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Protein

E-selectin

Gene

Sele

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
E-selectin
Alternative name(s):
CD62 antigen-like family member E
Endothelial leukocyte adhesion molecule 1
Short name:
ELAM-1
Leukocyte-endothelial cell adhesion molecule 2
Short name:
LECAM2
CD_antigen: CD62E
Gene namesi
Name:Sele
Synonyms:Elam-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98278. Sele.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 557ExtracellularSequence analysisAdd BLAST536
Transmembranei558 – 579HelicalSequence analysisAdd BLAST22
Topological domaini580 – 612CytoplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2545.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001749322 – 612E-selectinAdd BLAST591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi40 ↔ 138By similarity
Disulfide bondi111 ↔ 130By similarity
Disulfide bondi143 ↔ 154By similarity
Glycosylationi145N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi148 ↔ 163By similarity
Disulfide bondi165 ↔ 174By similarity
Disulfide bondi180 ↔ 225By similarity
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi203N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi210 ↔ 238By similarity
Disulfide bondi243 ↔ 287By similarity
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi273 ↔ 300By similarity
Disulfide bondi305 ↔ 350By similarity
Glycosylationi333N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi336 ↔ 363By similarity
Disulfide bondi368 ↔ 413By similarity
Glycosylationi391N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi399 ↔ 426By similarity
Disulfide bondi431 ↔ 476By similarity
Disulfide bondi462 ↔ 489By similarity
Disulfide bondi494 ↔ 535By similarity
Glycosylationi504N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi521 ↔ 548By similarity
Glycosylationi528N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ00690.
PRIDEiQ00690.

PTM databases

iPTMnetiQ00690.
PhosphoSitePlusiQ00690.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026582.
CleanExiMM_SELE.

Interactioni

Subunit structurei

Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-59328N.
STRINGi10090.ENSMUSP00000027874.

Chemistry databases

BindingDBiQ00690.

Structurei

3D structure databases

ProteinModelPortaliQ00690.
SMRiQ00690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 139C-type lectinPROSITE-ProRule annotationAdd BLAST118
Domaini140 – 175EGF-likePROSITE-ProRule annotationAdd BLAST36
Domaini178 – 240Sushi 1PROSITE-ProRule annotationAdd BLAST63
Domaini241 – 302Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini303 – 365Sushi 3PROSITE-ProRule annotationAdd BLAST63
Domaini366 – 428Sushi 4PROSITE-ProRule annotationAdd BLAST63
Domaini430 – 491Sushi 5PROSITE-ProRule annotationAdd BLAST62
Domaini492 – 550Sushi 6PROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 6 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOVERGENiHBG052375.
InParanoidiQ00690.
KOiK06494.
PhylomeDBiQ00690.

Family and domain databases

CDDicd00033. CCP. 6 hits.
Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 6 hits.
[Graphical view]
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 6 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 6 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNASRFLSAL VFVLLAGEST AWYYNASSEL MTYDEASAYC QRDYTHLVAI
60 70 80 90 100
QNKEEINYLN SNLKHSPSYY WIGIRKVNNV WIWVGTGKPL TEEAQNWAPG
110 120 130 140 150
EPNNKQRNED CVEIYIQRTK DSGMWNDERC NKKKLALCYT ASCTNASCSG
160 170 180 190 200
HGECIETINS YTCKCHPGFL GPNCEQAVTC KPQEHPDYGS LNCSHPFGPF
210 220 230 240 250
SYNSSCSFGC KRGYLPSSME TTVRCTSSGE WSAPAPACHV VECEALTHPA
260 270 280 290 300
HGIRKCSSNP GSYPWNTTCT FDCVEGYRRV GAQNLQCTSS GIWDNETPSC
310 320 330 340 350
KAVTCDAIPQ PQNGFVSCSH STAGELAFKS SCNFTCEQSF TLQGPAQVEC
360 370 380 390 400
SAQGQWTPQI PVCKAVQCEA LSAPQQGNMK CLPSASGPFQ NGSSCEFSCE
410 420 430 440 450
EGFELKGSRR LQCGPRGEWD SKKPTCSAVK CDDVPRPQNG VMECAHATTG
460 470 480 490 500
EFTYKSSCAF QCNEGFSLHG SAQLECTSQG KWTQEVPSCQ VVQCPSLDVP
510 520 530 540 550
GKMNMSCSGT AVFGTVCEFT CPDDWTLNGS AVLTCGATGR WSGMPPTCEA
560 570 580 590 600
PVSPTRPLVV ALSAAGTSLL TSSSLLYLLM RYFRKKAKKF VPASSCQSLQ
610
SFENYHVPSY NV
Length:612
Mass (Da):66,750
Last modified:April 1, 1993 - v1
Checksum:i86F05713F0EC2C3D
GO

Sequence cautioni

The sequence AAA37577 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80778 Genomic DNA. Translation: AAA37547.1.
M87862 mRNA. Translation: AAA37577.1. Different initiation.
PIRiS23174. B42755.
RefSeqiNP_035475.1. NM_011345.2.
XP_006496778.1. XM_006496715.2.
UniGeneiMm.5245.

Genome annotation databases

GeneIDi20339.
KEGGimmu:20339.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

E-selectin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80778 Genomic DNA. Translation: AAA37547.1.
M87862 mRNA. Translation: AAA37577.1. Different initiation.
PIRiS23174. B42755.
RefSeqiNP_035475.1. NM_011345.2.
XP_006496778.1. XM_006496715.2.
UniGeneiMm.5245.

3D structure databases

ProteinModelPortaliQ00690.
SMRiQ00690.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59328N.
STRINGi10090.ENSMUSP00000027874.

Chemistry databases

BindingDBiQ00690.
ChEMBLiCHEMBL2545.

PTM databases

iPTMnetiQ00690.
PhosphoSitePlusiQ00690.

Proteomic databases

PaxDbiQ00690.
PRIDEiQ00690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20339.
KEGGimmu:20339.

Organism-specific databases

CTDi6401.
MGIiMGI:98278. Sele.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
HOVERGENiHBG052375.
InParanoidiQ00690.
KOiK06494.
PhylomeDBiQ00690.

Miscellaneous databases

PROiQ00690.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026582.
CleanExiMM_SELE.

Family and domain databases

CDDicd00033. CCP. 6 hits.
Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 6 hits.
[Graphical view]
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 6 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
SM00179. EGF_CA. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 6 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYAM2_MOUSE
AccessioniPrimary (citable) accession number: Q00690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.