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Protein

Retinol-binding protein 4

Gene

Rbp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116SubstrateBy similarity1

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinol binding Source: MGI
  • retinol transmembrane transporter activity Source: InterPro

GO - Biological processi

  • cardiac muscle tissue development Source: BHF-UCL
  • detection of light stimulus involved in visual perception Source: MGI
  • embryonic organ morphogenesis Source: BHF-UCL
  • embryonic retina morphogenesis in camera-type eye Source: BHF-UCL
  • embryonic skeletal system development Source: BHF-UCL
  • eye development Source: BHF-UCL
  • female genitalia morphogenesis Source: BHF-UCL
  • gluconeogenesis Source: BHF-UCL
  • glucose homeostasis Source: MGI
  • heart development Source: BHF-UCL
  • heart trabecula formation Source: BHF-UCL
  • lung development Source: BHF-UCL
  • maintenance of gastrointestinal epithelium Source: MGI
  • male gonad development Source: MGI
  • negative regulation of cardiac muscle cell proliferation Source: BHF-UCL
  • positive regulation of immunoglobulin secretion Source: BHF-UCL
  • positive regulation of insulin secretion Source: MGI
  • response to insulin Source: MGI
  • response to retinoic acid Source: MGI
  • retina development in camera-type eye Source: MGI
  • retinal metabolic process Source: MGI
  • retinol metabolic process Source: MGI
  • retinol transport Source: MGI
  • spermatogenesis Source: MGI
  • urinary bladder development Source: BHF-UCL
  • uterus development Source: BHF-UCL
  • vagina development Source: BHF-UCL
  • vitamin A import Source: MGI

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiR-MMU-2453902 The canonical retinoid cycle in rods (twilight vision)
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 4
Alternative name(s):
Plasma retinol-binding protein
Short name:
PRBP
Short name:
RBP
Gene namesi
Name:Rbp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:97879 Rbp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000001796619 – 201Retinol-binding protein 4Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 178By similarity
Disulfide bondi88 ↔ 192By similarity
Disulfide bondi138 ↔ 147By similarity
Modified residuei139Omega-N-methylarginineCombined sources1

Keywords - PTMi

Disulfide bond, Methylation

Proteomic databases

MaxQBiQ00724
PaxDbiQ00724
PRIDEiQ00724

PTM databases

iPTMnetiQ00724
PhosphoSitePlusiQ00724
SwissPalmiQ00724

Expressioni

Gene expression databases

BgeeiENSMUSG00000024990
CleanExiMM_RBP4
ExpressionAtlasiQ00724 baseline and differential
GenevisibleiQ00724 MM

Interactioni

Subunit structurei

Interacts with TTR. Interaction with TTR prevents its loss by filtration through the kidney glomeruli. Interacts with STRA6.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025951

Structurei

3D structure databases

ProteinModelPortaliQ00724
SMRiQ00724
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJHC Eukaryota
ENOG4111K1Y LUCA
GeneTreeiENSGT00510000047107
HOGENOMiHOG000293156
HOVERGENiHBG004493
InParanoidiQ00724
KOiK18271
PhylomeDBiQ00724

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR022271 Lipocalin_ApoD
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002449 Retinol-bd/Purpurin
PANTHERiPTHR11873 PTHR11873, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PIRSFiPIRSF036893 Lipocalin_ApoD, 1 hit
PIRSF500204 RBP_purpurin, 1 hit
PRINTSiPR01174 RETINOLBNDNG
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00724-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWVWALVLL AALGGGSAER DCRVSSFRVK ENFDKARFSG LWYAIAKKDP
60 70 80 90 100
EGLFLQDNII AEFSVDEKGH MSATAKGRVR LLSNWEVCAD MVGTFTDTED
110 120 130 140 150
PAKFKMKYWG VASFLQRGND DHWIIDTDYD TFALQYSCRL QNLDGTCADS
160 170 180 190 200
YSFVFSRDPN GLSPETRRLV RQRQEELCLE RQYRWIEHNG YCQSRPSRNS

L
Length:201
Mass (Da):23,206
Last modified:December 15, 1998 - v2
Checksum:i8D187E293B37A75B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17S → T in AAA63395 (PubMed:1613076).Curated1
Sequence conflicti20R → P in AAA63395 (PubMed:1613076).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63146 mRNA Translation: AAB06955.1
AB124638 Genomic DNA Translation: BAD16678.1
AK008765 mRNA Translation: BAB25881.1
BC031809 mRNA Translation: AAH31809.1
BC093529 mRNA Translation: AAH93529.1
M74527 mRNA Translation: AAA63395.1
CCDSiCCDS29784.1
RefSeqiNP_001152959.1, NM_001159487.1
NP_035385.1, NM_011255.3
UniGeneiMm.2605

Genome annotation databases

EnsembliENSMUST00000112335; ENSMUSP00000107954; ENSMUSG00000024990
GeneIDi19662
KEGGimmu:19662
UCSCiuc008hjd.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRET4_MOUSE
AccessioniPrimary (citable) accession number: Q00724
Secondary accession number(s): P70357, Q566I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 15, 1998
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health