Reviewed,
UniProtKB/Swiss-Prot Q00536 (PCTK1_HUMAN)
Last modified
December 15, 2009.
Version 102.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Serine/threonine-protein kinase PCTAIRE-1 EC=2.7.11.22 Alternative name(s): PCTAIRE-motif protein kinase 1 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 496 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May play a role in signal transduction cascades in terminally differentiated cells. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Subunit structure | Found in a complex containing CABLE1, PCTK2 and TDRD7. Interacts with YWHAH, YWHAQ and YWHAZ By similarity. |
| Sequence similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Traceable author statement. Source: ProtInc |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein kinase activityInferred from electronic annotation. Source: EC protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 496 | 496 | Serine/threonine-protein kinase PCTAIRE-1 | PRO_0000086484 | |||||
Regions | |||||||||
| Domain | 165 – 446 | 282 | Protein kinase | ||||||
| Nucleotide binding | 171 – 179 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 286 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 194 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 12 | 1 | Phosphoserine Ref.10 | ||||||
| Modified residue | 36 | 1 | Phosphoserine Ref.10 | ||||||
| Modified residue | 42 | 1 | Phosphoserine Ref.10 | ||||||
| Modified residue | 65 | 1 | Phosphoserine Ref.10 | ||||||
| Modified residue | 78 | 1 | Phosphoserine Ref.10 | ||||||
| Modified residue | 82 | 1 | Phosphoserine Ref.10 | ||||||
| Modified residue | 95 | 1 | Phosphoserine Ref.10 | ||||||
| Modified residue | 110 | 1 | Phosphoserine Ref.10 | ||||||
| Modified residue | 119 | 1 | Phosphoserine Ref.10 Ref.7 Ref.9 | ||||||
| Modified residue | 138 | 1 | Phosphoserine Ref.10 Ref.9 Ref.11 | ||||||
| Modified residue | 153 | 1 | Phosphoserine Ref.10 Ref.7 Ref.9 Ref.11 | ||||||
| Modified residue | 155 | 1 | Phosphoserine Ref.11 | ||||||
| Modified residue | 175 | 1 | Phosphothreonine | ||||||
| Modified residue | 176 | 1 | Phosphotyrosine Ref.8 | ||||||
| Modified residue | 480 | 1 | Phosphoserine Ref.10 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A family of human cdc2-related protein kinases." Meyerson M., Enders G.H., Wu C.-L., Su L.-K., Gorka C., Nelson C., Harlow E., Tsai L.-H. EMBO J. 11:2909-2917(1992) [PubMed: 1639063] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain. |
| [2] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thalamus. |
| [4] | "The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Placenta. |
| [7] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119 AND SER-153, MASS SPECTROMETRY. Tissue: Epithelium. |
| [8] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-176, MASS SPECTROMETRY. Tissue: Lung. |
| [9] | "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry." Wissing J., Jaensch L., Nimtz M., Dieterich G., Hornberger R., Keri G., Wehland J., Daub H. Mol. Cell. Proteomics 6:537-547(2007) [PubMed: 17192257] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119; SER-138 AND SER-153, MASS SPECTROMETRY. |
| [10] | "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-36; SER-42; SER-65; SER-78; SER-82; SER-95; SER-110; SER-119; SER-138; SER-153 AND SER-480, MASS SPECTROMETRY. |
| [11] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138; SER-153 AND SER-155, MASS SPECTROMETRY. |
| [12] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, MASS SPECTROMETRY. |
| [13] | "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-175, MASS SPECTROMETRY. Tissue: T-cell. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X66363 mRNA. Translation: CAA47006.1. BT006827 mRNA. Translation: AAP35473.1. AK290145 mRNA. Translation: BAF82834.1. AL096791 Genomic DNA. Translation: CAD20055.1. CH471164 Genomic DNA. Translation: EAW59297.1. BC001048 mRNA. Translation: AAH01048.1. BC015607 mRNA. Translation: AAH15607.1. | |
| IPI | IPI00549858. |
| PIR | S23385. |
| RefSeq | NP_006192.1. NP_148978.2. |
| UniGene | Hs.496068 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q00536. 4 interactions. |
| STRING | Q00536. |
PTM databases | |
| PhosphoSite | Q00536. |
Proteomic databases | |
| PRIDE | Q00536. |
Genome annotation databases | |
| Ensembl | ENST00000276052; ENSP00000276052; ENSG00000102225; Homo sapiens. [Genome view] ENST00000357227; ENSP00000349762; ENSG00000102225; Homo sapiens. [Genome view] ENST00000457458; ENSP00000405798; ENSG00000102225; Homo sapiens. [Genome view] |
| GeneID | 5127. |
| KEGG | hsa:5127. |
| UCSC | uc004dhn.1. human. |
Organism-specific databases | |
| CTD | 5127. |
| GeneCards | GC0XP046962. |
| H-InvDB | HIX0016759. |
| HGNC | HGNC:8749. PCTK1. |
| HPA | CAB016535. HPA001366. |
| MIM | 311550. gene. |
| PharmGKB | PA33095. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q00536. |
| InParanoid | Q00536. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.22. 247. |
Gene expression databases | |
| ArrayExpress | Q00536. |
| Bgee | Q00536. |
| CleanEx | HS_PCTK1. |
| Genevestigator | Q00536. |
| GermOnline | ENSG00000102225. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 19762. |
| SOURCE | Search... |
Entry information
| Entry name | PCTK1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q00536 Secondary accession number(s): A8K280 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


