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Protein

Lactococcin-A transport/processing ATP-binding protein LcnC

Gene

lcnC

Organism
Lactococcus lactis subsp. lactis (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the export process of the bacteriocin lactococcin A.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei17PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi515 – 522ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processBacteriocin transport, Protein transport, Transport
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiC39.001.
TCDBi3.A.1.112.3. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Lactococcin-A transport/processing ATP-binding protein LcnC (EC:3.4.22.-)
Gene namesi
Name:lcnC
Encoded oniPlasmid pNP20 Publication
OrganismiLactococcus lactis subsp. lactis (Streptococcus lactis)
Taxonomic identifieri1360 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei167 – 187HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei197 – 217HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei237 – 257HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei282 – 302HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei307 – 327HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei396 – 416HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000923991 – 715Lactococcin-A transport/processing ATP-binding protein LcnCAdd BLAST715

Structurei

3D structure databases

ProteinModelPortaliQ00564.
SMRiQ00564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 138Peptidase C39PROSITE-ProRule annotationAdd BLAST128
Domaini168 – 450ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST283
Domaini482 – 715ABC transporterPROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005897. Pept_C39_ABC_bacteriocin.
IPR005074. Peptidase_C39.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF03412. Peptidase_C39. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR01193. bacteriocin_ABC. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS50990. PEPTIDASE_C39. 1 hit.

Sequencei

Sequence statusi: Complete.

Q00564-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFKKKNYTS QVDEMDCGCA ALSMILKSYG TEKSLASLRL LAGTTIEGTS
60 70 80 90 100
ALGIKKAAEI LEFSVQALRT DASLFEMKNA PYPFIAHVIK DQKYPHYYVI
110 120 130 140 150
TGANKNSVFI ADPDPTIKMT KLSKEAFLSE WTGISLFLST TPSYHPTKEK
160 170 180 190 200
ASSLLSFIPI ITRQKKVILN IVIASFIVTL INILGSYYLQ SMIDSYIPNA
210 220 230 240 250
LMGTLGIISV GLLLTYIIQQ VLEFAKAFLL NVLSQRLAID VILSYIRHIF
260 270 280 290 300
QLPMSFFSTR RTGEITSRFS DASSILDAIA STILSLFLDL TIVVMTGLIL
310 320 330 340 350
GLQNMQLFLL VLLAIPLYIV VIIIFTPLFE KQNHEVMQTN AVLNSSIIED
360 370 380 390 400
INGIETIKAL ASEQERYQKI DYEFASYLKK AFTLQKSEAI QGLIKAIIQL
410 420 430 440 450
TLSVTILWFG ATLVISQKIT LGQLITFNAL LSYFTNPITN IINLQTKLQK
460 470 480 490 500
ARVANERLNE VYLVPSEFEE KKTELSLSHF NLNMSDISYQ YGFGRKVLSE
510 520 530 540 550
IELSIKENEK LTIVGMSGSG KSTLVKLLVN FFQPTSGTIT LGGIDLQQFD
560 570 580 590 600
KHQLRRLINY LPQQPYIFTG SILDNLLLGA NENASQEEIL KAVELAEIRA
610 620 630 640 650
DIEQMQLGYQ TELSSDASSL SGGQKQRIAL ARALLSPAKI LILDEATSNL
660 670 680 690 700
DMITEKKILK NLLPLDKTII FIAHRLSVAE MSHRIIVVDQ GKVIESGSHV
710
DLLAQNGFYE QLYHN
Length:715
Mass (Da):79,810
Last modified:April 1, 1993 - v1
Checksum:iEF3717ECB0F5B0C4
GO

Sequence cautioni

The sequence AAA92854 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90969 Genomic DNA. Translation: AAA92852.1. Sequence problems.
M90969 Genomic DNA. Translation: AAA92854.1. Different initiation.
PIRiB43943.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90969 Genomic DNA. Translation: AAA92852.1. Sequence problems.
M90969 Genomic DNA. Translation: AAA92854.1. Different initiation.
PIRiB43943.

3D structure databases

ProteinModelPortaliQ00564.
SMRiQ00564.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC39.001.
TCDBi3.A.1.112.3. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR005897. Pept_C39_ABC_bacteriocin.
IPR005074. Peptidase_C39.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF03412. Peptidase_C39. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR01193. bacteriocin_ABC. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS50990. PEPTIDASE_C39. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLCNC_LACLL
AccessioniPrimary (citable) accession number: Q00564
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 12, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.