Q00771 (KCC1_EMENI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcium/calmodulin-dependent protein kinase
Short name=CMPK
EC=2.7.11.17

Gene names

Name:	cmkA
ORF Names:	AN2412

Organism

Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

Taxonomic identifier

227321 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain.
Sequence caution	The sequence EAA64523.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Ligand	ATP-binding Calmodulin-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	Calcium/calmodulin-dependent protein kinase		PRO_0000086087
Regions
	Domain	23 – 278	256	Protein kinase
	Nucleotide binding	29 – 37	9	ATP By similarity
	Region	291 – 301	11	Calmodulin-binding By similarity
Sites
	Active site	142	1	Proton acceptor By similarity
	Binding site	50	1	ATP By similarity
Experimental info
	Sequence conflict	408	1	A → R in AAB97502. Ref.1
	Sequence conflict	408	1	A → R in AAD22581. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q00771 [UniParc]. Last modified May 26, 2009. Version 2. Checksum: 1E8D58A1C0B2E85C	FASTA	414	46,804
	10 20 30 40 50 60 MSFANMFNKL SGQPESYEKK SLYRFGRTLG AGTYGIVREA DCSSGKVAVK IILKRNVRGN 70 80 90 100 110 120 ERMVYDELDL LQKLNHPHIV HFVDWFESKD KFYIVTQLAT GGELFDRICE YGKFTEKDAS 130 140 150 160 170 180 QTIRQVLDAV NYLHQRNIVH RDLKPENLLY LTRDLDSQLV LADFGIAKML DNPAEVLTSM 190 200 210 220 230 240 AGSFGYAAPE VMLKQGHGKA VDIWSLGVIT YTLLCGYSPF RSENLTDLIE ECRSGRVVFH 250 260 270 280 290 300 ERYWKDVSKD AKDFILSLLQ VDPAQRPTSE EALKHPWLKG ESASDRDLLP EIRAYIARSR 310 320 330 340 350 360 LKRGIEIIKL ANRIEALKMQ EEDEEDIPSA VDVQASEASD KSGLSPFPAL STENSNTHPA 370 380 390 400 410 STGNGESGGT KKRSLSKIAR GAIFREVVLA KVREMKENEE REKVEREARE RAHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequence determination of a cDNA encoding Aspergillus nidulans calmodulin-dependent multifunctional protein kinase." Kornstein L.B., Gaiso M.L., Hammell R.L., Bartelt D.C. Gene 113:75-82(1992) [PubMed: 1563634] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure of the cmkA gene encoding a CaMKII homolog in Emericella (Aspergillus) nidulans." Subbaramaiah K., Greene V., Bartelt D.C. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: R153.
[3]	"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed: 16372000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[4]	"The 2008 update of the Aspergillus nidulans genome annotation: a community effort." Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G. Fungal Genet. Biol. 46:S2-13(2009) [PubMed: 19146970] [Abstract] Cited for: GENOME REANNOTATION. Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M74120 mRNA. Translation: AAB97502.1. AF054580 Genomic DNA. Translation: AAD22581.1. AACD01000039 Genomic DNA. Translation: EAA64523.1. Sequence problems. BN001307 Genomic DNA. Translation: CBF86796.1.
PIR	JN0323.
RefSeq	XP_660016.1. XM_654924.1.
3D structure databases
ProteinModelPortal	Q00771.
ModBase	Search...
Protein-protein interaction databases
STRING	Q00771.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADANIAT00009119; CADANIAP00009119; CADANIAG00009119.
GeneID	2874845.
KEGG	ani:AN2412.2.
Phylogenomic databases
OMA	ASQTIRQ.
OrthoDB	EOG44N21S.
PhylomeDB	Q00771.
Enzyme and pathway databases
BRENDA	2.7.11.17. 2065.
Family and domain databases
InterPro	IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase. IPR020651. Ca/CaM-dep_pkinase_CMK_fungi. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR002290. Ser/Thr_kinase_dom. [Graphical view]
KO	K00908.
PANTHER	PTHR24347. PTHR24347. 1 hit. PTHR24347:SF29. PTHR24347:SF29. 1 hit.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KCC1_EMENI

Accession

Primary (citable) accession number: Q00771
Secondary accession number(s): C8VNX3, Q5BAL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program