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Q00690

- LYAM2_MOUSE

UniProt

Q00690 - LYAM2_MOUSE

Protein

E-selectin

Gene

Sele

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

    GO - Molecular functioni

    1. oligosaccharide binding Source: Ensembl
    2. sialic acid binding Source: Ensembl
    3. transmembrane signaling receptor activity Source: Ensembl

    GO - Biological processi

    1. actin filament-based process Source: Ensembl
    2. activation of phospholipase C activity Source: Ensembl
    3. heterophilic cell-cell adhesion Source: Ensembl
    4. leukocyte tethering or rolling Source: Ensembl
    5. positive regulation of leukocyte migration Source: MGI
    6. positive regulation of receptor internalization Source: Ensembl
    7. response to interleukin-1 Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Lectin

    Enzyme and pathway databases

    ReactomeiREACT_225233. Cell surface interactions at the vascular wall.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E-selectin
    Alternative name(s):
    CD62 antigen-like family member E
    Endothelial leukocyte adhesion molecule 1
    Short name:
    ELAM-1
    Leukocyte-endothelial cell adhesion molecule 2
    Short name:
    LECAM2
    CD_antigen: CD62E
    Gene namesi
    Name:Sele
    Synonyms:Elam-1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:98278. Sele.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: Ensembl
    2. coated pit Source: Ensembl
    3. cortical cytoskeleton Source: Ensembl
    4. extracellular space Source: Ensembl
    5. integral component of membrane Source: UniProtKB-KW
    6. perinuclear region of cytoplasm Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 612591E-selectinPRO_0000017493Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi40 ↔ 138By similarity
    Disulfide bondi111 ↔ 130By similarity
    Disulfide bondi143 ↔ 154By similarity
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi148 ↔ 163By similarity
    Disulfide bondi165 ↔ 174By similarity
    Disulfide bondi180 ↔ 225By similarity
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi210 ↔ 238By similarity
    Disulfide bondi243 ↔ 287By similarity
    Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi273 ↔ 300By similarity
    Disulfide bondi305 ↔ 350By similarity
    Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi336 ↔ 363By similarity
    Disulfide bondi368 ↔ 413By similarity
    Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi399 ↔ 426By similarity
    Disulfide bondi431 ↔ 476By similarity
    Disulfide bondi462 ↔ 489By similarity
    Disulfide bondi494 ↔ 535By similarity
    Glycosylationi504 – 5041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi521 ↔ 548By similarity
    Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ00690.
    PRIDEiQ00690.

    PTM databases

    PhosphoSiteiQ00690.

    Expressioni

    Gene expression databases

    BgeeiQ00690.
    CleanExiMM_SELE.
    GenevestigatoriQ00690.

    Interactioni

    Subunit structurei

    Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-59328N.
    STRINGi10090.ENSMUSP00000027874.

    Structurei

    3D structure databases

    ProteinModelPortaliQ00690.
    SMRiQ00690. Positions 22-178, 189-561.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 557536ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini580 – 61233CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei558 – 57922HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 139118C-type lectinPROSITE-ProRule annotationAdd
    BLAST
    Domaini140 – 17536EGF-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini178 – 24063Sushi 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini241 – 30262Sushi 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini303 – 36563Sushi 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini366 – 42863Sushi 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini430 – 49162Sushi 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini492 – 55059Sushi 6PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the selectin/LECAM family.Curated
    Contains 1 C-type lectin domain.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 6 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG242963.
    HOVERGENiHBG052375.
    InParanoidiQ00690.
    KOiK06494.
    PhylomeDBiQ00690.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR002396. Selectin_superfamily.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view]
    PfamiPF00008. EGF. 1 hit.
    PF00059. Lectin_C. 1 hit.
    PF00084. Sushi. 6 hits.
    [Graphical view]
    PRINTSiPR00343. SELECTIN.
    SMARTiSM00032. CCP. 6 hits.
    SM00034. CLECT. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    SSF57535. SSF57535. 6 hits.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50923. SUSHI. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q00690-1 [UniParc]FASTAAdd to Basket

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    MNASRFLSAL VFVLLAGEST AWYYNASSEL MTYDEASAYC QRDYTHLVAI    50
    QNKEEINYLN SNLKHSPSYY WIGIRKVNNV WIWVGTGKPL TEEAQNWAPG 100
    EPNNKQRNED CVEIYIQRTK DSGMWNDERC NKKKLALCYT ASCTNASCSG 150
    HGECIETINS YTCKCHPGFL GPNCEQAVTC KPQEHPDYGS LNCSHPFGPF 200
    SYNSSCSFGC KRGYLPSSME TTVRCTSSGE WSAPAPACHV VECEALTHPA 250
    HGIRKCSSNP GSYPWNTTCT FDCVEGYRRV GAQNLQCTSS GIWDNETPSC 300
    KAVTCDAIPQ PQNGFVSCSH STAGELAFKS SCNFTCEQSF TLQGPAQVEC 350
    SAQGQWTPQI PVCKAVQCEA LSAPQQGNMK CLPSASGPFQ NGSSCEFSCE 400
    EGFELKGSRR LQCGPRGEWD SKKPTCSAVK CDDVPRPQNG VMECAHATTG 450
    EFTYKSSCAF QCNEGFSLHG SAQLECTSQG KWTQEVPSCQ VVQCPSLDVP 500
    GKMNMSCSGT AVFGTVCEFT CPDDWTLNGS AVLTCGATGR WSGMPPTCEA 550
    PVSPTRPLVV ALSAAGTSLL TSSSLLYLLM RYFRKKAKKF VPASSCQSLQ 600
    SFENYHVPSY NV 612
    Length:612
    Mass (Da):66,750
    Last modified:April 1, 1993 - v1
    Checksum:i86F05713F0EC2C3D
    GO

    Sequence cautioni

    The sequence AAA37577.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80778 Genomic DNA. Translation: AAA37547.1.
    M87862 mRNA. Translation: AAA37577.1. Different initiation.
    PIRiS23174. B42755.
    RefSeqiNP_035475.1. NM_011345.2.
    XP_006496778.1. XM_006496715.1.
    UniGeneiMm.5245.

    Genome annotation databases

    GeneIDi20339.
    KEGGimmu:20339.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    E-selectin

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M80778 Genomic DNA. Translation: AAA37547.1 .
    M87862 mRNA. Translation: AAA37577.1 . Different initiation.
    PIRi S23174. B42755.
    RefSeqi NP_035475.1. NM_011345.2.
    XP_006496778.1. XM_006496715.1.
    UniGenei Mm.5245.

    3D structure databases

    ProteinModelPortali Q00690.
    SMRi Q00690. Positions 22-178, 189-561.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59328N.
    STRINGi 10090.ENSMUSP00000027874.

    Chemistry

    BindingDBi Q00690.
    ChEMBLi CHEMBL2545.

    PTM databases

    PhosphoSitei Q00690.

    Proteomic databases

    PaxDbi Q00690.
    PRIDEi Q00690.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 20339.
    KEGGi mmu:20339.

    Organism-specific databases

    CTDi 6401.
    MGIi MGI:98278. Sele.

    Phylogenomic databases

    eggNOGi NOG242963.
    HOVERGENi HBG052375.
    InParanoidi Q00690.
    KOi K06494.
    PhylomeDBi Q00690.

    Enzyme and pathway databases

    Reactomei REACT_225233. Cell surface interactions at the vascular wall.

    Miscellaneous databases

    NextBioi 298157.
    PROi Q00690.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q00690.
    CleanExi MM_SELE.
    Genevestigatori Q00690.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR002396. Selectin_superfamily.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view ]
    Pfami PF00008. EGF. 1 hit.
    PF00059. Lectin_C. 1 hit.
    PF00084. Sushi. 6 hits.
    [Graphical view ]
    PRINTSi PR00343. SELECTIN.
    SMARTi SM00032. CCP. 6 hits.
    SM00034. CLECT. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    SSF57535. SSF57535. 6 hits.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50923. SUSHI. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine endothelial leukocyte-adhesion molecule 1 is a close structural and functional homologue of the human protein."
      Becker-Andre M., van Huijsduijnen R.H., Losberger C., Whelan J., Delamarter J.F.
      Eur. J. Biochem. 206:401-411(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha."
      Weller A., Isenmann S., Vestweber D.
      J. Biol. Chem. 267:15176-15183(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiLYAM2_MOUSE
    AccessioniPrimary (citable) accession number: Q00690
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3