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Q00547

- HMMR_MOUSE

UniProt

Q00547 - HMMR_MOUSE

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Protein
Hyaluronan mediated motility receptor
Gene
Hmmr, Ihabp, Rhamm
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.

GO - Molecular functioni

  1. hyaluronic acid binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid

Enzyme and pathway databases

ReactomeiREACT_196554. Hyaluronan uptake and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan mediated motility receptor
Alternative name(s):
Intracellular hyaluronic acid-binding protein
Receptor for hyaluronan-mediated motility
CD_antigen: CD168
Gene namesi
Name:Hmmr
Synonyms:Ihabp, Rhamm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:104667. Hmmr.

Subcellular locationi

Cell surface. Cytoplasm 2 Publications

GO - Cellular componenti

  1. cell surface Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 794794Hyaluronan mediated motility receptor
PRO_0000084008Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Phosphoserine By similarity
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi279 – 2791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi446 – 4461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi467 – 4671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi488 – 4881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi509 – 5091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi530 – 5301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi561 – 5611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi601 – 6011N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ00547.
PRIDEiQ00547.

PTM databases

PhosphoSiteiQ00547.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

ArrayExpressiQ00547.
BgeeiQ00547.
CleanExiMM_HMMR.
GenevestigatoriQ00547.

Interactioni

Subunit structurei

Subunit of the HARC complex.

Protein-protein interaction databases

DIPiDIP-46343N.

Structurei

3D structure databases

ProteinModelPortaliQ00547.
SMRiQ00547. Positions 725-763.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati442 – 462211
Add
BLAST
Repeati463 – 483212
Add
BLAST
Repeati484 – 504213
Add
BLAST
Repeati505 – 525214
Add
BLAST
Repeati526 – 546215
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni442 – 5461055 X 21 AA tandem repeats
Add
BLAST
Regioni719 – 72911Hyaluronic acid-binding Reviewed prediction
Add
BLAST
Regioni741 – 75010Hyaluronic acid-binding Reviewed prediction

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG146600.
GeneTreeiENSGT00390000007135.
HOGENOMiHOG000112920.
HOVERGENiHBG044411.
KOiK06267.
OMAiQEKYNDT.
OrthoDBiEOG7J17ZD.
TreeFamiTF333963.

Family and domain databases

InterProiIPR026203. IHABP.
[Graphical view]
PANTHERiPTHR18956. PTHR18956. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform RHAMM1V4 (identifier: Q00547-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSFPKAPLKR FNDPSGCAPS PGAYDVKTSE ATKGPVSFQK SQRFKNQRES    50
QQNLNIDKDT TLLASAKKAK KSVSKKDSQK NDKDVKRLEK EIRALLQERG 100
TQDKRIQDME SELEKTEAKL NAAVREKTSL SASNASLEKR LTELTRANEL 150
LKAKFSEDGH QKNMRALSLE LMKLRNKRET KMRSMMVKQE GMELKLQATQ 200
KDLTESKGKI VQLEGKLVSI EKEKIDEKCE TEKLLEYIQE ISCASDQVEK 250
CKVDIAQLEE DLKEKDREIL SLKQSLEENI TFSKQIEDLT VKCQLLETER 300
DNLVSKDRER AETLSAEMQI LTERLALERQ EYEKLQQKEL QSQSLLQQEK 350
ELSARLQQQL CSFQEEMTSE KNVFKEELKL ALAELDAVQQ KEEQSERLVK 400
QLEEETKSTA EQLTRLDNLL REKEVELEKH IAAHAQAILI AQEKYNDTAQ 450
SLRDVTAQLE SVQEKYNDTA QSLRDVTAQL ESEQEKYNDT AQSLRDVTAQ 500
LESEQEKYND TAQSLRDVTA QLESVQEKYN DTAQSLRDVT AQLESYKSST 550
LKEIEDLKLE NLTLQEKVAM AEKSVEDVQQ QILTAESTNQ EYARMVQDLQ 600
NRSTLKEEEI KEITSSFLEK ITDLKNQLRQ QDEDFRKQLE EKGKRTAEKE 650
NVMTELTMEI NKWRLLYEEL YEKTKPFQQQ LDAFEAEKQA LLNEHGATQE 700
QLNKIRDSYA QLLGHQNLKQ KIKHVVKLKD ENSQLKSEVS KLRSQLVKRK 750
QNELRLQGEL DKALGIRHFD PSKAFCHASK ENFTPLKEGN PNCC 794
Length:794
Mass (Da):91,785
Last modified:July 27, 2011 - v4
Checksum:i58482E8587E4F4DA
GO
Isoform RHAMM1 (identifier: Q00547-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     218-242: Missing.

Show »
Length:769
Mass (Da):88,806
Checksum:i38C46D507A0E9C45
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei218 – 24225Missing in isoform RHAMM1.
VSP_004287Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191P → Q in CAA06768. 1 Publication
Sequence conflicti55 – 551N → S in AAC12655. 1 Publication
Sequence conflicti55 – 551N → S in CAA06768. 1 Publication
Sequence conflicti71 – 711K → T in AAD08670. 1 Publication
Sequence conflicti89 – 913EKE → QKH in AAD08670. 1 Publication
Sequence conflicti94 – 941A → V in CAA06768. 1 Publication
Sequence conflicti406 – 4061T → R in AAC12655. 1 Publication
Sequence conflicti406 – 4061T → R in AAD08670. 1 Publication
Sequence conflicti406 – 4061T → R in CAA45849. 1 Publication
Sequence conflicti406 – 4061T → R in CAA45848. 1 Publication
Sequence conflicti540 – 5401T → S in AAC12655. 1 Publication
Sequence conflicti540 – 5401T → S in CAA45849. 1 Publication
Sequence conflicti540 – 5401T → S in CAA45848. 1 Publication
Sequence conflicti668 – 6681E → D in AAD08670. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031932 mRNA. Translation: AAC12655.1.
AF079222 mRNA. Translation: AAD08670.1.
AL646055 Genomic DNA. Translation: CAI25425.1.
CH466609 Genomic DNA. Translation: EDL32330.1.
AJ005919
, AJ005920, AJ005921, AJ005922, AJ005923, AJ005924 Genomic DNA. Translation: CAA06768.1.
X64550 mRNA. Translation: CAA45849.1.
X64550 mRNA. Translation: CAA45848.1.
CCDSiCCDS24548.1. [Q00547-1]
PIRiJC4298.
RefSeqiNP_038580.2. NM_013552.2. [Q00547-1]
UniGeneiMm.116997.

Genome annotation databases

EnsembliENSMUST00000020579; ENSMUSP00000020579; ENSMUSG00000020330. [Q00547-1]
GeneIDi15366.
KEGGimmu:15366.
UCSCiuc007ils.2. mouse. [Q00547-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031932 mRNA. Translation: AAC12655.1 .
AF079222 mRNA. Translation: AAD08670.1 .
AL646055 Genomic DNA. Translation: CAI25425.1 .
CH466609 Genomic DNA. Translation: EDL32330.1 .
AJ005919
, AJ005920 , AJ005921 , AJ005922 , AJ005923 , AJ005924 Genomic DNA. Translation: CAA06768.1 .
X64550 mRNA. Translation: CAA45849.1 .
X64550 mRNA. Translation: CAA45848.1 .
CCDSi CCDS24548.1. [Q00547-1 ]
PIRi JC4298.
RefSeqi NP_038580.2. NM_013552.2. [Q00547-1 ]
UniGenei Mm.116997.

3D structure databases

ProteinModelPortali Q00547.
SMRi Q00547. Positions 725-763.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-46343N.

PTM databases

PhosphoSitei Q00547.

Proteomic databases

PaxDbi Q00547.
PRIDEi Q00547.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020579 ; ENSMUSP00000020579 ; ENSMUSG00000020330 . [Q00547-1 ]
GeneIDi 15366.
KEGGi mmu:15366.
UCSCi uc007ils.2. mouse. [Q00547-1 ]

Organism-specific databases

CTDi 3161.
MGIi MGI:104667. Hmmr.

Phylogenomic databases

eggNOGi NOG146600.
GeneTreei ENSGT00390000007135.
HOGENOMi HOG000112920.
HOVERGENi HBG044411.
KOi K06267.
OMAi QEKYNDT.
OrthoDBi EOG7J17ZD.
TreeFami TF333963.

Enzyme and pathway databases

Reactomei REACT_196554. Hyaluronan uptake and degradation.

Miscellaneous databases

ChiTaRSi HMMR. mouse.
NextBioi 287994.
PROi Q00547.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q00547.
Bgeei Q00547.
CleanExi MM_HMMR.
Genevestigatori Q00547.

Family and domain databases

InterProi IPR026203. IHABP.
[Graphical view ]
PANTHERi PTHR18956. PTHR18956. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of IHABP, a 95 kDa intracellular hyaluronate binding protein."
    Hofmann M., Fieber C., Assmann V., Goettlicher M., Sleeman J., Plug R., Howells N., von Stein O., Ponta H., Herrlich P.
    J. Cell Sci. 111:1673-1684(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Tissue: Lung.
  2. Zhao Y., Zhang S., Turley E.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Characterization of the murine gene encoding the intracellular hyaluronan receptor IHABP."
    Fieber C., Plug R., Sleeman J., Dall P., Ponta H., Hofmann M.
    Gene 226:41-50(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-183, TISSUE SPECIFICITY.
    Strain: 129/Sv.
  6. "Characterization of the murine gene encoding the hyaluronan receptor RHAMM."
    Entwistle J., Zhang S., Yang B., Wong C., Li Q., Hall C.L., Jingbo A., Mowat M., Greenberg A.H., Turley E.A.
    Gene 163:233-238(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 164-794, ALTERNATIVE SPLICING.
    Strain: BALB/c.
    Tissue: Fibroblast.
  7. "Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility."
    Hardwick C., Hoare K., Owens R., Hohn H.P., Hook M., Moore D., Cripps V., Austen L., Nance D.M., Turley E.A.
    J. Cell Biol. 117:1343-1350(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-794, CHARACTERIZATION.
    Strain: BALB/c.
  8. "Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity."
    Hall C.L., Wang C., Lange L.A., Turley E.A.
    J. Cell Biol. 126:575-588(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  9. "The hyaluronan receptor RHAMM regulates extracellular-regulated kinase."
    Zhang S., Chang M.C., Zylka D., Turley S., Harrison R., Turley E.A.
    J. Biol. Chem. 273:11342-11348(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: ERK REGULATION, SUBCELLULAR LOCATION.
  10. "Problems with RHAMM: a new link between surface adhesion and oncogenesis?"
    Hofmann M., Assmann V., Fieber C., Sleeman J.P., Moll J., Ponta H., Hart I.R., Herrlich P.
    Cell 95:591-592(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiHMMR_MOUSE
AccessioniPrimary (citable) accession number: Q00547
Secondary accession number(s): Q5NC88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 93 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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