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Q00734

- VP6_ROTBS

UniProt

Q00734 - VP6_ROTBS

Protein

Intermediate capsid protein VP6

Gene
N/A
Organism
Rotavirus C (isolate Cow/Japan/Shintoku/1991) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nacent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP By similarity.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. fusion of virus membrane with host plasma membrane Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intermediate capsid protein VP6
    OrganismiRotavirus C (isolate Cow/Japan/Shintoku/1991) (RV-C)
    Taxonomic identifieri33723 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiBos taurus (Bovine) [TaxID: 9913]

    Subcellular locationi

    Virion By similarity
    Note: Component of the intermediate capsid. Also found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging Potential.Curated

    GO - Cellular componenti

    1. viral envelope Source: InterPro
    2. viral intermediate capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Intermediate capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395Intermediate capsid protein VP6PRO_0000149563Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with VP2.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ00734.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the rotavirus VP6 family.Curated

    Family and domain databases

    InterProiIPR008980. Capsid_hemagglutn.
    IPR001385. Rotavirus_A/C_VP6.
    IPR008935. Virus_capsid_a-hlx_vir.
    [Graphical view]
    PfamiPF00980. Rota_Capsid_VP6. 1 hit.
    [Graphical view]
    ProDomiPD001812. Rota_Capsid_VP6. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF48345. SSF48345. 2 hits.
    SSF49818. SSF49818. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q00734-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVLFSIAKT VSELKKRVVV GTIYTNVEDI IQQTNELIRT LNGSTFHTGG    50
    IGTQPQKDWV VQLPQLGTTL LNLDDNYVQS ARGIIDYLAS FIEAVCDDEM 100
    VREASRNGMQ PQSPTLIALA SSKFKTINFN NSSQSIKNWS AQSRRENPVY 150
    EYKNPMVFEY RNSYILHRAD QQFGNAMGLR YYTTSNTCQI AAFDSTMAEN 200
    APNNTQRFIY HGRLKRPISN VLMKVERGAP NVNNPTILPD PTNQTTWLFN 250
    PVQVMNGTFT IEFYNNGQLV DMVRNMGIAT VRTFDSYRIT IDMIRPAAMT 300
    QYVQQLFPVG GPYSHQAAYM LTLSVLDATT ESVLCDSHSV DYSIVANTRR 350
    DSAMPAGTVF QPGFPWEQTL SNYTVAQEDN LERLLLVASV KRMVM 395
    Length:395
    Mass (Da):44,534
    Last modified:April 1, 1993 - v1
    Checksum:i0CDD6C52F8853816
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88768 mRNA. Translation: AAA03235.1.
    PIRiA43386.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M88768 mRNA. Translation: AAA03235.1 .
    PIRi A43386.

    3D structure databases

    ProteinModelPortali Q00734.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR008980. Capsid_hemagglutn.
    IPR001385. Rotavirus_A/C_VP6.
    IPR008935. Virus_capsid_a-hlx_vir.
    [Graphical view ]
    Pfami PF00980. Rota_Capsid_VP6. 1 hit.
    [Graphical view ]
    ProDomi PD001812. Rota_Capsid_VP6. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF48345. SSF48345. 2 hits.
    SSF49818. SSF49818. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of gene 5 encoding the inner capsid protein (VP6) of bovine group C rotavirus: comparison with corresponding genes of group C, A, and B rotaviruses."
      Jiang B., Tsunemitsu H., Gentsch J.R., Glass R.I., Green K.Y., Qian Y.A., Saif L.J.
      Virology 190:542-547(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiVP6_ROTBS
    AccessioniPrimary (citable) accession number: Q00734
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3