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Q00765

- REEP5_HUMAN

UniProt

Q00765 - REEP5_HUMAN

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Protein

Receptor expression-enhancing protein 5

Gene
REEP5, C5orf18, DP1, TB2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May promote functional cell surface expression of olfactory receptors.

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor expression-enhancing protein 5
Alternative name(s):
Polyposis locus protein 1
Protein TB2
Gene namesi
Name:REEP5
Synonyms:C5orf18, DP1, TB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:30077. REEP5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521Helical; Reviewed predictionAdd
BLAST
Transmembranei90 – 11021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134882361.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Receptor expression-enhancing protein 5PRO_0000101815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei162 – 1621N6-acetyllysine1 Publication
Modified residuei164 – 1641N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ00765.
PaxDbiQ00765.
PRIDEiQ00765.

PTM databases

PhosphoSiteiQ00765.

Expressioni

Gene expression databases

ArrayExpressiQ00765.
BgeeiQ00765.
CleanExiHS_REEP5.
GenevestigatoriQ00765.

Organism-specific databases

HPAiHPA003895.

Interactioni

Subunit structurei

Interacts with ATL1 By similarity. Interacts with ATL2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LETMD1Q6P1Q03EBI-1549827,EBI-1549822

Protein-protein interaction databases

BioGridi113637. 10 interactions.
IntActiQ00765. 8 interactions.
MINTiMINT-237079.
STRINGi9606.ENSP00000368959.

Structurei

3D structure databases

ProteinModelPortaliQ00765.

Family & Domainsi

Sequence similaritiesi

Belongs to the DP1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5052.
HOGENOMiHOG000172351.
HOVERGENiHBG000796.
InParanoidiQ00765.
KOiK17279.
OMAiKFIFLLW.
OrthoDBiEOG747PKP.
PhylomeDBiQ00765.
TreeFamiTF314913.

Family and domain databases

InterProiIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERiPTHR12300. PTHR12300. 1 hit.
PfamiPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00765-1 [UniParc]FASTAAdd to Basket

« Hide

MSAAMRERFD RFLHEKNCMT DLLAKLEAKT GVNRSFIALG VIGLVALYLV    50
FGYGASLLCN LIGFGYPAYI SIKAIESPNK EDDTQWLTYW VVYGVFSIAE 100
FFSDIFLSWF PFYYMLKCGF LLWCMAPSPS NGAELLYKRI IRPFFLKHES 150
QMDSVVKDLK DKAKETADAI TKEAKKATVN LLGEEKKST 189
Length:189
Mass (Da):21,493
Last modified:November 22, 2005 - v3
Checksum:iF4E57E500CB7C831
GO

Sequence cautioni

The sequence AAA60136.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAA66351.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH65926.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti115 – 1151M → I in AAA66351. 1 Publication
Sequence conflicti163 – 1631A → S in AAA60136. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73547 mRNA. Translation: AAA60136.1. Different initiation.
M74090 mRNA. Translation: AAA66351.1. Different initiation.
AY562243 mRNA. Translation: AAT70688.1.
CH471086 Genomic DNA. Translation: EAW48994.1.
CH471086 Genomic DNA. Translation: EAW48995.1.
BC000232 mRNA. Translation: AAH00232.2.
BC065926 mRNA. Translation: AAH65926.1. Different initiation.
CCDSiCCDS4109.2.
PIRiA39658.
RefSeqiNP_005660.4. NM_005669.4.
UniGeneiHs.429608.

Genome annotation databases

EnsembliENST00000379638; ENSP00000368959; ENSG00000129625.
GeneIDi7905.
KEGGihsa:7905.
UCSCiuc003kqe.1. human.

Polymorphism databases

DMDMi82654932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73547 mRNA. Translation: AAA60136.1 . Different initiation.
M74090 mRNA. Translation: AAA66351.1 . Different initiation.
AY562243 mRNA. Translation: AAT70688.1 .
CH471086 Genomic DNA. Translation: EAW48994.1 .
CH471086 Genomic DNA. Translation: EAW48995.1 .
BC000232 mRNA. Translation: AAH00232.2 .
BC065926 mRNA. Translation: AAH65926.1 . Different initiation.
CCDSi CCDS4109.2.
PIRi A39658.
RefSeqi NP_005660.4. NM_005669.4.
UniGenei Hs.429608.

3D structure databases

ProteinModelPortali Q00765.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113637. 10 interactions.
IntActi Q00765. 8 interactions.
MINTi MINT-237079.
STRINGi 9606.ENSP00000368959.

PTM databases

PhosphoSitei Q00765.

Polymorphism databases

DMDMi 82654932.

Proteomic databases

MaxQBi Q00765.
PaxDbi Q00765.
PRIDEi Q00765.

Protocols and materials databases

DNASUi 7905.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379638 ; ENSP00000368959 ; ENSG00000129625 .
GeneIDi 7905.
KEGGi hsa:7905.
UCSCi uc003kqe.1. human.

Organism-specific databases

CTDi 7905.
GeneCardsi GC05M112212.
HGNCi HGNC:30077. REEP5.
HPAi HPA003895.
MIMi 125265. gene.
neXtProti NX_Q00765.
PharmGKBi PA134882361.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5052.
HOGENOMi HOG000172351.
HOVERGENi HBG000796.
InParanoidi Q00765.
KOi K17279.
OMAi KFIFLLW.
OrthoDBi EOG747PKP.
PhylomeDBi Q00765.
TreeFami TF314913.

Miscellaneous databases

GeneWikii REEP5.
GenomeRNAii 7905.
NextBioi 30368.
PROi Q00765.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q00765.
Bgeei Q00765.
CleanExi HS_REEP5.
Genevestigatori Q00765.

Family and domain databases

InterProi IPR004345. TB2_DP1_HVA22.
[Graphical view ]
PANTHERi PTHR12300. PTHR12300. 1 hit.
Pfami PF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "RTP family members induce functional expression of mammalian odorant receptors."
    Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.
    Cell 119:679-691(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Skin.
  6. "A class of dynamin-like GTPases involved in the generation of the tubular ER network."
    Hu J., Shibata Y., Zhu P.-P., Voss C., Rismanchi N., Prinz W.A., Rapoport T.A., Blackstone C.
    Cell 138:549-561(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATL2.
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-162 AND LYS-164, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiREEP5_HUMAN
AccessioniPrimary (citable) accession number: Q00765
Secondary accession number(s): D3DT04
, Q04198, Q5QGT0, Q9BWH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 22, 2005
Last modified: September 3, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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