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Q00722

- PLCB2_HUMAN

UniProt

Q00722 - PLCB2_HUMAN

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Protein
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Gene
PLCB2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Binds 1 calcium ion per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei327 – 3271 By similarity
Metal bindingi328 – 3281Calcium
Metal bindingi357 – 3571Calcium
Metal bindingi359 – 3591Calcium
Active sitei374 – 3741 By similarity
Metal bindingi408 – 4081Calcium

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phosphatidylinositol phospholipase C activity Source: ProtInc
  3. phospholipase C activity Source: ProtInc
  4. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. activation of phospholipase C activity Source: ProtInc
  2. inositol phosphate metabolic process Source: Reactome
  3. intracellular signal transduction Source: InterPro
  4. lipid catabolic process Source: UniProtKB-KW
  5. phospholipid metabolic process Source: ProtInc
  6. sensory perception of bitter taste Source: Ensembl
  7. small molecule metabolic process Source: Reactome
  8. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS06408-MONOMER.
BRENDAi3.1.4.11. 2681.
ReactomeiREACT_150312. Synthesis of IP3 and IP4 in the cytosol.
REACT_15426. PLC beta mediated events.
REACT_172761. Ca2+ pathway.
REACT_18283. G alpha (q) signalling events.
REACT_18405. Acetylcholine regulates insulin secretion.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19193. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
REACT_21254. Presynaptic function of Kainate receptors.
SignaLinkiQ00722.

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C-beta-2
Phospholipase C-beta-2
Short name:
PLC-beta-2
Gene namesi
Name:PLCB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:9055. PLCB2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi52 – 521Q → A: Strongly reduces interaction with RAC1. 1 Publication

Organism-specific databases

PharmGKBiPA33385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118511851-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
PRO_0000088489Add
BLAST

Proteomic databases

MaxQBiQ00722.
PaxDbiQ00722.
PRIDEiQ00722.

PTM databases

PhosphoSiteiQ00722.

Expressioni

Gene expression databases

ArrayExpressiQ00722.
BgeeiQ00722.
CleanExiHS_PLCB2.
GenevestigatoriQ00722.

Organism-specific databases

HPAiCAB009443.

Interactioni

Subunit structurei

Interacts with RAC1.

Protein-protein interaction databases

BioGridi111346. 12 interactions.
DIPiDIP-29259N.
MINTiMINT-1726830.
STRINGi9606.ENSP00000260402.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi15 – 195
Beta strandi21 – 3111
Beta strandi33 – 408
Beta strandi46 – 516
Beta strandi56 – 605
Helixi61 – 633
Beta strandi64 – 696
Helixi70 – 723
Helixi79 – 846
Turni85 – 884
Helixi94 – 963
Beta strandi98 – 1036
Beta strandi105 – 1095
Beta strandi111 – 12111
Helixi122 – 13413
Helixi137 – 1404
Helixi144 – 15714
Helixi167 – 1737
Helixi178 – 18710
Beta strandi193 – 1953
Helixi200 – 2023
Helixi207 – 2159
Helixi219 – 2268
Helixi238 – 24710
Helixi269 – 2746
Helixi288 – 2969
Helixi305 – 3084
Helixi318 – 3203
Beta strandi321 – 3233
Beta strandi325 – 3284
Beta strandi331 – 3333
Beta strandi335 – 3384
Helixi343 – 3508
Beta strandi355 – 3617
Turni365 – 3684
Helixi384 – 39411
Turni395 – 3973
Beta strandi403 – 4097
Helixi414 – 42815
Helixi429 – 4313
Turni451 – 4566
Beta strandi458 – 4614
Turni523 – 53311
Helixi534 – 5374
Helixi544 – 5474
Helixi561 – 5677
Beta strandi572 – 5776
Helixi578 – 59821
Beta strandi599 – 6046
Helixi618 – 6225
Helixi637 – 6459
Turni646 – 6483
Helixi649 – 6513
Beta strandi653 – 6564
Helixi659 – 6613
Beta strandi683 – 69311
Beta strandi701 – 7088
Beta strandi724 – 7263
Beta strandi738 – 7403
Helixi746 – 7483
Beta strandi750 – 7578
Turni758 – 7603
Beta strandi761 – 7699
Helixi770 – 7723
Beta strandi776 – 7838
Beta strandi789 – 80214

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FJUX-ray2.20B1-803[»]
2ZKMX-ray1.62X1-799[»]
ProteinModelPortaliQ00722.
SMRiQ00722. Positions 11-803, 883-1151.

Miscellaneous databases

EvolutionaryTraceiQ00722.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini312 – 463152PI-PLC X-box
Add
BLAST
Domaini546 – 662117PI-PLC Y-box
Add
BLAST
Domaini669 – 76799C2
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili988 – 1147160 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi500 – 54546Glu-rich
Add
BLAST

Sequence similaritiesi

Contains 1 C2 domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG149692.
HOGENOMiHOG000232046.
HOVERGENiHBG053609.
InParanoidiQ00722.
KOiK05858.
OMAiFIKWDDE.
OrthoDBiEOG7WDN1N.
PhylomeDBiQ00722.
TreeFamiTF313216.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028403. PLC-beta2.
IPR014815. PLC-beta_C.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF10. PTHR10336:SF10. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q00722-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLLNPVLLP PKVKAYLSQG ERFIKWDDET TVASPVILRV DPKGYYLYWT     50
YQSKEMEFLD ITSIRDTRFG KFAKMPKSQK LRDVFNMDFP DNSFLLKTLT 100
VVSGPDMVDL TFHNFVSYKE NVGKAWAEDV LALVKHPLTA NASRSTFLDK 150
ILVKLKMQLN SEGKIPVKNF FQMFPADRKR VEAALSACHL PKGKNDAINP 200
EDFPEPVYKS FLMSLCPRPE IDEIFTSYHA KAKPYMTKEH LTKFINQKQR 250
DSRLNSLLFP PARPDQVQGL IDKYEPSGIN AQRGQLSPEG MVWFLCGPEN 300
SVLAQDKLLL HHDMTQPLNH YFINSSHNTY LTAGQFSGLS SAEMYRQVLL 350
SGCRCVELDC WKGKPPDEEP IITHGFTMTT DIFFKEAIEA IAESAFKTSP 400
YPIILSFENH VDSPRQQAKM AEYCRTIFGD MLLTEPLEKF PLKPGVPLPS 450
PEDLRGKILI KNKKNQFSGP TSSSKDTGGE AEGSSPPSAP AGEGTVWAGE 500
EGTELEEEEV EEEEEEESGN LDEEEIKKMQ SDEGTAGLEV TAYEEMSSLV 550
NYIQPTKFVS FEFSAQKNRS YVISSFTELK AYDLLSKASV QFVDYNKRQM 600
SRIYPKGTRM DSSNYMPQMF WNAGCQMVAL NFQTMDLPMQ QNMAVFEFNG 650
QSGYLLKHEF MRRPDKQFNP FSVDRIDVVV ATTLSITVIS GQFLSERSVR 700
TYVEVELFGL PGDPKRRYRT KLSPSTNSIN PVWKEEPFVF EKILMPELAS 750
LRVAVMEEGN KFLGHRIIPI NALNSGYHHL CLHSESNMPL TMPALFIFLE 800
MKDYIPGAWA DLTVALANPI KFFSAHDTKS VKLKEAMGGL PEKPFPLASP 850
VASQVNGALA PTSNGSPAAR AGAREEAMKE AAEPRTASLE ELRELKGVVK 900
LQRRHEKELR ELERRGARRW EELLQRGAAQ LAELGPPGVG GVGACKLGPG 950
KGSRKKRSLP REESAGAAPG EGPEGVDGRV RELKDRLELE LLRQGEEQYE 1000
CVLKRKEQHV AEQISKMMEL AREKQAAELK ALKETSENDT KEMKKKLETK 1050
RLERIQGMTK VTTDKMAQER LKREINNSHI QEVVQVIKQM TENLERHQEK 1100
LEEKQAACLE QIREMEKQFQ KEALAEYEAR MKGLEAEVKE SVRACLRTCF 1150
PSEAKDKPER ACECPPELCE QDPLIAKADA QESRL 1185
Length:1,185
Mass (Da):134,024
Last modified:November 25, 2008 - v2
Checksum:iA0397309D943672A
GO
Isoform 2 (identifier: Q00722-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     492-495: Missing.

Show »
Length:1,181
Mass (Da):133,680
Checksum:i7A6889F204D17FA4
GO
Isoform 3 (identifier: Q00722-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     868-882: Missing.

Note: No experimental confirmation available.

Show »
Length:1,170
Mass (Da):132,511
Checksum:iBC9DC96247E5762D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti324 – 3241N → I.
Corresponds to variant rs45628633 [ dbSNP | Ensembl ].
VAR_047509
Natural varianti598 – 5981R → H.
Corresponds to variant rs8025153 [ dbSNP | Ensembl ].
VAR_047510
Natural varianti664 – 6641P → L.
Corresponds to variant rs9972332 [ dbSNP | Ensembl ].
VAR_047511
Natural varianti712 – 7121G → R.
Corresponds to variant rs28395835 [ dbSNP | Ensembl ].
VAR_047512
Natural varianti1095 – 10951E → G.1 Publication
Corresponds to variant rs936212 [ dbSNP | Ensembl ].
VAR_047513

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei492 – 4954Missing in isoform 2.
VSP_035770
Alternative sequencei868 – 88215Missing in isoform 3.
VSP_054490Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191K → R in BAF84346. 1 Publication
Sequence conflicti1060 – 10601K → R in BAF84346. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95678 mRNA. Translation: AAA36453.1.
AK291657 mRNA. Translation: BAF84346.1.
AC020658 Genomic DNA. No translation available.
BC136467 mRNA. Translation: AAI36468.1.
CCDSiCCDS42020.1. [Q00722-1]
CCDS61591.1. [Q00722-3]
CCDS61592.1. [Q00722-2]
PIRiA43346.
RefSeqiNP_001271226.1. NM_001284297.1. [Q00722-2]
NP_001271227.1. NM_001284298.1. [Q00722-3]
NP_004564.2. NM_004573.2. [Q00722-1]
UniGeneiHs.355888.

Genome annotation databases

EnsembliENST00000260402; ENSP00000260402; ENSG00000137841. [Q00722-1]
ENST00000456256; ENSP00000411991; ENSG00000137841.
ENST00000557821; ENSP00000453975; ENSG00000137841. [Q00722-2]
GeneIDi5330.
KEGGihsa:5330.
UCSCiuc001zld.3. human. [Q00722-1]
uc010bbo.3. human. [Q00722-2]

Polymorphism databases

DMDMi215273902.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95678 mRNA. Translation: AAA36453.1 .
AK291657 mRNA. Translation: BAF84346.1 .
AC020658 Genomic DNA. No translation available.
BC136467 mRNA. Translation: AAI36468.1 .
CCDSi CCDS42020.1. [Q00722-1 ]
CCDS61591.1. [Q00722-3 ]
CCDS61592.1. [Q00722-2 ]
PIRi A43346.
RefSeqi NP_001271226.1. NM_001284297.1. [Q00722-2 ]
NP_001271227.1. NM_001284298.1. [Q00722-3 ]
NP_004564.2. NM_004573.2. [Q00722-1 ]
UniGenei Hs.355888.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2FJU X-ray 2.20 B 1-803 [» ]
2ZKM X-ray 1.62 X 1-799 [» ]
ProteinModelPortali Q00722.
SMRi Q00722. Positions 11-803, 883-1151.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111346. 12 interactions.
DIPi DIP-29259N.
MINTi MINT-1726830.
STRINGi 9606.ENSP00000260402.

PTM databases

PhosphoSitei Q00722.

Polymorphism databases

DMDMi 215273902.

Proteomic databases

MaxQBi Q00722.
PaxDbi Q00722.
PRIDEi Q00722.

Protocols and materials databases

DNASUi 5330.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000260402 ; ENSP00000260402 ; ENSG00000137841 . [Q00722-1 ]
ENST00000456256 ; ENSP00000411991 ; ENSG00000137841 .
ENST00000557821 ; ENSP00000453975 ; ENSG00000137841 . [Q00722-2 ]
GeneIDi 5330.
KEGGi hsa:5330.
UCSCi uc001zld.3. human. [Q00722-1 ]
uc010bbo.3. human. [Q00722-2 ]

Organism-specific databases

CTDi 5330.
GeneCardsi GC15M040580.
H-InvDB HIX0012125.
HGNCi HGNC:9055. PLCB2.
HPAi CAB009443.
MIMi 604114. gene.
neXtProti NX_Q00722.
PharmGKBi PA33385.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149692.
HOGENOMi HOG000232046.
HOVERGENi HBG053609.
InParanoidi Q00722.
KOi K05858.
OMAi FIKWDDE.
OrthoDBi EOG7WDN1N.
PhylomeDBi Q00722.
TreeFami TF313216.

Enzyme and pathway databases

BioCyci MetaCyc:HS06408-MONOMER.
BRENDAi 3.1.4.11. 2681.
Reactomei REACT_150312. Synthesis of IP3 and IP4 in the cytosol.
REACT_15426. PLC beta mediated events.
REACT_172761. Ca2+ pathway.
REACT_18283. G alpha (q) signalling events.
REACT_18405. Acetylcholine regulates insulin secretion.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19193. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
REACT_21254. Presynaptic function of Kainate receptors.
SignaLinki Q00722.

Miscellaneous databases

ChiTaRSi PLCB2. human.
EvolutionaryTracei Q00722.
GeneWikii PLCB2.
GenomeRNAii 5330.
NextBioi 20640.
PROi Q00722.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q00722.
Bgeei Q00722.
CleanExi HS_PLCB2.
Genevestigatori Q00722.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProi IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028403. PLC-beta2.
IPR014815. PLC-beta_C.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
PTHR10336:SF10. PTHR10336:SF10. 1 hit.
Pfami PF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000956. PLC-beta. 1 hit.
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEi PS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2."
    Park D., Jhon D.-Y., Kriz R., Knopf J., Rhee S.G.
    J. Biol. Chem. 267:16048-16055(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLY-1095.
    Tissue: Placenta.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  5. "Crystal structure of Rac1 bound to its effector phospholipase C-beta2."
    Jezyk M.R., Snyder J.T., Gershberg S., Worthylake D.K., Harden T.K., Sondek J.
    Nat. Struct. Mol. Biol. 13:1135-1140(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1-803 (ISOFORM 2) IN COMPLEX WITH RAC1, MUTAGENESIS OF GLN-52.

Entry informationi

Entry nameiPLCB2_HUMAN
AccessioniPrimary (citable) accession number: Q00722
Secondary accession number(s): A8K6J2, B9EGH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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