNLT SSAPGFIAAI 190 200 210 220 230 240 FEELALSAVR NSSLSKEEAF DFLIHSLYGT GKMLIEKNMS FEETLERVAT KGGITGEGAE 250 260 270 VIHASVPDVF DEVFERTLRK YELLTEQVGK QT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of the Bacillus subtilis genome between xlyA and ykoR." Devine K.M. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[3]	"A Bacillus subtilis dipeptide transport system expressed early during sporulation." Mathiopoulos C., Mueller J.P., Slack F.J., Murphy C.G., Patankar S., Bukusoglu G., Sonenshein A.L. Mol. Microbiol. 5:1903-1913(1991) [PubMed: 1766370] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 247-272. Strain: 168.
[4]	"Multiple genes for the last step of proline biosynthesis in Bacillus subtilis." Belitsky B.R., Brill J., Bremer E., Sonenshein A.L. J. Bacteriol. 183:4389-4392(2001) [PubMed: 11418582] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ002571 Genomic DNA. Translation: CAA05571.1. Z99110 Genomic DNA. Translation: CAB13148.1. X56678 Genomic DNA. Translation: CAA40001.1.
PIR	F69855.
RefSeq	NP_389174.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	936776.
GenomeReviews	Gene locus BSU12910 in contig AL009126_GR.
KEGG	bsu:BSU12910.
NMPDR	fig|224308.1.peg.1293.
Organism-specific databases
SubtiList	BG10841. proG. [Micado]
CMR	Search...
Phylogenomic databases
HOGENOM	Q00777.
Enzyme and pathway databases
BioCyc	BSUB224308:BSU1293-MON.
Family and domain databases
InterPro	IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
PROSITE	PS00521. P5CR. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	Q00777.

Entry information

Entry name

P5CR3_BACSU

Accession

Primary (citable) accession number: Q00777

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	July 15, 1999
Last modified:	November 25, 2008
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)