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Protein

Cdc42 effector protein 1

Gene

CDC42EP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ00587

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 1
Alternative name(s):
Binder of Rho GTPases 5
Serum protein MSE55
Gene namesi
Name:CDC42EP1
Synonyms:BORG5, CEP1, MSE55
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000128283.6
HGNCiHGNC:17014 CDC42EP1
MIMi606084 gene
neXtProtiNX_Q00587

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi36 – 47DMISH…GDFRH → AMISHALGDFRA: No binding with CDC42. 1 PublicationAdd BLAST12

Organism-specific databases

DisGeNETi11135
OpenTargetsiENSG00000128283
PharmGKBiPA38430

Polymorphism and mutation databases

BioMutaiCDC42EP1
DMDMi462623

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126571 – 391Cdc42 effector protein 1Add BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1
Modified residuei27PhosphoserineCombined sources1
Modified residuei34PhosphothreonineBy similarity1
Modified residuei39PhosphoserineBy similarity1
Modified residuei53Omega-N-methylarginineCombined sources1
Modified residuei65PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei139PhosphoserineBy similarity1
Modified residuei180PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Modified residuei192PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei303PhosphoserineBy similarity1
Modified residuei350PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ00587
MaxQBiQ00587
PaxDbiQ00587
PeptideAtlasiQ00587
PRIDEiQ00587
ProteomicsDBi57858
57859 [Q00587-2]

PTM databases

iPTMnetiQ00587
PhosphoSitePlusiQ00587

Expressioni

Tissue specificityi

Endothelial and bone marrow stromal cells.

Gene expression databases

BgeeiENSG00000128283
CleanExiHS_CDC42EP1
ExpressionAtlasiQ00587 baseline and differential
GenevisibleiQ00587 HS

Organism-specific databases

HPAiHPA006379

Interactioni

Subunit structurei

Interacts with RHOQ and CDC42, in a GTP-dependent manner.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116308, 17 interactors
IntActiQ00587, 34 interactors
MINTiQ00587
STRINGi9606.ENSP00000249014

Structurei

3D structure databases

ProteinModelPortaliQ00587
SMRiQ00587
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 52CRIBPROSITE-ProRule annotationAdd BLAST15
Repeati220 – 22617
Repeati227 – 23327
Repeati234 – 24037
Repeati241 – 24747
Repeati248 – 25457
Repeati255 – 26167
Repeati262 – 26877
Repeati269 – 27587

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni220 – 2758 X 7 AA tandem repeats of [PT]-[AT]-A-[ENT]-[PT]-[PTS]-[AG]Add BLAST56

Domaini

The CRIB domain mediates interaction with CDC42.

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGPN Eukaryota
ENOG4111PPX LUCA
GeneTreeiENSGT00730000110869
HOGENOMiHOG000095252
HOVERGENiHBG080906
InParanoidiQ00587
OMAiQANTFEF
OrthoDBiEOG091G0IY8
PhylomeDBiQ00587
TreeFamiTF331725

Family and domain databases

CDDicd00132 CRIB, 1 hit
InterProiView protein in InterPro
IPR029273 Cdc42_effect
IPR000095 CRIB_dom
PfamiView protein in Pfam
PF14957 BORG_CEP, 1 hit
PF00786 PBD, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q00587-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGPQGGRGA ATMSLGKLSP VGWVSSSQGK RRLTADMISH PLGDFRHTMH
60 70 80 90 100
VGRGGDVFGD TSFLSNHGGS SGSTHRSPRS FLAKKLQLVR RVGAPPRRMA
110 120 130 140 150
SPPAPSPAPP AISPIIKNAI SLPQLNQAAY DSLVVGKLSF DSSPTSSTDG
160 170 180 190 200
HSSYGLDSGF CTISRLPRSE KPHDRDRDGS FPSEPGLRRS DSLLSFRLDL
210 220 230 240 250
DLGPSLLSEL LGVMSLPEAP AAETPAPAAN PPAPTANPTG PAANPPATTA
260 270 280 290 300
NPPAPAANPS APAATPTGPA ANPPAPAASS TPHGHCPNGV TAGLGPVAEV
310 320 330 340 350
KSSPVGGGPR GPAGPALGRH WGAGWDGGHH YPEMDARQER VEVLPQARAS
360 370 380 390
WESLDEEWRA PQAGSRTPVP STVQANTFEF ADAEEDDEVK V
Length:391
Mass (Da):40,295
Last modified:February 1, 1994 - v1
Checksum:i625EA3C71F20CF2B
GO
Isoform 2 (identifier: Q00587-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-264: Missing.

Show »
Length:384
Mass (Da):39,686
Checksum:i3D056D62399AE422
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004325258 – 264Missing in isoform 2. 2 Publications7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88338 mRNA Translation: AAA36606.1
CR456524 mRNA Translation: CAG30410.1
AK292190 mRNA Translation: BAF84879.1
AL022315 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60164.1
BC009356 mRNA Translation: AAH09356.1
CCDSiCCDS13949.1 [Q00587-1]
PIRiA42973
RefSeqiNP_689449.1, NM_152243.2 [Q00587-1]
XP_006724170.1, XM_006724107.1 [Q00587-1]
XP_006724171.1, XM_006724108.1 [Q00587-1]
XP_006724172.1, XM_006724109.1 [Q00587-1]
XP_016884030.1, XM_017028541.1 [Q00587-1]
UniGeneiHs.225356

Genome annotation databases

EnsembliENST00000249014; ENSP00000249014; ENSG00000128283 [Q00587-1]
GeneIDi11135
KEGGihsa:11135
UCSCiuc003asz.5 human [Q00587-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBORG5_HUMAN
AccessioniPrimary (citable) accession number: Q00587
Secondary accession number(s): A8K825, Q96GN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 20, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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