Reviewed,
UniProtKB/Swiss-Prot Q00618 (PGTA_YEAST)
Last modified
November 3, 2009.
Version 84.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Geranylgeranyl transferase type-2 subunit alpha EC=2.5.1.60 Alternative name(s): Geranylgeranyl transferase type II subunit alpha Type II protein geranyl-geranyltransferase subunit alpha GGTase-II-alpha PGGT YPT1/SEC4 proteins geranylgeranyltransferase subunit alpha | ||||||
| Gene names |
| ||||||
| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||||
| Taxonomic identifier | 4932 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 327 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4. |
| Catalytic activity | Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. |
| Subunit structure | Heterodimer of an alpha and a beta subunit. |
| Sequence similarities | Belongs to the protein prenyltransferase subunit alpha family. Contains 5 PFTA repeats. |
| Caution | Was originally (Ref.1) thought to be MAD2. |
| Sequence caution | The sequence AAA21386.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAA89323.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
| Keywords | |
|---|---|
| Domain | Repeat |
| Molecular function | Prenyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | protein amino acid geranylgeranylation Inferred from direct assay. Source: SGD |
| Cellular component | Rab-protein geranylgeranyltransferase complex Inferred from direct assay. Source: SGD |
| Molecular function | Rab geranylgeranyltransferase activity Inferred from direct assay. Source: SGD protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Feedback control of mitosis in budding yeast." Li R., Murray A.W. Cell 66:519-531(1991) [PubMed: 1651172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | Li R., Chen R.-H., Murray A.W. Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 171. |
| [3] | "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X." Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C., Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D., Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J., Heumann K. Karpfinger-Hartl L.EMBO J. 15:2031-2049(1996) [PubMed: 8641269] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [4] | "Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii." Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A., Gates K., Gaffney T.D., Philippsen P. Genome Biol. 4:RESEARCH45.1-RESEARCH45.13(2003) [PubMed: 12844361] [Abstract] Cited for: REVISION OF GENE MODEL. Strain: ATCC 204511 / S288c / AB972. |
| [5] | "The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase." Li R., Havel C., Watson J.A., Murray A.W. Nature 366:82-84(1993) [PubMed: 8232541] [Abstract] Cited for: CHARACTERIZATION. |
| [6] | Erratum Li R., Havel C., Watson J.A., Murray A.W. Nature 371:438-438(1994) |
| [7] | "Bet2p and Mad2p are components of a prenyltransferase that adds geranylgeranyl onto Ypt1p and Sec4p." Jiang Y., Rossi G., Ferro-Novick S. Nature 366:84-86(1993) [PubMed: 8232542] [Abstract] Cited for: CHARACTERIZATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U14132 Genomic DNA. Translation: AAA21386.1. Sequence problems. Z49307 Genomic DNA. Translation: CAA89323.1. Sequence problems. | |
| PIR | S48301. |
| RefSeq | NP_012503.2. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1LTX based on UniProtKB Q08602. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:4994N. |
| IntAct | Q00618. 5 interactions. |
| STRING | Q00618. |
Genome annotation databases | |
| Ensembl | YJL031C; YJL031C; YJL031C; Saccharomyces cerevisiae. [Genome view] |
| GeneID | 853421. |
| GenomeReviews | Gene locus YJL031C in contig Y13136_GR. |
| KEGG | sce:YJL031C. |
| NMPDR | fig|4932.3.peg.3477. |
Organism-specific databases | |
| CYGD | YJL031c. |
| SGD | S000003568. BET4. |
Phylogenomic databases | |
| HOGENOM | Q00618. |
| OMA | WNYRRDI. |
Enzyme and pathway databases | |
| BRENDA | 2.5.1.60. 250. |
Gene expression databases | |
| ArrayExpress | Q00618. |
| Genevestigator | Q00618. |
| GermOnline | YJL031C. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR002088. Prenyl_trans_a. IPR008940. Prenyltransferase. [Graphical view] |
| Gene3D | G3DSA:1.25.40.120. Prenyl_trans. 1 hit. |
| Pfam | PF01239. PPTA. 5 hits. [Graphical view] |
| PROSITE | PS51147. PFTA. 5 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 973945. |
Entry information
| Entry name | PGTA_YEAST | ||||||||
| Accession | Primary (citable) accession number: Q00618 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome X Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names |

Clusters with


