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Protein

Hyaluronan mediated motility receptor

Gene

Hmmr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.

GO - Molecular functioni

  1. hyaluronic acid binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid

Enzyme and pathway databases

ReactomeiREACT_353590. Hyaluronan uptake and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan mediated motility receptor
Alternative name(s):
Intracellular hyaluronic acid-binding protein
Receptor for hyaluronan-mediated motility
CD_antigen: CD168
Gene namesi
Name:Hmmr
Synonyms:Ihabp, Rhamm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104667. Hmmr.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB-SubCell
  3. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 794794Hyaluronan mediated motility receptorPRO_0000084008Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201PhosphoserineBy similarity
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi467 – 4671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi509 – 5091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi530 – 5301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi561 – 5611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi601 – 6011N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ00547.
PaxDbiQ00547.
PRIDEiQ00547.

PTM databases

PhosphoSiteiQ00547.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ00547.
CleanExiMM_HMMR.
ExpressionAtlasiQ00547. baseline and differential.
GenevestigatoriQ00547.

Interactioni

Subunit structurei

Subunit of the HARC complex.

Protein-protein interaction databases

DIPiDIP-46343N.

Structurei

3D structure databases

ProteinModelPortaliQ00547.
SMRiQ00547. Positions 725-763.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati442 – 462211Add
BLAST
Repeati463 – 483212Add
BLAST
Repeati484 – 504213Add
BLAST
Repeati505 – 525214Add
BLAST
Repeati526 – 546215Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni442 – 5461055 X 21 AA tandem repeatsAdd
BLAST
Regioni719 – 72911Hyaluronic acid-bindingSequence AnalysisAdd
BLAST
Regioni741 – 75010Hyaluronic acid-bindingSequence Analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG146600.
GeneTreeiENSGT00390000007135.
HOGENOMiHOG000112920.
HOVERGENiHBG044411.
InParanoidiQ00547.
KOiK06267.
OMAiQEKYNDT.
OrthoDBiEOG7J17ZD.
TreeFamiTF333963.

Family and domain databases

InterProiIPR026203. IHABP.
[Graphical view]
PANTHERiPTHR18956. PTHR18956. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform RHAMM1V4 (identifier: Q00547-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFPKAPLKR FNDPSGCAPS PGAYDVKTSE ATKGPVSFQK SQRFKNQRES
60 70 80 90 100
QQNLNIDKDT TLLASAKKAK KSVSKKDSQK NDKDVKRLEK EIRALLQERG
110 120 130 140 150
TQDKRIQDME SELEKTEAKL NAAVREKTSL SASNASLEKR LTELTRANEL
160 170 180 190 200
LKAKFSEDGH QKNMRALSLE LMKLRNKRET KMRSMMVKQE GMELKLQATQ
210 220 230 240 250
KDLTESKGKI VQLEGKLVSI EKEKIDEKCE TEKLLEYIQE ISCASDQVEK
260 270 280 290 300
CKVDIAQLEE DLKEKDREIL SLKQSLEENI TFSKQIEDLT VKCQLLETER
310 320 330 340 350
DNLVSKDRER AETLSAEMQI LTERLALERQ EYEKLQQKEL QSQSLLQQEK
360 370 380 390 400
ELSARLQQQL CSFQEEMTSE KNVFKEELKL ALAELDAVQQ KEEQSERLVK
410 420 430 440 450
QLEEETKSTA EQLTRLDNLL REKEVELEKH IAAHAQAILI AQEKYNDTAQ
460 470 480 490 500
SLRDVTAQLE SVQEKYNDTA QSLRDVTAQL ESEQEKYNDT AQSLRDVTAQ
510 520 530 540 550
LESEQEKYND TAQSLRDVTA QLESVQEKYN DTAQSLRDVT AQLESYKSST
560 570 580 590 600
LKEIEDLKLE NLTLQEKVAM AEKSVEDVQQ QILTAESTNQ EYARMVQDLQ
610 620 630 640 650
NRSTLKEEEI KEITSSFLEK ITDLKNQLRQ QDEDFRKQLE EKGKRTAEKE
660 670 680 690 700
NVMTELTMEI NKWRLLYEEL YEKTKPFQQQ LDAFEAEKQA LLNEHGATQE
710 720 730 740 750
QLNKIRDSYA QLLGHQNLKQ KIKHVVKLKD ENSQLKSEVS KLRSQLVKRK
760 770 780 790
QNELRLQGEL DKALGIRHFD PSKAFCHASK ENFTPLKEGN PNCC
Length:794
Mass (Da):91,785
Last modified:July 27, 2011 - v4
Checksum:i58482E8587E4F4DA
GO
Isoform RHAMM1 (identifier: Q00547-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     218-242: Missing.

Show »
Length:769
Mass (Da):88,806
Checksum:i38C46D507A0E9C45
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191P → Q in CAA06768 (PubMed:9889313).Curated
Sequence conflicti55 – 551N → S in AAC12655 (PubMed:9601097).Curated
Sequence conflicti55 – 551N → S in CAA06768 (PubMed:9889313).Curated
Sequence conflicti71 – 711K → T in AAD08670 (Ref. 2) Curated
Sequence conflicti89 – 913EKE → QKH in AAD08670 (Ref. 2) Curated
Sequence conflicti94 – 941A → V in CAA06768 (PubMed:9889313).Curated
Sequence conflicti406 – 4061T → R in AAC12655 (PubMed:9601097).Curated
Sequence conflicti406 – 4061T → R in AAD08670 (Ref. 2) Curated
Sequence conflicti406 – 4061T → R in CAA45849 (PubMed:7590272).Curated
Sequence conflicti406 – 4061T → R in CAA45848 (PubMed:1376732).Curated
Sequence conflicti540 – 5401T → S in AAC12655 (PubMed:9601097).Curated
Sequence conflicti540 – 5401T → S in CAA45849 (PubMed:7590272).Curated
Sequence conflicti540 – 5401T → S in CAA45848 (PubMed:1376732).Curated
Sequence conflicti668 – 6681E → D in AAD08670 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei218 – 24225Missing in isoform RHAMM1. CuratedVSP_004287Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031932 mRNA. Translation: AAC12655.1.
AF079222 mRNA. Translation: AAD08670.1.
AL646055 Genomic DNA. Translation: CAI25425.1.
CH466609 Genomic DNA. Translation: EDL32330.1.
AJ005919
, AJ005920, AJ005921, AJ005922, AJ005923, AJ005924 Genomic DNA. Translation: CAA06768.1.
X64550 mRNA. Translation: CAA45849.1.
X64550 mRNA. Translation: CAA45848.1.
CCDSiCCDS24548.1. [Q00547-1]
PIRiJC4298.
RefSeqiNP_038580.2. NM_013552.2. [Q00547-1]
UniGeneiMm.116997.

Genome annotation databases

EnsembliENSMUST00000020579; ENSMUSP00000020579; ENSMUSG00000020330. [Q00547-1]
GeneIDi15366.
KEGGimmu:15366.
UCSCiuc007ils.2. mouse. [Q00547-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031932 mRNA. Translation: AAC12655.1.
AF079222 mRNA. Translation: AAD08670.1.
AL646055 Genomic DNA. Translation: CAI25425.1.
CH466609 Genomic DNA. Translation: EDL32330.1.
AJ005919
, AJ005920, AJ005921, AJ005922, AJ005923, AJ005924 Genomic DNA. Translation: CAA06768.1.
X64550 mRNA. Translation: CAA45849.1.
X64550 mRNA. Translation: CAA45848.1.
CCDSiCCDS24548.1. [Q00547-1]
PIRiJC4298.
RefSeqiNP_038580.2. NM_013552.2. [Q00547-1]
UniGeneiMm.116997.

3D structure databases

ProteinModelPortaliQ00547.
SMRiQ00547. Positions 725-763.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46343N.

PTM databases

PhosphoSiteiQ00547.

Proteomic databases

MaxQBiQ00547.
PaxDbiQ00547.
PRIDEiQ00547.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020579; ENSMUSP00000020579; ENSMUSG00000020330. [Q00547-1]
GeneIDi15366.
KEGGimmu:15366.
UCSCiuc007ils.2. mouse. [Q00547-1]

Organism-specific databases

CTDi3161.
MGIiMGI:104667. Hmmr.

Phylogenomic databases

eggNOGiNOG146600.
GeneTreeiENSGT00390000007135.
HOGENOMiHOG000112920.
HOVERGENiHBG044411.
InParanoidiQ00547.
KOiK06267.
OMAiQEKYNDT.
OrthoDBiEOG7J17ZD.
TreeFamiTF333963.

Enzyme and pathway databases

ReactomeiREACT_353590. Hyaluronan uptake and degradation.

Miscellaneous databases

ChiTaRSiHmmr. mouse.
NextBioi287994.
PROiQ00547.
SOURCEiSearch...

Gene expression databases

BgeeiQ00547.
CleanExiMM_HMMR.
ExpressionAtlasiQ00547. baseline and differential.
GenevestigatoriQ00547.

Family and domain databases

InterProiIPR026203. IHABP.
[Graphical view]
PANTHERiPTHR18956. PTHR18956. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of IHABP, a 95 kDa intracellular hyaluronate binding protein."
    Hofmann M., Fieber C., Assmann V., Goettlicher M., Sleeman J., Plug R., Howells N., von Stein O., Ponta H., Herrlich P.
    J. Cell Sci. 111:1673-1684(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Tissue: Lung.
  2. Zhao Y., Zhang S., Turley E.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Characterization of the murine gene encoding the intracellular hyaluronan receptor IHABP."
    Fieber C., Plug R., Sleeman J., Dall P., Ponta H., Hofmann M.
    Gene 226:41-50(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-183, TISSUE SPECIFICITY.
    Strain: 129/Sv.
  6. "Characterization of the murine gene encoding the hyaluronan receptor RHAMM."
    Entwistle J., Zhang S., Yang B., Wong C., Li Q., Hall C.L., Jingbo A., Mowat M., Greenberg A.H., Turley E.A.
    Gene 163:233-238(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 164-794, ALTERNATIVE SPLICING.
    Strain: BALB/c.
    Tissue: Fibroblast.
  7. "Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility."
    Hardwick C., Hoare K., Owens R., Hohn H.P., Hook M., Moore D., Cripps V., Austen L., Nance D.M., Turley E.A.
    J. Cell Biol. 117:1343-1350(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-794, CHARACTERIZATION.
    Strain: BALB/c.
  8. "Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity."
    Hall C.L., Wang C., Lange L.A., Turley E.A.
    J. Cell Biol. 126:575-588(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  9. "The hyaluronan receptor RHAMM regulates extracellular-regulated kinase."
    Zhang S., Chang M.C., Zylka D., Turley S., Harrison R., Turley E.A.
    J. Biol. Chem. 273:11342-11348(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: ERK REGULATION, SUBCELLULAR LOCATION.
  10. "Problems with RHAMM: a new link between surface adhesion and oncogenesis?"
    Hofmann M., Assmann V., Fieber C., Sleeman J.P., Moll J., Ponta H., Hart I.R., Herrlich P.
    Cell 95:591-592(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiHMMR_MOUSE
AccessioniPrimary (citable) accession number: Q00547
Secondary accession number(s): Q5NC88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: April 1, 2015
This is version 100 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.