Q00724 (RET4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retinol-binding protein 4

Alternative name(s):
Plasma retinol-binding protein
Short name=PRBP
Short name=RBP

Gene names

Name:

Rbp4

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
Subcellular location	Secreted.
Sequence similarities	Belongs to the calycin superfamily. Lipocalin family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Secreted
Domain	Signal
Ligand	Retinol-binding Vitamin A
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cardiac muscle tissue development Inferred from mutant phenotype. Source: BHF-UCL detection of light stimulus involved in visual perception Inferred from mutant phenotype. Source: MGI embryonic organ morphogenesis Inferred from mutant phenotype. Source: BHF-UCL embryonic retina morphogenesis in camera-type eye Inferred from mutant phenotype. Source: BHF-UCL embryonic skeletal system development Inferred from mutant phenotype. Source: BHF-UCL female genitalia morphogenesis Inferred from mutant phenotype. Source: BHF-UCL gluconeogenesis Inferred from mutant phenotype. Source: BHF-UCL heart trabecula formation Inferred from mutant phenotype. Source: BHF-UCL lung development Inferred from mutant phenotype. Source: BHF-UCL male gonad development Inferred from mutant phenotype. Source: MGI negative regulation of cardiac muscle cell proliferation Inferred from mutant phenotype. Source: BHF-UCL positive regulation of immunoglobulin secretion Inferred from direct assay. Source: BHF-UCL response to insulin stimulus Inferred from mutant phenotype. Source: MGI retinal metabolic process Inferred from mutant phenotype. Source: MGI retinol metabolic process Inferred from genetic interaction. Source: MGI spermatogenesis Inferred from mutant phenotype. Source: MGI urinary bladder development Inferred from mutant phenotype. Source: BHF-UCL uterus development Inferred from mutant phenotype. Source: BHF-UCL vagina development Inferred from mutant phenotype. Source: BHF-UCL
Cellular component	extracellular space Inferred from direct assay. Source: BHF-UCL
Molecular function	retinal binding Inferred from electronic annotation. Source: UniProtKB-KW retinol binding Inferred from direct assay. Source: MGI retinol transporter activity Inferred from mutant phenotype. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	By similarity
	Chain	19 – 201	183	Retinol-binding protein 4		PRO_0000017966
Amino acid modifications
	Disulfide bond	22 ↔ 178		By similarity
	Disulfide bond	88 ↔ 192		By similarity
	Disulfide bond	138 ↔ 147		By similarity
Experimental info
	Sequence conflict	17	1	S → T in AAA63395. Ref.5
	Sequence conflict	20	1	R → P in AAA63395. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q00724 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: 8D187E293B37A75B	FASTA	201	23,206
	10 20 30 40 50 60 MEWVWALVLL AALGGGSAER DCRVSSFRVK ENFDKARFSG LWYAIAKKDP EGLFLQDNII 70 80 90 100 110 120 AEFSVDEKGH MSATAKGRVR LLSNWEVCAD MVGTFTDTED PAKFKMKYWG VASFLQRGND 130 140 150 160 170 180 DHWIIDTDYD TFALQYSCRL QNLDGTCADS YSFVFSRDPN GLSPETRRLV RQRQEELCLE 190 200 RQYRWIEHNG YCQSRPSRNS L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Induction of mouse retinol binding protein gene expression by cyclic AMP in Hepa 1-6 cells." Jessen K.A., Satre M.A. Arch. Biochem. Biophys. 357:126-130(1998) [PubMed: 9721191] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA.
[2]	"Genomic sequence of mouse retinol binding protein 4 region, complete sequence." Maekawa K., Kojima T., Fujiyama A., Hattori M., Sakaki Y. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Stomach.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver.
[5]	"Chromosomal localization of the retinol binding protein gene and its elimination as a candidate gene for the repeated epilation (Er) mutation in mice." Dale B., Jones A.H., Presland R., Adler D.A., Disteche C.M. J. Craniofac. Genet. Dev. Biol. 12:76-81(1992) [PubMed: 1613076] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-179.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U63146 mRNA. Translation: AAB06955.1. AB124638 Genomic DNA. Translation: BAD16678.1. AK008765 mRNA. Translation: BAB25881.1. BC031809 mRNA. Translation: AAH31809.1. BC093529 mRNA. Translation: AAH93529.1. M74527 mRNA. Translation: AAA63395.1.
IPI	IPI00122429.
RefSeq	NP_001152959.1. NM_001159487.1. NP_035385.1. NM_011255.3.
UniGene	Mm.2605.
3D structure databases
ProteinModelPortal	Q00724.
SMR	Q00724. Positions 19-192.
ModBase	Search...
Protein-protein interaction databases
STRING	Q00724.
Proteomic databases
PRIDE	Q00724.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000112335; ENSMUSP00000107954; ENSMUSG00000024990.
GeneID	19662.
KEGG	mmu:19662.
UCSC	uc008hjd.2. mouse.
Organism-specific databases
CTD	5950.
MGI	MGI:97879. Rbp4.
Phylogenomic databases
HOGENOM	HBG715497.
HOVERGEN	HBG004493.
InParanoid	Q00724.
OMA	MEWVWAL.
OrthoDB	EOG4T4CWM.
PhylomeDB	Q00724.
Gene expression databases
ArrayExpress	Q00724.
Bgee	Q00724.
CleanEx	MM_RBP4.
Genevestigator	Q00724.
GermOnline	ENSMUSG00000024990. Mus musculus.
Family and domain databases
InterPro	IPR012674. Calycin. IPR011038. Calycin-like. IPR002345. Lipocalin. IPR022271. Lipocalin_ApoD. IPR022272. Lipocalin_CS. IPR000566. Lipocln_cytosolic_FA-bd_dom. IPR002449. Retinol-bd. [Graphical view]
Gene3D	G3DSA:2.40.128.20. Calycin. 1 hit.
PANTHER	PTHR11873. Retinol_bd. 1 hit.
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PIRSF	PIRSF036893. Lipocalin_ApoD. 1 hit.
PRINTS	PR00179. LIPOCALIN. PR01174. RETINOLBNDNG.
SUPFAM	SSF50814. Calycin. 1 hit.
PROSITE	PS00213. LIPOCALIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	296954.
SOURCE	Search...

Entry information

Entry name

RET4_MOUSE

Accession

Primary (citable) accession number: Q00724
Secondary accession number(s): P70357, Q566I5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	December 15, 1998
Last modified:	September 21, 2011
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program