Q00610 (CLH1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Clathrin heavy chain 1

Alternative name(s):
Clathrin heavy chain on chromosome 17
Short name=CLH-17

Gene names

Name:	CLTC
Synonyms:	CLH17, CLTCL2, KIAA0034

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1675 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
Subunit structure	Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium. Interacts with HIP1. Interacts with DENND1A, DENND1B and DENND1C By similarity. May interact with OCRL. Interacts with ERBB2 By similarity. Ref.8 Ref.9
Subcellular location	Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane › coated pit; Peripheral membrane protein; Cytoplasmic side. Melanosome. Note: Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.10
Domain	The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It consitutes a major protein-protein interaction node.
Sequence similarities	Belongs to the clathrin heavy chain family. Contains 7 CHCR (clathrin heavy-chain) repeats.
Sequence caution	The sequence BAA04801.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Coated pit Cytoplasmic vesicle Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II Traceable author statement. Source: Reactome cellular membrane organization Traceable author statement. Source: Reactome intracellular protein transport Non-traceable author statement Ref.5. Source: UniProtKB mitosis Inferred from mutant phenotype PubMed 15858577. Source: UniProtKB post-Golgi vesicle-mediated transport Traceable author statement. Source: Reactome receptor internalization Inferred from mutant phenotype PubMed 14985334. Source: BHF-UCL transferrin transport Inferred from mutant phenotype PubMed 14985334. Source: BHF-UCL
Cellular_component	clathrin coat Non-traceable author statement Ref.5. Source: UniProtKB clathrin coat of coated pit Inferred from electronic annotation. Source: InterPro clathrin coat of trans-Golgi network vesicle Inferred from electronic annotation. Source: InterPro clathrin-coated endocytic vesicle membrane Traceable author statement. Source: Reactome cytosol Traceable author statement. Source: Reactome extracellular vesicular exosome Inferred from direct assay PubMed 21362503. Source: UniProtKB melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from electronic annotation. Source: Compara spindle Inferred from direct assay PubMed 15858577. Source: UniProtKB trans-Golgi network membrane Traceable author statement. Source: Reactome
Molecular_function	structural molecule activity Non-traceable author statement Ref.5. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q00610-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q00610-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1636-1639: QPQL → NLSL
     1640-1675: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.6 Ref.7

Chain

2 – 1675

1674

Clathrin heavy chain 1

PRO_0000205778

Regions

Repeat

537 – 683

147

CHCR 1

Repeat

686 – 828

143

CHCR 2

Repeat

833 – 972

140

CHCR 3

Repeat

979 – 1124

146

CHCR 4

Repeat

1128 – 1269

142

CHCR 5

Repeat

1274 – 1420

147

CHCR 6

Repeat

1423 – 1566

144

CHCR 7

Region

2 – 479

478

Globular terminal domain

Region

24 – 67

44

WD40-like repeat 1

Region

68 – 107

40

WD40-like repeat 2

Region

108 – 149

42

WD40-like repeat 3

Region

150 – 195

46

WD40-like repeat 4

Region

196 – 257

62

WD40-like repeat 5

Region

258 – 301

44

WD40-like repeat 6

Region

302 – 330

29

WD40-like repeat 7

Region

449 – 465

17

Binding site for the uncoating ATPase, involved in lattice disassembly Potential

Region

480 – 523

44

Flexible linker

Region

524 – 1675

1152

Heavy chain arm

Region

524 – 634

111

Distal segment

Region

639 – 1675

1037

Proximal segment

Region

1213 – 1522

310

Involved in binding clathrin light chain By similarity

Region

1550 – 1675

126

Trimerization By similarity

Amino acid modifications

Modified residue

2

1

N-acetylalanine Ref.7

Modified residue

184

1

Phosphotyrosine By similarity

Modified residue

394

1

Phosphothreonine Ref.12

Modified residue

634

1

Phosphotyrosine Ref.14

Modified residue

856

1

N6-acetyllysine Ref.15

Modified residue

899

1

Phosphotyrosine By similarity

Modified residue

1206

1

Phosphotyrosine By similarity

Modified residue

1441

1

N6-acetyllysine Ref.15

Modified residue

1477

1

Phosphotyrosine Ref.14

Modified residue

1487

1

Phosphotyrosine By similarity

Modified residue

1494

1

Phosphoserine Ref.13

Modified residue

1501

1

N6-acetyllysine Ref.15

Natural variations

Alternative sequence

1636 – 1639

4

QPQL → NLSL in isoform 2.

VSP_011570

Alternative sequence

1640 – 1675

36

Missing in isoform 2.

VSP_011571

Experimental info

Sequence conflict

560

1

Q → R in CAA39363. Ref.5

Sequence conflict

817

1

G → V in CAA39363. Ref.5

Sequence conflict

923

1

R → H in CAE45761. Ref.2

Sequence conflict

1563

1

R → G in CAE45761. Ref.2

Sequence conflict

1652

1

Q → R in CAE45761. Ref.2

Secondary structure

1

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1675

Helix Strand Turn

Details...

Beta strand

6 – 14

9

Helix

15 – 18

4

Helix

22 – 24

3

Turn

27 – 29

3

Beta strand

30 – 34

5

Beta strand

37 – 44

8

Beta strand

47 – 54

8

Beta strand

62 – 65

4

Beta strand

69 – 73

5

Beta strand

75 – 84

10

Beta strand

87 – 92

6

Turn

93 – 96

4

Beta strand

97 – 103

7

Beta strand

108 – 113

6

Beta strand

115 – 133

19

Beta strand

139 – 143

5

Helix

146 – 148

3

Beta strand

152 – 158

7

Beta strand

164 – 173

10

Beta strand

176 – 185

10

Turn

186 – 189

4

Beta strand

190 – 194

5

Beta strand

197 – 204

8

Beta strand

213 – 222

10

Beta strand

225 – 232

8

Beta strand

246 – 250

5

Beta strand

261 – 267

7

Turn

268 – 271

4

Beta strand

272 – 277

6

Beta strand

280 – 286

7

Turn

287 – 289

3

Beta strand

292 – 297

6

Beta strand

303 – 309

7

Helix

310 – 312

3

Beta strand

314 – 319

6

Beta strand

323 – 329

7

Turn

331 – 333

3

Helix

334 – 340

7

Helix

345 – 354

10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 5. Checksum: 6C4F2D54950079E2	FASTA	1,675	191,615
	10 20 30 40 50 60 MAQILPIRFQ EHLQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV VIIDMNDPSN 70 80 90 100 110 120 PIRRPISADS AIMNPASKVI ALKAGKTLQI FNIEMKSKMK AHTMTDDVTF WKWISLNTVA 130 140 150 160 170 180 LVTDNAVYHW SMEGESQPVK MFDRHSSLAG CQIINYRTDA KQKWLLLTGI SAQQNRVVGA 190 200 210 220 230 240 MQLYSVDRKV SQPIEGHAAS FAQFKMEGNA EESTLFCFAV RGQAGGKLHI IEVGTPPTGN 250 260 270 280 290 300 QPFPKKAVDV FFPPEAQNDF PVAMQISEKH DVVFLITKYG YIHLYDLETG TCIYMNRISG 310 320 330 340 350 360 ETIFVTAPHE ATAGIIGVNR KGQVLSVCVE EENIIPYITN VLQNPDLALR MAVRNNLAGA 370 380 390 400 410 420 EELFARKFNA LFAQGNYSEA AKVAANAPKG ILRTPDTIRR FQSVPAQPGQ TSPLLQYFGI 430 440 450 460 470 480 LLDQGQLNKY ESLELCRPVL QQGRKQLLEK WLKEDKLECS EELGDLVKSV DPTLALSVYL 490 500 510 520 530 540 RANVPNKVIQ CFAETGQVQK IVLYAKKVGY TPDWIFLLRN VMRISPDQGQ QFAQMLVQDE 550 560 570 580 590 600 EPLADITQIV DVFMEYNLIQ QCTAFLLDAL KNNRPSEGPL QTRLLEMNLM HAPQVADAIL 610 620 630 640 650 660 GNQMFTHYDR AHIAQLCEKA GLLQRALEHF TDLYDIKRAV VHTHLLNPEW LVNYFGSLSV 670 680 690 700 710 720 EDSLECLRAM LSANIRQNLQ ICVQVASKYH EQLSTQSLIE LFESFKSFEG LFYFLGSIVN 730 740 750 760 770 780 FSQDPDVHFK YIQAACKTGQ IKEVERICRE SNCYDPERVK NFLKEAKLTD QLPLIIVCDR 790 800 810 820 830 840 FDFVHDLVLY LYRNNLQKYI EIYVQKVNPS RLPVVIGGLL DVDCSEDVIK NLILVVRGQF 850 860 870 880 890 900 STDELVAEVE KRNRLKLLLP WLEARIHEGC EEPATHNALA KIYIDSNNNP ERFLRENPYY 910 920 930 940 950 960 DSRVVGKYCE KRDPHLACVA YERGQCDLEL INVCNENSLF KSLSRYLVRR KDPELWGSVL 970 980 990 1000 1010 1020 LESNPYRRPL IDQVVQTALS ETQDPEEVSV TVKAFMTADL PNELIELLEK IVLDNSVFSE 1030 1040 1050 1060 1070 1080 HRNLQNLLIL TAIKADRTRV MEYINRLDNY DAPDIANIAI SNELFEEAFA IFRKFDVNTS 1090 1100 1110 1120 1130 1140 AVQVLIEHIG NLDRAYEFAE RCNEPAVWSQ LAKAQLQKGM VKEAIDSYIK ADDPSSYMEV 1150 1160 1170 1180 1190 1200 VQAANTSGNW EELVKYLQMA RKKARESYVE TELIFALAKT NRLAELEEFI NGPNNAHIQQ 1210 1220 1230 1240 1250 1260 VGDRCYDEKM YDAAKLLYNN VSNFGRLAST LVHLGEYQAA VDGARKANST RTWKEVCFAC 1270 1280 1290 1300 1310 1320 VDGKEFRLAQ MCGLHIVVHA DELEELINYY QDRGYFEELI TMLEAALGLE RAHMGMFTEL 1330 1340 1350 1360 1370 1380 AILYSKFKPQ KMREHLELFW SRVNIPKVLR AAEQAHLWAE LVFLYDKYEE YDNAIITMMN 1390 1400 1410 1420 1430 1440 HPTDAWKEGQ FKDIITKVAN VELYYRAIQF YLEFKPLLLN DLLMVLSPRL DHTRAVNYFS 1450 1460 1470 1480 1490 1500 KVKQLPLVKP YLRSVQNHNN KSVNESLNNL FITEEDYQAL RTSIDAYDNF DNISLAQRLE 1510 1520 1530 1540 1550 1560 KHELIEFRRI AAYLFKGNNR WKQSVELCKK DSLYKDAMQY ASESKDTELA EELLQWFLQE 1570 1580 1590 1600 1610 1620 EKRECFGACL FTCYDLLRPD VVLETAWRHN IMDFAMPYFI QVMKEYLTKV DKLDASESLR 1630 1640 1650 1660 1670 KEEEQATETQ PIVYGQPQLM LTAGPSVAVP PQAPFGYGYT APPYGQPQPG FGYSM
	Isoform 2 [UniParc]. Checksum: 9CE5237A31C9B0C6	FASTA	1,639	187,890
	10 20 30 40 50 60 MAQILPIRFQ EHLQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV VIIDMNDPSN 70 80 90 100 110 120 PIRRPISADS AIMNPASKVI ALKAGKTLQI FNIEMKSKMK AHTMTDDVTF WKWISLNTVA 130 140 150 160 170 180 LVTDNAVYHW SMEGESQPVK MFDRHSSLAG CQIINYRTDA KQKWLLLTGI SAQQNRVVGA 190 200 210 220 230 240 MQLYSVDRKV SQPIEGHAAS FAQFKMEGNA EESTLFCFAV RGQAGGKLHI IEVGTPPTGN 250 260 270 280 290 300 QPFPKKAVDV FFPPEAQNDF PVAMQISEKH DVVFLITKYG YIHLYDLETG TCIYMNRISG 310 320 330 340 350 360 ETIFVTAPHE ATAGIIGVNR KGQVLSVCVE EENIIPYITN VLQNPDLALR MAVRNNLAGA 370 380 390 400 410 420 EELFARKFNA LFAQGNYSEA AKVAANAPKG ILRTPDTIRR FQSVPAQPGQ TSPLLQYFGI 430 440 450 460 470 480 LLDQGQLNKY ESLELCRPVL QQGRKQLLEK WLKEDKLECS EELGDLVKSV DPTLALSVYL 490 500 510 520 530 540 RANVPNKVIQ CFAETGQVQK IVLYAKKVGY TPDWIFLLRN VMRISPDQGQ QFAQMLVQDE 550 560 570 580 590 600 EPLADITQIV DVFMEYNLIQ QCTAFLLDAL KNNRPSEGPL QTRLLEMNLM HAPQVADAIL 610 620 630 640 650 660 GNQMFTHYDR AHIAQLCEKA GLLQRALEHF TDLYDIKRAV VHTHLLNPEW LVNYFGSLSV 670 680 690 700 710 720 EDSLECLRAM LSANIRQNLQ ICVQVASKYH EQLSTQSLIE LFESFKSFEG LFYFLGSIVN 730 740 750 760 770 780 FSQDPDVHFK YIQAACKTGQ IKEVERICRE SNCYDPERVK NFLKEAKLTD QLPLIIVCDR 790 800 810 820 830 840 FDFVHDLVLY LYRNNLQKYI EIYVQKVNPS RLPVVIGGLL DVDCSEDVIK NLILVVRGQF 850 860 870 880 890 900 STDELVAEVE KRNRLKLLLP WLEARIHEGC EEPATHNALA KIYIDSNNNP ERFLRENPYY 910 920 930 940 950 960 DSRVVGKYCE KRDPHLACVA YERGQCDLEL INVCNENSLF KSLSRYLVRR KDPELWGSVL 970 980 990 1000 1010 1020 LESNPYRRPL IDQVVQTALS ETQDPEEVSV TVKAFMTADL PNELIELLEK IVLDNSVFSE 1030 1040 1050 1060 1070 1080 HRNLQNLLIL TAIKADRTRV MEYINRLDNY DAPDIANIAI SNELFEEAFA IFRKFDVNTS 1090 1100 1110 1120 1130 1140 AVQVLIEHIG NLDRAYEFAE RCNEPAVWSQ LAKAQLQKGM VKEAIDSYIK ADDPSSYMEV 1150 1160 1170 1180 1190 1200 VQAANTSGNW EELVKYLQMA RKKARESYVE TELIFALAKT NRLAELEEFI NGPNNAHIQQ 1210 1220 1230 1240 1250 1260 VGDRCYDEKM YDAAKLLYNN VSNFGRLAST LVHLGEYQAA VDGARKANST RTWKEVCFAC 1270 1280 1290 1300 1310 1320 VDGKEFRLAQ MCGLHIVVHA DELEELINYY QDRGYFEELI TMLEAALGLE RAHMGMFTEL 1330 1340 1350 1360 1370 1380 AILYSKFKPQ KMREHLELFW SRVNIPKVLR AAEQAHLWAE LVFLYDKYEE YDNAIITMMN 1390 1400 1410 1420 1430 1440 HPTDAWKEGQ FKDIITKVAN VELYYRAIQF YLEFKPLLLN DLLMVLSPRL DHTRAVNYFS 1450 1460 1470 1480 1490 1500 KVKQLPLVKP YLRSVQNHNN KSVNESLNNL FITEEDYQAL RTSIDAYDNF DNISLAQRLE 1510 1520 1530 1540 1550 1560 KHELIEFRRI AAYLFKGNNR WKQSVELCKK DSLYKDAMQY ASESKDTELA EELLQWFLQE 1570 1580 1590 1600 1610 1620 EKRECFGACL FTCYDLLRPD VVLETAWRHN IMDFAMPYFI QVMKEYLTKV DKLDASESLR 1630 KEEEQATETQ PIVYGNLSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1." Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S. DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Fetal kidney.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: PNS and Testis.
[5]	"Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter." Dodge G.R., Kovalszky I., McBride O.W., Yi H.F., Chu M.-L., Saitta B., Stokes D.G., Iozzo R.V. Genomics 11:174-178(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 560-864 (ISOFORMS 1/2). Tissue: Colon.
[6]	"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-8. Tissue: Platelet.
[7]	Bienvenut W.V., Calvo F., Matallanas D., Cooper W.N., Boldt K., von Kriegsheim A.F., Kolch W. Submitted (FEB-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-8; 64-78; 87-96; 164-205; 228-245; 270-278; 298-320; 355-382; 469-481; 507-519; 572-610; 626-638; 799-806; 831-852; 855-865; 882-903; 1011-1037; 1074-1101; 1123-1130; 1166-1179; 1183-1204; 1216-1245; 1312-1326; 1398-1406; 1435-1453; 1482-1498; 1502-1508; 1510-1516 AND 1610-1620, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Cervix carcinoma, Hepatoma and Mammary carcinoma.
[8]	"The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis." Waelter S., Scherzinger E., Hasenbank R., Nordhoff E., Lurz R., Goehler H., Gauss C., Sathasivam K., Bates G.P., Lehrach H., Wanker E.E. Hum. Mol. Genet. 10:1807-1817(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HIP1.
[9]	"Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor." Giri D.K., Ali-Seyed M., Li L.Y., Lee D.F., Ling P., Bartholomeusz G., Wang S.C., Hung M.C. Mol. Cell. Biol. 25:11005-11018(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ERBB2.
[10]	"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes." Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F. J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Melanoma.
[11]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1494, MASS SPECTROMETRY.
[14]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-634 AND TYR-1477, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[15]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-856; LYS-1441 AND LYS-1501, MASS SPECTROMETRY.
[16]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[17]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]	"Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition." von Kleist L., Stahlschmidt W., Bulut H., Gromova K., Puchkov D., Robertson M.J., MacGregor K.A., Tomilin N., Pechstein A., Chau N., Chircop M., Sakoff J., von Kries J.P., Saenger W., Krausslich H.G., Shupliakov O., Robinson P.J., McCluskey A., Haucke V. Cell 146:471-484(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.69 ANGSTROMS) OF 1-364 IN COMPLEX WITH INHIBITORS, WD40-LIKE REPEATS.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Wikipedia

Clathrin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D21260 mRNA. Translation: BAA04801.2. Different initiation.
BX640615 mRNA. Translation: CAE45761.1.
CH471109 Genomic DNA. Translation: EAW94396.1.
CH471109 Genomic DNA. Translation: EAW94399.1.
BC051800 mRNA. Translation: AAH51800.1.
BC054489 mRNA. Translation: AAH54489.1.
X55878 mRNA. Translation: CAA39363.1.

IPI

IPI00024067.
IPI00455383.

PIR

A40573.

RefSeq

NP_004850.1. NM_004859.3.

UniGene

Hs.491351.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2XZG	X-ray	1.70	A	1-364	[»]
4G55	X-ray	1.69	A	1-364	[»]

ProteinModelPortal

Q00610.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q00610. 37 interactions.

MINT

MINT-4998595.

STRING

9606.ENSP00000269122.

PTM databases

PhosphoSite

Q00610.

Polymorphism databases

DMDM

1705916.

Proteomic databases

PaxDb

Q00610.

PRIDE

Q00610.

Protocols and materials databases

DNASU

1213.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000269122; ENSP00000269122; ENSG00000141367.
ENST00000393043; ENSP00000376763; ENSG00000141367.

GeneID

1213.

KEGG

hsa:1213.

UCSC

uc002ixp.3. human.
uc002ixq.1. human.

Organism-specific databases

CTD

1213.

GeneCards

GC17P057697.

H-InvDB

HIX0039315.

HGNC

HGNC:2092. CLTC.

HPA

CAB010389.
CAB011571.
CAB017155.

MIM

118955. gene.

neXtProt

NX_Q00610.

Orphanet

319308. Translocation renal cell carcinoma.

PharmGKB

PA26618.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG314149.

HOGENOM

HOG000188877.

HOVERGEN

HBG005344.

InParanoid

Q00610.

KO

K04646.

OMA

FTNYDRA.

OrthoDB

EOG4TXBR0.

PhylomeDB

Q00610.

Enzyme and pathway databases

Pathway_Interaction_DB

arf6_traffickingpathway. Arf6 trafficking events.

Reactome

REACT_111045. Developmental Biology.
REACT_111102. Signal Transduction.
REACT_11123. Membrane Trafficking.
REACT_116125. Disease.
REACT_6900. Immune System.

SignaLink

Q00610.

Gene expression databases

ArrayExpress

Q00610.

Bgee

Q00610.

CleanEx

HS_CLTC.

Genevestigator

Q00610.

GermOnline

ENSG00000141367. Homo sapiens.

Family and domain databases

Gene3D

1.25.40.10. 4 hits.
2.130.10.110. 1 hit.

InterPro

IPR016024. ARM-type_fold.
IPR000547. Clathrin_H-chain/VPS_repeat.
IPR016025. Clathrin_H-chain_link/propller.
IPR015348. Clathrin_H-chain_linker_core.
IPR001473. Clathrin_H-chain_propeller_N.
IPR022365. Clathrin_H-chain_propeller_rpt.
IPR016341. Clathrin_heavy_chain.
IPR011990. TPR-like_helical.
[Graphical view]

Pfam

PF00637. Clathrin. 7 hits.
PF09268. Clathrin-link. 1 hit.
PF01394. Clathrin_propel. 3 hits.
[Graphical view]

PIRSF

PIRSF002290. Clathrin_H_chain. 1 hit.

SMART

SM00299. CLH. 7 hits.
[Graphical view]

SUPFAM

SSF48371. ARM-type_fold. 5 hits.
SSF50989. Clathrin_H-chain_propeller_N. 1 hit.

PROSITE

PS50236. CHCR. 7 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

CLTC. human.

EvolutionaryTrace

Q00610.

GenomeRNAi

1213.

NextBio

4999.

SOURCE

Search...

Entry information

Entry name

CLH1_HUMAN

Accession

Primary (citable) accession number: Q00610
Secondary accession number(s): D3DU00, Q6N0A0, Q86TF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	January 23, 2007
Last modified:	May 29, 2013
This is version 135 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.