Q00705 (MCP_SUHVS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Major capsid protein Short name=MCP Alternative name(s): MCP142
Organism	Suid herpesvirus 1 (strain Indiana S) (SuHV-1) (Pseudorabies virus (strain Indiana S))
Taxonomic identifier	31522 [NCBI]
Taxonomic lineage	Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus › Suid herpesvirus 1
Virus host	Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length	1330 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.
Subunit structure	Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with VP19C and VP23; Adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of VP19C and two molecules of VP23. Interacts with VP22A; this interaction allows efficient MCP transport to the host nucleus. Interacts with VP26. Interacts with virion-packaging protein UL25.
Subcellular location	Virion. Host nucleus.
Sequence similarities	Belongs to the herpesviridae major capsid protein family.

Ontologies

Keywords
Cellular component	Host nucleus Virion
Molecular function	Capsid protein T=16 icosahedral capsid protein
Gene Ontology (GO)
Cellular_component	T=16 icosahedral viral capsid Inferred from electronic annotation. Source: UniProtKB-KW host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1330	1330	Major capsid protein		PRO_0000115708

Sequences

	Sequence		Length	Mass (Da)
	Q00705 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 4E228145F773A522	FASTA	1,330	145,938
	10 20 30 40 50 60 MERPAILPSG QILSNIEVHS HRALFDIFKR FRSDDNNLYG AEFDALLGTY CSTLSLVRFL 70 80 90 100 110 120 ELGLSVACVC TKFPELSYVA EGTIQFEVQQ PMIARDGPHP ADQPVHNYMI KRLDRRSLNA 130 140 150 160 170 180 AFSIAVEALG LISGENLDGT HISSAMRLRA IQQLARNVQA VLDSFERGTA DQMLRVLMEK 190 200 210 220 230 240 APPLSLLAPF TLYEGRLADR VACAALVSEL KRRVRDDTFF LTKHERNKDA VLDRLSDLVN 250 260 270 280 290 300 CTAPSVAVAR MTHADTQGRP VDGVLVTTAG VRQRLLHHVL TLADTHADVP VTYGEMVIAN 310 320 330 340 350 360 TNLVTALVMG KAVSNMDDVA RYLLGGEPAP DDGKPVGSAR VRADLVVVGD RLVFLEALEK 370 380 390 400 410 420 RVYQATQVPY PLVGNLDVTF VMPLGVFKPA ADRYARHAGS FAPTPGLPDP RTHPPRAVHF 430 440 450 460 470 480 FNKDGVPCHV TFEHAMGTLC HPSFLDVDAT LAALRQEPAE VQCAFGAYVA DARPDALVGL 490 500 510 520 530 540 MQRFLEEWPG MMPVRPRWAA PAAADQLLAP GNADLRLELH PAFDFFVAPE VDVPGPFAVP 550 560 570 580 590 600 QVMGQVRAMP RIINGNIPLA LCPVDFRDAR GFELSVDRHR LAPATVAAVR GAFRDANYPM 610 620 630 640 650 660 VFYIIEAVIH GSERTFCALA RLVAQCIQSY WRNTHNAAFV NNFYMVMYIN TYLGNGELPE 670 680 690 700 710 720 DCAAVYKDLL EHVHALRRLI GEFTLPGDPL GNQPQEELNH ALADATLLPP LIWDCDPILY 730 740 750 760 770 780 RDGLAERLPE LRVNGAHFQH ILWVEMAQVN FRNVGGGLVH NRPVRNENQP LHPHHDAEWS 790 800 810 820 830 840 VLSKIYYYAV VPAFSRGNCC TMGVRYDRVY QLVQTMVVPE TDEEVGTDDP RHPLHPRNLV 850 860 870 880 890 900 PNSLNVLFHN ACVAVDADAM LILQETVTNM AERTTPLLAS VAPDAGMATV ATRDMRTHDG 910 920 930 940 950 960 SLHHGLLMMA YQPNDATLLE GAFFYPAPVN ALFACADHLG AMRDVGAEVR AAAQHVPCVP 970 980 990 1000 1010 1020 HFLGANYYAT VRQPVAQHAA QSRADENTLS YALMAGYFKM SPVAFTHQLR RQLHPGFALT 1030 1040 1050 1060 1070 1080 VVRQDRFATE NVLFAEKASE SYFMGQMQVA RTESGGGLHL QLTQPRANVD LGVGFTAAYA 1090 1100 1110 1120 1130 1140 AAALRAPVTD MGNLPQNLFA TRGAPPMLDA DADDYLRRTV NAGNRLAPVP VFGQMLPQVP 1150 1160 1170 1180 1190 1200 AGLARGQQSV CEFIATPVSV DLAYFRRACN PRGRAAGEVH GEEGLMFDHS HADPAHPHRA 1210 1220 1230 1240 1250 1260 TANPWASQRH SYADRLYNGQ YNMSGPAYSP CFKFFTPAEA VAKSRGLARL IADTGAAASP 1270 1280 1290 1300 1310 1320 TSNGEYQFKR PVGAGELVED PCALFQEAYP PLCASDSALL RTPLGAEEHF AQYLIRDESP 1330 LKGCFQHASA

References

[1]	"Nucleotide sequence and transcriptional mapping of the major capsid protein gene of pseudorabies virus." Yamada S., Imada T., Watanabe W., Honda Y., Nakajima-Iijima S., Shimizu Y., Sekikawa K. Virology 185:56-66(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
PIR	VCBES5. A40777.
3D structure databases
ProteinModelPortal	Q00705.
SMR	Q00705. Positions 464-1014.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000912. Herpes_MCP. IPR023233. Herpes_MCP_upper. [Graphical view]
Pfam	PF03122. Herpes_MCP. 1 hit. [Graphical view]
PRINTS	PR00235. HSVCAPSIDMCP.
SUPFAM	SSF103417. Herpes_MCP_upper. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MCP_SUHVS

Accession

Primary (citable) accession number: Q00705

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	April 3, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program