Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q00547

- HMMR_MOUSE

UniProt

Q00547 - HMMR_MOUSE

Protein

Hyaluronan mediated motility receptor

Gene

Hmmr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 4 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.

    GO - Molecular functioni

    1. hyaluronic acid binding Source: UniProtKB-KW

    Keywords - Ligandi

    Hyaluronic acid

    Enzyme and pathway databases

    ReactomeiREACT_196554. Hyaluronan uptake and degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronan mediated motility receptor
    Alternative name(s):
    Intracellular hyaluronic acid-binding protein
    Receptor for hyaluronan-mediated motility
    CD_antigen: CD168
    Gene namesi
    Name:Hmmr
    Synonyms:Ihabp, Rhamm
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:104667. Hmmr.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 794794Hyaluronan mediated motility receptorPRO_0000084008Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei20 – 201PhosphoserineBy similarity
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi467 – 4671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi509 – 5091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi530 – 5301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi561 – 5611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi601 – 6011N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ00547.
    PRIDEiQ00547.

    PTM databases

    PhosphoSiteiQ00547.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ00547.
    BgeeiQ00547.
    CleanExiMM_HMMR.
    GenevestigatoriQ00547.

    Interactioni

    Subunit structurei

    Subunit of the HARC complex.

    Protein-protein interaction databases

    DIPiDIP-46343N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ00547.
    SMRiQ00547. Positions 725-763.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati442 – 462211Add
    BLAST
    Repeati463 – 483212Add
    BLAST
    Repeati484 – 504213Add
    BLAST
    Repeati505 – 525214Add
    BLAST
    Repeati526 – 546215Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni442 – 5461055 X 21 AA tandem repeatsAdd
    BLAST
    Regioni719 – 72911Hyaluronic acid-bindingSequence AnalysisAdd
    BLAST
    Regioni741 – 75010Hyaluronic acid-bindingSequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG146600.
    GeneTreeiENSGT00390000007135.
    HOGENOMiHOG000112920.
    HOVERGENiHBG044411.
    KOiK06267.
    OMAiQEKYNDT.
    OrthoDBiEOG7J17ZD.
    TreeFamiTF333963.

    Family and domain databases

    InterProiIPR026203. IHABP.
    [Graphical view]
    PANTHERiPTHR18956. PTHR18956. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform RHAMM1V4 (identifier: Q00547-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFPKAPLKR FNDPSGCAPS PGAYDVKTSE ATKGPVSFQK SQRFKNQRES    50
    QQNLNIDKDT TLLASAKKAK KSVSKKDSQK NDKDVKRLEK EIRALLQERG 100
    TQDKRIQDME SELEKTEAKL NAAVREKTSL SASNASLEKR LTELTRANEL 150
    LKAKFSEDGH QKNMRALSLE LMKLRNKRET KMRSMMVKQE GMELKLQATQ 200
    KDLTESKGKI VQLEGKLVSI EKEKIDEKCE TEKLLEYIQE ISCASDQVEK 250
    CKVDIAQLEE DLKEKDREIL SLKQSLEENI TFSKQIEDLT VKCQLLETER 300
    DNLVSKDRER AETLSAEMQI LTERLALERQ EYEKLQQKEL QSQSLLQQEK 350
    ELSARLQQQL CSFQEEMTSE KNVFKEELKL ALAELDAVQQ KEEQSERLVK 400
    QLEEETKSTA EQLTRLDNLL REKEVELEKH IAAHAQAILI AQEKYNDTAQ 450
    SLRDVTAQLE SVQEKYNDTA QSLRDVTAQL ESEQEKYNDT AQSLRDVTAQ 500
    LESEQEKYND TAQSLRDVTA QLESVQEKYN DTAQSLRDVT AQLESYKSST 550
    LKEIEDLKLE NLTLQEKVAM AEKSVEDVQQ QILTAESTNQ EYARMVQDLQ 600
    NRSTLKEEEI KEITSSFLEK ITDLKNQLRQ QDEDFRKQLE EKGKRTAEKE 650
    NVMTELTMEI NKWRLLYEEL YEKTKPFQQQ LDAFEAEKQA LLNEHGATQE 700
    QLNKIRDSYA QLLGHQNLKQ KIKHVVKLKD ENSQLKSEVS KLRSQLVKRK 750
    QNELRLQGEL DKALGIRHFD PSKAFCHASK ENFTPLKEGN PNCC 794
    Length:794
    Mass (Da):91,785
    Last modified:July 27, 2011 - v4
    Checksum:i58482E8587E4F4DA
    GO
    Isoform RHAMM1 (identifier: Q00547-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         218-242: Missing.

    Show »
    Length:769
    Mass (Da):88,806
    Checksum:i38C46D507A0E9C45
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti19 – 191P → Q in CAA06768. (PubMed:9889313)Curated
    Sequence conflicti55 – 551N → S in AAC12655. (PubMed:9601097)Curated
    Sequence conflicti55 – 551N → S in CAA06768. (PubMed:9889313)Curated
    Sequence conflicti71 – 711K → T in AAD08670. 1 PublicationCurated
    Sequence conflicti89 – 913EKE → QKH in AAD08670. 1 PublicationCurated
    Sequence conflicti94 – 941A → V in CAA06768. (PubMed:9889313)Curated
    Sequence conflicti406 – 4061T → R in AAC12655. (PubMed:9601097)Curated
    Sequence conflicti406 – 4061T → R in AAD08670. 1 PublicationCurated
    Sequence conflicti406 – 4061T → R in CAA45849. (PubMed:7590272)Curated
    Sequence conflicti406 – 4061T → R in CAA45848. (PubMed:1376732)Curated
    Sequence conflicti540 – 5401T → S in AAC12655. (PubMed:9601097)Curated
    Sequence conflicti540 – 5401T → S in CAA45849. (PubMed:7590272)Curated
    Sequence conflicti540 – 5401T → S in CAA45848. (PubMed:1376732)Curated
    Sequence conflicti668 – 6681E → D in AAD08670. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei218 – 24225Missing in isoform RHAMM1. CuratedVSP_004287Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031932 mRNA. Translation: AAC12655.1.
    AF079222 mRNA. Translation: AAD08670.1.
    AL646055 Genomic DNA. Translation: CAI25425.1.
    CH466609 Genomic DNA. Translation: EDL32330.1.
    AJ005919
    , AJ005920, AJ005921, AJ005922, AJ005923, AJ005924 Genomic DNA. Translation: CAA06768.1.
    X64550 mRNA. Translation: CAA45849.1.
    X64550 mRNA. Translation: CAA45848.1.
    CCDSiCCDS24548.1. [Q00547-1]
    PIRiJC4298.
    RefSeqiNP_038580.2. NM_013552.2. [Q00547-1]
    UniGeneiMm.116997.

    Genome annotation databases

    EnsembliENSMUST00000020579; ENSMUSP00000020579; ENSMUSG00000020330. [Q00547-1]
    GeneIDi15366.
    KEGGimmu:15366.
    UCSCiuc007ils.2. mouse. [Q00547-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031932 mRNA. Translation: AAC12655.1 .
    AF079222 mRNA. Translation: AAD08670.1 .
    AL646055 Genomic DNA. Translation: CAI25425.1 .
    CH466609 Genomic DNA. Translation: EDL32330.1 .
    AJ005919
    , AJ005920 , AJ005921 , AJ005922 , AJ005923 , AJ005924 Genomic DNA. Translation: CAA06768.1 .
    X64550 mRNA. Translation: CAA45849.1 .
    X64550 mRNA. Translation: CAA45848.1 .
    CCDSi CCDS24548.1. [Q00547-1 ]
    PIRi JC4298.
    RefSeqi NP_038580.2. NM_013552.2. [Q00547-1 ]
    UniGenei Mm.116997.

    3D structure databases

    ProteinModelPortali Q00547.
    SMRi Q00547. Positions 725-763.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-46343N.

    PTM databases

    PhosphoSitei Q00547.

    Proteomic databases

    PaxDbi Q00547.
    PRIDEi Q00547.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020579 ; ENSMUSP00000020579 ; ENSMUSG00000020330 . [Q00547-1 ]
    GeneIDi 15366.
    KEGGi mmu:15366.
    UCSCi uc007ils.2. mouse. [Q00547-1 ]

    Organism-specific databases

    CTDi 3161.
    MGIi MGI:104667. Hmmr.

    Phylogenomic databases

    eggNOGi NOG146600.
    GeneTreei ENSGT00390000007135.
    HOGENOMi HOG000112920.
    HOVERGENi HBG044411.
    KOi K06267.
    OMAi QEKYNDT.
    OrthoDBi EOG7J17ZD.
    TreeFami TF333963.

    Enzyme and pathway databases

    Reactomei REACT_196554. Hyaluronan uptake and degradation.

    Miscellaneous databases

    ChiTaRSi HMMR. mouse.
    NextBioi 287994.
    PROi Q00547.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q00547.
    Bgeei Q00547.
    CleanExi MM_HMMR.
    Genevestigatori Q00547.

    Family and domain databases

    InterProi IPR026203. IHABP.
    [Graphical view ]
    PANTHERi PTHR18956. PTHR18956. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of IHABP, a 95 kDa intracellular hyaluronate binding protein."
      Hofmann M., Fieber C., Assmann V., Goettlicher M., Sleeman J., Plug R., Howells N., von Stein O., Ponta H., Herrlich P.
      J. Cell Sci. 111:1673-1684(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
      Tissue: Lung.
    2. Zhao Y., Zhang S., Turley E.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Characterization of the murine gene encoding the intracellular hyaluronan receptor IHABP."
      Fieber C., Plug R., Sleeman J., Dall P., Ponta H., Hofmann M.
      Gene 226:41-50(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-183, TISSUE SPECIFICITY.
      Strain: 129/Sv.
    6. "Characterization of the murine gene encoding the hyaluronan receptor RHAMM."
      Entwistle J., Zhang S., Yang B., Wong C., Li Q., Hall C.L., Jingbo A., Mowat M., Greenberg A.H., Turley E.A.
      Gene 163:233-238(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 164-794, ALTERNATIVE SPLICING.
      Strain: BALB/c.
      Tissue: Fibroblast.
    7. "Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility."
      Hardwick C., Hoare K., Owens R., Hohn H.P., Hook M., Moore D., Cripps V., Austen L., Nance D.M., Turley E.A.
      J. Cell Biol. 117:1343-1350(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 318-794, CHARACTERIZATION.
      Strain: BALB/c.
    8. "Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity."
      Hall C.L., Wang C., Lange L.A., Turley E.A.
      J. Cell Biol. 126:575-588(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    9. "The hyaluronan receptor RHAMM regulates extracellular-regulated kinase."
      Zhang S., Chang M.C., Zylka D., Turley S., Harrison R., Turley E.A.
      J. Biol. Chem. 273:11342-11348(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: ERK REGULATION, SUBCELLULAR LOCATION.
    10. "Problems with RHAMM: a new link between surface adhesion and oncogenesis?"
      Hofmann M., Assmann V., Fieber C., Sleeman J.P., Moll J., Ponta H., Hart I.R., Herrlich P.
      Cell 95:591-592(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiHMMR_MOUSE
    AccessioniPrimary (citable) accession number: Q00547
    Secondary accession number(s): Q5NC88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 94 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3