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Protein

Hyaluronan mediated motility receptor

Gene

Hmmr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for hyaluronic acid (HA) (PubMed:1376732). Involved in cell motility (PubMed:1376732). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenesis (PubMed:22666460).2 Publications

GO - Molecular functioni

Keywordsi

LigandHyaluronic acid

Enzyme and pathway databases

ReactomeiR-MMU-2160916 Hyaluronan uptake and degradation
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan mediated motility receptor
Alternative name(s):
Intracellular hyaluronic acid-binding protein
Receptor for hyaluronan-mediated motility
CD_antigen: CD168
Gene namesi
Name:Hmmr
Synonyms:Ihabp, Rhamm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104667 Hmmr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000840081 – 794Hyaluronan mediated motility receptorAdd BLAST794

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineBy similarity1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi467N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi488N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi509N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi530N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi561N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi601N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei784PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ00547
MaxQBiQ00547
PaxDbiQ00547
PeptideAtlasiQ00547
PRIDEiQ00547

PTM databases

iPTMnetiQ00547
PhosphoSitePlusiQ00547

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000020330
CleanExiMM_HMMR
GenevisibleiQ00547 MM

Interactioni

Subunit structurei

Subunit of the HARC complex. Interacts with ANKRD26.By similarity

Protein-protein interaction databases

BioGridi200343, 1 interactor
DIPiDIP-46343N
IntActiQ00547, 1 interactor
STRINGi10090.ENSMUSP00000020579

Structurei

3D structure databases

ProteinModelPortaliQ00547
SMRiQ00547
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati442 – 4621Add BLAST21
Repeati463 – 4832Add BLAST21
Repeati484 – 5043Add BLAST21
Repeati505 – 5254Add BLAST21
Repeati526 – 5465Add BLAST21

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni442 – 5465 X 21 AA tandem repeatsAdd BLAST105
Regioni719 – 729Hyaluronic acid-bindingSequence analysisAdd BLAST11
Regioni741 – 750Hyaluronic acid-bindingSequence analysis10

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJ28 Eukaryota
ENOG4111G1K LUCA
GeneTreeiENSGT00390000007135
HOGENOMiHOG000112920
HOVERGENiHBG044411
InParanoidiQ00547
KOiK06267
OMAiISCASDQ
OrthoDBiEOG091G03MO
TreeFamiTF333963

Family and domain databases

InterProiView protein in InterPro
IPR031794 HMMR_C
IPR031787 HMMR_N
IPR026203 IHABP
PANTHERiPTHR18956 PTHR18956, 1 hit
PfamiView protein in Pfam
PF15908 HMMR_C, 1 hit
PF15905 HMMR_N, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform RHAMM1V4 (identifier: Q00547-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFPKAPLKR FNDPSGCAPS PGAYDVKTSE ATKGPVSFQK SQRFKNQRES
60 70 80 90 100
QQNLNIDKDT TLLASAKKAK KSVSKKDSQK NDKDVKRLEK EIRALLQERG
110 120 130 140 150
TQDKRIQDME SELEKTEAKL NAAVREKTSL SASNASLEKR LTELTRANEL
160 170 180 190 200
LKAKFSEDGH QKNMRALSLE LMKLRNKRET KMRSMMVKQE GMELKLQATQ
210 220 230 240 250
KDLTESKGKI VQLEGKLVSI EKEKIDEKCE TEKLLEYIQE ISCASDQVEK
260 270 280 290 300
CKVDIAQLEE DLKEKDREIL SLKQSLEENI TFSKQIEDLT VKCQLLETER
310 320 330 340 350
DNLVSKDRER AETLSAEMQI LTERLALERQ EYEKLQQKEL QSQSLLQQEK
360 370 380 390 400
ELSARLQQQL CSFQEEMTSE KNVFKEELKL ALAELDAVQQ KEEQSERLVK
410 420 430 440 450
QLEEETKSTA EQLTRLDNLL REKEVELEKH IAAHAQAILI AQEKYNDTAQ
460 470 480 490 500
SLRDVTAQLE SVQEKYNDTA QSLRDVTAQL ESEQEKYNDT AQSLRDVTAQ
510 520 530 540 550
LESEQEKYND TAQSLRDVTA QLESVQEKYN DTAQSLRDVT AQLESYKSST
560 570 580 590 600
LKEIEDLKLE NLTLQEKVAM AEKSVEDVQQ QILTAESTNQ EYARMVQDLQ
610 620 630 640 650
NRSTLKEEEI KEITSSFLEK ITDLKNQLRQ QDEDFRKQLE EKGKRTAEKE
660 670 680 690 700
NVMTELTMEI NKWRLLYEEL YEKTKPFQQQ LDAFEAEKQA LLNEHGATQE
710 720 730 740 750
QLNKIRDSYA QLLGHQNLKQ KIKHVVKLKD ENSQLKSEVS KLRSQLVKRK
760 770 780 790
QNELRLQGEL DKALGIRHFD PSKAFCHASK ENFTPLKEGN PNCC
Length:794
Mass (Da):91,785
Last modified:July 27, 2011 - v4
Checksum:i58482E8587E4F4DA
GO
Isoform RHAMM1 (identifier: Q00547-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     218-242: Missing.

Show »
Length:769
Mass (Da):88,806
Checksum:i38C46D507A0E9C45
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19P → Q in CAA06768 (PubMed:9889313).Curated1
Sequence conflicti55N → S in AAC12655 (PubMed:9601097).Curated1
Sequence conflicti55N → S in CAA06768 (PubMed:9889313).Curated1
Sequence conflicti71K → T in AAD08670 (Ref. 2) Curated1
Sequence conflicti89 – 91EKE → QKH in AAD08670 (Ref. 2) Curated3
Sequence conflicti94A → V in CAA06768 (PubMed:9889313).Curated1
Sequence conflicti406T → R in AAC12655 (PubMed:9601097).Curated1
Sequence conflicti406T → R in AAD08670 (Ref. 2) Curated1
Sequence conflicti406T → R in CAA45849 (PubMed:7590272).Curated1
Sequence conflicti406T → R in CAA45848 (PubMed:1376732).Curated1
Sequence conflicti540T → S in AAC12655 (PubMed:9601097).Curated1
Sequence conflicti540T → S in CAA45849 (PubMed:7590272).Curated1
Sequence conflicti540T → S in CAA45848 (PubMed:1376732).Curated1
Sequence conflicti668E → D in AAD08670 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004287218 – 242Missing in isoform RHAMM1. CuratedAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031932 mRNA Translation: AAC12655.1
AF079222 mRNA Translation: AAD08670.1
AL646055 Genomic DNA Translation: CAI25425.1
CH466609 Genomic DNA Translation: EDL32330.1
AJ005919
, AJ005920, AJ005921, AJ005922, AJ005923, AJ005924 Genomic DNA Translation: CAA06768.1
X64550 mRNA Translation: CAA45849.1
X64550 mRNA Translation: CAA45848.1
CCDSiCCDS24548.1 [Q00547-1]
PIRiJC4298
RefSeqiNP_038580.2, NM_013552.2 [Q00547-1]
UniGeneiMm.116997

Genome annotation databases

EnsembliENSMUST00000020579; ENSMUSP00000020579; ENSMUSG00000020330 [Q00547-1]
GeneIDi15366
KEGGimmu:15366
UCSCiuc007ils.2 mouse [Q00547-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHMMR_MOUSE
AccessioniPrimary (citable) accession number: Q00547
Secondary accession number(s): Q5NC88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 116 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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