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Protein

Heat shock protein beta-1

Gene

HSPB1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Markedly reduces low-shear viscosity of F-actin and suppresses the rate of polymerization in vitro. May behave as a barbed-end capping protein devoid of nucleating activity.

GO - Molecular functioni

  • identical protein binding Source: AgBase
  • protein kinase C binding Source: AgBase
  • protein kinase C inhibitor activity Source: AgBase

GO - Biological processi

  • barbed-end actin filament capping Source: AgBase
  • negative regulation of actin filament polymerization Source: AgBase
  • negative regulation of apoptotic signaling pathway Source: AgBase
  • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: AgBase
  • negative regulation of protein kinase activity Source: AgBase
  • negative regulation of protein serine/threonine kinase activity Source: AgBase
  • positive regulation of interleukin-1 beta production Source: AgBase
  • positive regulation of tumor necrosis factor biosynthetic process Source: AgBase
  • regulation of I-kappaB kinase/NF-kappaB signaling Source: AgBase
  • response to heat Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Actin capping, Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-1
Short name:
HspB1
Alternative name(s):
25 kDa IAP
Actin polymerization inhibitor
Heat shock 25 kDa protein
Short name:
HSP 25
Heat shock 27 kDa protein
Short name:
HSP 27
Gene namesi
Name:HSPB1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • contractile fiber Source: AgBase
  • cytoplasm Source: AgBase
  • intracellular Source: AgBase
  • mitochondrion Source: AgBase
  • nucleus Source: AgBase
  • plasma membrane Source: AgBase
  • Z disc Source: AgBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259311 – 193Heat shock protein beta-1Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineBy similarity1
Modified residuei80PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ00649.

PTM databases

iPTMnetiQ00649.

Expressioni

Tissue specificityi

Smooth, cardiac and skeletal muscle, hardly detectable in fibroblasts or focal contacts.

Interactioni

Subunit structurei

Associates with CRYAB.By similarity

GO - Molecular functioni

  • identical protein binding Source: AgBase
  • protein kinase C binding Source: AgBase

Protein-protein interaction databases

BioGridi676487. 1 interactor.
IntActiQ00649. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ00649.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233955.
HOVERGENiHBG054766.
InParanoidiQ00649.
KOiK04455.
PhylomeDBiQ00649.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERRVPFTF LTSPSWEPFR DWYHGSRLFD QSFGMPHIPE DWYKWPSGSA
60 70 80 90 100
WPGYFRLLPS ESALLPAPGS PYGRALSELS SGISEIRQSA DSWKVTLDVN
110 120 130 140 150
HFAPEELVVK TKDNIVEITG KHEEKQDEHG FISRCFTRKY TLPPGVEATA
160 170 180 190
VRSSLSPDGM LTVEAPLPKP AIQSSEITIP VTVEAKKEEP AKK
Length:193
Mass (Da):21,672
Last modified:April 1, 1993 - v1
Checksum:i57C33F9454DA7B0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59541 mRNA. Translation: CAA42114.1.
PIRiA39644.
RefSeqiNP_990621.1. NM_205290.1.
UniGeneiGga.1809.

Genome annotation databases

GeneIDi396227.
KEGGigga:396227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59541 mRNA. Translation: CAA42114.1.
PIRiA39644.
RefSeqiNP_990621.1. NM_205290.1.
UniGeneiGga.1809.

3D structure databases

ProteinModelPortaliQ00649.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676487. 1 interactor.
IntActiQ00649. 1 interactor.

PTM databases

iPTMnetiQ00649.

Proteomic databases

PRIDEiQ00649.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396227.
KEGGigga:396227.

Organism-specific databases

CTDi3315.

Phylogenomic databases

HOGENOMiHOG000233955.
HOVERGENiHBG054766.
InParanoidiQ00649.
KOiK04455.
PhylomeDBiQ00649.

Miscellaneous databases

PROiQ00649.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB1_CHICK
AccessioniPrimary (citable) accession number: Q00649
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 5, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.