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Protein

Cdc42 effector protein 1

Gene

CDC42EP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ00587.

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 1
Alternative name(s):
Binder of Rho GTPases 5
Serum protein MSE55
Gene namesi
Name:CDC42EP1
Synonyms:BORG5, CEP1, MSE55
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:17014. CDC42EP1.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: HPA
  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: HPA
  • focal adhesion Source: UniProtKB
  • Golgi apparatus Source: HPA
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi36 – 4712DMISH…GDFRH → AMISHALGDFRA: No binding with CDC42. 1 PublicationAdd
BLAST

Organism-specific databases

PharmGKBiPA38430.

Polymorphism and mutation databases

BioMutaiCDC42EP1.
DMDMi462623.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Cdc42 effector protein 1PRO_0000212657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191PhosphoserineCombined sources
Modified residuei27 – 271PhosphoserineCombined sources
Modified residuei34 – 341PhosphothreonineBy similarity
Modified residuei39 – 391PhosphoserineBy similarity
Modified residuei65 – 651PhosphoserineCombined sources
Modified residuei73 – 731PhosphoserineCombined sources
Modified residuei77 – 771PhosphoserineCombined sources
Modified residuei101 – 1011PhosphoserineCombined sources
Modified residuei113 – 1131PhosphoserineCombined sources
Modified residuei121 – 1211PhosphoserineCombined sources
Modified residuei139 – 1391PhosphoserineBy similarity
Modified residuei180 – 1801PhosphoserineCombined sources
Modified residuei190 – 1901PhosphoserineCombined sources
Modified residuei192 – 1921PhosphoserineCombined sources
Modified residuei195 – 1951PhosphoserineCombined sources
Modified residuei303 – 3031PhosphoserineBy similarity
Modified residuei350 – 3501PhosphoserineCombined sources
Modified residuei353 – 3531PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ00587.
MaxQBiQ00587.
PaxDbiQ00587.
PeptideAtlasiQ00587.
PRIDEiQ00587.

PTM databases

iPTMnetiQ00587.
PhosphoSiteiQ00587.

Expressioni

Tissue specificityi

Endothelial and bone marrow stromal cells.

Gene expression databases

BgeeiENSG00000128283.
CleanExiHS_CDC42EP1.
ExpressionAtlasiQ00587. baseline and differential.
GenevisibleiQ00587. HS.

Organism-specific databases

HPAiHPA006379.

Interactioni

Subunit structurei

Interacts with RHOQ and CDC42, in a GTP-dependent manner.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC42P609536EBI-744130,EBI-81752
DEF6Q9H4E73EBI-744130,EBI-745369
RHOJQ9H4E53EBI-744130,EBI-6285694

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • GTP-Rho binding Source: GO_Central

Protein-protein interaction databases

BioGridi116308. 14 interactions.
IntActiQ00587. 16 interactions.
MINTiMINT-1454089.
STRINGi9606.ENSP00000249014.

Structurei

3D structure databases

ProteinModelPortaliQ00587.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 5215CRIBPROSITE-ProRule annotationAdd
BLAST
Repeati220 – 22671
Repeati227 – 23372
Repeati234 – 24073
Repeati241 – 24774
Repeati248 – 25475
Repeati255 – 26176
Repeati262 – 26877
Repeati269 – 27578

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni220 – 275568 X 7 AA tandem repeats of [PT]-[AT]-A-[ENT]-[PT]-[PTS]-[AG]Add
BLAST

Domaini

The CRIB domain mediates interaction with CDC42.

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated
Contains 1 CRIB domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGPN. Eukaryota.
ENOG4111PPX. LUCA.
GeneTreeiENSGT00730000110869.
HOGENOMiHOG000095252.
HOVERGENiHBG080906.
InParanoidiQ00587.
OMAiQANTFEF.
OrthoDBiEOG091G0IY8.
PhylomeDBiQ00587.
TreeFamiTF331725.

Family and domain databases

InterProiIPR029273. Cdc42_effect.
IPR000095. CRIB_dom.
[Graphical view]
PfamiPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q00587-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGPQGGRGA ATMSLGKLSP VGWVSSSQGK RRLTADMISH PLGDFRHTMH
60 70 80 90 100
VGRGGDVFGD TSFLSNHGGS SGSTHRSPRS FLAKKLQLVR RVGAPPRRMA
110 120 130 140 150
SPPAPSPAPP AISPIIKNAI SLPQLNQAAY DSLVVGKLSF DSSPTSSTDG
160 170 180 190 200
HSSYGLDSGF CTISRLPRSE KPHDRDRDGS FPSEPGLRRS DSLLSFRLDL
210 220 230 240 250
DLGPSLLSEL LGVMSLPEAP AAETPAPAAN PPAPTANPTG PAANPPATTA
260 270 280 290 300
NPPAPAANPS APAATPTGPA ANPPAPAASS TPHGHCPNGV TAGLGPVAEV
310 320 330 340 350
KSSPVGGGPR GPAGPALGRH WGAGWDGGHH YPEMDARQER VEVLPQARAS
360 370 380 390
WESLDEEWRA PQAGSRTPVP STVQANTFEF ADAEEDDEVK V
Length:391
Mass (Da):40,295
Last modified:February 1, 1994 - v1
Checksum:i625EA3C71F20CF2B
GO
Isoform 2 (identifier: Q00587-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-264: Missing.

Show »
Length:384
Mass (Da):39,686
Checksum:i3D056D62399AE422
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei258 – 2647Missing in isoform 2. 2 PublicationsVSP_004325

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88338 mRNA. Translation: AAA36606.1.
CR456524 mRNA. Translation: CAG30410.1.
AK292190 mRNA. Translation: BAF84879.1.
AL022315 Genomic DNA. Translation: CAB42833.1.
CH471095 Genomic DNA. Translation: EAW60164.1.
BC009356 mRNA. Translation: AAH09356.1.
CCDSiCCDS13949.1. [Q00587-1]
PIRiA42973.
RefSeqiNP_689449.1. NM_152243.2. [Q00587-1]
XP_006724170.1. XM_006724107.1. [Q00587-1]
XP_006724171.1. XM_006724108.1. [Q00587-1]
XP_006724172.1. XM_006724109.1. [Q00587-1]
UniGeneiHs.225356.

Genome annotation databases

EnsembliENST00000249014; ENSP00000249014; ENSG00000128283. [Q00587-1]
GeneIDi11135.
KEGGihsa:11135.
UCSCiuc003asz.5. human. [Q00587-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88338 mRNA. Translation: AAA36606.1.
CR456524 mRNA. Translation: CAG30410.1.
AK292190 mRNA. Translation: BAF84879.1.
AL022315 Genomic DNA. Translation: CAB42833.1.
CH471095 Genomic DNA. Translation: EAW60164.1.
BC009356 mRNA. Translation: AAH09356.1.
CCDSiCCDS13949.1. [Q00587-1]
PIRiA42973.
RefSeqiNP_689449.1. NM_152243.2. [Q00587-1]
XP_006724170.1. XM_006724107.1. [Q00587-1]
XP_006724171.1. XM_006724108.1. [Q00587-1]
XP_006724172.1. XM_006724109.1. [Q00587-1]
UniGeneiHs.225356.

3D structure databases

ProteinModelPortaliQ00587.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116308. 14 interactions.
IntActiQ00587. 16 interactions.
MINTiMINT-1454089.
STRINGi9606.ENSP00000249014.

PTM databases

iPTMnetiQ00587.
PhosphoSiteiQ00587.

Polymorphism and mutation databases

BioMutaiCDC42EP1.
DMDMi462623.

Proteomic databases

EPDiQ00587.
MaxQBiQ00587.
PaxDbiQ00587.
PeptideAtlasiQ00587.
PRIDEiQ00587.

Protocols and materials databases

DNASUi11135.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249014; ENSP00000249014; ENSG00000128283. [Q00587-1]
GeneIDi11135.
KEGGihsa:11135.
UCSCiuc003asz.5. human. [Q00587-1]

Organism-specific databases

CTDi11135.
GeneCardsiCDC42EP1.
H-InvDBHIX0016445.
HGNCiHGNC:17014. CDC42EP1.
HPAiHPA006379.
MIMi606084. gene.
neXtProtiNX_Q00587.
PharmGKBiPA38430.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGPN. Eukaryota.
ENOG4111PPX. LUCA.
GeneTreeiENSGT00730000110869.
HOGENOMiHOG000095252.
HOVERGENiHBG080906.
InParanoidiQ00587.
OMAiQANTFEF.
OrthoDBiEOG091G0IY8.
PhylomeDBiQ00587.
TreeFamiTF331725.

Enzyme and pathway databases

SignaLinkiQ00587.

Miscellaneous databases

ChiTaRSiCDC42EP1. human.
GeneWikiiCDC42EP1.
GenomeRNAii11135.
PROiQ00587.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128283.
CleanExiHS_CDC42EP1.
ExpressionAtlasiQ00587. baseline and differential.
GenevisibleiQ00587. HS.

Family and domain databases

InterProiIPR029273. Cdc42_effect.
IPR000095. CRIB_dom.
[Graphical view]
PfamiPF14957. BORG_CEP. 1 hit.
PF00786. PBD. 1 hit.
[Graphical view]
SMARTiSM00285. PBD. 1 hit.
[Graphical view]
PROSITEiPS50108. CRIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBORG5_HUMAN
AccessioniPrimary (citable) accession number: Q00587
Secondary accession number(s): A8K825, Q96GN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 7, 2016
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.