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Protein

Apolipoprotein A-I

Gene

Apoa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

GO - Molecular functioni

  1. apolipoprotein A-I receptor binding Source: MGI
  2. apolipoprotein receptor binding Source: MGI
  3. beta-amyloid binding Source: MGI
  4. chemorepellent activity Source: MGI
  5. cholesterol binding Source: MGI
  6. cholesterol transporter activity Source: MGI
  7. enzyme binding Source: MGI
  8. high-density lipoprotein particle binding Source: MGI
  9. high-density lipoprotein particle receptor binding Source: MGI
  10. identical protein binding Source: MGI
  11. lipase inhibitor activity Source: Ensembl
  12. lipid binding Source: MGI
  13. lipid transporter activity Source: MGI
  14. lipoprotein particle binding Source: MGI
  15. phosphatidylcholine binding Source: GO_Central
  16. phosphatidylcholine-sterol O-acyltransferase activator activity Source: MGI
  17. phospholipid binding Source: MGI
  18. phospholipid transporter activity Source: Ensembl

GO - Biological processi

  1. adrenal gland development Source: MGI
  2. blood vessel endothelial cell migration Source: MGI
  3. cholesterol biosynthetic process Source: MGI
  4. cholesterol efflux Source: MGI
  5. cholesterol homeostasis Source: MGI
  6. cholesterol import Source: MGI
  7. cholesterol metabolic process Source: MGI
  8. cholesterol transport Source: MGI
  9. endothelial cell proliferation Source: MGI
  10. glucocorticoid metabolic process Source: MGI
  11. G-protein coupled receptor signaling pathway Source: MGI
  12. high-density lipoprotein particle assembly Source: MGI
  13. integrin-mediated signaling pathway Source: MGI
  14. lipid storage Source: MGI
  15. lipoprotein biosynthetic process Source: MGI
  16. negative chemotaxis Source: MGI
  17. negative regulation of cell adhesion molecule production Source: MGI
  18. negative regulation of cytokine secretion involved in immune response Source: MGI
  19. negative regulation of heterotypic cell-cell adhesion Source: MGI
  20. negative regulation of hydrolase activity Source: MGI
  21. negative regulation of inflammatory response Source: MGI
  22. negative regulation of interleukin-1 beta secretion Source: MGI
  23. negative regulation of lipase activity Source: Ensembl
  24. negative regulation of response to cytokine stimulus Source: MGI
  25. negative regulation of tumor necrosis factor-mediated signaling pathway Source: MGI
  26. negative regulation of very-low-density lipoprotein particle remodeling Source: MGI
  27. organ regeneration Source: Ensembl
  28. peptidyl-methionine modification Source: UniProtKB
  29. phosphatidylcholine biosynthetic process Source: MGI
  30. phosphatidylcholine metabolic process Source: GO_Central
  31. phospholipid efflux Source: MGI
  32. phospholipid homeostasis Source: MGI
  33. phospholipid metabolic process Source: MGI
  34. positive regulation of cholesterol esterification Source: MGI
  35. positive regulation of fatty acid biosynthetic process Source: GO_Central
  36. positive regulation of hydrolase activity Source: MGI
  37. positive regulation of lipoprotein lipase activity Source: GO_Central
  38. positive regulation of Rho protein signal transduction Source: MGI
  39. positive regulation of stress fiber assembly Source: MGI
  40. positive regulation of substrate adhesion-dependent cell spreading Source: MGI
  41. positive regulation of transferase activity Source: MGI
  42. positive regulation of triglyceride catabolic process Source: GO_Central
  43. protein oxidation Source: UniProtKB
  44. protein stabilization Source: MGI
  45. regulation of Cdc42 protein signal transduction Source: MGI
  46. regulation of intestinal cholesterol absorption Source: MGI
  47. regulation of protein phosphorylation Source: MGI
  48. response to drug Source: Ensembl
  49. response to estrogen Source: Ensembl
  50. response to nutrient Source: Ensembl
  51. reverse cholesterol transport Source: MGI
  52. triglyceride homeostasis Source: MGI
  53. very-low-density lipoprotein particle remodeling Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

ReactomeiREACT_272139. PPARA activates gene expression.
REACT_282527. Scavenging by Class B Receptors.
REACT_295031. Retinoid metabolism and transport.
REACT_303694. Scavenging of heme from plasma.
REACT_307071. Platelet degranulation.
REACT_314625. Chylomicron-mediated lipid transport.
REACT_326379. HDL-mediated lipid transport.
REACT_342573. Amyloids.
REACT_346149. ABCA transporters in lipid homeostasis.
REACT_346699. Scavenging by Class A Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein A-I
Short name:
Apo-AI
Short name:
ApoA-I
Alternative name(s):
Apolipoprotein A1
Cleaved into the following 2 chains:
Gene namesi
Name:Apoa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88049. Apoa1.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: MGI
  2. cell surface Source: Ensembl
  3. chylomicron Source: GO_Central
  4. cytoplasmic vesicle Source: MGI
  5. cytosol Source: Reactome
  6. discoidal high-density lipoprotein particle Source: Ensembl
  7. endocytic vesicle Source: MGI
  8. extracellular region Source: MGI
  9. extracellular space Source: MGI
  10. extracellular vesicular exosome Source: MGI
  11. high-density lipoprotein particle Source: MGI
  12. nucleus Source: Ensembl
  13. spherical high-density lipoprotein particle Source: MGI
  14. very-low-density lipoprotein particle Source: MGI
  15. vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 264246Proapolipoprotein A-IPRO_0000425326Add
BLAST
Chaini25 – 264240Apolipoprotein A-IPRO_0000001946Add
BLAST
Chaini25 – 263239Truncated apolipoprotein A-IBy similarityPRO_0000416576Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091Methionine sulfoxideBy similarity
Modified residuei193 – 1931Methionine sulfoxide1 Publication
Modified residuei240 – 2401Methionine sulfoxide1 Publication
Modified residuei242 – 2421Methionine sulfoxide1 Publication

Post-translational modificationi

Glycosylated.By similarity
Palmitoylated.By similarity
May be acylated.
Phosphorylation sites are present in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Oxidation, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ00623.
PaxDbiQ00623.
PRIDEiQ00623.

2D gel databases

REPRODUCTION-2DPAGEIPI00121209.
Q00623.
SWISS-2DPAGEQ00623.

PTM databases

PhosphoSiteiQ00623.

Expressioni

Tissue specificityi

Major protein of plasma HDL, also found in chylomicrons.

Gene expression databases

CleanExiMM_APOA1.
GenevestigatoriQ00623.

Interactioni

Subunit structurei

Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnma1Q084604EBI-1634106,EBI-1633915

Protein-protein interaction databases

IntActiQ00623. 5 interactions.
MINTiMINT-1855786.
STRINGi10090.ENSMUSP00000034588.

Structurei

Secondary structure

1
264
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi30 – 7142Combined sources
Turni72 – 754Combined sources
Helixi83 – 11937Combined sources
Turni120 – 1234Combined sources
Helixi126 – 14116Combined sources
Helixi145 – 15410Combined sources
Helixi167 – 20640Combined sources
Beta strandi217 – 2193Combined sources
Helixi220 – 2267Combined sources
Helixi233 – 2375Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LEMNMR-A25-240[»]
ProteinModelPortaliQ00623.
SMRiQ00623. Positions 25-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati67 – 88221Add
BLAST
Repeati89 – 110222Add
BLAST
Repeati111 – 121113; half-lengthAdd
BLAST
Repeati122 – 143224Add
BLAST
Repeati144 – 165225Add
BLAST
Repeati166 – 187226Add
BLAST
Repeati188 – 207207; truncatedAdd
BLAST
Repeati208 – 229228Add
BLAST
Repeati230 – 240119; half-lengthAdd
BLAST
Repeati241 – 2642410Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 26419810 X approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG39720.
GeneTreeiENSGT00530000063081.
HOGENOMiHOG000033998.
HOVERGENiHBG105708.
InParanoidiQ00623.
KOiK08757.
OMAiYRQKVAP.
OrthoDBiEOG7TBC3N.
TreeFamiTF334458.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00623-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVVLAVAL VFLTGSQAWH VWQQDEPQSQ WDKVKDFANV YVDAVKDSGR
60 70 80 90 100
DYVSQFESSS LGQQLNLNLL ENWDTLGSTV SQLQERLGPL TRDFWDNLEK
110 120 130 140 150
ETDWVRQEMN KDLEEVKQKV QPYLDEFQKK WKEDVELYRQ KVAPLGAELQ
160 170 180 190 200
ESARQKLQEL QGRLSPVAEE FRDRMRTHVD SLRTQLAPHS EQMRESLAQR
210 220 230 240 250
LAELKSNPTL NEYHTRAKTH LKTLGEKARP ALEDLRHSLM PMLETLKTQV
260
QSVIDKASET LTAQ
Length:264
Mass (Da):30,616
Last modified:October 2, 2012 - v2
Checksum:i5E33FF201963583B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431A → G in AAB58424 (Ref. 3) Curated
Sequence conflicti143 – 1431A → G in AAB58425 (Ref. 3) Curated
Sequence conflicti143 – 1431A → G in AAB58426 (Ref. 3) Curated
Sequence conflicti143 – 1431A → G in AAB58427 (Ref. 3) Curated
Sequence conflicti146 – 1461Missing in AAB58424 (Ref. 3) Curated
Sequence conflicti146 – 1461Missing in AAB58425 (Ref. 3) Curated
Sequence conflicti146 – 1461Missing in AAB58426 (Ref. 3) Curated
Sequence conflicti146 – 1461Missing in AAB58427 (Ref. 3) Curated

Mass spectrometryi

Molecular mass is 27951.3±1.343 Da from positions 25 - 264. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication
Molecular mass is 27923.8 Da from positions 25 - 264. Determined by ESI. Strain BALB/c. Without methionine sulfoxide.1 Publication
Molecular mass is 27965 Da from positions 25 - 264. Determined by ESI. Strain C57BL/6. With 1 methionine sulfoxide.1 Publication
Molecular mass is 28819.7 Da from positions 19 - 264. Determined by ESI. Strain C57BL/6. Without methionine sulfoxide.1 Publication
Molecular mass is 28790.7 Da from positions 19 - 264. Determined by ESI. Strain BALB/c. Without methionine sulfoxide.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti249 – 2502QV → KA in strain: BALB/c, C3H and ICR.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64262 mRNA. Translation: CAA45560.1.
X64263 Genomic DNA. Translation: CAA45561.1.
L04149 Genomic DNA. No translation available.
L04151 mRNA. No translation available.
U79572 Genomic DNA. Translation: AAB58424.1.
U79574 Genomic DNA. Translation: AAB58426.1.
U79573 Genomic DNA. Translation: AAB58425.1.
U79575 Genomic DNA. Translation: AAB58427.1.
AK076187 mRNA. Translation: BAC36241.1.
AK149576 mRNA. Translation: BAE28968.1.
AK161536 mRNA. Translation: BAE36448.1.
AC116503 Genomic DNA. No translation available.
BC012253 mRNA. Translation: AAH12253.1.
BC019837 mRNA. Translation: AAH19837.1.
CCDSiCCDS40610.1.
PIRiS22420.
RefSeqiNP_033822.2. NM_009692.4.
UniGeneiMm.26743.

Genome annotation databases

EnsembliENSMUST00000034588; ENSMUSP00000034588; ENSMUSG00000032083.
GeneIDi11806.
KEGGimmu:11806.
UCSCiuc009phb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64262 mRNA. Translation: CAA45560.1.
X64263 Genomic DNA. Translation: CAA45561.1.
L04149 Genomic DNA. No translation available.
L04151 mRNA. No translation available.
U79572 Genomic DNA. Translation: AAB58424.1.
U79574 Genomic DNA. Translation: AAB58426.1.
U79573 Genomic DNA. Translation: AAB58425.1.
U79575 Genomic DNA. Translation: AAB58427.1.
AK076187 mRNA. Translation: BAC36241.1.
AK149576 mRNA. Translation: BAE28968.1.
AK161536 mRNA. Translation: BAE36448.1.
AC116503 Genomic DNA. No translation available.
BC012253 mRNA. Translation: AAH12253.1.
BC019837 mRNA. Translation: AAH19837.1.
CCDSiCCDS40610.1.
PIRiS22420.
RefSeqiNP_033822.2. NM_009692.4.
UniGeneiMm.26743.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LEMNMR-A25-240[»]
ProteinModelPortaliQ00623.
SMRiQ00623. Positions 25-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ00623. 5 interactions.
MINTiMINT-1855786.
STRINGi10090.ENSMUSP00000034588.

PTM databases

PhosphoSiteiQ00623.

2D gel databases

REPRODUCTION-2DPAGEIPI00121209.
Q00623.
SWISS-2DPAGEQ00623.

Proteomic databases

MaxQBiQ00623.
PaxDbiQ00623.
PRIDEiQ00623.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034588; ENSMUSP00000034588; ENSMUSG00000032083.
GeneIDi11806.
KEGGimmu:11806.
UCSCiuc009phb.2. mouse.

Organism-specific databases

CTDi335.
MGIiMGI:88049. Apoa1.

Phylogenomic databases

eggNOGiNOG39720.
GeneTreeiENSGT00530000063081.
HOGENOMiHOG000033998.
HOVERGENiHBG105708.
InParanoidiQ00623.
KOiK08757.
OMAiYRQKVAP.
OrthoDBiEOG7TBC3N.
TreeFamiTF334458.

Enzyme and pathway databases

ReactomeiREACT_272139. PPARA activates gene expression.
REACT_282527. Scavenging by Class B Receptors.
REACT_295031. Retinoid metabolism and transport.
REACT_303694. Scavenging of heme from plasma.
REACT_307071. Platelet degranulation.
REACT_314625. Chylomicron-mediated lipid transport.
REACT_326379. HDL-mediated lipid transport.
REACT_342573. Amyloids.
REACT_346149. ABCA transporters in lipid homeostasis.
REACT_346699. Scavenging by Class A Receptors.

Miscellaneous databases

ChiTaRSiApoa1. mouse.
NextBioi279667.
PROiQ00623.
SOURCEiSearch...

Gene expression databases

CleanExiMM_APOA1.
GenevestigatoriQ00623.

Family and domain databases

InterProiIPR000074. ApoA_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse apolipoprotein AI. cDNA-derived primary structure, gene organisation and complete nucleotide sequence."
    Stoffel W., Mueller R., Binczek E., Hofmann K.
    Biol. Chem. Hoppe-Seyler 373:187-193(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "Characterization of the mouse apolipoprotein Apoa-1/Apoc-3 gene locus: genomic, mRNA, and protein sequences with comparisons to other species."
    Januzzi J.L., Azrolan N., O'Connell A., Aalto-Setala K., Breslow J.L.
    Genomics 14:1081-1088(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. Chiang A.-N., Fan K.-C., Shaw G.-C., Yang U.-C.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT 249-LYS-ALA--250.
    Strain: BALB/c, C3H, C57BL/6 and ICR.
    Tissue: Spleen.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT 249-GLN-VAL-250.
    Strain: C57BL/6J.
    Tissue: Liver, Ovary, Placenta and Uterus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT 249-GLN-VAL-250.
    Strain: C57BL/6J.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  7. "Mass spectral analysis of the apolipoproteins on mouse high density lipoproteins. Detection of post-translational modifications."
    Puppione D.L., Yam L.M., Bassilian S., Souda P., Castellani L.W., Schumaker V.N., Whitelegge J.P.
    Biochim. Biophys. Acta 1764:1363-1371(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-46; 93-106; 120-129; 131-139; 142-154; 157-172; 177-194; 201-216 AND 223-256, MASS SPECTROMETRY, OXIDATION AT MET-193; MET-240 AND MET-242.

Entry informationi

Entry nameiAPOA1_MOUSE
AccessioniPrimary (citable) accession number: Q00623
Secondary accession number(s): O08855, O09042, Q8BPD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 31, 1993
Last sequence update: October 2, 2012
Last modified: March 31, 2015
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.