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Protein

Superoxide dismutase [Mn], mitochondrial

Gene

Sod2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi43ManganeseBy similarity1
Metal bindingi91ManganeseBy similarity1
Metal bindingi175ManganeseBy similarity1
Metal bindingi179ManganeseBy similarity1

GO - Molecular functioni

  • antioxidant activity Source: FlyBase
  • metal ion binding Source: UniProtKB-KW
  • superoxide dismutase activity Source: FlyBase

GO - Biological processi

  • determination of adult lifespan Source: FlyBase
  • heart morphogenesis Source: FlyBase
  • paracrine signaling Source: FlyBase
  • reactive oxygen species metabolic process Source: FlyBase
  • regulation of autophagy of mitochondrion Source: FlyBase
  • regulation of hemocyte proliferation Source: FlyBase
  • regulation of metabolic process Source: FlyBase
  • removal of superoxide radicals Source: FlyBase

Keywordsi

Molecular functionOxidoreductase
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn], mitochondrial (EC:1.15.1.1)
Gene namesi
Name:Sod2
ORF Names:CG8905
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010213 Sod2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Protein family/group databases

Allergomei868 Dro m MnSOD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 17MitochondrionBy similarityAdd BLAST17
ChainiPRO_000003287918 – 217Superoxide dismutase [Mn], mitochondrialAdd BLAST200

Proteomic databases

PaxDbiQ00637
PRIDEiQ00637

Expressioni

Gene expression databases

BgeeiFBgn0010213
ExpressionAtlasiQ00637 baseline and differential
GenevisibleiQ00637 DM

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi62587, 16 interactors
STRINGi7227.FBpp0086226

Structurei

3D structure databases

ProteinModelPortaliQ00637
SMRiQ00637
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0876 Eukaryota
COG0605 LUCA
InParanoidiQ00637
KOiK04564
OrthoDBiEOG091G0MVL
PhylomeDBiQ00637

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00637-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVARKISPN CKPGVRGKHT LPKLPYDYAA LEPIICREIM ELHHQKHHQT
60 70 80 90 100
YVNNLNAAEE QLEEAKSKSD TTKLIQLAPA LRFNGGGHIN HTIFWQNLSP
110 120 130 140 150
NKTQPSDDLK KAIESQWKSL EEFKKELTTL TVAVQGSGWG WLGFNKKSGK
160 170 180 190 200
LQLAALPNQD PLEASTGLIP LFGIDVWEHA YYLQYKNVRP SYVEAIWDIA
210
NWDDISCRFQ EAKKLGC
Length:217
Mass (Da):24,684
Last modified:November 1, 1995 - v3
Checksum:i05900339EA92432B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9 – 14PNCKPG → QTASLA (Ref. 2) Curated6
Sequence conflicti9 – 14PNCKPG → QTASLA (PubMed:10731132).Curated6
Sequence conflicti127L → V in CAA45418 (PubMed:1556751).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L18947 mRNA Translation: AAA20533.1
L34276 Genomic DNA Translation: AAA28694.1
AE013599 Genomic DNA Translation: AAF57955.1
BT004505 mRNA Translation: AAO42669.1
X64062 mRNA Translation: CAA45418.1
PIRiS23657
RefSeqiNP_001286503.1, NM_001299574.1
NP_476925.1, NM_057577.4
UniGeneiDm.4800

Genome annotation databases

GeneIDi36878
KEGGidme:Dmel_CG8905

Similar proteinsi

Entry informationi

Entry nameiSODM_DROME
AccessioniPrimary (citable) accession number: Q00637
Secondary accession number(s): Q9V7T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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