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Q00765

- REEP5_HUMAN

UniProt

Q00765 - REEP5_HUMAN

Protein

Receptor expression-enhancing protein 5

Gene

REEP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 3 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    May promote functional cell surface expression of olfactory receptors.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor expression-enhancing protein 5
    Alternative name(s):
    Polyposis locus protein 1
    Protein TB2
    Gene namesi
    Name:REEP5
    Synonyms:C5orf18, DP1, TB2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:30077. REEP5.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134882361.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 189189Receptor expression-enhancing protein 5PRO_0000101815Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei162 – 1621N6-acetyllysine1 Publication
    Modified residuei164 – 1641N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ00765.
    PaxDbiQ00765.
    PRIDEiQ00765.

    PTM databases

    PhosphoSiteiQ00765.

    Expressioni

    Gene expression databases

    ArrayExpressiQ00765.
    BgeeiQ00765.
    CleanExiHS_REEP5.
    GenevestigatoriQ00765.

    Organism-specific databases

    HPAiHPA003895.

    Interactioni

    Subunit structurei

    Interacts with ATL1 By similarity. Interacts with ATL2.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LETMD1Q6P1Q03EBI-1549827,EBI-1549822

    Protein-protein interaction databases

    BioGridi113637. 10 interactions.
    IntActiQ00765. 8 interactions.
    MINTiMINT-237079.
    STRINGi9606.ENSP00000368959.

    Structurei

    3D structure databases

    ProteinModelPortaliQ00765.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DP1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5052.
    HOGENOMiHOG000172351.
    HOVERGENiHBG000796.
    InParanoidiQ00765.
    KOiK17279.
    OMAiKFIFLLW.
    OrthoDBiEOG747PKP.
    PhylomeDBiQ00765.
    TreeFamiTF314913.

    Family and domain databases

    InterProiIPR004345. TB2_DP1_HVA22.
    [Graphical view]
    PANTHERiPTHR12300. PTHR12300. 1 hit.
    PfamiPF03134. TB2_DP1_HVA22. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q00765-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAAMRERFD RFLHEKNCMT DLLAKLEAKT GVNRSFIALG VIGLVALYLV    50
    FGYGASLLCN LIGFGYPAYI SIKAIESPNK EDDTQWLTYW VVYGVFSIAE 100
    FFSDIFLSWF PFYYMLKCGF LLWCMAPSPS NGAELLYKRI IRPFFLKHES 150
    QMDSVVKDLK DKAKETADAI TKEAKKATVN LLGEEKKST 189
    Length:189
    Mass (Da):21,493
    Last modified:November 22, 2005 - v3
    Checksum:iF4E57E500CB7C831
    GO
    Isoform 2 (identifier: Q00765-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         118-189: CGFLLWCMAP...NLLGEEKKST → VWSGLGFLLPRCLL

    Note: No experimental confirmation available.

    Show »
    Length:131
    Mass (Da):14,997
    Checksum:iD6B307C92BDA7E0C
    GO

    Sequence cautioni

    The sequence AAA60136.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAA66351.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH65926.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti115 – 1151M → I in AAA66351. (PubMed:1651562)Curated
    Sequence conflicti163 – 1631A → S in AAA60136. (PubMed:1678319)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei118 – 18972CGFLL…EKKST → VWSGLGFLLPRCLL in isoform 2. 1 PublicationVSP_056633Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73547 mRNA. Translation: AAA60136.1. Different initiation.
    M74090 mRNA. Translation: AAA66351.1. Different initiation.
    AY562243 mRNA. Translation: AAT70688.1.
    AK299902 mRNA. Translation: BAH13167.1.
    AC008536 Genomic DNA. No translation available.
    AC008575 Genomic DNA. No translation available.
    CH471086 Genomic DNA. Translation: EAW48994.1.
    CH471086 Genomic DNA. Translation: EAW48995.1.
    BC000232 mRNA. Translation: AAH00232.2.
    BC065926 mRNA. Translation: AAH65926.1. Different initiation.
    CCDSiCCDS4109.2.
    PIRiA39658.
    RefSeqiNP_005660.4. NM_005669.4.
    UniGeneiHs.429608.

    Genome annotation databases

    EnsembliENST00000379638; ENSP00000368959; ENSG00000129625.
    ENST00000545426; ENSP00000442940; ENSG00000129625.
    GeneIDi7905.
    KEGGihsa:7905.
    UCSCiuc003kqe.1. human.

    Polymorphism databases

    DMDMi82654932.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73547 mRNA. Translation: AAA60136.1 . Different initiation.
    M74090 mRNA. Translation: AAA66351.1 . Different initiation.
    AY562243 mRNA. Translation: AAT70688.1 .
    AK299902 mRNA. Translation: BAH13167.1 .
    AC008536 Genomic DNA. No translation available.
    AC008575 Genomic DNA. No translation available.
    CH471086 Genomic DNA. Translation: EAW48994.1 .
    CH471086 Genomic DNA. Translation: EAW48995.1 .
    BC000232 mRNA. Translation: AAH00232.2 .
    BC065926 mRNA. Translation: AAH65926.1 . Different initiation.
    CCDSi CCDS4109.2.
    PIRi A39658.
    RefSeqi NP_005660.4. NM_005669.4.
    UniGenei Hs.429608.

    3D structure databases

    ProteinModelPortali Q00765.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113637. 10 interactions.
    IntActi Q00765. 8 interactions.
    MINTi MINT-237079.
    STRINGi 9606.ENSP00000368959.

    PTM databases

    PhosphoSitei Q00765.

    Polymorphism databases

    DMDMi 82654932.

    Proteomic databases

    MaxQBi Q00765.
    PaxDbi Q00765.
    PRIDEi Q00765.

    Protocols and materials databases

    DNASUi 7905.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379638 ; ENSP00000368959 ; ENSG00000129625 .
    ENST00000545426 ; ENSP00000442940 ; ENSG00000129625 .
    GeneIDi 7905.
    KEGGi hsa:7905.
    UCSCi uc003kqe.1. human.

    Organism-specific databases

    CTDi 7905.
    GeneCardsi GC05M112212.
    HGNCi HGNC:30077. REEP5.
    HPAi HPA003895.
    MIMi 125265. gene.
    neXtProti NX_Q00765.
    PharmGKBi PA134882361.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5052.
    HOGENOMi HOG000172351.
    HOVERGENi HBG000796.
    InParanoidi Q00765.
    KOi K17279.
    OMAi KFIFLLW.
    OrthoDBi EOG747PKP.
    PhylomeDBi Q00765.
    TreeFami TF314913.

    Miscellaneous databases

    GeneWikii REEP5.
    GenomeRNAii 7905.
    NextBioi 30368.
    PROi Q00765.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q00765.
    Bgeei Q00765.
    CleanExi HS_REEP5.
    Genevestigatori Q00765.

    Family and domain databases

    InterProi IPR004345. TB2_DP1_HVA22.
    [Graphical view ]
    PANTHERi PTHR12300. PTHR12300. 1 hit.
    Pfami PF03134. TB2_DP1_HVA22. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "RTP family members induce functional expression of mammalian odorant receptors."
      Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.
      Cell 119:679-691(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye and Skin.
    8. "A class of dynamin-like GTPases involved in the generation of the tubular ER network."
      Hu J., Shibata Y., Zhu P.-P., Voss C., Rismanchi N., Prinz W.A., Rapoport T.A., Blackstone C.
      Cell 138:549-561(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATL2.
    9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-162 AND LYS-164, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiREEP5_HUMAN
    AccessioniPrimary (citable) accession number: Q00765
    Secondary accession number(s): B7Z681
    , D3DT04, Q04198, Q5QGT0, Q9BWH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3