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Q00618

- PGTA_YEAST

UniProt

Q00618 - PGTA_YEAST

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Protein

Geranylgeranyl transferase type-2 subunit alpha

Gene

BET4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4.

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

GO - Molecular functioni

  1. Rab geranylgeranyltransferase activity Source: SGD
  2. Rab GTPase binding Source: UniProtKB

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: SGD
  2. protein geranylgeranylation Source: SGD
  3. protein targeting to membrane Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-3.

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)
Alternative name(s):
GGTase-II-alpha
Geranylgeranyl transferase type II subunit alpha
PGGT
Type II protein geranyl-geranyltransferase subunit alpha
YPT1/SEC4 proteins geranylgeranyltransferase subunit alpha
Gene namesi
Name:BET4
Ordered Locus Names:YJL031C
ORF Names:J1254
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome X

Organism-specific databases

CYGDiYJL031c.
SGDiS000003568. BET4.

Subcellular locationi

GO - Cellular componenti

  1. Rab-protein geranylgeranyltransferase complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Geranylgeranyl transferase type-2 subunit alphaPRO_0000119756Add
BLAST

Proteomic databases

MaxQBiQ00618.
PaxDbiQ00618.

Expressioni

Gene expression databases

GenevestigatoriQ00618.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

Binary interactionsi

WithEntry#Exp.IntActNotes
BET2P201333EBI-3573,EBI-3559

Protein-protein interaction databases

BioGridi33728. 13 interactions.
DIPiDIP-4994N.
IntActiQ00618. 1 interaction.
MINTiMINT-568965.
STRINGi4932.YJL031C.

Structurei

3D structure databases

ProteinModelPortaliQ00618.
SMRiQ00618. Positions 2-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati44 – 7835PFTA 1Add
BLAST
Repeati84 – 11835PFTA 2Add
BLAST
Repeati123 – 15735PFTA 3Add
BLAST
Repeati163 – 19735PFTA 4Add
BLAST
Repeati207 – 24135PFTA 5Add
BLAST

Sequence similaritiesi

Contains 5 PFTA repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5536.
GeneTreeiENSGT00550000075121.
HOGENOMiHOG000190796.
InParanoidiQ00618.
KOiK14050.
OMAiGWHYRRI.
OrthoDBiEOG77Q569.

Family and domain databases

InterProiIPR002088. Prenyl_trans_a.
[Graphical view]
PfamiPF01239. PPTA. 5 hits.
[Graphical view]
PROSITEiPS51147. PFTA. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00618 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHGIKRKQWT KELLRQKRVQ DEKKIYDYRS LTENVLNMRD EKIYSIEALK
60 70 80 90 100
KTSELLEKNP EFNAIWNYRR DIIASLASEL EIPFWDKELV FVMMLLKDYP
110 120 130 140 150
KVYWIWNHRL WVLKHYPTSS PKVWQTELAV VNKLLEQDAR NYHGWHYRRI
160 170 180 190 200
VVGNIESITN KSLDKEEFEY TTIKINNNIS NYSAWHQRVQ IISRMFQKGE
210 220 230 240 250
VGNQKEYIRT EISYIINAMF TDAEDQSVWF YIKWFIKNDI VCKTLDEQEY
260 270 280 290 300
LKMLKDLREN ILLINNDEIE FSGKQNIWCL KILLVLEDIL EEKEALTERS
310 320
SEQYLVQLID ADPLRKNRYL HLLEQHK
Length:327
Mass (Da):39,675
Last modified:August 30, 2005 - v3
Checksum:iA7C3E16C14DDD09C
GO

Sequence cautioni

The sequence AAA21386.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAA89323.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14132 Genomic DNA. Translation: AAA21386.1. Sequence problems.
Z49307 Genomic DNA. Translation: CAA89323.1. Sequence problems.
BK006943 Genomic DNA. Translation: DAA08767.1.
PIRiS48301.
RefSeqiNP_012503.2. NM_001181465.1.

Genome annotation databases

EnsemblFungiiYJL031C; YJL031C; YJL031C.
GeneIDi853421.
KEGGisce:YJL031C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14132 Genomic DNA. Translation: AAA21386.1 . Sequence problems.
Z49307 Genomic DNA. Translation: CAA89323.1 . Sequence problems.
BK006943 Genomic DNA. Translation: DAA08767.1 .
PIRi S48301.
RefSeqi NP_012503.2. NM_001181465.1.

3D structure databases

ProteinModelPortali Q00618.
SMRi Q00618. Positions 2-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33728. 13 interactions.
DIPi DIP-4994N.
IntActi Q00618. 1 interaction.
MINTi MINT-568965.
STRINGi 4932.YJL031C.

Proteomic databases

MaxQBi Q00618.
PaxDbi Q00618.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YJL031C ; YJL031C ; YJL031C .
GeneIDi 853421.
KEGGi sce:YJL031C.

Organism-specific databases

CYGDi YJL031c.
SGDi S000003568. BET4.

Phylogenomic databases

eggNOGi COG5536.
GeneTreei ENSGT00550000075121.
HOGENOMi HOG000190796.
InParanoidi Q00618.
KOi K14050.
OMAi GWHYRRI.
OrthoDBi EOG77Q569.

Enzyme and pathway databases

BioCyci YEAST:MONOMER3O-3.

Miscellaneous databases

NextBioi 973945.
PROi Q00618.

Gene expression databases

Genevestigatori Q00618.

Family and domain databases

InterProi IPR002088. Prenyl_trans_a.
[Graphical view ]
Pfami PF01239. PPTA. 5 hits.
[Graphical view ]
PROSITEi PS51147. PFTA. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Feedback control of mitosis in budding yeast."
    Li R., Murray A.W.
    Cell 66:519-531(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Li R., Chen R.-H., Murray A.W.
    Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 171.
  3. "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X."
    Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K.
    , Hilger F., Hollenberg C.P., Huang M.-E., Jacq C., Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E., Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T., Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R., Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N., To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H., von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.
    EMBO J. 15:2031-2049(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii."
    Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A., Gates K., Gaffney T.D., Philippsen P.
    Genome Biol. 4:R45.1-R45.13(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.
    Strain: ATCC 204511 / S288c / AB972.
  6. "The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase."
    Li R., Havel C., Watson J.A., Murray A.W.
    Nature 366:82-84(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  7. Erratum
    Li R., Havel C., Watson J.A., Murray A.W.
    Nature 371:438-438(1994)
  8. "Bet2p and Mad2p are components of a prenyltransferase that adds geranylgeranyl onto Ypt1p and Sec4p."
    Jiang Y., Rossi G., Ferro-Novick S.
    Nature 366:84-86(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiPGTA_YEAST
AccessioniPrimary (citable) accession number: Q00618
Secondary accession number(s): D6VWF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: August 30, 2005
Last modified: October 29, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be MAD2.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

External Data

Dasty 3