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Q00765 (REEP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor expression-enhancing protein 5
Alternative name(s):
Polyposis locus protein 1
Protein TB2
Gene names
Name:REEP5
Synonyms:C5orf18, DP1, TB2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May promote functional cell surface expression of olfactory receptors.

Subunit structure

Interacts with ATL1 By similarity. Interacts with ATL2. Ref.6

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the DP1 family.

Sequence caution

The sequence AAA60136.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAA66351.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH65926.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

LETMD1Q6P1Q03EBI-1549827,EBI-1549822

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 189189Receptor expression-enhancing protein 5
PRO_0000101815

Regions

Transmembrane35 – 5521Helical; Potential
Transmembrane90 – 11021Helical; Potential

Amino acid modifications

Modified residue1621N6-acetyllysine Ref.7
Modified residue1641N6-acetyllysine Ref.7

Experimental info

Sequence conflict1151M → I in AAA66351. Ref.2
Sequence conflict1631A → S in AAA60136. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q00765 [UniParc].

Last modified November 22, 2005. Version 3.
Checksum: F4E57E500CB7C831

FASTA18921,493
        10         20         30         40         50         60 
MSAAMRERFD RFLHEKNCMT DLLAKLEAKT GVNRSFIALG VIGLVALYLV FGYGASLLCN 

        70         80         90        100        110        120 
LIGFGYPAYI SIKAIESPNK EDDTQWLTYW VVYGVFSIAE FFSDIFLSWF PFYYMLKCGF 

       130        140        150        160        170        180 
LLWCMAPSPS NGAELLYKRI IRPFFLKHES QMDSVVKDLK DKAKETADAI TKEAKKATVN 


LLGEEKKST 

« Hide

References

« Hide 'large scale' references
[1]"Identification of deletion mutations and three new genes at the familial polyposis locus."
Joslyn G., Carlson M., Thliveris A., Albertsen H., Gelbert L., Samowitz W., Groden J., Stevens J., Spirio L., Robertson M., Sargeant L., Krapcho K., Wolff E., Burt R., Hughes J.P., Warrington J., McPherson J.D., Wasmuth J.J. expand/collapse author list , le Paslier D., Abderrahim H., Cohen D., Leppert M., White R.
Cell 66:601-613(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Identification of FAP locus genes from chromosome 5q21."
Kinzler K.W., Nilbert M.C., Su L.-K., Vogelstein B., Bryan T.M., Levy D.B., Smith K.J., Preisinger A.C., Hedge P., McKechnie D., Finniear R., Markham A., Groffen J., Boguski M.S., Altschul S.F., Horii A.K., Ando H., Miyoshi Y. expand/collapse author list , Miki Y., Nishisho I., Nakamura Y.
Science 253:661-665(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"RTP family members induce functional expression of mammalian odorant receptors."
Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.
Cell 119:679-691(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye and Skin.
[6]"A class of dynamin-like GTPases involved in the generation of the tubular ER network."
Hu J., Shibata Y., Zhu P.-P., Voss C., Rismanchi N., Prinz W.A., Rapoport T.A., Blackstone C.
Cell 138:549-561(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ATL2.
[7]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-162 AND LYS-164, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M73547 mRNA. Translation: AAA60136.1. Different initiation.
M74090 mRNA. Translation: AAA66351.1. Different initiation.
AY562243 mRNA. Translation: AAT70688.1.
CH471086 Genomic DNA. Translation: EAW48994.1.
CH471086 Genomic DNA. Translation: EAW48995.1.
BC000232 mRNA. Translation: AAH00232.2.
BC065926 mRNA. Translation: AAH65926.1. Different initiation.
PIRA39658.
RefSeqNP_005660.4. NM_005669.4.
UniGeneHs.429608.

3D structure databases

ProteinModelPortalQ00765.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113637. 10 interactions.
IntActQ00765. 8 interactions.
MINTMINT-237079.
STRING9606.ENSP00000368959.

PTM databases

PhosphoSiteQ00765.

Polymorphism databases

DMDM82654932.

Proteomic databases

PaxDbQ00765.
PRIDEQ00765.

Protocols and materials databases

DNASU7905.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000379638; ENSP00000368959; ENSG00000129625.
GeneID7905.
KEGGhsa:7905.
UCSCuc003kqe.1. human.

Organism-specific databases

CTD7905.
GeneCardsGC05M112212.
HGNCHGNC:30077. REEP5.
HPAHPA003895.
MIM125265. gene.
neXtProtNX_Q00765.
PharmGKBPA134882361.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5052.
HOGENOMHOG000172351.
HOVERGENHBG000796.
InParanoidQ00765.
KOK17279.
OMAVPKSYAF.
OrthoDBEOG747PKP.
PhylomeDBQ00765.
TreeFamTF314913.

Gene expression databases

ArrayExpressQ00765.
BgeeQ00765.
CleanExHS_REEP5.
GenevestigatorQ00765.

Family and domain databases

InterProIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERPTHR12300. PTHR12300. 1 hit.
PfamPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiREEP5.
GenomeRNAi7905.
NextBio30368.
PROQ00765.
SOURCESearch...

Entry information

Entry nameREEP5_HUMAN
AccessionPrimary (citable) accession number: Q00765
Secondary accession number(s): D3DT04 expand/collapse secondary AC list , Q04198, Q5QGT0, Q9BWH9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 22, 2005
Last modified: April 16, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM