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Q00667 (HGD_EMENI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:hmgA
ORF Names:AN1897
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]
Taxonomic identifier227321 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate.

Cofactor

Iron.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.

Induction

During growth with phenylacetate and phenylalanine.

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Homogentisate 1,2-dioxygenase
PRO_0000220245

Sites

Metal binding3401Iron By similarity
Metal binding3461Iron By similarity
Metal binding3771Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q00667 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 4AE6414823A04C0D

FASTA44850,168
        10         20         30         40         50         60 
MPVTEFSFKD PYTYQNGFDS YHESEAIEGA LPVGHNSPQK APYGLYAEKL SGTAFTAPRH 

        70         80         90        100        110        120 
ENKQTWVYRI LPAAAHENFV EEDASSYHTL SDAKKLQHIP NQLRWDPFDL DETVDWVHGL 

       130        140        150        160        170        180 
HLVAGSGDPT VKQGLGILLY AAGKDMGKEA FYSADGDFLI VAQHGVLDIQ TELGRLLVRP 

       190        200        210        220        230        240 
NEICVIPRGV RYRVTLPDGP VRGYICELYQ GHYQLPELGP IGSNGLANAR DFQAPVAAFD 

       250        260        270        280        290        300 
DEEGPTEYRL YSKFNNHLFS ARQDHTPFDI VAWHGNYYPY KYDLGRFNTM GSVSFDHPDP 

       310        320        330        340        350        360 
SIYTVLTGPS DHVGTAIADF VIFPPRWLVA EKTFRPPWYH RNTMSEFMGL ITGNYDAKTG 

       370        380        390        400        410        420 
GGFQPAGASL HNIMSAHGPD MHAFEGASNA DLKPTKIGDG SMAFMFESSL MVGVSEWGLK 

       430        440 
TCQKVQEEYN EHSWQPLKRH FKDPRKAQ 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization of a gene encoding a homogentisate dioxygenase from Aspergillus nidulans and identification of its human and plant homologues."
Fernandez-Canon J.M., Penalva M.A.
J. Biol. Chem. 270:21199-21205(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: biA1.
[2]"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae."
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. expand/collapse author list , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.
Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[3]"The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. expand/collapse author list , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U30797 Genomic DNA. Translation: AAC49071.1.
AJ001836 Genomic DNA. Translation: CAA05042.1.
AACD01000029 Genomic DNA. Translation: EAA65062.1.
BN001307 Genomic DNA. Translation: CBF85779.1.
PIRA57435.
RefSeqXP_659501.1. XM_654409.1.

3D structure databases

ProteinModelPortalQ00667.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING162425.CADANIAP00008553.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANIAT00008553; CADANIAP00008553; CADANIAG00008553.
GeneID2874820.
KEGGani:AN1897.2.

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHOG000139824.
KOK00451.
OMACWEPLKS.
OrthoDBEOG72NS04.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-12040.
UniPathwayUPA00139; UER00339.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
InterProIPR005708. Homogentis_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_EMENI
AccessionPrimary (citable) accession number: Q00667
Secondary accession number(s): C8VKJ8, Q5BC33
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 22, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways