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Q00682

- NSP5_ROTHC

UniProt

Q00682 - NSP5_ROTHC

Protein

Non-structural protein 5

Gene
N/A
Organism
Rotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.By similarity

    Cofactori

    Magnesium for ATPase activity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi86 – 861MagnesiumSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. magnesium ion binding Source: InterPro
    3. nucleotide binding Source: UniProtKB-KW
    4. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. viral genome replication Source: InterPro

    Keywords - Ligandi

    Magnesium, Metal-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-structural protein 5
    Short name:
    NSP5
    OrganismiRotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
    Taxonomic identifieri31567 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000007664: Genome

    Subcellular locationi

    Host cytoplasm
    Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.By similarity

    GO - Cellular componenti

    1. host cell cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Non-structural protein 5PRO_0000149643Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.By similarity

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 8483Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the rotavirus C NSP5 family.Curated

    Family and domain databases

    InterProiIPR002512. Rotavirus_A/C_NSP5.
    [Graphical view]
    PfamiPF01525. Rota_NS26. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004006. Rota_NS26. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q00682-1 [UniParc]FASTAAdd to Basket

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    MSDFGINLDA ICDNVKKGQT ESRTGSQLSN RSSRRMDFVD DEELSTYFNS    50
    KASVTQSDSC SNDLEIKHSI ITEAVVCDES AHVSADAIQE KDETVPQMDH 100
    RIMKWMLDSH DGVSLNGGIN FTKAKSKLKE TENEITEMKS KTNLLVNASV 150
    GINSNVGAFN PINQTIKTEA VSDMFEDEDI EGCICKNCPY REKYRKLRSK 200
    MKNVLIDMIN EM 212
    Length:212
    Mass (Da):23,793
    Last modified:April 1, 1993 - v1
    Checksum:i3C6FA60E17E46C5D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81488 Genomic RNA. Translation: AAA47354.1.
    PIRiA42188. MNXRB1.
    RefSeqiYP_392511.1. NC_007569.1.

    Genome annotation databases

    GeneIDi3773138.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81488 Genomic RNA. Translation: AAA47354.1 .
    PIRi A42188. MNXRB1.
    RefSeqi YP_392511.1. NC_007569.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3773138.

    Family and domain databases

    InterProi IPR002512. Rotavirus_A/C_NSP5.
    [Graphical view ]
    Pfami PF01525. Rota_NS26. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004006. Rota_NS26. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of noncultivatable human rotavirus by single primer amplification."
      Lambden P.R., Cooke S.J., Caul E.O., Clarke I.N.
      J. Virol. 66:1817-1822(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiNSP5_ROTHC
    AccessioniPrimary (citable) accession number: Q00682
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3