Reviewed,
UniProtKB/Swiss-Prot Q00646 (CDC2_EMENI)
Last modified
January 19, 2010.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cell division control protein 2 EC=2.7.11.22 EC=2.7.11.23 Alternative name(s): Cyclin-dependent protein kinase | ||||
| Gene names |
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| Organism | Emericella nidulans (Aspergillus nidulans) [Complete proteome] | ||||
| Taxonomic identifier | 162425 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella |
Protein attributes
| Sequence length | 323 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis By similarity. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. |
| Enzyme regulation | Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-180 activates it By similarity. |
| Subunit structure | Forms a stable but non-covalent complex with a regulatory subunit (SUC1) and with a cyclin. |
| Sequence similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle Cell division Mitosis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosisInferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylationInferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II carboxy-terminal domain kinase activityInferred from electronic annotation. Source: EC cyclin-dependent protein kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 323 | 323 | Cell division control protein 2 | PRO_0000085719 | |||||
Regions | |||||||||
| Domain | 4 – 306 | 303 | Protein kinase | ||||||
| Nucleotide binding | 10 – 18 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 147 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 34 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 14 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 15 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 180 | 1 | Phosphothreonine; by CAK By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A single p34cdc2 protein kinase (encoded by nimXcdc2) is required at G1 and G2 in Aspergillus nidulans." Osmani A.H., van Peij N., Mischke M., O'Connell M.J., Osmani S.A. J. Cell Sci. 107:1519-1528(1994) [PubMed: 7962194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mycelium. |
| [2] | "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. Birren B.W.Nature 438:1105-1115(2005) [PubMed: 16372000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC A4 / M139. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U07169 mRNA. Translation: AAA20597.1. AACD01000068 Genomic DNA. Translation: EAA59281.1. |
| RefSeq | XP_661786.1. |
3D structure databases | |
| SMR | Q00646. Positions 1-307. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2873604. |
| KEGG | ani:AN4182.2. |
Phylogenomic databases | |
| PhylomeDB | Q00646. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.22. 3859. 2.7.11.23. 3859. |
Family and domain databases | |
| InterPro | IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CDC2_EMENI | ||||||||
| Accession | Primary (citable) accession number: Q00646 Secondary accession number(s): Q5B5J8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||

Clusters with


