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Protein

GTP-binding protein GTR1

Gene

GTR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTPase component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome. Functionally associated with the inorganic phosphate transporter PHO84. It is probably required for modulation of PHO84 or involved in its intracellular localization.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208GTPSequence analysis
Nucleotide bindingi61 – 655GTPBy similarity
Nucleotide bindingi126 – 1294GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • cellular response to amino acid stimulus Source: GO_Central
  • cellular response to starvation Source: GO_Central
  • chromatin silencing at telomere Source: SGD
  • negative regulation of autophagy Source: SGD
  • phosphate ion transport Source: SGD
  • positive regulation of TORC1 signaling Source: SGD
  • protein localization to vacuolar membrane Source: SGD
  • protein transport Source: UniProtKB-KW
  • transcription from RNA polymerase III promoter Source: SGD
  • transcription from RNA polymerase I promoter Source: SGD
Complete GO annotation...

Keywords - Biological processi

Phosphate transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32701-MONOMER.
ReactomeiR-SCE-165159. mTOR signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein GTR1
Gene namesi
Name:GTR1
Ordered Locus Names:YML121W
ORF Names:YM7056.05
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML121W.
SGDiS000004590. GTR1.

Subcellular locationi

GO - Cellular componenti

  • chromosome, telomeric region Source: GOC
  • cytoplasm Source: SGD
  • EGO complex Source: SGD
  • fungal-type vacuole membrane Source: SGD
  • Gtr1-Gtr2 GTPase complex Source: SGD
  • late endosome membrane Source: SGD
  • lysosome Source: GO_Central
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310GTP-binding protein GTR1PRO_0000122486Add
BLAST

Proteomic databases

MaxQBiQ00582.

Interactioni

Subunit structurei

Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1.1 Publication

Protein-protein interaction databases

BioGridi35083. 197 interactions.
DIPiDIP-1358N.
IntActiQ00582. 10 interactions.
MINTiMINT-394906.

Structurei

Secondary structure

1
310
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 125Combined sources
Helixi19 – 279Combined sources
Helixi33 – 375Combined sources
Beta strandi43 – 519Combined sources
Turni52 – 543Combined sources
Beta strandi55 – 628Combined sources
Helixi66 – 738Combined sources
Turni74 – 763Combined sources
Helixi77 – 815Combined sources
Beta strandi85 – 928Combined sources
Helixi98 – 11518Combined sources
Beta strandi120 – 1267Combined sources
Helixi128 – 1303Combined sources
Helixi133 – 15220Combined sources
Turni153 – 1553Combined sources
Beta strandi160 – 1634Combined sources
Helixi170 – 18011Combined sources
Helixi186 – 20015Combined sources
Beta strandi202 – 2098Combined sources
Turni210 – 2123Combined sources
Beta strandi215 – 2184Combined sources
Helixi242 – 25716Combined sources
Helixi258 – 2603Combined sources
Beta strandi264 – 2696Combined sources
Turni270 – 2723Combined sources
Beta strandi273 – 2797Combined sources
Beta strandi282 – 2898Combined sources
Helixi295 – 3017Combined sources
Turni302 – 3054Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R7WX-ray2.77A/C8-310[»]
4ARZX-ray3.10A1-310[»]
ProteinModelPortaliQ00582.
SMRiQ00582. Positions 4-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTR/RAG GTP-binding protein family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074769.
HOGENOMiHOG000173258.
InParanoidiQ00582.
KOiK16185.
OMAiISHCQRK.
OrthoDBiEOG715QDR.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006762. Gtr1_RagA.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11259. PTHR11259. 1 hit.
PfamiPF04670. Gtr1_RagA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q00582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNNRKKLL LMGRSGSGKS SMRSIIFSNY SAFDTRRLGA TIDVEHSHLR
60 70 80 90 100
FLGNMTLNLW DCGGQDVFME NYFTKQKDHI FQMVQVLIHV FDVESTEVLK
110 120 130 140 150
DIEIFAKALK QLRKYSPDAK IFVLLHKMDL VQLDKREELF QIMMKNLSET
160 170 180 190 200
SSEFGFPNLI GFPTSIWDES LYKAWSQIVC SLIPNMSNHQ SNLKKFKEIM
210 220 230 240 250
NALEIILFER TTFLVICSSN GENSNENHDS SDNNNVLLDP KRFEKISNIM
260 270 280 290 300
KNFKQSCTKL KSGFKTLILN NNIYVSELSS NMVCFIVLKD MNIPQELVLE
310
NIKKAKEFFQ
Length:310
Mass (Da):35,847
Last modified:October 1, 1993 - v1
Checksum:iB79CE7FE7AD2FDBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10018 Genomic DNA. Translation: BAA00907.1.
Z49218 Genomic DNA. Translation: CAA89159.1.
AY692917 Genomic DNA. Translation: AAT92936.1.
BK006946 Genomic DNA. Translation: DAA09777.1.
PIRiS31303.
RefSeqiNP_013585.1. NM_001182484.1.

Genome annotation databases

EnsemblFungiiYML121W; YML121W; YML121W.
GeneIDi854918.
KEGGisce:YML121W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10018 Genomic DNA. Translation: BAA00907.1.
Z49218 Genomic DNA. Translation: CAA89159.1.
AY692917 Genomic DNA. Translation: AAT92936.1.
BK006946 Genomic DNA. Translation: DAA09777.1.
PIRiS31303.
RefSeqiNP_013585.1. NM_001182484.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R7WX-ray2.77A/C8-310[»]
4ARZX-ray3.10A1-310[»]
ProteinModelPortaliQ00582.
SMRiQ00582. Positions 4-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35083. 197 interactions.
DIPiDIP-1358N.
IntActiQ00582. 10 interactions.
MINTiMINT-394906.

Proteomic databases

MaxQBiQ00582.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML121W; YML121W; YML121W.
GeneIDi854918.
KEGGisce:YML121W.

Organism-specific databases

EuPathDBiFungiDB:YML121W.
SGDiS000004590. GTR1.

Phylogenomic databases

GeneTreeiENSGT00550000074769.
HOGENOMiHOG000173258.
InParanoidiQ00582.
KOiK16185.
OMAiISHCQRK.
OrthoDBiEOG715QDR.

Enzyme and pathway databases

BioCyciYEAST:G3O-32701-MONOMER.
ReactomeiR-SCE-165159. mTOR signalling.

Miscellaneous databases

PROiQ00582.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006762. Gtr1_RagA.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11259. PTHR11259. 1 hit.
PfamiPF04670. Gtr1_RagA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Putative GTP-binding protein, Gtr1, associated with the function of the Pho84 inorganic phosphate transporter in Saccharomyces cerevisiae."
    Bun-Ya M., Harashima S., Oshima Y.
    Mol. Cell. Biol. 12:2958-2966(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast."
    Gao M., Kaiser C.A.
    Nat. Cell Biol. 8:657-667(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE GSE COMPLEX.

Entry informationi

Entry nameiGTR1_YEAST
AccessioniPrimary (citable) accession number: Q00582
Secondary accession number(s): D6W0G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 6, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 907 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.