Q00670 (ADH_DROCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase
EC=1.1.1.1

Gene names

Name:

Adh

Organism

Drosophila crassifemur (Fruit fly)

Taxonomic identifier

13053 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Scaptomyza

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	alcohol metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	alcohol dehydrogenase (NAD) activity Inferred from sequence or structural similarity. Source: UniProtKB nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Alcohol dehydrogenase		PRO_0000054457
Regions
	Nucleotide binding	10 – 33	24	NAD By similarity
Sites
	Active site	151	1	Proton acceptor By similarity
	Binding site	138	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q00670 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 9E1C92645246053C	FASTA	254	27,406
	10 20 30 40 50 60 MFIAGKNIIF VAGLGGIGLE TSREIVKSGP KNLVILDRAP NPAAIAELQA LNPKVTVSFY 70 80 90 100 110 120 LYDVTVPQSE TVKLLKTIFA KLKTIDLLIN GAGILDDHQI ERTIAVNFTG TVNTTTAIME 130 140 150 160 170 180 FWDKRKGGPG GVVANICSVT GFNSIYQVPV YSASKAAALS FTSSIAKLAT ITGVTVYSIN 190 200 210 220 230 240 PGITDTTLVH KFNSWLDVEP HVAEKLLAFP TQTSLACAKN FVKAIEANKN GAIWKLDLGR 250 LDEIEWTKHW DSGI

References

[1]	"The molecular evolution of the alcohol dehydrogenase locus and the phylogeny of Hawaiian Drosophila." Thomas R.H., Hunt J.A. Mol. Biol. Evol. 8:687-702(1991) [PubMed: 1766364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M60790 Genomic DNA. Translation: AAA72979.1.
3D structure databases
ProteinModelPortal	Q00670.
SMR	Q00670. Positions 3-254.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0012243. Dcra\Adh.
Family and domain databases
InterPro	IPR002425. ADH_Drosophila-type. IPR002424. ADH_insect. IPR002198. DH_sc/Rdtase_SDR. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR01168. ALCDHDRGNASE. PR01167. INSADHFAMILY. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH_DROCR

Accession

Primary (citable) accession number: Q00670

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project