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Q00765

- REEP5_HUMAN

UniProt

Q00765 - REEP5_HUMAN

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Protein
Receptor expression-enhancing protein 5
Gene
REEP5, C5orf18, DP1, TB2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May promote functional cell surface expression of olfactory receptors.

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor expression-enhancing protein 5
Alternative name(s):
Polyposis locus protein 1
Protein TB2
Gene namesi
Name:REEP5
Synonyms:C5orf18, DP1, TB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:30077. REEP5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521Helical; Reviewed prediction
Add
BLAST
Transmembranei90 – 11021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134882361.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Receptor expression-enhancing protein 5
PRO_0000101815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei162 – 1621N6-acetyllysine1 Publication
Modified residuei164 – 1641N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ00765.
PaxDbiQ00765.
PRIDEiQ00765.

PTM databases

PhosphoSiteiQ00765.

Expressioni

Gene expression databases

ArrayExpressiQ00765.
BgeeiQ00765.
CleanExiHS_REEP5.
GenevestigatoriQ00765.

Organism-specific databases

HPAiHPA003895.

Interactioni

Subunit structurei

Interacts with ATL1 By similarity. Interacts with ATL2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LETMD1Q6P1Q03EBI-1549827,EBI-1549822

Protein-protein interaction databases

BioGridi113637. 10 interactions.
IntActiQ00765. 8 interactions.
MINTiMINT-237079.
STRINGi9606.ENSP00000368959.

Structurei

3D structure databases

ProteinModelPortaliQ00765.

Family & Domainsi

Sequence similaritiesi

Belongs to the DP1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5052.
HOGENOMiHOG000172351.
HOVERGENiHBG000796.
InParanoidiQ00765.
KOiK17279.
OMAiKFIFLLW.
OrthoDBiEOG747PKP.
PhylomeDBiQ00765.
TreeFamiTF314913.

Family and domain databases

InterProiIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERiPTHR12300. PTHR12300. 1 hit.
PfamiPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00765-1 [UniParc]FASTAAdd to Basket

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MSAAMRERFD RFLHEKNCMT DLLAKLEAKT GVNRSFIALG VIGLVALYLV    50
FGYGASLLCN LIGFGYPAYI SIKAIESPNK EDDTQWLTYW VVYGVFSIAE 100
FFSDIFLSWF PFYYMLKCGF LLWCMAPSPS NGAELLYKRI IRPFFLKHES 150
QMDSVVKDLK DKAKETADAI TKEAKKATVN LLGEEKKST 189
Length:189
Mass (Da):21,493
Last modified:November 22, 2005 - v3
Checksum:iF4E57E500CB7C831
GO

Sequence cautioni

The sequence AAA60136.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAA66351.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH65926.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti115 – 1151M → I in AAA66351. 1 Publication
Sequence conflicti163 – 1631A → S in AAA60136. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73547 mRNA. Translation: AAA60136.1. Different initiation.
M74090 mRNA. Translation: AAA66351.1. Different initiation.
AY562243 mRNA. Translation: AAT70688.1.
CH471086 Genomic DNA. Translation: EAW48994.1.
CH471086 Genomic DNA. Translation: EAW48995.1.
BC000232 mRNA. Translation: AAH00232.2.
BC065926 mRNA. Translation: AAH65926.1. Different initiation.
CCDSiCCDS4109.2.
PIRiA39658.
RefSeqi