Q00731 (VEGFA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vascular endothelial growth factor A
Short name=VEGF-A

Alternative name(s):
Vascular permeability factor
Short name=VPF

Gene names

Name:	Vegfa
Synonyms:	Vegf

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis By similarity.
Subunit structure	Homodimer; disulfide-linked. Also found as heterodimer with PGF By similarity.
Subcellular location	Isoform VEGF-1: Secreted. Isoform VEGF-2: Secreted. Isoform VEGF-3: Cell membrane; Peripheral membrane protein. Note: Remains cell-surface associated unless released by heparin.
Tissue specificity	In developing embryos, expressed mainly in the choroid plexus, paraventricular neuroepithelium, placenta and kidney glomeruli. Also found in bronchial epithelium, adrenal gland and in seminiferous tubules of testis. High expression of VEGF continues in kidney glomeruli and choroid plexus in adults.
Developmental stage	Levels increase during pregnancy (maximum 5.5-fold at 5 days) and a more marked increase occurs during lactation (maximal 9.7-fold at 7 days). Levels decrease progressively during the phase of involution. Ref.9
Induction	By IL-6 and FSH in vitro. Ref.10
Domain	Isoform VEGF-3 contains a basic insert which acts as a cell retention signal.
Sequence similarities	Belongs to the PDGF/VEGF growth factor family.
Sequence caution	The sequence AAH61468.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Angiogenesis Differentiation
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative initiation Alternative promoter usage Alternative splicing
Domain	Signal
Ligand	Heparin-binding
Molecular function	Developmental protein Growth factor Mitogen
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of protein kinase activity Inferred from sequence or structural similarity. Source: UniProtKB artery morphogenesis Inferred from mutant phenotype PubMed 10229225. Source: MGI behavior Inferred from mutant phenotype PubMed 10229225. Source: MGI camera-type eye morphogenesis Inferred from mutant phenotype PubMed 16251428. Source: MGI cardiac muscle fiber development Inferred from mutant phenotype PubMed 10229225. Source: MGI cardiac vascular smooth muscle cell development Inferred from mutant phenotype PubMed 18093989. Source: BHF-UCL cell maturation Inferred from mutant phenotype PubMed 12053176. Source: MGI cell migration involved in sprouting angiogenesis Inferred from sequence or structural similarity. Source: UniProtKB cell proliferation Inferred from mutant phenotype PubMed 14722611. Source: MGI cellular response to hypoxia Inferred from sequence or structural similarity. Source: UniProtKB coronary artery morphogenesis Inferred from mutant phenotype PubMed 18093989. Source: BHF-UCL coronary vein morphogenesis Inferred from mutant phenotype PubMed 18093989. Source: BHF-UCL dopaminergic neuron differentiation Inferred from genetic interaction PubMed 17215402. Source: MGI endothelial cell chemotaxis Inferred from sequence or structural similarity. Source: UniProtKB epithelial cell differentiation Inferred from mutant phenotype PubMed 16251428. Source: MGI eye photoreceptor cell development Inferred from mutant phenotype PubMed 16251428. Source: MGI growth Inferred from mutant phenotype PubMed 10229225. Source: MGI heart morphogenesis Inferred from mutant phenotype PubMed 10229225. Source: MGI in utero embryonic development Inferred from mutant phenotype PubMed 10229225. Source: MGI kidney development Inferred from mutant phenotype PubMed 10229225. Source: MGI lactation Inferred from mutant phenotype PubMed 17625068. Source: MGI lung development Inferred from direct assay PubMed 16375885. Source: MGI lymph vessel morphogenesis Inferred from mutant phenotype PubMed 18093989. Source: BHF-UCL macrophage differentiation Inferred from sequence or structural similarity. Source: UniProtKB mammary gland alveolus development Inferred from mutant phenotype PubMed 17625068. Source: MGI mesoderm development Inferred from mutant phenotype PubMed 12890722. Source: MGI monocyte differentiation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB outflow tract morphogenesis Inferred from mutant phenotype PubMed 18093989. Source: BHF-UCL ovarian follicle development Inferred from mutant phenotype PubMed 17050862. Source: MGI patterning of blood vessels Inferred from mutant phenotype PubMed 17428830. Source: MGI positive regulation of CREB transcription factor activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of MAP kinase activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of branching involved in ureteric bud morphogenesis Inferred from direct assay PubMed 16291795. Source: UniProtKB positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cell migration involved in sprouting angiogenesis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of endothelial cell proliferation Inferred from direct assay Ref.1. Source: MGI positive regulation of focal adhesion assembly Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of lymphangiogenesis Inferred from direct assay PubMed 20133819. Source: MGI positive regulation of mesenchymal cell proliferation Inferred from direct assay PubMed 16375885. Source: MGI positive regulation of neuroblast proliferation Inferred from genetic interaction PubMed 17215402. Source: MGI positive regulation of peptidyl-serine phosphorylation Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of peptidyl-tyrosine autophosphorylation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of positive chemotaxis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of protein complex assembly Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of protein kinase C signaling cascade Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of receptor internalization Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of vascular endothelial growth factor receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of vascular permeability Inferred from direct assay PubMed 10617467. Source: MGI post-embryonic camera-type eye development Inferred from mutant phenotype PubMed 10229225. Source: MGI primitive erythrocyte differentiation Inferred from mutant phenotype PubMed 14729577. Source: MGI regulation of cell shape Inferred from sequence or structural similarity. Source: UniProtKB surfactant homeostasis Inferred from mutant phenotype PubMed 12053176. Source: MGI tube formation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cell surface Inferred from sequence or structural similarity. Source: UniProtKB extracellular space Inferred from direct assay PubMed 12053176Ref.1PubMed 17475663PubMed 18559975PubMed 18753609. Source: MGI plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell secretory granule Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	cell surface binding Inferred from sequence or structural similarity. Source: UniProtKB chemoattractant activity Inferred from sequence or structural similarity. Source: UniProtKB cytokine activity Inferred from sequence or structural similarity. Source: UniProtKB fibronectin binding Inferred from sequence or structural similarity. Source: UniProtKB growth factor activity Inferred from sequence or structural similarity. Source: UniProtKB heparin binding Inferred from sequence or structural similarity. Source: UniProtKB platelet-derived growth factor receptor binding Inferred from sequence or structural similarity. Source: UniProtKB protein heterodimerization activity Inferred from sequence orthology PubMed 8702615. Source: MGI receptor agonist activity Inferred from sequence or structural similarity. Source: UniProtKB vascular endothelial growth factor receptor 1 binding Inferred from sequence or structural similarity. Source: UniProtKB vascular endothelial growth factor receptor 2 binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative promoter usage, alternative splicing and alternative initiation. [Align] [Select]

Isoform VEGF-3 (identifier: Q00731-1)

Also known as: VEGF188;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform VEGF-1 (identifier: Q00731-2)

Also known as: VEGF164;

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: K → N
     141-164: Missing.

Isoform VEGF-2 (identifier: Q00731-3)

Also known as: VEGF120;

The sequence of this isoform differs from the canonical sequence as follows:
     141-208: Missing.

Isoform VEGF-4 (identifier: Q00731-4)

Also known as: VEGF115;

The sequence of this isoform differs from the canonical sequence as follows:
     105-141: IMRIKPHQSQHIGEMSFLQHSRCECRPKKDRTKPEKK → VGTCGTGDGAGAGGGRRTVVQGGALEGCLGLCLGNFW
     142-214: Missing.

Isoform VEGF-5 (identifier: Q00731-5)

Also known as: VEGF102;

The sequence of this isoform differs from the canonical sequence as follows:
     105-128: IMRIKPHQSQHIGEMSFLQHSRCE → VGTCGTGDGAGAGGAGGQWYKEGH
     129-214: Missing.

Isoform L-VEGF-1 (identifier: Q00731-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTDRQTDTAP...AGPGRASETM
     140-140: K → N
     141-164: Missing.

Note: Gene prediction based on EST data. Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	By similarity
	Chain	27 – 214	188	Vascular endothelial growth factor A		PRO_0000023388
Amino acid modifications
	Glycosylation	100	1	N-linked (GlcNAc...) Probable
	Disulfide bond	51 ↔ 93		By similarity
	Disulfide bond	76		Interchain By similarity
	Disulfide bond	82 ↔ 127		By similarity
	Disulfide bond	85		Interchain By similarity
	Disulfide bond	86 ↔ 129		By similarity
Natural variations
	Alternative sequence	1	1	M → MTDRQTDTAPSPSAHLLAGG LPTVDAAASREEPKPAPGGG VEGVGARGIARKLFVQLLGS SRSVVAVVCAAGDKPIGAGR SASSGLEKPGPEKRGEEEKE EERGPQWALGSQEPSSWTGE AAVCADSAPAARAPQAPARA SVPEGRGARQGAQESGLPRS PSRRGSASRAGPGRASETM in isoform L-VEGF-1.		VSP_038746
	Alternative sequence	105 – 141	37	IMRIK…KPEKK → VGTCGTGDGAGAGGGRRTVV QGGALEGCLGLCLGNFW in isoform VEGF-4.		VSP_016418
	Alternative sequence	105 – 128	24	IMRIK…HSRCE → VGTCGTGDGAGAGGAGGQWY KEGH in isoform VEGF-5.		VSP_016419
	Alternative sequence	129 – 214	86	Missing in isoform VEGF-5.		VSP_016420
	Alternative sequence	140	1	K → N in isoform VEGF-1 and isoform L-VEGF-1.		VSP_004626
	Alternative sequence	141 – 208	68	Missing in isoform VEGF-2.		VSP_004628
	Alternative sequence	141 – 164	24	Missing in isoform VEGF-1 and isoform L-VEGF-1.		VSP_004627
	Alternative sequence	142 – 214	73	Missing in isoform VEGF-4.		VSP_016421
Experimental info
	Sequence conflict	61	1	F → I in AAC05442. Ref.3
	Sequence conflict	117 – 118	2	GE → ER in AAA40547. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform VEGF-3 (VEGF188) [UniParc]. Last modified October 1, 1996. Version 2. Checksum: B5540B51E4BB6E17	FASTA	214	25,283
	10 20 30 40 50 60 MNFLLSWVHW TLALLLYLHH AKWSQAAPTT EGEQKSHEVI KFMDVYQRSY CRPIETLVDI 70 80 90 100 110 120 FQEYPDEIEY IFKPSCVPLM RCAGCCNDEA LECVPTSESN ITMQIMRIKP HQSQHIGEMS 130 140 150 160 170 180 FLQHSRCECR PKKDRTKPEK KSVRGKGKGQ KRKRKKSRFK SWSVHCEPCS ERRKHLFVQD 190 200 210 PQTCKCSCKN TDSRCKARQL ELNERTCRCD KPRR
	Isoform VEGF-1 (VEGF164) [UniParc]. Checksum: 7B0BE0B9541E3805	FASTA	190	22,440
	10 20 30 40 50 60 MNFLLSWVHW TLALLLYLHH AKWSQAAPTT EGEQKSHEVI KFMDVYQRSY CRPIETLVDI 70 80 90 100 110 120 FQEYPDEIEY IFKPSCVPLM RCAGCCNDEA LECVPTSESN ITMQIMRIKP HQSQHIGEMS 130 140 150 160 170 180 FLQHSRCECR PKKDRTKPEN HCEPCSERRK HLFVQDPQTC KCSCKNTDSR CKARQLELNE 190 RTCRCDKPRR
	Isoform VEGF-2 (VEGF120) [UniParc]. Checksum: 30635EADAD328C29	FASTA	146	17,233
	10 20 30 40 50 60 MNFLLSWVHW TLALLLYLHH AKWSQAAPTT EGEQKSHEVI KFMDVYQRSY CRPIETLVDI 70 80 90 100 110 120 FQEYPDEIEY IFKPSCVPLM RCAGCCNDEA LECVPTSESN ITMQIMRIKP HQSQHIGEMS 130 140 FLQHSRCECR PKKDRTKPEK CDKPRR
	Isoform VEGF-4 (VEGF115) [UniParc]. Checksum: A9AC452E770CC338	FASTA	141	15,584
	10 20 30 40 50 60 MNFLLSWVHW TLALLLYLHH AKWSQAAPTT EGEQKSHEVI KFMDVYQRSY CRPIETLVDI 70 80 90 100 110 120 FQEYPDEIEY IFKPSCVPLM RCAGCCNDEA LECVPTSESN ITMQVGTCGT GDGAGAGGGR 130 140 RTVVQGGALE GCLGLCLGNF W
	Isoform VEGF-5 (VEGF102) [UniParc]. Checksum: 44405AD86973E191	FASTA	128	14,309
	10 20 30 40 50 60 MNFLLSWVHW TLALLLYLHH AKWSQAAPTT EGEQKSHEVI KFMDVYQRSY CRPIETLVDI 70 80 90 100 110 120 FQEYPDEIEY IFKPSCVPLM RCAGCCNDEA LECVPTSESN ITMQVGTCGT GDGAGAGGAG GQWYKEGH
	Isoform L-VEGF-1 [UniParc]. Checksum: 8B8EAC32ADE8BDFD	FASTA	368	40,288
	10 20 30 40 50 60 MTDRQTDTAP SPSAHLLAGG LPTVDAAASR EEPKPAPGGG VEGVGARGIA RKLFVQLLGS 70 80 90 100 110 120 SRSVVAVVCA AGDKPIGAGR SASSGLEKPG PEKRGEEEKE EERGPQWALG SQEPSSWTGE 130 140 150 160 170 180 AAVCADSAPA ARAPQAPARA SVPEGRGARQ GAQESGLPRS PSRRGSASRA GPGRASETMN 190 200 210 220 230 240 FLLSWVHWTL ALLLYLHHAK WSQAAPTTEG EQKSHEVIKF MDVYQRSYCR PIETLVDIFQ 250 260 270 280 290 300 EYPDEIEYIF KPSCVPLMRC AGCCNDEALE CVPTSESNIT MQIMRIKPHQ SQHIGEMSFL 310 320 330 340 350 360 QHSRCECRPK KDRTKPENHC EPCSERRKHL FVQDPQTCKC SCKNTDSRCK ARQLELNERT CRCDKPRR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation." Breier G., Albrecht U., Sterrer S., Risau W. Development 114:521-532(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS VEGF-1; VEGF-2 AND VEGF-3).
[2]	"Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways." Claffey K.P., Wilkison W.O., Spiegelman B.M. J. Biol. Chem. 267:16317-16322(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF-1).
[3]	"A novel alternatively spliced form of murine vascular endothelial growth factor, VEGF 115." Sugihara T., Wadhwa R., Kaul S.C., Mitsui Y. J. Biol. Chem. 273:3033-3038(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF-4). Strain: ICR.
[4]	"Identification of a unique Mus musculus VEGF isoform of 102 amino acids." Jankowsky J.A., Adamski F.M., Robertson F.M. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM VEGF-5). Strain: FVB/N.
[5]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM L-VEGF-1). Strain: C57BL/6. Tissue: Brain.
[7]	"Alternatively spliced forms of mouse VEGF." Minchenko O.H., Minchenko D.O., Opentanova I.L. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-123 (ISOFORMS VEGF-1/VEGF-2/VEGF-3). Strain: C57BL/6. Tissue: Retina.
[8]	"The mouse gene for vascular endothelial growth factor. Genomic structure, definition of the transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequences." Shima D.T., Kuroki M., Deutsch U., Ng Y., Adamis A.P., D'Amore P.A. J. Biol. Chem. 271:3877-3883(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3 (ISOFORMS VEGF-1/VEGF-2/VEGF-3/VEGF-4/VEGF-5).
[9]	"Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution." Pepper M.S., Baetens D., Mandriota S.J., Di Sanza C., Oikemus S., Lane T.F., Soriano J.V., Montesano R., Iruela-Arispe M.L. Dev. Dyn. 218:507-524(2000) [PubMed] [Europe PMC] [Abstract] Cited for: DEVELOPMENTAL STAGE.
[10]	"The regulators of VEGF expression in mouse ovaries." Shin S.-Y., Lee H.-J., Ko D.-S., Lee H.-C., Park W.I. Yonsei Med. J. 46:679-686(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S37052 mRNA. Translation: AAB22252.1. S38083 mRNA. Translation: AAB22253.1. S38100 mRNA. Translation: AAB22254.1. M95200 mRNA. Translation: AAA40547.1. U50279 mRNA. Translation: AAC05442.1. AY263146 mRNA. Translation: AAP86647.1. AC127690 Genomic DNA. No translation available. BC061468 mRNA. Translation: AAH61468.1. Different initiation. AY707864 mRNA. Translation: AAU11325.1. AY750956 mRNA. Translation: AAU95484.1. AY750957 mRNA. Translation: AAU95485.1. U41383 Genomic DNA. No translation available.
IPI	IPI00402915. IPI00475372. IPI00656297. IPI00955379. IPI00989242. IPI00989633.
PIR	A44881. B44881.
RefSeq	NP_001020421.2. NM_001025250.3. NP_001020428.2. NM_001025257.3. NP_001103736.1. NM_001110266.1. NP_001103737.1. NM_001110267.1. NP_001103738.1. NM_001110268.1. NP_033531.3. NM_009505.4.
UniGene	Mm.282184.
3D structure databases
ProteinModelPortal	Q00731.
SMR	Q00731. Positions 37-134, 166-214.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q00731. 2 interactions.
PTM databases
PhosphoSite	Q00731.
Proteomic databases
PaxDb	Q00731.
PRIDE	Q00731.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000024747; ENSMUSP00000024747; ENSMUSG00000023951.
GeneID	22339.
KEGG	mmu:22339.
UCSC	uc008cro.3. mouse. uc008crr.3. mouse. uc012aui.2. mouse.
Organism-specific databases
CTD	7422.
MGI	MGI:103178. Vegfa.
Phylogenomic databases
eggNOG	NOG73329.
GeneTree	ENSGT00530000062930.
HOGENOM	HOG000230896.
HOVERGEN	HBG000105.
InParanoid	Q00731.
KO	K05448.
OrthoDB	EOG45757X.
Gene expression databases
ArrayExpress	Q00731.
Bgee	Q00731.
CleanEx	MM_VEGFA.
Genevestigator	Q00731.
GermOnline	ENSMUSG00000023951. Mus musculus.
Family and domain databases
InterPro	IPR000072. PD_growth_factor. IPR023581. PD_growth_factor_CS. [Graphical view]
Pfam	PF00341. PDGF. 1 hit. [Graphical view]
SMART	SM00141. PDGF. 1 hit. [Graphical view]
PROSITE	PS00249. PDGF_1. 1 hit. PS50278. PDGF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	VEGFA. mouse.
NextBio	302593.
SOURCE	Search...

Entry information

Entry name

VEGFA_MOUSE

Accession

Primary (citable) accession number: Q00731
Secondary accession number(s): O70123 , Q66S31, Q6GT23, Q6WZL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	October 1, 1996
Last modified:	May 29, 2013
This is version 133 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program