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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Gene

PLCB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Ca2+Note: Binds 1 Ca2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei327PROSITE-ProRule annotation1
Metal bindingi328Calcium1
Metal bindingi357Calcium1
Metal bindingi359Calcium1
Active sitei374PROSITE-ProRule annotation1
Metal bindingi408Calcium1

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • phosphatidylinositol phospholipase C activity Source: AgBase
  • phospholipase C activity Source: ProtInc
  • signal transducer activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS06408-MONOMER.
ZFISH:HS06408-MONOMER.
BRENDAi3.1.4.11. 2681.
ReactomeiR-HSA-112043. PLC beta mediated events.
R-HSA-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-HSA-399997. Acetylcholine regulates insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-434316. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
R-HSA-500657. Presynaptic function of Kainate receptors.
SABIO-RKQ00722.
SignaLinkiQ00722.
SIGNORiQ00722.

Chemistry databases

SwissLipidsiSLP:000000948.

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C-beta-2
Phospholipase C-beta-2
Short name:
PLC-beta-2
Gene namesi
Name:PLCB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:9055. PLCB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi52Q → A: Strongly reduces interaction with RAC1. 1 Publication1

Organism-specific databases

DisGeNETi5330.
OpenTargetsiENSG00000137841.
PharmGKBiPA33385.

Polymorphism and mutation databases

BioMutaiPLCB2.
DMDMi215273902.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000884891 – 11851-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2Add BLAST1185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei953PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ00722.
MaxQBiQ00722.
PaxDbiQ00722.
PeptideAtlasiQ00722.
PRIDEiQ00722.

PTM databases

iPTMnetiQ00722.
PhosphoSitePlusiQ00722.

Expressioni

Gene expression databases

BgeeiENSG00000137841.
CleanExiHS_PLCB2.
ExpressionAtlasiQ00722. baseline and differential.
GenevisibleiQ00722. HS.

Organism-specific databases

HPAiCAB009443.
HPA041298.

Interactioni

Subunit structurei

Interacts with RAC1.

Protein-protein interaction databases

BioGridi111346. 13 interactors.
DIPiDIP-29259N.
MINTiMINT-1726830.
STRINGi9606.ENSP00000260402.

Structurei

Secondary structure

11185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 19Combined sources5
Beta strandi21 – 26Combined sources6
Turni28 – 30Combined sources3
Beta strandi33 – 40Combined sources8
Beta strandi46 – 51Combined sources6
Beta strandi56 – 60Combined sources5
Helixi61 – 63Combined sources3
Beta strandi64 – 69Combined sources6
Helixi70 – 72Combined sources3
Helixi79 – 84Combined sources6
Turni85 – 88Combined sources4
Helixi94 – 96Combined sources3
Beta strandi98 – 103Combined sources6
Beta strandi105 – 109Combined sources5
Beta strandi111 – 121Combined sources11
Helixi122 – 135Combined sources14
Helixi139 – 141Combined sources3
Helixi144 – 157Combined sources14
Helixi167 – 173Combined sources7
Helixi178 – 187Combined sources10
Beta strandi193 – 195Combined sources3
Helixi200 – 202Combined sources3
Helixi205 – 215Combined sources11
Helixi219 – 222Combined sources4
Helixi238 – 247Combined sources10
Helixi267 – 274Combined sources8
Helixi288 – 296Combined sources9
Helixi305 – 308Combined sources4
Helixi318 – 320Combined sources3
Beta strandi321 – 323Combined sources3
Beta strandi325 – 328Combined sources4
Beta strandi331 – 333Combined sources3
Beta strandi335 – 338Combined sources4
Helixi343 – 350Combined sources8
Beta strandi355 – 361Combined sources7
Turni365 – 368Combined sources4
Helixi384 – 394Combined sources11
Turni395 – 397Combined sources3
Beta strandi403 – 409Combined sources7
Helixi414 – 428Combined sources15
Helixi429 – 431Combined sources3
Turni451 – 456Combined sources6
Beta strandi458 – 461Combined sources4
Helixi523 – 531Combined sources9
Helixi534 – 538Combined sources5
Helixi544 – 547Combined sources4
Helixi561 – 567Combined sources7
Beta strandi572 – 577Combined sources6
Helixi578 – 587Combined sources10
Helixi589 – 598Combined sources10
Beta strandi599 – 604Combined sources6
Helixi618 – 622Combined sources5
Beta strandi626 – 628Combined sources3
Helixi637 – 645Combined sources9
Turni646 – 648Combined sources3
Helixi649 – 651Combined sources3
Beta strandi653 – 656Combined sources4
Helixi659 – 661Combined sources3
Turni675 – 680Combined sources6
Beta strandi682 – 693Combined sources12
Beta strandi701 – 708Combined sources8
Beta strandi724 – 726Combined sources3
Beta strandi738 – 745Combined sources8
Helixi746 – 748Combined sources3
Beta strandi750 – 757Combined sources8
Turni758 – 760Combined sources3
Beta strandi761 – 769Combined sources9
Helixi770 – 772Combined sources3
Beta strandi776 – 783Combined sources8
Beta strandi789 – 802Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FJUX-ray2.20B1-803[»]
2ZKMX-ray1.62X1-799[»]
ProteinModelPortaliQ00722.
SMRiQ00722.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00722.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini312 – 463PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST152
Domaini546 – 662PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini669 – 767C2PROSITE-ProRule annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili988 – 1147Sequence analysisAdd BLAST160

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi500 – 545Glu-richAdd BLAST46

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
GeneTreeiENSGT00760000118936.
HOGENOMiHOG000232046.
HOVERGENiHBG053609.
InParanoidiQ00722.
KOiK05858.
OMAiYEPSGIN.
OrthoDBiEOG091G00XL.
PhylomeDBiQ00722.
TreeFamiTF313216.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028403. PLC-beta2.
IPR014815. PLC-beta_C.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF10. PTHR10336:SF10. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q00722-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLLNPVLLP PKVKAYLSQG ERFIKWDDET TVASPVILRV DPKGYYLYWT
60 70 80 90 100
YQSKEMEFLD ITSIRDTRFG KFAKMPKSQK LRDVFNMDFP DNSFLLKTLT
110 120 130 140 150
VVSGPDMVDL TFHNFVSYKE NVGKAWAEDV LALVKHPLTA NASRSTFLDK
160 170 180 190 200
ILVKLKMQLN SEGKIPVKNF FQMFPADRKR VEAALSACHL PKGKNDAINP
210 220 230 240 250
EDFPEPVYKS FLMSLCPRPE IDEIFTSYHA KAKPYMTKEH LTKFINQKQR
260 270 280 290 300
DSRLNSLLFP PARPDQVQGL IDKYEPSGIN AQRGQLSPEG MVWFLCGPEN
310 320 330 340 350
SVLAQDKLLL HHDMTQPLNH YFINSSHNTY LTAGQFSGLS SAEMYRQVLL
360 370 380 390 400
SGCRCVELDC WKGKPPDEEP IITHGFTMTT DIFFKEAIEA IAESAFKTSP
410 420 430 440 450
YPIILSFENH VDSPRQQAKM AEYCRTIFGD MLLTEPLEKF PLKPGVPLPS
460 470 480 490 500
PEDLRGKILI KNKKNQFSGP TSSSKDTGGE AEGSSPPSAP AGEGTVWAGE
510 520 530 540 550
EGTELEEEEV EEEEEEESGN LDEEEIKKMQ SDEGTAGLEV TAYEEMSSLV
560 570 580 590 600
NYIQPTKFVS FEFSAQKNRS YVISSFTELK AYDLLSKASV QFVDYNKRQM
610 620 630 640 650
SRIYPKGTRM DSSNYMPQMF WNAGCQMVAL NFQTMDLPMQ QNMAVFEFNG
660 670 680 690 700
QSGYLLKHEF MRRPDKQFNP FSVDRIDVVV ATTLSITVIS GQFLSERSVR
710 720 730 740 750
TYVEVELFGL PGDPKRRYRT KLSPSTNSIN PVWKEEPFVF EKILMPELAS
760 770 780 790 800
LRVAVMEEGN KFLGHRIIPI NALNSGYHHL CLHSESNMPL TMPALFIFLE
810 820 830 840 850
MKDYIPGAWA DLTVALANPI KFFSAHDTKS VKLKEAMGGL PEKPFPLASP
860 870 880 890 900
VASQVNGALA PTSNGSPAAR AGAREEAMKE AAEPRTASLE ELRELKGVVK
910 920 930 940 950
LQRRHEKELR ELERRGARRW EELLQRGAAQ LAELGPPGVG GVGACKLGPG
960 970 980 990 1000
KGSRKKRSLP REESAGAAPG EGPEGVDGRV RELKDRLELE LLRQGEEQYE
1010 1020 1030 1040 1050
CVLKRKEQHV AEQISKMMEL AREKQAAELK ALKETSENDT KEMKKKLETK
1060 1070 1080 1090 1100
RLERIQGMTK VTTDKMAQER LKREINNSHI QEVVQVIKQM TENLERHQEK
1110 1120 1130 1140 1150
LEEKQAACLE QIREMEKQFQ KEALAEYEAR MKGLEAEVKE SVRACLRTCF
1160 1170 1180
PSEAKDKPER ACECPPELCE QDPLIAKADA QESRL
Length:1,185
Mass (Da):134,024
Last modified:November 25, 2008 - v2
Checksum:iA0397309D943672A
GO
Isoform 2 (identifier: Q00722-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     492-495: Missing.

Show »
Length:1,181
Mass (Da):133,680
Checksum:i7A6889F204D17FA4
GO
Isoform 3 (identifier: Q00722-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     868-882: Missing.

Note: No experimental confirmation available.
Show »
Length:1,170
Mass (Da):132,511
Checksum:iBC9DC96247E5762D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119K → R in BAF84346 (PubMed:14702039).Curated1
Sequence conflicti1060K → R in BAF84346 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047509324N → I.Corresponds to variant rs45628633dbSNPEnsembl.1
Natural variantiVAR_047510598R → H.Corresponds to variant rs8025153dbSNPEnsembl.1
Natural variantiVAR_047511664P → L.Corresponds to variant rs9972332dbSNPEnsembl.1
Natural variantiVAR_047512712G → R.Corresponds to variant rs28395835dbSNPEnsembl.1
Natural variantiVAR_0475131095E → G.1 PublicationCorresponds to variant rs936212dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035770492 – 495Missing in isoform 2. 1 Publication4
Alternative sequenceiVSP_054490868 – 882Missing in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95678 mRNA. Translation: AAA36453.1.
AK291657 mRNA. Translation: BAF84346.1.
AC020658 Genomic DNA. No translation available.
BC136467 mRNA. Translation: AAI36468.1.
CCDSiCCDS42020.1. [Q00722-1]
CCDS61591.1. [Q00722-3]
CCDS61592.1. [Q00722-2]
PIRiA43346.
RefSeqiNP_001271226.1. NM_001284297.1. [Q00722-2]
NP_001271227.1. NM_001284298.1. [Q00722-3]
NP_004564.2. NM_004573.2. [Q00722-1]
UniGeneiHs.355888.

Genome annotation databases

EnsembliENST00000260402; ENSP00000260402; ENSG00000137841. [Q00722-1]
ENST00000456256; ENSP00000411991; ENSG00000137841. [Q00722-3]
ENST00000557821; ENSP00000453975; ENSG00000137841. [Q00722-2]
GeneIDi5330.
KEGGihsa:5330.
UCSCiuc001zld.4. human. [Q00722-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95678 mRNA. Translation: AAA36453.1.
AK291657 mRNA. Translation: BAF84346.1.
AC020658 Genomic DNA. No translation available.
BC136467 mRNA. Translation: AAI36468.1.
CCDSiCCDS42020.1. [Q00722-1]
CCDS61591.1. [Q00722-3]
CCDS61592.1. [Q00722-2]
PIRiA43346.
RefSeqiNP_001271226.1. NM_001284297.1. [Q00722-2]
NP_001271227.1. NM_001284298.1. [Q00722-3]
NP_004564.2. NM_004573.2. [Q00722-1]
UniGeneiHs.355888.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FJUX-ray2.20B1-803[»]
2ZKMX-ray1.62X1-799[»]
ProteinModelPortaliQ00722.
SMRiQ00722.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111346. 13 interactors.
DIPiDIP-29259N.
MINTiMINT-1726830.
STRINGi9606.ENSP00000260402.

Chemistry databases

SwissLipidsiSLP:000000948.

PTM databases

iPTMnetiQ00722.
PhosphoSitePlusiQ00722.

Polymorphism and mutation databases

BioMutaiPLCB2.
DMDMi215273902.

Proteomic databases

EPDiQ00722.
MaxQBiQ00722.
PaxDbiQ00722.
PeptideAtlasiQ00722.
PRIDEiQ00722.

Protocols and materials databases

DNASUi5330.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260402; ENSP00000260402; ENSG00000137841. [Q00722-1]
ENST00000456256; ENSP00000411991; ENSG00000137841. [Q00722-3]
ENST00000557821; ENSP00000453975; ENSG00000137841. [Q00722-2]
GeneIDi5330.
KEGGihsa:5330.
UCSCiuc001zld.4. human. [Q00722-1]

Organism-specific databases

CTDi5330.
DisGeNETi5330.
GeneCardsiPLCB2.
H-InvDBHIX0012125.
HGNCiHGNC:9055. PLCB2.
HPAiCAB009443.
HPA041298.
MIMi604114. gene.
neXtProtiNX_Q00722.
OpenTargetsiENSG00000137841.
PharmGKBiPA33385.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
GeneTreeiENSGT00760000118936.
HOGENOMiHOG000232046.
HOVERGENiHBG053609.
InParanoidiQ00722.
KOiK05858.
OMAiYEPSGIN.
OrthoDBiEOG091G00XL.
PhylomeDBiQ00722.
TreeFamiTF313216.

Enzyme and pathway databases

BioCyciMetaCyc:HS06408-MONOMER.
ZFISH:HS06408-MONOMER.
BRENDAi3.1.4.11. 2681.
ReactomeiR-HSA-112043. PLC beta mediated events.
R-HSA-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-HSA-399997. Acetylcholine regulates insulin secretion.
R-HSA-4086398. Ca2+ pathway.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418217. G beta:gamma signalling through PLC beta.
R-HSA-434316. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
R-HSA-500657. Presynaptic function of Kainate receptors.
SABIO-RKQ00722.
SignaLinkiQ00722.
SIGNORiQ00722.

Miscellaneous databases

ChiTaRSiPLCB2. human.
EvolutionaryTraceiQ00722.
GeneWikiiPLCB2.
GenomeRNAii5330.
PROiQ00722.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137841.
CleanExiHS_PLCB2.
ExpressionAtlasiQ00722. baseline and differential.
GenevisibleiQ00722. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028403. PLC-beta2.
IPR014815. PLC-beta_C.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF10. PTHR10336:SF10. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLCB2_HUMAN
AccessioniPrimary (citable) accession number: Q00722
Secondary accession number(s): A8K6J2, B9EGH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 166 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.