Reviewed,
UniProtKB/Swiss-Prot Q00724 (RET4_MOUSE)
Last modified
November 25, 2008.
Version 73.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Retinol-binding protein 4 Alternative name(s): Plasma retinol-binding protein Short name=PRBP Short name=RBP | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 201 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. |
| Subcellular location | |
| Sequence similarities | Belongs to the calycin superfamily. Lipocalin family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 18 | 18 | By similarity | ||||||||
| Chain | 19 – 201 | 183 | Retinol-binding protein 4 | PRO_0000017966 | |||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 22 ↔ 178 | By similarity | |||||||||
| Disulfide bond | 88 ↔ 192 | By similarity | |||||||||
| Disulfide bond | 138 ↔ 147 | By similarity | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 17 | 1 | S → T in AAA63395. Ref.5 | ||||||||
| Sequence conflict | 20 | 1 | R → P in AAA63395. Ref.5 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Induction of mouse retinol binding protein gene expression by cyclic AMP in Hepa 1-6 cells." Jessen K.A., Satre M.A. Arch. Biochem. Biophys. 357:126-130(1998) [PubMed: 9721191] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA. |
| [2] | "Genomic sequence of mouse retinol binding protein 4 region, complete sequence." Maekawa K., Kojima T., Fujiyama A., Hattori M., Sakaki Y. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Stomach. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver. |
| [5] | "Chromosomal localization of the retinol binding protein gene and its elimination as a candidate gene for the repeated epilation (Er) mutation in mice." Dale B., Jones A.H., Presland R., Adler D.A., Disteche C.M. J. Craniofac. Genet. Dev. Biol. 12:76-81(1992) [PubMed: 1613076] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-179. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U63146 mRNA. Translation: AAB06955.1. AB124638 Genomic DNA. Translation: BAD16678.1. AK008765 mRNA. Translation: BAB25881.1. BC031809 mRNA. Translation: AAH31809.1. BC093529 mRNA. Translation: AAH93529.1. M74527 mRNA. Translation: AAA63395.1. | |
| RefSeq | NP_035385.1. |
| UniGene | Mm.2605 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1AQB based on UniProtKB P27485. |
| SMR | Q00724. Positions 19-192. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUSG00000024990. Mus musculus. [Contig view] |
| GeneID | 19662. |
| KEGG | mmu:19662. |
Organism-specific databases | |
| MGI | MGI:97879. Rbp4. |
Phylogenomic databases | |
| HOGENOM | Q00724. |
| HOVERGEN | Q00724. |
Gene expression databases | |
| ArrayExpress | Q00724. |
| CleanEx | MM_RBP4. |
| GermOnline | ENSMUSG00000024990. Mus musculus. |
Family and domain databases | |
| InterPro | IPR012674. Calycin. IPR002345. Lipocalin. IPR000566. Lipocln_cytFABP. IPR002449. Retinol_bd. [Graphical view] |
| Gene3D | G3DSA:2.40.128.20. Calycin. 1 hit. |
| PANTHER | PTHR11873. Retinol_bd. 1 hit. |
| Pfam | PF00061. Lipocalin. 1 hit. [Graphical view] |
| PRINTS | PR00179. LIPOCALIN. PR01174. RETINOLBNDNG. |
| PROSITE | PS00213. LIPOCALIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 296954. |
| SOURCE | Search... |
Entry information
| Entry name | RET4_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q00724 Secondary accession number(s): P70357, Q566I5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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