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Q00557

- CP1A1_MESAU

UniProt

Q00557 - CP1A1_MESAU

Protein

Cytochrome P450 1A1

Gene

CYP1A1

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (15 Dec 1998)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei228 – 2281SubstrateBy similarity
    Metal bindingi461 – 4611Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Cytochrome P-450MC
    Gene namesi
    Name:CYP1A1
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 524524Cytochrome P450 1A1PRO_0000051630Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi71 – 711O-linked (GlcNAc)By similarity

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Inductioni

    By 3-methylcholanthrene (3MC).

    Structurei

    3D structure databases

    ProteinModelPortaliQ00557.
    SMRiQ00557. Positions 36-513.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q00557-1 [UniParc]FASTAAdd to Basket

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    MSSIYGLLNF MSATELLLAI TVFCLGFWVV RALRTQVPKG LKTPPGPWGL    50
    PILGHVLTLG KNPHLSLTKL SKQYGDVLQI RIGSTPVVVL SGLDTIRQAL 100
    VRQGDDFKGR PDFYSFTLIT NGKSMTFNPD CGPVWAARRR LAQDALKSFS 150
    IALDPASASS CYLEEYVIKE ADYLISKFQK LMAEVGHFDP DRYLVVSVTN 200
    VICAMCFGQR YDHDDQELLS IVNLSNEFGK VTGSGYPPDF IPILRYLPNS 250
    SLDAFKDLNK KFYSFMQKSV KEHYRTFEKG HIRDITDSLI EHCQDKSLDE 300
    NANVQLSDDR VINIIVDLFG AGFDTVTTAI SWSLMYLVTN PGVQRKIQEE 350
    LDTVIGRSRR PRLCDRSQLP YLEAFILETF RHSSFLPFTI PHSTTRDTSL 400
    CGFYIPKGHC VFVNQWQINH NQELWGDPNK FRPERFLTSS GTLDKVLSGK 450
    VTLFGLGKRK CIGETIGRLE VFLFLAILLQ QIEFTVSPGE KVDMTPIYGL 500
    TLKHARCEYF QAQTRSSGPQ HPQA 524
    Length:524
    Mass (Da):59,136
    Last modified:December 15, 1998 - v2
    Checksum:i2A4C6AF9AE5FD8E0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181L → V in BAA01096. (PubMed:1778988)Curated
    Sequence conflicti521 – 5211H → Y in BAA01096. (PubMed:1778988)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10251 mRNA. Translation: BAA01096.1.
    D12977 mRNA. Translation: BAA02354.1.
    D10913 Genomic DNA. Translation: BAA01717.1.
    PIRiJX0189.
    RefSeqiNP_001268352.1. NM_001281423.1.

    Genome annotation databases

    GeneIDi101844540.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10251 mRNA. Translation: BAA01096.1 .
    D12977 mRNA. Translation: BAA02354.1 .
    D10913 Genomic DNA. Translation: BAA01717.1 .
    PIRi JX0189.
    RefSeqi NP_001268352.1. NM_001281423.1.

    3D structure databases

    ProteinModelPortali Q00557.
    SMRi Q00557. Positions 36-513.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101844540.

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hamster cytochrome P-450 IA gene family, P-450IA1 and P-450IA2 in lung and liver: cDNA cloning and sequence analysis."
      Sagami I., Ohmachi T., Fujii H., Kikuchi H., Watanabe M.
      J. Biochem. 110:641-647(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Molecular cloning and expression of hamster cytochrome P450 1A1 and cytochrome P450 reductase."
      Ohgiya S., Goda T., Ishizaki K., Morimoto M., Sakamoto T., Kamataki T., Shinriki N.
      Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiCP1A1_MESAU
    AccessioniPrimary (citable) accession number: Q00557
    Secondary accession number(s): Q64665
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3