Q00682 (NSP5_ROTHC) Reviewed, UniProtKB/Swiss-Prot
Last modified April 3, 2013. Version 46. History...
Names and origin
|Protein names||Recommended name:|
Non-structural protein 5
|Organism||Rotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C) [Reference proteome]|
|Taxonomic identifier||31567 [NCBI]|
|Taxonomic lineage||Viruses › dsRNA viruses › Reoviridae › Sedoreovirinae › Rotavirus ›|
|Virus host||Homo sapiens (Human) [TaxID: 9606]|
|Sequence length||212 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.
Magnesium for ATPase activity.
Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.
Host cytoplasm. Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.
Belongs to the rotavirus C NSP5 family.
|Cellular component||Host cytoplasm|
|Technical term||Complete proteome|
|Gene Ontology (GO)|
|Biological_process||viral genome replication|
Inferred from electronic annotation. Source: InterPro
|Cellular_component||host cell cytoplasm|
Inferred from electronic annotation. Source: UniProtKB-SubCell
Inferred from electronic annotation. Source: InterProRNA binding
Inferred from electronic annotation. Source: UniProtKB-KWmagnesium ion binding
Inferred from electronic annotation. Source: InterPronucleotide binding
Inferred from electronic annotation. Source: UniProtKB-KW
|Complete GO annotation...|
Sequence annotation (Features)
|M81488 Genomic RNA. Translation: AAA47354.1.|
|PIR||MNXRB1. A42188. |
|RefSeq||YP_392511.1. NC_007569.1. |
3D structure databases
Protocols and materials databases
Genome annotation databases
Family and domain databases
|InterPro||IPR002512. Rotavirus_A/C_NSP5. |
|Pfam||PF01525. Rota_NS26. 1 hit. |
|PIRSF||PIRSF004006. Rota_NS26. 1 hit. |
|Accession||Primary (citable) accession number: Q00682|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families