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Q00673

- NDUS3_CANMA

UniProt

Q00673 - NDUS3_CANMA

Protein

Probable NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial

Gene

ALI1

Organism
Candida maltosa (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Essential for N-alkane assimilation.By similarity1 Publication

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    Alkane-inducible protein 1
    CI-31kD
    Complex I-30kD
    Gene namesi
    Name:ALI1
    OrganismiCandida maltosa (Yeast)
    Taxonomic identifieri5479 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 276Probable NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrialPRO_0000020001
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Interactioni

    Subunit structurei

    Complex I is composed of about 30 different subunits. This is a component of the iron-sulfur protein fraction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ00673.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 30 kDa subunit family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    HAMAPiMF_01357. NDH1_NuoC.
    InterProiIPR010218. NADH_DH_suC.
    IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    IPR020396. NADH_UbQ_OxRdtase_CS.
    [Graphical view]
    PfamiPF00329. Complex1_30kDa. 1 hit.
    [Graphical view]
    ProDomiPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    TIGRFAMsiTIGR01961. NuoC_fam. 1 hit.
    PROSITEiPS00542. COMPLEX1_30K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q00673-1 [UniParc]FASTAAdd to Basket

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    MISRTLLKRT VPASRLLRSF TTSNVRLSAH EEDLVNVNNL PRPKPTENYV    50
    PLINPTEKYK VQIEELHKFG TYIMSCLPKY IQQFSVWKDE LTIYVAPSAI 100
    RPVMSYLKNH TSCQFKAVMD ITAADYPSRT NRFDVVYNLL SDRHNSRIRV 150
    KTYANETSPV PSVTPLFNGA NWYERETYDL FGVFFVGHPD LRRIMTDYGF 200
    EGHPLRKDFP TTGYTEVRYD EEKKRVIYEP LELTQAWRNF TVGSSVWEPV 250
    GEGKDFTPES FKLPTPQPEP EQEEKK 276
    Length:276
    Mass (Da):32,158
    Last modified:October 1, 1993 - v1
    Checksum:i1CA55A6CF1459A72
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M61102 Genomic DNA. Translation: AAA34360.1.
    PIRiJT0591.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M61102 Genomic DNA. Translation: AAA34360.1 .
    PIRi JT0591.

    3D structure databases

    ProteinModelPortali Q00673.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    HAMAPi MF_01357. NDH1_NuoC.
    InterProi IPR010218. NADH_DH_suC.
    IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    IPR020396. NADH_UbQ_OxRdtase_CS.
    [Graphical view ]
    Pfami PF00329. Complex1_30kDa. 1 hit.
    [Graphical view ]
    ProDomi PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    TIGRFAMsi TIGR01961. NuoC_fam. 1 hit.
    PROSITEi PS00542. COMPLEX1_30K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences of two tandem genes regulated by carbon sources, one being essential for n-alkane assimilation in Candida maltosa."
      Hwang C.W., Yano K., Takagi M.
      Gene 106:61-69(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
      Strain: ATCC 28140 / CBS 5611 / IAM 12247 / JCM 1504 / NBRC 1977.

    Entry informationi

    Entry nameiNDUS3_CANMA
    AccessioniPrimary (citable) accession number: Q00673
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3