Q00765 (REEP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Receptor expression-enhancing protein 5

Alternative name(s):
Polyposis locus protein 1
Protein TB2

Gene names

Name:	REEP5
Synonyms:	C5orf18, DP1, TB2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May promote functional cell surface expression of olfactory receptors.
Subunit structure	Interacts with ATL1 By similarity. Interacts with ATL2. Ref.6
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the DP1 family.
Sequence caution	The sequence AAA60136.1 differs from that shown. Reason: Erroneous initiation. The sequence AAA66351.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH65926.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LETMD1	Q6P1Q0	3	EBI-1549827,EBI-1549822

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Receptor expression-enhancing protein 5		PRO_0000101815
Regions
	Transmembrane	35 – 55	21	Helical; Potential
	Transmembrane	90 – 110	21	Helical; Potential
Amino acid modifications
	Modified residue	162	1	N6-acetyllysine Ref.7
	Modified residue	164	1	N6-acetyllysine Ref.7
Experimental info
	Sequence conflict	115	1	M → I in AAA66351. Ref.2
	Sequence conflict	163	1	A → S in AAA60136. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q00765 [UniParc]. Last modified November 22, 2005. Version 3. Checksum: F4E57E500CB7C831	FASTA	189	21,493
	10 20 30 40 50 60 MSAAMRERFD RFLHEKNCMT DLLAKLEAKT GVNRSFIALG VIGLVALYLV FGYGASLLCN 70 80 90 100 110 120 LIGFGYPAYI SIKAIESPNK EDDTQWLTYW VVYGVFSIAE FFSDIFLSWF PFYYMLKCGF 130 140 150 160 170 180 LLWCMAPSPS NGAELLYKRI IRPFFLKHES QMDSVVKDLK DKAKETADAI TKEAKKATVN LLGEEKKST

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of deletion mutations and three new genes at the familial polyposis locus." Joslyn G., Carlson M., Thliveris A., Albertsen H., Gelbert L., Samowitz W., Groden J., Stevens J., Spirio L., Robertson M., Sargeant L., Krapcho K., Wolff E., Burt R., Hughes J.P., Warrington J., McPherson J.D., Wasmuth J.J. , le Paslier D., Abderrahim H., Cohen D., Leppert M., White R. Cell 66:601-613(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of FAP locus genes from chromosome 5q21." Kinzler K.W., Nilbert M.C., Su L.-K., Vogelstein B., Bryan T.M., Levy D.B., Smith K.J., Preisinger A.C., Hedge P., McKechnie D., Finniear R., Markham A., Groffen J., Boguski M.S., Altschul S.F., Horii A.K., Ando H., Miyoshi Y. , Miki Y., Nishisho I., Nakamura Y. Science 253:661-665(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"RTP family members induce functional expression of mammalian odorant receptors." Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H. Cell 119:679-691(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye and Skin.
[6]	"A class of dynamin-like GTPases involved in the generation of the tubular ER network." Hu J., Shibata Y., Zhu P.-P., Voss C., Rismanchi N., Prinz W.A., Rapoport T.A., Blackstone C. Cell 138:549-561(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ATL2.
[7]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-162 AND LYS-164, MASS SPECTROMETRY.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M73547 mRNA. Translation: AAA60136.1. Different initiation. M74090 mRNA. Translation: AAA66351.1. Different initiation. AY562243 mRNA. Translation: AAT70688.1. CH471086 Genomic DNA. Translation: EAW48994.1. CH471086 Genomic DNA. Translation: EAW48995.1. BC000232 mRNA. Translation: AAH00232.2. BC065926 mRNA. Translation: AAH65926.1. Different initiation.
IPI	IPI00024670.
PIR	A39658.
RefSeq	NP_005660.4. NM_005669.4.
UniGene	Hs.429608.
3D structure databases
ProteinModelPortal	Q00765.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q00765. 4 interactions.
MINT	MINT-237079.
STRING	9606.ENSP00000368959.
PTM databases
PhosphoSite	Q00765.
Polymorphism databases
DMDM	82654932.
Proteomic databases
PaxDb	Q00765.
PRIDE	Q00765.
Protocols and materials databases
DNASU	7905.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000379638; ENSP00000368959; ENSG00000129625.
GeneID	7905.
KEGG	hsa:7905.
UCSC	uc003kqe.1. human.
Organism-specific databases
CTD	7905.
GeneCards	GC05M112212.
HGNC	HGNC:30077. REEP5.
HPA	HPA003895.
MIM	125265. gene.
neXtProt	NX_Q00765.
PharmGKB	PA134882361.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5052.
HOGENOM	HOG000172351.
HOVERGEN	HBG000796.
InParanoid	Q00765.
OMA	QFLHQKN.
OrthoDB	EOG4CZBH2.
Gene expression databases
ArrayExpress	Q00765.
Bgee	Q00765.
CleanEx	HS_REEP5.
Genevestigator	Q00765.
GermOnline	ENSG00000129625. Homo sapiens.
Family and domain databases
InterPro	IPR004345. TB2_DP1_HVA22. [Graphical view]
PANTHER	PTHR12300. PTHR12300. 1 hit.
Pfam	PF03134. TB2_DP1_HVA22. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7905.
NextBio	30368.
SOURCE	Search...

Entry information

Entry name

REEP5_HUMAN

Accession

Primary (citable) accession number: Q00765
Secondary accession number(s): D3DT04 , Q04198, Q5QGT0, Q9BWH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	November 22, 2005
Last modified:	April 3, 2013
This is version 106 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.