Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Receptor expression-enhancing protein 5

Gene

REEP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May promote functional cell surface expression of olfactory receptors.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129625-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor expression-enhancing protein 5
Alternative name(s):
Polyposis locus protein 1
Protein TB2
Gene namesi
Name:REEP5
Synonyms:C5orf18, DP1, TB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30077. REEP5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum tubular network Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7905.
OpenTargetsiENSG00000129625.
PharmGKBiPA134882361.

Polymorphism and mutation databases

BioMutaiREEP5.
DMDMi82654932.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001018151 – 189Receptor expression-enhancing protein 5Add BLAST189

Proteomic databases

EPDiQ00765.
MaxQBiQ00765.
PaxDbiQ00765.
PeptideAtlasiQ00765.
PRIDEiQ00765.
TopDownProteomicsiQ00765-1. [Q00765-1]

PTM databases

iPTMnetiQ00765.
PhosphoSitePlusiQ00765.
SwissPalmiQ00765.

Expressioni

Tissue specificityi

Expressed in circumvallate papillae and testis.1 Publication

Gene expression databases

BgeeiENSG00000129625.
CleanExiHS_REEP5.
ExpressionAtlasiQ00765. baseline and differential.
GenevisibleiQ00765. HS.

Organism-specific databases

HPAiHPA003895.

Interactioni

Subunit structurei

Interacts with ATL1 (By similarity). Interacts with ATL2 (PubMed:19665976). Interacts with ZFYVE27 (PubMed:23969831).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LETMD1Q6P1Q03EBI-1549827,EBI-1549822

Protein-protein interaction databases

BioGridi113637. 74 interactors.
IntActiQ00765. 34 interactors.
MINTiMINT-237079.
STRINGi9606.ENSP00000368959.

Structurei

3D structure databases

ProteinModelPortaliQ00765.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1725. Eukaryota.
COG5052. LUCA.
GeneTreeiENSGT00550000074535.
HOGENOMiHOG000172351.
HOVERGENiHBG000796.
InParanoidiQ00765.
KOiK17279.
OMAiQVPKSYA.
OrthoDBiEOG091G0X58.
PhylomeDBiQ00765.
TreeFamiTF314913.

Family and domain databases

InterProiIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERiPTHR12300. PTHR12300. 1 hit.
PfamiPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q00765-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAAMRERFD RFLHEKNCMT DLLAKLEAKT GVNRSFIALG VIGLVALYLV
60 70 80 90 100
FGYGASLLCN LIGFGYPAYI SIKAIESPNK EDDTQWLTYW VVYGVFSIAE
110 120 130 140 150
FFSDIFLSWF PFYYMLKCGF LLWCMAPSPS NGAELLYKRI IRPFFLKHES
160 170 180
QMDSVVKDLK DKAKETADAI TKEAKKATVN LLGEEKKST
Length:189
Mass (Da):21,493
Last modified:November 22, 2005 - v3
Checksum:iF4E57E500CB7C831
GO
Isoform 2 (identifier: Q00765-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-189: CGFLLWCMAP...NLLGEEKKST → VWSGLGFLLPRCLL

Note: No experimental confirmation available.
Show »
Length:131
Mass (Da):14,997
Checksum:iD6B307C92BDA7E0C
GO

Sequence cautioni

The sequence AAA60136 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA66351 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH65926 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115M → I in AAA66351 (PubMed:1651562).Curated1
Sequence conflicti163A → S in AAA60136 (PubMed:1678319).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056633118 – 189CGFLL…EKKST → VWSGLGFLLPRCLL in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73547 mRNA. Translation: AAA60136.1. Different initiation.
M74090 mRNA. Translation: AAA66351.1. Different initiation.
AY562243 mRNA. Translation: AAT70688.1.
AK299902 mRNA. Translation: BAH13167.1.
AC008536 Genomic DNA. No translation available.
AC008575 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW48994.1.
CH471086 Genomic DNA. Translation: EAW48995.1.
BC000232 mRNA. Translation: AAH00232.2.
BC065926 mRNA. Translation: AAH65926.1. Different initiation.
CCDSiCCDS4109.2. [Q00765-1]
PIRiA39658.
RefSeqiNP_005660.4. NM_005669.4. [Q00765-1]
UniGeneiHs.429608.

Genome annotation databases

EnsembliENST00000379638; ENSP00000368959; ENSG00000129625. [Q00765-1]
GeneIDi7905.
KEGGihsa:7905.
UCSCiuc003kqe.2. human. [Q00765-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73547 mRNA. Translation: AAA60136.1. Different initiation.
M74090 mRNA. Translation: AAA66351.1. Different initiation.
AY562243 mRNA. Translation: AAT70688.1.
AK299902 mRNA. Translation: BAH13167.1.
AC008536 Genomic DNA. No translation available.
AC008575 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW48994.1.
CH471086 Genomic DNA. Translation: EAW48995.1.
BC000232 mRNA. Translation: AAH00232.2.
BC065926 mRNA. Translation: AAH65926.1. Different initiation.
CCDSiCCDS4109.2. [Q00765-1]
PIRiA39658.
RefSeqiNP_005660.4. NM_005669.4. [Q00765-1]
UniGeneiHs.429608.

3D structure databases

ProteinModelPortaliQ00765.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113637. 74 interactors.
IntActiQ00765. 34 interactors.
MINTiMINT-237079.
STRINGi9606.ENSP00000368959.

PTM databases

iPTMnetiQ00765.
PhosphoSitePlusiQ00765.
SwissPalmiQ00765.

Polymorphism and mutation databases

BioMutaiREEP5.
DMDMi82654932.

Proteomic databases

EPDiQ00765.
MaxQBiQ00765.
PaxDbiQ00765.
PeptideAtlasiQ00765.
PRIDEiQ00765.
TopDownProteomicsiQ00765-1. [Q00765-1]

Protocols and materials databases

DNASUi7905.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379638; ENSP00000368959; ENSG00000129625. [Q00765-1]
GeneIDi7905.
KEGGihsa:7905.
UCSCiuc003kqe.2. human. [Q00765-1]

Organism-specific databases

CTDi7905.
DisGeNETi7905.
GeneCardsiREEP5.
HGNCiHGNC:30077. REEP5.
HPAiHPA003895.
MIMi125265. gene.
neXtProtiNX_Q00765.
OpenTargetsiENSG00000129625.
PharmGKBiPA134882361.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1725. Eukaryota.
COG5052. LUCA.
GeneTreeiENSGT00550000074535.
HOGENOMiHOG000172351.
HOVERGENiHBG000796.
InParanoidiQ00765.
KOiK17279.
OMAiQVPKSYA.
OrthoDBiEOG091G0X58.
PhylomeDBiQ00765.
TreeFamiTF314913.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129625-MONOMER.

Miscellaneous databases

GeneWikiiREEP5.
GenomeRNAii7905.
PROiQ00765.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129625.
CleanExiHS_REEP5.
ExpressionAtlasiQ00765. baseline and differential.
GenevisibleiQ00765. HS.

Family and domain databases

InterProiIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERiPTHR12300. PTHR12300. 1 hit.
PfamiPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREEP5_HUMAN
AccessioniPrimary (citable) accession number: Q00765
Secondary accession number(s): B7Z681
, D3DT04, Q04198, Q5QGT0, Q9BWH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.