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Q00646

- CDK1_EMENI

UniProt

Q00646 - CDK1_EMENI

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Protein
Cyclin-dependent kinase 1
Gene
nimX, cdk1, AN4182
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-180 activates it By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341ATP By similarity
Active sitei147 – 1471Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: ASPGD
  4. protein kinase activity Source: ASPGD

GO - Biological processi

  1. Hulle cell development Source: ASPGD
  2. cellular response to light stimulus Source: ASPGD
  3. conidium formation Source: ASPGD
  4. mitotic nuclear division Source: UniProtKB-KW
  5. negative regulation of Hulle cell development Source: ASPGD
  6. negative regulation of sexual sporulation resulting in formation of a cellular spore Source: ASPGD
  7. positive regulation of mitotic cell cycle Source: ASPGD
  8. positive regulation of sterigmatocystin biosynthetic process Source: ASPGD
  9. protein phosphorylation Source: ASPGD
  10. regulation of conidium formation Source: ASPGD
  11. sexual sporulation resulting in formation of a cellular spore Source: ASPGD
  12. sporocarp development involved in sexual reproduction Source: ASPGD
  13. sterigmatocystin biosynthetic process Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 2065.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 1 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDK1
Alternative name(s):
Cell division control protein 2
Cell division protein kinase 1
Never in mitosis protein X
Gene namesi
Name:nimX
Synonyms:cdk1
ORF Names:AN4182
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome II

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: ASPGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Cyclin-dependent kinase 1
PRO_0000085719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphothreonine By similarity
Modified residuei15 – 151Phosphotyrosine By similarity
Modified residuei180 – 1801Phosphothreonine; by CAK By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ00646.

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit (SUC1) and with a cyclin.

Protein-protein interaction databases

MINTiMINT-242233.

Structurei

3D structure databases

ProteinModelPortaliQ00646.
SMRiQ00646. Positions 1-307.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 306303Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
KOiK04563.
OMAiLVHRFFR.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00646-1 [UniParc]FASTAAdd to Basket

« Hide

MENYQKIEKI GEGTYGVVYK ARELTHPNRI VALKKIRLEA EDEGVPSTAI    50
REISLLKEMN DPNIVRLLNI VHADGHKLYL VFEFLDLDLK KYMEALPVSE 100
GGRGRALPDG STLSRNLGLG DAMVKKFMAQ LIEGIRFCHS HRVLHRDLKP 150
QNLLIDRDGN LKLADFGLAR AFGVPLRTYT HEVVTLWYRS PEILLGGRQY 200
STGVDMWSCG AIFAEMCTRK PLFPGDSEID EIFKIFRILG TPDETIWPGV 250
TSFPDFKPTF PKWKREDIQN VVPGLEEDGL DLLEALLEYD PARRISAKQA 300
CMHPYFQHGS SYYSGRARRN GFH 323
Length:323
Mass (Da):36,779
Last modified:November 1, 1996 - v1
Checksum:i3178CAFBDDC32224
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07169 mRNA. Translation: AAA20597.1.
AACD01000068 Genomic DNA. Translation: EAA59281.1.
BN001302 Genomic DNA. Translation: CBF74540.1.
RefSeqiXP_661786.1. XM_656694.1.

Genome annotation databases

EnsemblFungiiCADANIAT00004488; CADANIAP00004488; CADANIAG00004488.
GeneIDi2873604.
KEGGiani:AN4182.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07169 mRNA. Translation: AAA20597.1 .
AACD01000068 Genomic DNA. Translation: EAA59281.1 .
BN001302 Genomic DNA. Translation: CBF74540.1 .
RefSeqi XP_661786.1. XM_656694.1.

3D structure databases

ProteinModelPortali Q00646.
SMRi Q00646. Positions 1-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-242233.

Proteomic databases

PRIDEi Q00646.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00004488 ; CADANIAP00004488 ; CADANIAG00004488 .
GeneIDi 2873604.
KEGGi ani:AN4182.2.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
KOi K04563.
OMAi LVHRFFR.
OrthoDBi EOG7K3TWD.

Enzyme and pathway databases

BRENDAi 2.7.11.22. 2065.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A single p34cdc2 protein kinase (encoded by nimXcdc2) is required at G1 and G2 in Aspergillus nidulans."
    Osmani A.H., van Peij N., Mischke M., O'Connell M.J., Osmani S.A.
    J. Cell Sci. 107:1519-1528(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mycelium.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiCDK1_EMENI
AccessioniPrimary (citable) accession number: Q00646
Secondary accession number(s): C8V4M9, Q5B5J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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