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Q00682

- NSP5_ROTHC

UniProt

Q00682 - NSP5_ROTHC

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Protein

Non-structural protein 5

Gene
N/A
Organism
Rotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in genome replication. Plays a crucial role, together with NSP2, in the formation of virus factories (viroplasms) which are large inclusions in the cytoplasm where core-like replication intermediates are assembled and RNA replication takes place By similarity.

Cofactori

Magnesium for ATPase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi86 – 861Magnesium Reviewed prediction

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. magnesium ion binding Source: InterPro
  3. nucleotide binding Source: UniProtKB-KW
  4. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. viral genome replication Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Magnesium, Metal-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 5
Short name:
NSP5
OrganismiRotavirus C (isolate Human/United Kingdom/Bristol/1989) (RV-C)
Taxonomic identifieri31567 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007664: Genome

Subcellular locationi

Host cytoplasm
Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging By similarity.

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Non-structural protein 5PRO_0000149643Add
BLAST

Interactioni

Subunit structurei

Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2; this interaction leads to formation of virus factories By similarity.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 8483Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the rotavirus C NSP5 family.

Family and domain databases

InterProiIPR002512. Rotavirus_A/C_NSP5.
[Graphical view]
PfamiPF01525. Rota_NS26. 1 hit.
[Graphical view]
PIRSFiPIRSF004006. Rota_NS26. 1 hit.

Sequencei

Sequence statusi: Complete.

Q00682-1 [UniParc]FASTAAdd to Basket

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MSDFGINLDA ICDNVKKGQT ESRTGSQLSN RSSRRMDFVD DEELSTYFNS    50
KASVTQSDSC SNDLEIKHSI ITEAVVCDES AHVSADAIQE KDETVPQMDH 100
RIMKWMLDSH DGVSLNGGIN FTKAKSKLKE TENEITEMKS KTNLLVNASV 150
GINSNVGAFN PINQTIKTEA VSDMFEDEDI EGCICKNCPY REKYRKLRSK 200
MKNVLIDMIN EM 212
Length:212
Mass (Da):23,793
Last modified:April 1, 1993 - v1
Checksum:i3C6FA60E17E46C5D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81488 Genomic RNA. Translation: AAA47354.1.
PIRiA42188. MNXRB1.
RefSeqiYP_392511.1. NC_007569.1.

Genome annotation databases

GeneIDi3773138.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M81488 Genomic RNA. Translation: AAA47354.1 .
PIRi A42188. MNXRB1.
RefSeqi YP_392511.1. NC_007569.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3773138.

Family and domain databases

InterProi IPR002512. Rotavirus_A/C_NSP5.
[Graphical view ]
Pfami PF01525. Rota_NS26. 1 hit.
[Graphical view ]
PIRSFi PIRSF004006. Rota_NS26. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning of noncultivatable human rotavirus by single primer amplification."
    Lambden P.R., Cooke S.J., Caul E.O., Clarke I.N.
    J. Virol. 66:1817-1822(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNSP5_ROTHC
AccessioniPrimary (citable) accession number: Q00682
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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