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Q00646

- CDK1_EMENI

UniProt

Q00646 - CDK1_EMENI

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Protein

Cyclin-dependent kinase 1

Gene

nimX

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-180 activates it.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341ATPPROSITE-ProRule annotation
Active sitei147 – 1471Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: ASPGD
  3. protein kinase activity Source: ASPGD
  4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular response to light stimulus Source: ASPGD
  2. conidium formation Source: ASPGD
  3. Hulle cell development Source: ASPGD
  4. mitotic nuclear division Source: UniProtKB-KW
  5. negative regulation of Hulle cell development Source: ASPGD
  6. negative regulation of sexual sporulation resulting in formation of a cellular spore Source: ASPGD
  7. positive regulation of mitotic cell cycle Source: ASPGD
  8. positive regulation of sterigmatocystin biosynthetic process Source: ASPGD
  9. protein phosphorylation Source: ASPGD
  10. regulation of conidium formation Source: ASPGD
  11. sexual sporulation resulting in formation of a cellular spore Source: ASPGD
  12. sporocarp development involved in sexual reproduction Source: ASPGD
  13. sterigmatocystin biosynthetic process Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 2065.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 1 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDK1
Alternative name(s):
Cell division control protein 2
Cell division protein kinase 1
Never in mitosis protein X
Gene namesi
Name:nimX
Synonyms:cdk1
ORF Names:AN4182
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome II

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: ASPGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Cyclin-dependent kinase 1PRO_0000085719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphothreonineBy similarity
Modified residuei15 – 151PhosphotyrosineBy similarity
Modified residuei180 – 1801Phosphothreonine; by CAKBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ00646.

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit (SUC1) and with a cyclin.

Protein-protein interaction databases

MINTiMINT-242233.

Structurei

3D structure databases

ProteinModelPortaliQ00646.
SMRiQ00646. Positions 1-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 306303Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ00646.
KOiK04563.
OMAiLVHRFFR.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00646-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENYQKIEKI GEGTYGVVYK ARELTHPNRI VALKKIRLEA EDEGVPSTAI
60 70 80 90 100
REISLLKEMN DPNIVRLLNI VHADGHKLYL VFEFLDLDLK KYMEALPVSE
110 120 130 140 150
GGRGRALPDG STLSRNLGLG DAMVKKFMAQ LIEGIRFCHS HRVLHRDLKP
160 170 180 190 200
QNLLIDRDGN LKLADFGLAR AFGVPLRTYT HEVVTLWYRS PEILLGGRQY
210 220 230 240 250
STGVDMWSCG AIFAEMCTRK PLFPGDSEID EIFKIFRILG TPDETIWPGV
260 270 280 290 300
TSFPDFKPTF PKWKREDIQN VVPGLEEDGL DLLEALLEYD PARRISAKQA
310 320
CMHPYFQHGS SYYSGRARRN GFH
Length:323
Mass (Da):36,779
Last modified:November 1, 1996 - v1
Checksum:i3178CAFBDDC32224
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07169 mRNA. Translation: AAA20597.1.
AACD01000068 Genomic DNA. Translation: EAA59281.1.
BN001302 Genomic DNA. Translation: CBF74540.1.
RefSeqiXP_661786.1. XM_656694.1.

Genome annotation databases

EnsemblFungiiCADANIAT00004488; CADANIAP00004488; CADANIAG00004488.
GeneIDi2873604.
KEGGiani:AN4182.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07169 mRNA. Translation: AAA20597.1 .
AACD01000068 Genomic DNA. Translation: EAA59281.1 .
BN001302 Genomic DNA. Translation: CBF74540.1 .
RefSeqi XP_661786.1. XM_656694.1.

3D structure databases

ProteinModelPortali Q00646.
SMRi Q00646. Positions 1-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-242233.

Proteomic databases

PRIDEi Q00646.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00004488 ; CADANIAP00004488 ; CADANIAG00004488 .
GeneIDi 2873604.
KEGGi ani:AN4182.2.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi Q00646.
KOi K04563.
OMAi LVHRFFR.
OrthoDBi EOG7K3TWD.

Enzyme and pathway databases

BRENDAi 2.7.11.22. 2065.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A single p34cdc2 protein kinase (encoded by nimXcdc2) is required at G1 and G2 in Aspergillus nidulans."
    Osmani A.H., van Peij N., Mischke M., O'Connell M.J., Osmani S.A.
    J. Cell Sci. 107:1519-1528(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mycelium.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiCDK1_EMENI
AccessioniPrimary (citable) accession number: Q00646
Secondary accession number(s): C8V4M9, Q5B5J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3