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Protein

Probable NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial

Gene

ALI1

Organism
Candida maltosa (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Essential for N-alkane assimilation.By similarity1 Publication

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
Probable NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Alkane-inducible protein 1
CI-31kD
Complex I-30kD
Gene namesi
Name:ALI1
OrganismiCandida maltosa (Yeast)
Taxonomic identifieri5479 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000020001? – 276Probable NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Interactioni

Subunit structurei

Complex I is composed of about 30 different subunits. This is a component of the iron-sulfur protein fraction.

Structurei

3D structure databases

ProteinModelPortaliQ00673
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 30 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.30.460.80, 1 hit
HAMAPiMF_01357 NDH1_NuoC, 1 hit
InterProiView protein in InterPro
IPR010218 NADH_DH_suC
IPR037232 NADH_quin_OxRdtase_su_C/D-like
IPR001268 NADH_UbQ_OxRdtase_30kDa_su
IPR020396 NADH_UbQ_OxRdtase_CS
PfamiView protein in Pfam
PF00329 Complex1_30kDa, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001581 NADH_UbQ_OxRdtase_30kDa_su, 1 hit
SUPFAMiSSF143243 SSF143243, 1 hit
TIGRFAMsiTIGR01961 NuoC_fam, 1 hit
PROSITEiView protein in PROSITE
PS00542 COMPLEX1_30K, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISRTLLKRT VPASRLLRSF TTSNVRLSAH EEDLVNVNNL PRPKPTENYV
60 70 80 90 100
PLINPTEKYK VQIEELHKFG TYIMSCLPKY IQQFSVWKDE LTIYVAPSAI
110 120 130 140 150
RPVMSYLKNH TSCQFKAVMD ITAADYPSRT NRFDVVYNLL SDRHNSRIRV
160 170 180 190 200
KTYANETSPV PSVTPLFNGA NWYERETYDL FGVFFVGHPD LRRIMTDYGF
210 220 230 240 250
EGHPLRKDFP TTGYTEVRYD EEKKRVIYEP LELTQAWRNF TVGSSVWEPV
260 270
GEGKDFTPES FKLPTPQPEP EQEEKK
Length:276
Mass (Da):32,158
Last modified:October 1, 1993 - v1
Checksum:i1CA55A6CF1459A72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61102 Genomic DNA Translation: AAA34360.1
PIRiJT0591

Similar proteinsi

Entry informationi

Entry nameiNDUS3_CANMA
AccessioniPrimary (citable) accession number: Q00673
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health