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Q00682 (NSP5_ROTHC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Non-structural protein 5

Short name=NSP5
OrganismRotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C) [Reference proteome]
Taxonomic identifier31567 [NCBI]
Taxonomic lineageVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.

Cofactor

Magnesium for ATPase activity.

Subunit structure

Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.

Subcellular location

Host cytoplasm. Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.

Sequence similarities

Belongs to the rotavirus C NSP5 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Non-structural protein 5
PRO_0000149643

Regions

Compositional bias2 – 8483Ser-rich

Sites

Metal binding861Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
Q00682 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 3C6FA60E17E46C5D

FASTA21223,793
        10         20         30         40         50         60 
MSDFGINLDA ICDNVKKGQT ESRTGSQLSN RSSRRMDFVD DEELSTYFNS KASVTQSDSC 

        70         80         90        100        110        120 
SNDLEIKHSI ITEAVVCDES AHVSADAIQE KDETVPQMDH RIMKWMLDSH DGVSLNGGIN 

       130        140        150        160        170        180 
FTKAKSKLKE TENEITEMKS KTNLLVNASV GINSNVGAFN PINQTIKTEA VSDMFEDEDI 

       190        200        210 
EGCICKNCPY REKYRKLRSK MKNVLIDMIN EM 

« Hide

References

[1]"Cloning of noncultivatable human rotavirus by single primer amplification."
Lambden P.R., Cooke S.J., Caul E.O., Clarke I.N.
J. Virol. 66:1817-1822(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M81488 Genomic RNA. Translation: AAA47354.1.
PIRMNXRB1. A42188.
RefSeqYP_392511.1. NC_007569.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3773138.

Family and domain databases

InterProIPR002512. Rotavirus_A/C_NSP5.
[Graphical view]
PfamPF01525. Rota_NS26. 1 hit.
[Graphical view]
PIRSFPIRSF004006. Rota_NS26. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNSP5_ROTHC
AccessionPrimary (citable) accession number: Q00682
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families