Reviewed, UniProtKB/Swiss-Prot Q00610 (CLH1_HUMAN)

Names and origin

Protein names

Recommended name:
    Clathrin heavy chain 1
Alternative name(s):
    CLH-17

Gene names

Name:	CLTC
Synonyms:	CLH17, CLTCL2, KIAA0034

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1675 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
Subunit structure	Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium. Interacts with HIP1. Ref.7
Subcellular location	Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane › coated pit; Peripheral membrane protein; Cytoplasmic side. Melanosome. Note: Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Ref.9
Sequence similarities	Belongs to the clathrin heavy chain family.

Ontologies

Keywords
Cellular component	Coated pit Cytoplasmic vesicle Membrane
Coding sequence diversity	Alternative splicing
PTM	Acetylation Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	intracellular protein transport Ref.4 Non-traceable author statement. Source: UniProtKB vesicle-mediated transport Inferred from electronic annotation. Source: InterPro
Cellular component	clathrin coat of coated pit Inferred from electronic annotation. Source: InterPro clathrin coat of trans-Golgi network vesicle Inferred from electronic annotation. Source: InterPro melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct structural molecule activity Ref.4 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ACK2	O02742	1	EBI-354967,EBI-457220	From a different organism.
IKBKE	Q14164	1	EBI-354967,EBI-307369
MCC	P23508	1	EBI-354967,EBI-307531
NDRG1	Q92597	1	EBI-354967,EBI-716486
TFE3	P19532	1	EBI-354967,EBI-1048957

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q00610-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q00610-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1636-1639: QPQL → NLSL
     1640-1675: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.5 Ref.6
	Chain	2 – 1675	1674	Clathrin heavy chain 1		PRO_0000205778
Regions
	Region	2 – 479	478	Globular terminal domain
	Region	449 – 465	17	Binding site for the uncoating ATPase, involved in lattice disassembly Potential
	Region	480 – 523	44	Flexible linker
	Region	524 – 1675	1152	Heavy chain arm
	Region	524 – 634	111	Distal segment
	Region	639 – 1675	1037	Proximal segment
	Region	1213 – 1522	310	Involved in binding clathrin light chain By similarity
	Region	1550 – 1675	126	Trimerization By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.6
	Modified residue	394	1	Phosphothreonine Ref.8 Ref.11 Ref.12
	Modified residue	634	1	Phosphotyrosine Ref.10
	Modified residue	883	1	Phosphotyrosine Ref.11
	Modified residue	899	1	Phosphotyrosine Ref.10
	Modified residue	1494	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1636 – 1639	4	QPQL → NLSL in isoform 2.		VSP_011570
	Alternative sequence	1640 – 1675	36	Missing in isoform 2.		VSP_011571
Experimental info
	Sequence conflict	560	1	Q → R in CAA39363. Ref.4
	Sequence conflict	817	1	G → V in CAA39363. Ref.4
	Sequence conflict	923	1	R → H in CAE45761. Ref.2
	Sequence conflict	1563	1	R → G in CAE45761. Ref.2
	Sequence conflict	1652	1	Q → R in CAE45761. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 5. Checksum: 6C4F2D54950079E2	FASTA	1,675	191,615
	10 20 30 40 50 60 MAQILPIRFQ EHLQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV VIIDMNDPSN 70 80 90 100 110 120 PIRRPISADS AIMNPASKVI ALKAGKTLQI FNIEMKSKMK AHTMTDDVTF WKWISLNTVA 130 140 150 160 170 180 LVTDNAVYHW SMEGESQPVK MFDRHSSLAG CQIINYRTDA KQKWLLLTGI SAQQNRVVGA 190 200 210 220 230 240 MQLYSVDRKV SQPIEGHAAS FAQFKMEGNA EESTLFCFAV RGQAGGKLHI IEVGTPPTGN 250 260 270 280 290 300 QPFPKKAVDV FFPPEAQNDF PVAMQISEKH DVVFLITKYG YIHLYDLETG TCIYMNRISG 310 320 330 340 350 360 ETIFVTAPHE ATAGIIGVNR KGQVLSVCVE EENIIPYITN VLQNPDLALR MAVRNNLAGA 370 380 390 400 410 420 EELFARKFNA LFAQGNYSEA AKVAANAPKG ILRTPDTIRR FQSVPAQPGQ TSPLLQYFGI 430 440 450 460 470 480 LLDQGQLNKY ESLELCRPVL QQGRKQLLEK WLKEDKLECS EELGDLVKSV DPTLALSVYL 490 500 510 520 530 540 RANVPNKVIQ CFAETGQVQK IVLYAKKVGY TPDWIFLLRN VMRISPDQGQ QFAQMLVQDE 550 560 570 580 590 600 EPLADITQIV DVFMEYNLIQ QCTAFLLDAL KNNRPSEGPL QTRLLEMNLM HAPQVADAIL 610 620 630 640 650 660 GNQMFTHYDR AHIAQLCEKA GLLQRALEHF TDLYDIKRAV VHTHLLNPEW LVNYFGSLSV 670 680 690 700 710 720 EDSLECLRAM LSANIRQNLQ ICVQVASKYH EQLSTQSLIE LFESFKSFEG LFYFLGSIVN 730 740 750 760 770 780 FSQDPDVHFK YIQAACKTGQ IKEVERICRE SNCYDPERVK NFLKEAKLTD QLPLIIVCDR 790 800 810 820 830 840 FDFVHDLVLY LYRNNLQKYI EIYVQKVNPS RLPVVIGGLL DVDCSEDVIK NLILVVRGQF 850 860 870 880 890 900 STDELVAEVE KRNRLKLLLP WLEARIHEGC EEPATHNALA KIYIDSNNNP ERFLRENPYY 910 920 930 940 950 960 DSRVVGKYCE KRDPHLACVA YERGQCDLEL INVCNENSLF KSLSRYLVRR KDPELWGSVL 970 980 990 1000 1010 1020 LESNPYRRPL IDQVVQTALS ETQDPEEVSV TVKAFMTADL PNELIELLEK IVLDNSVFSE 1030 1040 1050 1060 1070 1080 HRNLQNLLIL TAIKADRTRV MEYINRLDNY DAPDIANIAI SNELFEEAFA IFRKFDVNTS 1090 1100 1110 1120 1130 1140 AVQVLIEHIG NLDRAYEFAE RCNEPAVWSQ LAKAQLQKGM VKEAIDSYIK ADDPSSYMEV 1150 1160 1170 1180 1190 1200 VQAANTSGNW EELVKYLQMA RKKARESYVE TELIFALAKT NRLAELEEFI NGPNNAHIQQ 1210 1220 1230 1240 1250 1260 VGDRCYDEKM YDAAKLLYNN VSNFGRLAST LVHLGEYQAA VDGARKANST RTWKEVCFAC 1270 1280 1290 1300 1310 1320 VDGKEFRLAQ MCGLHIVVHA DELEELINYY QDRGYFEELI TMLEAALGLE RAHMGMFTEL 1330 1340 1350 1360 1370 1380 AILYSKFKPQ KMREHLELFW SRVNIPKVLR AAEQAHLWAE LVFLYDKYEE YDNAIITMMN 1390 1400 1410 1420 1430 1440 HPTDAWKEGQ FKDIITKVAN VELYYRAIQF YLEFKPLLLN DLLMVLSPRL DHTRAVNYFS 1450 1460 1470 1480 1490 1500 KVKQLPLVKP YLRSVQNHNN KSVNESLNNL FITEEDYQAL RTSIDAYDNF DNISLAQRLE 1510 1520 1530 1540 1550 1560 KHELIEFRRI AAYLFKGNNR WKQSVELCKK DSLYKDAMQY ASESKDTELA EELLQWFLQE 1570 1580 1590 1600 1610 1620 EKRECFGACL FTCYDLLRPD VVLETAWRHN IMDFAMPYFI QVMKEYLTKV DKLDASESLR 1630 1640 1650 1660 1670 KEEEQATETQ PIVYGQPQLM LTAGPSVAVP PQAPFGYGYT APPYGQPQPG FGYSM
	Isoform 2. Checksum: 9CE5237A31C9B0C6	FASTA	1,639	187,890
	10 20 30 40 50 60 MAQILPIRFQ EHLQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV VIIDMNDPSN 70 80 90 100 110 120 PIRRPISADS AIMNPASKVI ALKAGKTLQI FNIEMKSKMK AHTMTDDVTF WKWISLNTVA 130 140 150 160 170 180 LVTDNAVYHW SMEGESQPVK MFDRHSSLAG CQIINYRTDA KQKWLLLTGI SAQQNRVVGA 190 200 210 220 230 240 MQLYSVDRKV SQPIEGHAAS FAQFKMEGNA EESTLFCFAV RGQAGGKLHI IEVGTPPTGN 250 260 270 280 290 300 QPFPKKAVDV FFPPEAQNDF PVAMQISEKH DVVFLITKYG YIHLYDLETG TCIYMNRISG 310 320 330 340 350 360 ETIFVTAPHE ATAGIIGVNR KGQVLSVCVE EENIIPYITN VLQNPDLALR MAVRNNLAGA 370 380 390 400 410 420 EELFARKFNA LFAQGNYSEA AKVAANAPKG ILRTPDTIRR FQSVPAQPGQ TSPLLQYFGI 430 440 450 460 470 480 LLDQGQLNKY ESLELCRPVL QQGRKQLLEK WLKEDKLECS EELGDLVKSV DPTLALSVYL 490 500 510 520 530 540 RANVPNKVIQ CFAETGQVQK IVLYAKKVGY TPDWIFLLRN VMRISPDQGQ QFAQMLVQDE 550 560 570 580 590 600 EPLADITQIV DVFMEYNLIQ QCTAFLLDAL KNNRPSEGPL QTRLLEMNLM HAPQVADAIL 610 620 630 640 650 660 GNQMFTHYDR AHIAQLCEKA GLLQRALEHF TDLYDIKRAV VHTHLLNPEW LVNYFGSLSV 670 680 690 700 710 720 EDSLECLRAM LSANIRQNLQ ICVQVASKYH EQLSTQSLIE LFESFKSFEG LFYFLGSIVN 730 740 750 760 770 780 FSQDPDVHFK YIQAACKTGQ IKEVERICRE SNCYDPERVK NFLKEAKLTD QLPLIIVCDR 790 800 810 820 830 840 FDFVHDLVLY LYRNNLQKYI EIYVQKVNPS RLPVVIGGLL DVDCSEDVIK NLILVVRGQF 850 860 870 880 890 900 STDELVAEVE KRNRLKLLLP WLEARIHEGC EEPATHNALA KIYIDSNNNP ERFLRENPYY 910 920 930 940 950 960 DSRVVGKYCE KRDPHLACVA YERGQCDLEL INVCNENSLF KSLSRYLVRR KDPELWGSVL 970 980 990 1000 1010 1020 LESNPYRRPL IDQVVQTALS ETQDPEEVSV TVKAFMTADL PNELIELLEK IVLDNSVFSE 1030 1040 1050 1060 1070 1080 HRNLQNLLIL TAIKADRTRV MEYINRLDNY DAPDIANIAI SNELFEEAFA IFRKFDVNTS 1090 1100 1110 1120 1130 1140 AVQVLIEHIG NLDRAYEFAE RCNEPAVWSQ LAKAQLQKGM VKEAIDSYIK ADDPSSYMEV 1150 1160 1170 1180 1190 1200 VQAANTSGNW EELVKYLQMA RKKARESYVE TELIFALAKT NRLAELEEFI NGPNNAHIQQ 1210 1220 1230 1240 1250 1260 VGDRCYDEKM YDAAKLLYNN VSNFGRLAST LVHLGEYQAA VDGARKANST RTWKEVCFAC 1270 1280 1290 1300 1310 1320 VDGKEFRLAQ MCGLHIVVHA DELEELINYY QDRGYFEELI TMLEAALGLE RAHMGMFTEL 1330 1340 1350 1360 1370 1380 AILYSKFKPQ KMREHLELFW SRVNIPKVLR AAEQAHLWAE LVFLYDKYEE YDNAIITMMN 1390 1400 1410 1420 1430 1440 HPTDAWKEGQ FKDIITKVAN VELYYRAIQF YLEFKPLLLN DLLMVLSPRL DHTRAVNYFS 1450 1460 1470 1480 1490 1500 KVKQLPLVKP YLRSVQNHNN KSVNESLNNL FITEEDYQAL RTSIDAYDNF DNISLAQRLE 1510 1520 1530 1540 1550 1560 KHELIEFRRI AAYLFKGNNR WKQSVELCKK DSLYKDAMQY ASESKDTELA EELLQWFLQE 1570 1580 1590 1600 1610 1620 EKRECFGACL FTCYDLLRPD VVLETAWRHN IMDFAMPYFI QVMKEYLTKV DKLDASESLR 1630 KEEEQATETQ PIVYGNLSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1." Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S. DNA Res. 1:27-35(1994) [PubMed: 7584026] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Fetal kidney.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: PNS and Testis.
[4]	"Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter." Dodge G.R., Kovalszky I., McBride O.W., Yi H.F., Chu M.-L., Saitta B., Stokes D.G., Iozzo R.V. Genomics 11:174-178(1991) [PubMed: 1765375] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 560-864 (ISOFORMS 1/2). Tissue: Colon.
[5]	"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed: 12665801] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-8. Tissue: Platelet.
[6]	Bienvenut W.V., Calvo F., Matallanas D., Cooper W.N., Boldt K., von Kriegsheim A.F., Kolch W. Submitted (FEB-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-8; 64-78; 87-96; 164-205; 228-245; 270-278; 298-320; 355-382; 469-481; 507-519; 572-610; 626-638; 799-806; 831-852; 855-865; 882-903; 1011-1037; 1074-1101; 1123-1130; 1166-1179; 1183-1204; 1216-1245; 1312-1326; 1398-1406; 1435-1453; 1482-1498; 1502-1508; 1510-1516 AND 1610-1620, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: Cervix carcinoma, Hepatoma and Mammary carcinoma.
[7]	"The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis." Waelter S., Scherzinger E., Hasenbank R., Nordhoff E., Lurz R., Goehler H., Gauss C., Sathasivam K., Bates G.P., Lehrach H., Wanker E.E. Hum. Mol. Genet. 10:1807-1817(2001) [PubMed: 11532990] [Abstract] Cited for: INTERACTION WITH HIP1.
[8]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394 AND SER-1494, MASS SPECTROMETRY. Tissue: Epithelium.
[9]	"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes." Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H., Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R., Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E., Hunt D.F. J. Proteome Res. 5:3135-3144(2006) [PubMed: 17081065] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[10]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-634 AND TYR-899, MASS SPECTROMETRY.
[11]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394 AND TYR-883, MASS SPECTROMETRY.
[12]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394, MASS SPECTROMETRY.
[13]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Wikipedia

Clathrin entry

Cross-references

Sequence databases
EMBLGenBankDDBJ	D21260 mRNA. Translation: BAA04801.2. Different initiation. BX640615 mRNA. Translation: CAE45761.1. BC051800 mRNA. Translation: AAH51800.1. BC054489 mRNA. Translation: AAH54489.1. X55878 mRNA. Translation: CAA39363.1.
IPI	IPI00024067. IPI00455383.
PIR	A40573.
RefSeq	NP_004850.1.
UniGene	Hs.491351 Hs.663896
3D structure databases
HSSP	HSSP built from PDB template 1BPO based on UniProtKB P11442.
SMR	Q00610. Positions 1-493.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q00610. 34 interactions.
PTM databases
PhosphoSite	Q00610.
Proteomic databases
PRIDE	Q00610.
Genome annotation databases
Ensembl	ENSG00000141367. Homo sapiens. [Contig view]
GeneID	1213.
KEGG	hsa:1213.
Organism-specific databases
GeneCards	GC17P055052.
H-InvDB	HIX0014044.
HGNC	HGNC:2092. CLTC.
HPA	CAB010389. CAB017155.
MIM	118955. gene.
PharmGKB	PA26618.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q00610.
HOVERGEN	Q00610.
OMA	Q00610. LDFRSTT.
Enzyme and pathway databases
Pathway_Interaction_DB	arf6_traffickingpathway. Arf6 trafficking events.
Reactome	REACT_11061. Signalling by NGF. REACT_11123. Membrane Trafficking. REACT_9417. Signaling by EGFR. REACT_9480. Gap junction trafficking and regulation.
Gene expression databases
ArrayExpress	Q00610.
Bgee	Q00610.
CleanEx	HS_CLTC.
GermOnline	ENSG00000141367. Homo sapiens.
Family and domain databases
InterPro	IPR000547. Clathrin_H-chain/VPS_repeat. IPR016025. Clathrin_H-chain_link/propller. IPR015348. Clathrin_H-chain_linker_core. IPR001473. Clathrin_H-chain_propeller_N. IPR016341. Clathrin_heavy_chain. IPR011990. TPR-like_helical. [Graphical view]
Gene3D	G3DSA:2.130.10.110. Clathrin_H-chain_link/propller. 1 hit. G3DSA:1.25.40.10. TPR-like_helical. 1 hit.
Pfam	PF00637. Clathrin. 7 hits. PF09268. Clathrin-link. 1 hit. PF01394. Clathrin_propel. 7 hits. [Graphical view]
PIRSF	PIRSF002290. Clathrin_H_chain. 1 hit.
SMART	SM00299. CLH. 7 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	4999.
SOURCE	Search...

Entry information

Entry name

CLH1_HUMAN

Accession

Primary (citable) accession number: Q00610
Secondary accession number(s): Q6N0A0, Q86TF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 90 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)