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Q00610

- CLH1_HUMAN

UniProt

Q00610 - CLH1_HUMAN

Protein

Clathrin heavy chain 1

Gene

CLTC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 149 (01 Oct 2014)
      Sequence version 5 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.

    GO - Molecular functioni

    1. clathrin light chain binding Source: FlyBase
    2. double-stranded RNA binding Source: MGI
    3. poly(A) RNA binding Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. protein kinase binding Source: ParkinsonsUK-UCL
    6. structural molecule activity Source: UniProtKB

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. intracellular protein transport Source: UniProtKB
    3. membrane organization Source: Reactome
    4. mitotic nuclear division Source: UniProtKB
    5. negative regulation of hyaluronan biosynthetic process Source: UniProtKB
    6. osteoblast differentiation Source: UniProt
    7. post-Golgi vesicle-mediated transport Source: Reactome
    8. receptor internalization Source: BHF-UCL
    9. receptor-mediated endocytosis Source: UniProtKB
    10. transferrin transport Source: BHF-UCL

    Enzyme and pathway databases

    ReactomeiREACT_11035. Gap junction degradation.
    REACT_11049. Formation of annular gap junctions.
    REACT_121399. MHC class II antigen presentation.
    REACT_172599. WNT5A-dependent internalization of FZD4.
    REACT_19287. Lysosome Vesicle Biogenesis.
    REACT_19400. Golgi Associated Vesicle Biogenesis.
    SignaLinkiQ00610.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Clathrin heavy chain 1
    Alternative name(s):
    Clathrin heavy chain on chromosome 17
    Short name:
    CLH-17
    Gene namesi
    Name:CLTC
    Synonyms:CLH17, CLTCL2, KIAA0034
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:2092. CLTC.

    Subcellular locationi

    Cytoplasmic vesicle membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication. Membranecoated pit 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication. Melanosome 1 Publication
    Note: Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

    GO - Cellular componenti

    1. clathrin coat Source: UniProtKB
    2. clathrin-coated endocytic vesicle membrane Source: Reactome
    3. clathrin-coated vesicle Source: UniProtKB
    4. clathrin coat of coated pit Source: InterPro
    5. clathrin coat of trans-Golgi network vesicle Source: InterPro
    6. clathrin complex Source: FlyBase
    7. cytosol Source: Reactome
    8. extracellular vesicular exosome Source: UniProtKB
    9. melanosome Source: UniProtKB-SubCell
    10. membrane Source: UniProtKB
    11. mitochondrion Source: Ensembl
    12. plasma membrane Source: Reactome
    13. protein complex Source: MGI
    14. spindle Source: UniProtKB
    15. trans-Golgi network membrane Source: Reactome

    Keywords - Cellular componenti

    Coated pit, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti178342. Inflammatory myofibroblastic tumor.
    319308. Translocation renal cell carcinoma.
    PharmGKBiPA26618.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed4 Publications
    Chaini2 – 16751674Clathrin heavy chain 1PRO_0000205778Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications
    Modified residuei184 – 1841PhosphotyrosineBy similarity
    Modified residuei394 – 3941Phosphothreonine1 Publication
    Modified residuei634 – 6341Phosphotyrosine1 Publication
    Modified residuei737 – 7371N6-succinyllysineBy similarity
    Modified residuei856 – 8561N6-acetyllysine1 Publication
    Modified residuei899 – 8991PhosphotyrosineBy similarity
    Modified residuei1206 – 12061PhosphotyrosineBy similarity
    Modified residuei1441 – 14411N6-acetyllysine; alternate1 Publication
    Modified residuei1441 – 14411N6-succinyllysine; alternateBy similarity
    Modified residuei1477 – 14771Phosphotyrosine1 Publication
    Modified residuei1487 – 14871PhosphotyrosineBy similarity
    Modified residuei1494 – 14941Phosphoserine1 Publication
    Modified residuei1501 – 15011N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ00610.
    PaxDbiQ00610.
    PRIDEiQ00610.

    PTM databases

    PhosphoSiteiQ00610.

    Expressioni

    Gene expression databases

    ArrayExpressiQ00610.
    BgeeiQ00610.
    CleanExiHS_CLTC.
    GenevestigatoriQ00610.

    Organism-specific databases

    HPAiCAB010389.
    CAB011571.
    CAB017155.

    Interactioni

    Subunit structurei

    Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium. Interacts with HIP1. Interacts with DENND1A, DENND1B and DENND1C By similarity. May interact with OCRL. Interacts with ERBB2 By similarity. Interacts with FKBP6.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MYBP102424EBI-354967,EBI-298355
    OCRLQ019684EBI-354967,EBI-6148898
    TOM1L1O756744EBI-354967,EBI-712991

    Protein-protein interaction databases

    BioGridi107623. 124 interactions.
    IntActiQ00610. 49 interactions.
    MINTiMINT-4998595.
    STRINGi9606.ENSP00000269122.

    Structurei

    Secondary structure

    1
    1675
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 149
    Helixi15 – 184
    Helixi22 – 243
    Turni27 – 293
    Beta strandi30 – 345
    Beta strandi37 – 448
    Beta strandi47 – 548
    Beta strandi62 – 654
    Beta strandi69 – 735
    Beta strandi75 – 8410
    Beta strandi87 – 926
    Turni93 – 964
    Beta strandi97 – 1037
    Beta strandi108 – 1136
    Beta strandi115 – 13319
    Beta strandi139 – 1435
    Helixi146 – 1483
    Beta strandi152 – 1587
    Beta strandi164 – 17310
    Beta strandi176 – 18510
    Turni186 – 1894
    Beta strandi190 – 1945
    Beta strandi197 – 2048
    Beta strandi213 – 22210
    Beta strandi225 – 2328
    Beta strandi246 – 2505
    Beta strandi261 – 2677
    Turni268 – 2714
    Beta strandi272 – 2776
    Beta strandi280 – 2867
    Turni287 – 2893
    Beta strandi292 – 2976
    Beta strandi303 – 3097
    Helixi310 – 3123
    Beta strandi314 – 3196
    Beta strandi323 – 3297
    Turni331 – 3333
    Helixi334 – 3407
    Helixi345 – 35410

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XZGX-ray1.70A1-364[»]
    4G55X-ray1.69A1-364[»]
    ProteinModelPortaliQ00610.
    SMRiQ00610. Positions 1-493, 1077-1630.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ00610.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati537 – 683147CHCR 11 PublicationPROSITE-ProRule annotationAdd
    BLAST
    Repeati686 – 828143CHCR 21 PublicationPROSITE-ProRule annotationAdd
    BLAST
    Repeati833 – 972140CHCR 31 PublicationPROSITE-ProRule annotationAdd
    BLAST
    Repeati979 – 1124146CHCR 41 PublicationPROSITE-ProRule annotationAdd
    BLAST
    Repeati1128 – 1269142CHCR 51 PublicationPROSITE-ProRule annotationAdd
    BLAST
    Repeati1274 – 1420147CHCR 61 PublicationPROSITE-ProRule annotationAdd
    BLAST
    Repeati1423 – 1566144CHCR 71 PublicationPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 479478Globular terminal domainAdd
    BLAST
    Regioni24 – 6744WD40-like repeat 1Add
    BLAST
    Regioni68 – 10740WD40-like repeat 2Add
    BLAST
    Regioni108 – 14942WD40-like repeat 3Add
    BLAST
    Regioni150 – 19546WD40-like repeat 4Add
    BLAST
    Regioni196 – 25762WD40-like repeat 5Add
    BLAST
    Regioni258 – 30144WD40-like repeat 6Add
    BLAST
    Regioni302 – 33029WD40-like repeat 7Add
    BLAST
    Regioni449 – 46517Binding site for the uncoating ATPase, involved in lattice disassemblySequence AnalysisAdd
    BLAST
    Regioni480 – 52344Flexible linkerAdd
    BLAST
    Regioni524 – 16751152Heavy chain armAdd
    BLAST
    Regioni524 – 634111Distal segmentAdd
    BLAST
    Regioni639 – 16751037Proximal segmentAdd
    BLAST
    Regioni1213 – 1522310Involved in binding clathrin light chainBy similarityAdd
    BLAST
    Regioni1550 – 1675126TrimerizationBy similarityAdd
    BLAST

    Domaini

    The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It consitutes a major protein-protein interaction node.

    Sequence similaritiesi

    Belongs to the clathrin heavy chain family.Curated
    Contains 7 CHCR (clathrin heavy-chain) repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG314149.
    HOGENOMiHOG000188877.
    HOVERGENiHBG005344.
    InParanoidiQ00610.
    KOiK04646.
    OMAiWKWFSEK.
    OrthoDBiEOG7Z0JVM.
    PhylomeDBiQ00610.
    TreeFamiTF300059.

    Family and domain databases

    Gene3Di1.25.40.10. 4 hits.
    2.130.10.110. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000547. Clathrin_H-chain/VPS_repeat.
    IPR016025. Clathrin_H-chain_link/propller.
    IPR015348. Clathrin_H-chain_linker_core.
    IPR001473. Clathrin_H-chain_propeller_N.
    IPR022365. Clathrin_H-chain_propeller_rpt.
    IPR016341. Clathrin_heavy_chain.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PfamiPF00637. Clathrin. 7 hits.
    PF09268. Clathrin-link. 1 hit.
    PF01394. Clathrin_propel. 3 hits.
    [Graphical view]
    PIRSFiPIRSF002290. Clathrin_H_chain. 1 hit.
    SMARTiSM00299. CLH. 7 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 6 hits.
    SSF50989. SSF50989. 1 hit.
    PROSITEiPS50236. CHCR. 7 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q00610-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQILPIRFQ EHLQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV     50
    VIIDMNDPSN PIRRPISADS AIMNPASKVI ALKAGKTLQI FNIEMKSKMK 100
    AHTMTDDVTF WKWISLNTVA LVTDNAVYHW SMEGESQPVK MFDRHSSLAG 150
    CQIINYRTDA KQKWLLLTGI SAQQNRVVGA MQLYSVDRKV SQPIEGHAAS 200
    FAQFKMEGNA EESTLFCFAV RGQAGGKLHI IEVGTPPTGN QPFPKKAVDV 250
    FFPPEAQNDF PVAMQISEKH DVVFLITKYG YIHLYDLETG TCIYMNRISG 300
    ETIFVTAPHE ATAGIIGVNR KGQVLSVCVE EENIIPYITN VLQNPDLALR 350
    MAVRNNLAGA EELFARKFNA LFAQGNYSEA AKVAANAPKG ILRTPDTIRR 400
    FQSVPAQPGQ TSPLLQYFGI LLDQGQLNKY ESLELCRPVL QQGRKQLLEK 450
    WLKEDKLECS EELGDLVKSV DPTLALSVYL RANVPNKVIQ CFAETGQVQK 500
    IVLYAKKVGY TPDWIFLLRN VMRISPDQGQ QFAQMLVQDE EPLADITQIV 550
    DVFMEYNLIQ QCTAFLLDAL KNNRPSEGPL QTRLLEMNLM HAPQVADAIL 600
    GNQMFTHYDR AHIAQLCEKA GLLQRALEHF TDLYDIKRAV VHTHLLNPEW 650
    LVNYFGSLSV EDSLECLRAM LSANIRQNLQ ICVQVASKYH EQLSTQSLIE 700
    LFESFKSFEG LFYFLGSIVN FSQDPDVHFK YIQAACKTGQ IKEVERICRE 750
    SNCYDPERVK NFLKEAKLTD QLPLIIVCDR FDFVHDLVLY LYRNNLQKYI 800
    EIYVQKVNPS RLPVVIGGLL DVDCSEDVIK NLILVVRGQF STDELVAEVE 850
    KRNRLKLLLP WLEARIHEGC EEPATHNALA KIYIDSNNNP ERFLRENPYY 900
    DSRVVGKYCE KRDPHLACVA YERGQCDLEL INVCNENSLF KSLSRYLVRR 950
    KDPELWGSVL LESNPYRRPL IDQVVQTALS ETQDPEEVSV TVKAFMTADL 1000
    PNELIELLEK IVLDNSVFSE HRNLQNLLIL TAIKADRTRV MEYINRLDNY 1050
    DAPDIANIAI SNELFEEAFA IFRKFDVNTS AVQVLIEHIG NLDRAYEFAE 1100
    RCNEPAVWSQ LAKAQLQKGM VKEAIDSYIK ADDPSSYMEV VQAANTSGNW 1150
    EELVKYLQMA RKKARESYVE TELIFALAKT NRLAELEEFI NGPNNAHIQQ 1200
    VGDRCYDEKM YDAAKLLYNN VSNFGRLAST LVHLGEYQAA VDGARKANST 1250
    RTWKEVCFAC VDGKEFRLAQ MCGLHIVVHA DELEELINYY QDRGYFEELI 1300
    TMLEAALGLE RAHMGMFTEL AILYSKFKPQ KMREHLELFW SRVNIPKVLR 1350
    AAEQAHLWAE LVFLYDKYEE YDNAIITMMN HPTDAWKEGQ FKDIITKVAN 1400
    VELYYRAIQF YLEFKPLLLN DLLMVLSPRL DHTRAVNYFS KVKQLPLVKP 1450
    YLRSVQNHNN KSVNESLNNL FITEEDYQAL RTSIDAYDNF DNISLAQRLE 1500
    KHELIEFRRI AAYLFKGNNR WKQSVELCKK DSLYKDAMQY ASESKDTELA 1550
    EELLQWFLQE EKRECFGACL FTCYDLLRPD VVLETAWRHN IMDFAMPYFI 1600
    QVMKEYLTKV DKLDASESLR KEEEQATETQ PIVYGQPQLM LTAGPSVAVP 1650
    PQAPFGYGYT APPYGQPQPG FGYSM 1675
    Length:1,675
    Mass (Da):191,615
    Last modified:January 23, 2007 - v5
    Checksum:i6C4F2D54950079E2
    GO
    Isoform 2 (identifier: Q00610-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1636-1639: QPQL → NLSL
         1640-1675: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,639
    Mass (Da):187,890
    Checksum:i9CE5237A31C9B0C6
    GO

    Sequence cautioni

    The sequence BAA04801.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti560 – 5601Q → R in CAA39363. (PubMed:1765375)Curated
    Sequence conflicti817 – 8171G → V in CAA39363. (PubMed:1765375)Curated
    Sequence conflicti923 – 9231R → H in CAE45761. (PubMed:17974005)Curated
    Sequence conflicti1563 – 15631R → G in CAE45761. (PubMed:17974005)Curated
    Sequence conflicti1652 – 16521Q → R in CAE45761. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1636 – 16394QPQL → NLSL in isoform 2. 1 PublicationVSP_011570
    Alternative sequencei1640 – 167536Missing in isoform 2. 1 PublicationVSP_011571Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21260 mRNA. Translation: BAA04801.2. Different initiation.
    BX640615 mRNA. Translation: CAE45761.1.
    CH471109 Genomic DNA. Translation: EAW94396.1.
    CH471109 Genomic DNA. Translation: EAW94399.1.
    BC051800 mRNA. Translation: AAH51800.1.
    BC054489 mRNA. Translation: AAH54489.1.
    X55878 mRNA. Translation: CAA39363.1.
    CCDSiCCDS32696.1. [Q00610-1]
    PIRiA40573.
    RefSeqiNP_004850.1. NM_004859.3. [Q00610-1]
    UniGeneiHs.491351.

    Genome annotation databases

    EnsembliENST00000269122; ENSP00000269122; ENSG00000141367. [Q00610-1]
    ENST00000393043; ENSP00000376763; ENSG00000141367. [Q00610-2]
    GeneIDi1213.
    KEGGihsa:1213.
    UCSCiuc002ixp.3. human. [Q00610-2]
    uc002ixq.1. human. [Q00610-1]

    Polymorphism databases

    DMDMi1705916.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia

    Clathrin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21260 mRNA. Translation: BAA04801.2 . Different initiation.
    BX640615 mRNA. Translation: CAE45761.1 .
    CH471109 Genomic DNA. Translation: EAW94396.1 .
    CH471109 Genomic DNA. Translation: EAW94399.1 .
    BC051800 mRNA. Translation: AAH51800.1 .
    BC054489 mRNA. Translation: AAH54489.1 .
    X55878 mRNA. Translation: CAA39363.1 .
    CCDSi CCDS32696.1. [Q00610-1 ]
    PIRi A40573.
    RefSeqi NP_004850.1. NM_004859.3. [Q00610-1 ]
    UniGenei Hs.491351.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XZG X-ray 1.70 A 1-364 [» ]
    4G55 X-ray 1.69 A 1-364 [» ]
    ProteinModelPortali Q00610.
    SMRi Q00610. Positions 1-493, 1077-1630.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107623. 124 interactions.
    IntActi Q00610. 49 interactions.
    MINTi MINT-4998595.
    STRINGi 9606.ENSP00000269122.

    PTM databases

    PhosphoSitei Q00610.

    Polymorphism databases

    DMDMi 1705916.

    Proteomic databases

    MaxQBi Q00610.
    PaxDbi Q00610.
    PRIDEi Q00610.

    Protocols and materials databases

    DNASUi 1213.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000269122 ; ENSP00000269122 ; ENSG00000141367 . [Q00610-1 ]
    ENST00000393043 ; ENSP00000376763 ; ENSG00000141367 . [Q00610-2 ]
    GeneIDi 1213.
    KEGGi hsa:1213.
    UCSCi uc002ixp.3. human. [Q00610-2 ]
    uc002ixq.1. human. [Q00610-1 ]

    Organism-specific databases

    CTDi 1213.
    GeneCardsi GC17P057697.
    H-InvDB HIX0039315.
    HGNCi HGNC:2092. CLTC.
    HPAi CAB010389.
    CAB011571.
    CAB017155.
    MIMi 118955. gene.
    neXtProti NX_Q00610.
    Orphaneti 178342. Inflammatory myofibroblastic tumor.
    319308. Translocation renal cell carcinoma.
    PharmGKBi PA26618.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314149.
    HOGENOMi HOG000188877.
    HOVERGENi HBG005344.
    InParanoidi Q00610.
    KOi K04646.
    OMAi WKWFSEK.
    OrthoDBi EOG7Z0JVM.
    PhylomeDBi Q00610.
    TreeFami TF300059.

    Enzyme and pathway databases

    Reactomei REACT_11035. Gap junction degradation.
    REACT_11049. Formation of annular gap junctions.
    REACT_121399. MHC class II antigen presentation.
    REACT_172599. WNT5A-dependent internalization of FZD4.
    REACT_19287. Lysosome Vesicle Biogenesis.
    REACT_19400. Golgi Associated Vesicle Biogenesis.
    SignaLinki Q00610.

    Miscellaneous databases

    ChiTaRSi CLTC. human.
    EvolutionaryTracei Q00610.
    GeneWikii CLTC.
    GenomeRNAii 1213.
    NextBioi 4999.
    PROi Q00610.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q00610.
    Bgeei Q00610.
    CleanExi HS_CLTC.
    Genevestigatori Q00610.

    Family and domain databases

    Gene3Di 1.25.40.10. 4 hits.
    2.130.10.110. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000547. Clathrin_H-chain/VPS_repeat.
    IPR016025. Clathrin_H-chain_link/propller.
    IPR015348. Clathrin_H-chain_linker_core.
    IPR001473. Clathrin_H-chain_propeller_N.
    IPR022365. Clathrin_H-chain_propeller_rpt.
    IPR016341. Clathrin_heavy_chain.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    Pfami PF00637. Clathrin. 7 hits.
    PF09268. Clathrin-link. 1 hit.
    PF01394. Clathrin_propel. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF002290. Clathrin_H_chain. 1 hit.
    SMARTi SM00299. CLH. 7 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 6 hits.
    SSF50989. SSF50989. 1 hit.
    PROSITEi PS50236. CHCR. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
      Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
      DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Fetal kidney.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: PNS and Testis.
    5. "Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter."
      Dodge G.R., Kovalszky I., McBride O.W., Yi H.F., Chu M.-L., Saitta B., Stokes D.G., Iozzo R.V.
      Genomics 11:174-178(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 560-864 (ISOFORMS 1/2).
      Tissue: Colon.
    6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-8.
      Tissue: Platelet.
    7. Cited for: PROTEIN SEQUENCE OF 2-8; 64-78; 87-96; 164-205; 228-245; 270-278; 298-320; 355-382; 469-481; 507-519; 572-610; 626-638; 799-806; 831-852; 855-865; 882-903; 1011-1037; 1074-1101; 1123-1130; 1166-1179; 1183-1204; 1216-1245; 1312-1326; 1398-1406; 1435-1453; 1482-1498; 1502-1508; 1510-1516 AND 1610-1620, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma, Hepatoma and Mammary carcinoma.
    8. "The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis."
      Waelter S., Scherzinger E., Hasenbank R., Nordhoff E., Lurz R., Goehler H., Gauss C., Sathasivam K., Bates G.P., Lehrach H., Wanker E.E.
      Hum. Mol. Genet. 10:1807-1817(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HIP1.
    9. "Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor."
      Giri D.K., Ali-Seyed M., Li L.Y., Lee D.F., Ling P., Bartholomeusz G., Wang S.C., Hung M.C.
      Mol. Cell. Biol. 25:11005-11018(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ERBB2.
    10. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Melanoma.
    11. "FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes."
      Jarczowski F., Fischer G., Edlich F.
      Biochemistry 47:6946-6952(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FKBP6.
    12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1494, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-634 AND TYR-1477, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-856; LYS-1441 AND LYS-1501, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    21. Cited for: X-RAY CRYSTALLOGRAPHY (1.69 ANGSTROMS) OF 1-364 IN COMPLEX WITH INHIBITORS, WD40-LIKE REPEATS.

    Entry informationi

    Entry nameiCLH1_HUMAN
    AccessioniPrimary (citable) accession number: Q00610
    Secondary accession number(s): D3DU00, Q6N0A0, Q86TF2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 149 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3