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Protein

Retinol-binding protein 4

Gene

Rbp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinol binding Source: MGI
  • retinol transporter activity Source: MGI

GO - Biological processi

  • cardiac muscle tissue development Source: BHF-UCL
  • detection of light stimulus involved in visual perception Source: MGI
  • embryonic organ morphogenesis Source: BHF-UCL
  • embryonic retina morphogenesis in camera-type eye Source: BHF-UCL
  • embryonic skeletal system development Source: BHF-UCL
  • eye development Source: BHF-UCL
  • female genitalia morphogenesis Source: BHF-UCL
  • gluconeogenesis Source: BHF-UCL
  • glucose homeostasis Source: MGI
  • heart development Source: BHF-UCL
  • heart trabecula formation Source: BHF-UCL
  • lung development Source: BHF-UCL
  • maintenance of gastrointestinal epithelium Source: MGI
  • male gonad development Source: MGI
  • negative regulation of cardiac muscle cell proliferation Source: BHF-UCL
  • positive regulation of immunoglobulin secretion Source: BHF-UCL
  • positive regulation of insulin secretion Source: MGI
  • response to insulin Source: MGI
  • response to retinoic acid Source: MGI
  • retina development in camera-type eye Source: MGI
  • retinal metabolic process Source: MGI
  • retinol metabolic process Source: MGI
  • retinol transport Source: MGI
  • spermatogenesis Source: MGI
  • urinary bladder development Source: BHF-UCL
  • uterus development Source: BHF-UCL
  • vagina development Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Retinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiR-MMU-2453902. The canonical retinoid cycle in rods (twilight vision).
R-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 4
Alternative name(s):
Plasma retinol-binding protein
Short name:
PRBP
Short name:
RBP
Gene namesi
Name:Rbp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:97879. Rbp4.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 201183Retinol-binding protein 4PRO_0000017966Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 178By similarity
Disulfide bondi88 ↔ 192By similarity
Disulfide bondi138 ↔ 147By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ00724.
PaxDbiQ00724.
PRIDEiQ00724.

PTM databases

iPTMnetiQ00724.
PhosphoSiteiQ00724.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024990.
CleanExiMM_RBP4.
ExpressionAtlasiQ00724. baseline and differential.
GenevisibleiQ00724. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-1870176.
STRINGi10090.ENSMUSP00000025951.

Structurei

3D structure databases

ProteinModelPortaliQ00724.
SMRiQ00724. Positions 19-192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJHC. Eukaryota.
ENOG4111K1Y. LUCA.
GeneTreeiENSGT00510000047107.
HOGENOMiHOG000293156.
HOVERGENiHBG004493.
InParanoidiQ00724.
KOiK18271.
PhylomeDBiQ00724.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002449. Retinol-bd/Purpurin.
[Graphical view]
PANTHERiPTHR11873. PTHR11873. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PIRSF500204. RBP_purpurin. 1 hit.
PRINTSiPR00179. LIPOCALIN.
PR01174. RETINOLBNDNG.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00724-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWVWALVLL AALGGGSAER DCRVSSFRVK ENFDKARFSG LWYAIAKKDP
60 70 80 90 100
EGLFLQDNII AEFSVDEKGH MSATAKGRVR LLSNWEVCAD MVGTFTDTED
110 120 130 140 150
PAKFKMKYWG VASFLQRGND DHWIIDTDYD TFALQYSCRL QNLDGTCADS
160 170 180 190 200
YSFVFSRDPN GLSPETRRLV RQRQEELCLE RQYRWIEHNG YCQSRPSRNS

L
Length:201
Mass (Da):23,206
Last modified:December 15, 1998 - v2
Checksum:i8D187E293B37A75B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171S → T in AAA63395 (PubMed:1613076).Curated
Sequence conflicti20 – 201R → P in AAA63395 (PubMed:1613076).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63146 mRNA. Translation: AAB06955.1.
AB124638 Genomic DNA. Translation: BAD16678.1.
AK008765 mRNA. Translation: BAB25881.1.
BC031809 mRNA. Translation: AAH31809.1.
BC093529 mRNA. Translation: AAH93529.1.
M74527 mRNA. Translation: AAA63395.1.
CCDSiCCDS29784.1.
RefSeqiNP_001152959.1. NM_001159487.1.
NP_035385.1. NM_011255.3.
UniGeneiMm.2605.

Genome annotation databases

EnsembliENSMUST00000112335; ENSMUSP00000107954; ENSMUSG00000024990.
GeneIDi19662.
KEGGimmu:19662.
UCSCiuc008hjd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63146 mRNA. Translation: AAB06955.1.
AB124638 Genomic DNA. Translation: BAD16678.1.
AK008765 mRNA. Translation: BAB25881.1.
BC031809 mRNA. Translation: AAH31809.1.
BC093529 mRNA. Translation: AAH93529.1.
M74527 mRNA. Translation: AAA63395.1.
CCDSiCCDS29784.1.
RefSeqiNP_001152959.1. NM_001159487.1.
NP_035385.1. NM_011255.3.
UniGeneiMm.2605.

3D structure databases

ProteinModelPortaliQ00724.
SMRiQ00724. Positions 19-192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1870176.
STRINGi10090.ENSMUSP00000025951.

PTM databases

iPTMnetiQ00724.
PhosphoSiteiQ00724.

Proteomic databases

MaxQBiQ00724.
PaxDbiQ00724.
PRIDEiQ00724.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112335; ENSMUSP00000107954; ENSMUSG00000024990.
GeneIDi19662.
KEGGimmu:19662.
UCSCiuc008hjd.2. mouse.

Organism-specific databases

CTDi5950.
MGIiMGI:97879. Rbp4.

Phylogenomic databases

eggNOGiENOG410IJHC. Eukaryota.
ENOG4111K1Y. LUCA.
GeneTreeiENSGT00510000047107.
HOGENOMiHOG000293156.
HOVERGENiHBG004493.
InParanoidiQ00724.
KOiK18271.
PhylomeDBiQ00724.

Enzyme and pathway databases

ReactomeiR-MMU-2453902. The canonical retinoid cycle in rods (twilight vision).
R-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

ChiTaRSiRbp4. mouse.
PROiQ00724.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024990.
CleanExiMM_RBP4.
ExpressionAtlasiQ00724. baseline and differential.
GenevisibleiQ00724. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002449. Retinol-bd/Purpurin.
[Graphical view]
PANTHERiPTHR11873. PTHR11873. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PIRSF500204. RBP_purpurin. 1 hit.
PRINTSiPR00179. LIPOCALIN.
PR01174. RETINOLBNDNG.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRET4_MOUSE
AccessioniPrimary (citable) accession number: Q00724
Secondary accession number(s): P70357, Q566I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 15, 1998
Last modified: September 7, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.