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Protein

Cyclin-dependent kinase 1

Gene

nimX

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-180 activates it.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34ATPPROSITE-ProRule annotation1
Active sitei147Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cyclin-dependent protein serine/threonine kinase activity Source: AspGD

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 517

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 1 (EC:2.7.11.22)
Short name:
CDK1
Alternative name(s):
Cell division control protein 2
Cell division protein kinase 1
Never in mitosis protein X
Gene namesi
Name:nimX
Synonyms:cdk1
ORF Names:AN4182
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome II
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857191 – 323Cyclin-dependent kinase 1Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15PhosphotyrosineBy similarity1
Modified residuei180Phosphothreonine; by CAKBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ00646

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit (SUC1) and with a cyclin.

Protein-protein interaction databases

IntActiQ00646, 1 interactor
MINTiQ00646
STRINGi162425.CADANIAP00004488

Structurei

3D structure databases

ProteinModelPortaliQ00646
SMRiQ00646
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 306Protein kinasePROSITE-ProRule annotationAdd BLAST303

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233024
InParanoidiQ00646
KOiK04563
OMAiEMMLVYD
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q00646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENYQKIEKI GEGTYGVVYK ARELTHPNRI VALKKIRLEA EDEGVPSTAI
60 70 80 90 100
REISLLKEMN DPNIVRLLNI VHADGHKLYL VFEFLDLDLK KYMEALPVSE
110 120 130 140 150
GGRGRALPDG STLSRNLGLG DAMVKKFMAQ LIEGIRFCHS HRVLHRDLKP
160 170 180 190 200
QNLLIDRDGN LKLADFGLAR AFGVPLRTYT HEVVTLWYRS PEILLGGRQY
210 220 230 240 250
STGVDMWSCG AIFAEMCTRK PLFPGDSEID EIFKIFRILG TPDETIWPGV
260 270 280 290 300
TSFPDFKPTF PKWKREDIQN VVPGLEEDGL DLLEALLEYD PARRISAKQA
310 320
CMHPYFQHGS SYYSGRARRN GFH
Length:323
Mass (Da):36,779
Last modified:November 1, 1996 - v1
Checksum:i3178CAFBDDC32224
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07169 mRNA Translation: AAA20597.1
AACD01000068 Genomic DNA Translation: EAA59281.1
BN001302 Genomic DNA Translation: CBF74540.1
RefSeqiXP_661786.1, XM_656694.1

Genome annotation databases

EnsemblFungiiCADANIAT00004488; CADANIAP00004488; CADANIAG00004488
EAA59281; EAA59281; AN4182.2
GeneIDi2873604
KEGGiani:AN4182.2

Similar proteinsi

Entry informationi

Entry nameiCDK1_EMENI
AccessioniPrimary (citable) accession number: Q00646
Secondary accession number(s): C8V4M9, Q5B5J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health