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Q00535

- CDK5_HUMAN

UniProt

Q00535 - CDK5_HUMAN

Protein

Cyclin-dependent-like kinase 5

Gene

CDK5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 164 (01 Oct 2014)
      Sequence version 3 (15 Dec 1998)
      Previous versions | rss
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    Functioni

    Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.21 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Inhibited by 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine), 1-isopropyl-4-aminobenzyl-6-ether-linked benzimidazoles, resveratrol, AT-7519 and olomoucine. Activated by CDK5R1 (p35) and CDK5R2 (p39) during the development of the nervous system; degradation of CDK5R1 (p35) and CDK5R2 (p39) by proteasome result in down regulation of kinase activity, during this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation. Kinase activity is mainly determined by the amount of p35 available and subcellular location; reversible association to plasma membrane inhibits activity. Long-term inactivation as well as CDK5R1 (p25)-mediated hyperactivation of CDK5 triggers cell death. The pro-death activity of hyperactivated CDK5 is suppressed by membrane association of CDK5, via myristoylation of p35. Brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor (NGF), retinoic acid, laminin and neuregulin promote activity. Neurotoxicity enhances nuclear activity, thus leading to MEF2 phosphorylation and inhibition prior to apoptosis of cortical neurons. Repression by GSTP1 via p25/p35 translocation prevents neurodegeneration.5 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. acetylcholine receptor activator activity Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW
    3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    4. ErbB-2 class receptor binding Source: UniProtKB
    5. ErbB-3 class receptor binding Source: UniProtKB
    6. kinase activity Source: UniProtKB
    7. protein binding Source: UniProtKB
    8. protein kinase activity Source: ProtInc
    9. protein serine/threonine kinase activity Source: UniProtKB
    10. tau-protein kinase activity Source: UniProtKB

    GO - Biological processi

    1. axon extension Source: UniProtKB
    2. axon guidance Source: Reactome
    3. behavioral response to cocaine Source: Ensembl
    4. blood coagulation Source: Reactome
    5. calcium ion import Source: Ensembl
    6. cell cycle Source: UniProtKB-KW
    7. cell division Source: UniProtKB-KW
    8. cell-matrix adhesion Source: Ensembl
    9. cell proliferation Source: ProtInc
    10. central nervous system neuron development Source: Ensembl
    11. cerebellar cortex formation Source: Ensembl
    12. corpus callosum development Source: Ensembl
    13. cortical actin cytoskeleton organization Source: Ensembl
    14. dendrite morphogenesis Source: Ensembl
    15. embryo development Source: UniProtKB
    16. hippocampus development Source: Ensembl
    17. intracellular protein transport Source: Ensembl
    18. layer formation in cerebral cortex Source: Ensembl
    19. motor neuron axon guidance Source: Ensembl
    20. negative regulation of axon extension Source: Ensembl
    21. negative regulation of cell cycle Source: Ensembl
    22. negative regulation of neuron death Source: ParkinsonsUK-UCL
    23. negative regulation of protein export from nucleus Source: Ensembl
    24. negative regulation of protein ubiquitination Source: Ensembl
    25. negative regulation of proteolysis Source: ParkinsonsUK-UCL
    26. negative regulation of synaptic plasticity Source: Ensembl
    27. negative regulation of transcription, DNA-templated Source: DFLAT
    28. neuron apoptotic process Source: UniProtKB
    29. neuron differentiation Source: UniProtKB
    30. neuron migration Source: UniProtKB
    31. neuron projection development Source: UniProtKB
    32. nucleocytoplasmic transport Source: Ensembl
    33. oligodendrocyte differentiation Source: UniProtKB
    34. peptidyl-serine phosphorylation Source: UniProtKB
    35. peptidyl-threonine phosphorylation Source: Ensembl
    36. phosphorylation Source: DFLAT
    37. positive regulation of actin cytoskeleton reorganization Source: UniProtKB
    38. positive regulation of calcium ion-dependent exocytosis Source: Ensembl
    39. positive regulation of neuron apoptotic process Source: UniProtKB
    40. positive regulation of protein binding Source: Ensembl
    41. positive regulation of protein kinase activity Source: Ensembl
    42. positive regulation of protein targeting to membrane Source: Ensembl
    43. positive regulation of receptor activity Source: GOC
    44. protein autophosphorylation Source: Ensembl
    45. protein localization to synapse Source: Ensembl
    46. receptor catabolic process Source: Ensembl
    47. receptor clustering Source: Ensembl
    48. regulated secretory pathway Source: Ensembl
    49. regulation of apoptotic process Source: UniProtKB
    50. regulation of cell cycle arrest Source: UniProtKB
    51. regulation of cell migration Source: Ensembl
    52. regulation of dendritic spine morphogenesis Source: UniProtKB
    53. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    54. regulation of synaptic plasticity Source: UniProtKB
    55. rhythmic process Source: UniProtKB-KW
    56. Schwann cell development Source: Ensembl
    57. sensory perception of pain Source: Ensembl
    58. serine phosphorylation of STAT3 protein Source: Ensembl
    59. skeletal muscle tissue development Source: Ensembl
    60. synapse assembly Source: UniProtKB
    61. synaptic transmission Source: UniProtKB
    62. synaptic transmission, dopaminergic Source: Ensembl
    63. synaptic transmission, glutamatergic Source: Ensembl
    64. synaptic vesicle endocytosis Source: UniProtKB
    65. synaptic vesicle exocytosis Source: UniProtKB
    66. visual learning Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Apoptosis, Biological rhythms, Cell cycle, Cell division, Neurogenesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.22. 2681.
    ReactomeiREACT_15334. DARPP-32 events.
    REACT_19199. CRMPs in Sema3A signaling.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    SignaLinkiQ00535.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent-like kinase 5 (EC:2.7.11.1)
    Alternative name(s):
    Cell division protein kinase 5
    Serine/threonine-protein kinase PSSALRE
    Tau protein kinase II catalytic subunit
    Short name:
    TPKII catalytic subunit
    Gene namesi
    Name:CDK5
    Synonyms:CDKN5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:1774. CDK5.

    Subcellular locationi

    Isoform 1 : Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projectionlamellipodium By similarity. Cell projectiongrowth cone By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity
    Note: In axonal growth cone with extension to the peripheral lamellipodia By similarity. Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5.By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. cell junction Source: UniProtKB-KW
    3. cyclin-dependent protein kinase 5 holoenzyme complex Source: Ensembl
    4. cytoplasm Source: UniProtKB
    5. cytosol Source: Reactome
    6. dendrite Source: UniProtKB
    7. filopodium Source: Ensembl
    8. growth cone Source: UniProtKB
    9. lamellipodium Source: UniProtKB-SubCell
    10. membrane Source: UniProtKB
    11. neuromuscular junction Source: UniProtKB
    12. neuronal cell body Source: UniProtKB
    13. nucleus Source: UniProtKB
    14. perikaryon Source: UniProtKB-SubCell
    15. postsynaptic density Source: UniProtKB
    16. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi159 – 1591S → A: No phenotype. 1 Publication
    Mutagenesisi159 – 1591S → T: Impaired p35/p25 (CDK5R1) binding. 1 Publication

    Keywords - Diseasei

    Neurodegeneration

    Organism-specific databases

    PharmGKBiPA26310.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Cyclin-dependent-like kinase 5PRO_0000085784Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei15 – 151Phosphotyrosine; by ABL1, EPHA4 and FYN2 Publications
    Modified residuei56 – 561N6-acetyllysine1 Publication
    Modified residuei72 – 721Phosphoserine2 Publications
    Modified residuei159 – 1591Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By contrast, phosphorylation at Thr-14 inhibits activity.3 Publications
    Phosphorylation at Ser-159 is essential for maximal catalytic activity.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ00535.
    PaxDbiQ00535.
    PRIDEiQ00535.

    PTM databases

    PhosphoSiteiQ00535.

    Expressioni

    Tissue specificityi

    Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level). Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary.2 Publications

    Gene expression databases

    BgeeiQ00535.
    CleanExiHS_CDK5.
    GenevestigatoriQ00535.

    Organism-specific databases

    HPAiCAB008909.
    HPA018977.

    Interactioni

    Subunit structurei

    Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate p25 that hyperactivates CDK5, that becomes functionally disabled and often toxic. Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 and CABLES2 By similarity. Interacts with AATK and GSTP1. Binds to HDAC1 when in complex with p25. Interaction with myristoylation p35 promotes CDK5 association with membranes. Both isoforms 1 and 2 interacts with beta-catenin/CTNNB1. Interacts with delta-catenin/CTNND2 and APEX1. Interacts with P53/TP53 in neurons. Interacts with EPHA4; may mediate the activation of NGEF by EPHA4. Interacts with PTK2/FAK1 By similarity. The complex p35/CDK5 interacts with CLOCK.By similarity9 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CABLES1Q8TDN44EBI-1041567,EBI-604615
    CDK5R1Q150786EBI-1041567,EBI-746189
    CDKN1AP389364EBI-1041567,EBI-375077
    CDKN1BP465276EBI-1041567,EBI-519280
    PPARGP37231-22EBI-1041567,EBI-781416

    Protein-protein interaction databases

    BioGridi107455. 77 interactions.
    DIPiDIP-24221N.
    IntActiQ00535. 42 interactions.
    MINTiMINT-1037488.
    STRINGi9606.ENSP00000297518.

    Structurei

    Secondary structure

    1
    292
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 129
    Beta strandi14 – 2310
    Turni24 – 263
    Beta strandi29 – 357
    Beta strandi40 – 423
    Helixi46 – 5510
    Beta strandi66 – 705
    Beta strandi76 – 816
    Beta strandi84 – 863
    Helixi87 – 948
    Helixi100 – 11920
    Helixi129 – 1313
    Beta strandi132 – 1343
    Beta strandi140 – 1423
    Helixi145 – 1473
    Helixi165 – 1673
    Helixi170 – 1734
    Helixi182 – 19615
    Turni197 – 1993
    Helixi208 – 21912
    Turni224 – 2263
    Helixi228 – 2325
    Helixi248 – 2503
    Helixi257 – 26610
    Helixi271 – 2733
    Helixi277 – 2815
    Helixi284 – 2863

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1H4LX-ray2.65A/B1-292[»]
    1LFRmodel-A1-292[»]
    1UNGX-ray2.30A/B1-292[»]
    1UNHX-ray2.35A/B1-292[»]
    1UNLX-ray2.20A/B1-292[»]
    3O0GX-ray1.95A/B1-292[»]
    4AU8X-ray1.90A/B2-292[»]
    ProteinModelPortaliQ00535.
    SMRiQ00535. Positions 1-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ00535.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 286283Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiQ00535.
    KOiK02090.
    OMAiTMTKLPD.
    OrthoDBiEOG7966H8.
    PhylomeDBiQ00535.
    TreeFamiTF101023.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q00535-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR    50
    EICLLKELKH KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP 100
    EIVKSFLFQL LKGLGFCHSR NVLHRDLKPQ NLLINRNGEL KLADFGLARA 150
    FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS TSIDMWSAGC IFAELANAGR 200
    PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP MYPATTSLVN 250
    VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP 292
    Length:292
    Mass (Da):33,304
    Last modified:December 15, 1998 - v3
    Checksum:i54D10495F017D527
    GO
    Isoform 2 (identifier: Q00535-2) [UniParc]FASTAAdd to Basket

    Also known as: CDK5-SV

    The sequence of this isoform differs from the canonical sequence as follows:
         105-136: Missing.

    Show »
    Length:260
    Mass (Da):29,544
    Checksum:i808E46028B657622
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti225 – 2251E → D.1 Publication
    Corresponds to variant rs35186917 [ dbSNP | Ensembl ].
    VAR_041977

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei105 – 13632Missing in isoform 2. 1 PublicationVSP_041948Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66364 mRNA. Translation: CAA47007.1.
    DQ411039 mRNA. Translation: ABD66016.1.
    AY049778 mRNA. Translation: AAL15435.1.
    BT006680 mRNA. Translation: AAP35326.1.
    AC010973 Genomic DNA. No translation available.
    BC005115 mRNA. Translation: AAH05115.1.
    CCDSiCCDS47748.1. [Q00535-1]
    CCDS55184.1. [Q00535-2]
    PIRiS23386.
    RefSeqiNP_001157882.1. NM_001164410.1. [Q00535-2]
    NP_004926.1. NM_004935.3. [Q00535-1]
    UniGeneiHs.647078.

    Genome annotation databases

    EnsembliENST00000297518; ENSP00000297518; ENSG00000164885. [Q00535-2]
    ENST00000485972; ENSP00000419782; ENSG00000164885. [Q00535-1]
    GeneIDi1020.
    KEGGihsa:1020.
    UCSCiuc003wir.2. human. [Q00535-1]
    uc003wis.2. human. [Q00535-2]

    Polymorphism databases

    DMDMi4033704.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66364 mRNA. Translation: CAA47007.1 .
    DQ411039 mRNA. Translation: ABD66016.1 .
    AY049778 mRNA. Translation: AAL15435.1 .
    BT006680 mRNA. Translation: AAP35326.1 .
    AC010973 Genomic DNA. No translation available.
    BC005115 mRNA. Translation: AAH05115.1 .
    CCDSi CCDS47748.1. [Q00535-1 ]
    CCDS55184.1. [Q00535-2 ]
    PIRi S23386.
    RefSeqi NP_001157882.1. NM_001164410.1. [Q00535-2 ]
    NP_004926.1. NM_004935.3. [Q00535-1 ]
    UniGenei Hs.647078.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1H4L X-ray 2.65 A/B 1-292 [» ]
    1LFR model - A 1-292 [» ]
    1UNG X-ray 2.30 A/B 1-292 [» ]
    1UNH X-ray 2.35 A/B 1-292 [» ]
    1UNL X-ray 2.20 A/B 1-292 [» ]
    3O0G X-ray 1.95 A/B 1-292 [» ]
    4AU8 X-ray 1.90 A/B 2-292 [» ]
    ProteinModelPortali Q00535.
    SMRi Q00535. Positions 1-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107455. 77 interactions.
    DIPi DIP-24221N.
    IntActi Q00535. 42 interactions.
    MINTi MINT-1037488.
    STRINGi 9606.ENSP00000297518.

    Chemistry

    BindingDBi Q00535.
    ChEMBLi CHEMBL1907600.
    GuidetoPHARMACOLOGYi 1977.

    PTM databases

    PhosphoSitei Q00535.

    Polymorphism databases

    DMDMi 4033704.

    Proteomic databases

    MaxQBi Q00535.
    PaxDbi Q00535.
    PRIDEi Q00535.

    Protocols and materials databases

    DNASUi 1020.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297518 ; ENSP00000297518 ; ENSG00000164885 . [Q00535-2 ]
    ENST00000485972 ; ENSP00000419782 ; ENSG00000164885 . [Q00535-1 ]
    GeneIDi 1020.
    KEGGi hsa:1020.
    UCSCi uc003wir.2. human. [Q00535-1 ]
    uc003wis.2. human. [Q00535-2 ]

    Organism-specific databases

    CTDi 1020.
    GeneCardsi GC07M150750.
    HGNCi HGNC:1774. CDK5.
    HPAi CAB008909.
    HPA018977.
    MIMi 123831. gene.
    neXtProti NX_Q00535.
    PharmGKBi PA26310.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi Q00535.
    KOi K02090.
    OMAi TMTKLPD.
    OrthoDBi EOG7966H8.
    PhylomeDBi Q00535.
    TreeFami TF101023.

    Enzyme and pathway databases

    BRENDAi 2.7.11.22. 2681.
    Reactomei REACT_15334. DARPP-32 events.
    REACT_19199. CRMPs in Sema3A signaling.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    SignaLinki Q00535.

    Miscellaneous databases

    EvolutionaryTracei Q00535.
    GeneWikii Cyclin-dependent_kinase_5.
    GenomeRNAii 1020.
    NextBioi 4287.
    PROi Q00535.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q00535.
    CleanExi HS_CDK5.
    Genevestigatori Q00535.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of human cdc2-related protein kinases."
      Meyerson M., Enders G.H., Wu C.-L., Su L.-K., Gorka C., Nelson C., Harlow E., Tsai L.-H.
      EMBO J. 11:2909-2917(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal brain.
    2. Meyerson M.
      Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling."
      Li Q., Liu X., Zhang M., Ye G., Qiao Q., Ling Y., Wu Y., Zhang Y., Yu L.
      Mol. Biol. Rep. 37:2415-2421(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CTNNB1, FUNCTION IN WNT/B-CATENIN SIGNALING PATHWAY.
      Tissue: Testis.
    4. Hu X., Xu Y., Zhang B., Peng X., Yuan J., Qiang B.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    8. "Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5."
      Meijer L., Borgne A., Mulner O., Chong J.P.J., Blow J.J., Inagaki N., Inagaki M., Delcros J.-G., Moulinoux J.-P.
      Eur. J. Biochem. 243:527-536(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION BY ROSCOVITINE AND OLOMOUCINE.
    9. "Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth."
      Paglini G., Pigino G., Kunda P., Morfini G., Maccioni R., Quiroga S., Ferreira A., Caceres A.
      J. Neurosci. 18:9858-9869(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN AXON GROWTH.
    10. "Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation."
      Sharma P., Sharma M., Amin N.D., Albers R.W., Pant H.C.
      Proc. Natl. Acad. Sci. U.S.A. 96:11156-11160(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-159.
    11. "Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35."
      Kerokoski P., Suuronen T., Salminen A., Soininen H., Pirttilae T.
      Brain Res. Mol. Brain Res. 106:50-56(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS P35/CDK5R1 KINASE.
    12. Cited for: INTERACTION WITH AATK.
    13. "Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis."
      Gong X., Tang X., Wiedmann M., Wang X., Peng J., Zheng D., Blair L.A.C., Marshall J., Mao Z.
      Neuron 38:33-46(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS MEF2A KINASE, ENZYME REGULATION, SUBCELLULAR LOCATION.
    14. "Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation."
      Zhu Y.-S., Saito T., Asada A., Maekawa S., Hisanaga S.
      J. Neurochem. 94:1535-1545(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS P35 KINASE, SUBCELLULAR LOCATION, ENZYME REGULATION.
    15. "Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation."
      Kamei H., Saito T., Ozawa M., Fujita Y., Asada A., Bibb J.A., Saido T.C., Sorimachi H., Hisanaga S.
      J. Biol. Chem. 282:1687-1694(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS P35/CDK5R KINASE.
    16. "cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cells."
      Munoz J.P., Huichalaf C.H., Orellana D., Maccioni R.B.
      J. Cell. Biochem. 100:738-749(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS CTNNB1 AND CTNND2 KINASE, INTERACTION WITH CTNNB1 AND CTNND2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    17. "Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death."
      Lee J.-H., Kim H.-S., Lee S.-J., Kim K.-T.
      J. Cell Sci. 120:2259-2271(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS P53/TP53 KINASE, INTERACTION WITH P53/TP53, SUBCELLULAR LOCATION.
    18. "Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin."
      Miyamoto Y., Yamauchi J., Chan J.R., Okada A., Tomooka Y., Hisanaga S., Tanoue A.
      J. Cell Sci. 120:4355-4366(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS PXN KINASE.
    19. "Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons."
      Anne S.L., Saudou F., Humbert S.
      J. Neurosci. 27:7318-7328(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS HUNTINGTIN KINASE, ENZYME REGULATION BY ROSCOVITINE.
    20. "Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35."
      Sato K., Zhu Y.-S., Saito T., Yotsumoto K., Asada A., Hasegawa M., Hisanaga S.
      J. Neurosci. Res. 85:3071-3078(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS P35/CDK5R KINASE, INTERACTION WITH P35/CDK5R, SUBCELLULAR LOCATION.
    21. "Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism."
      Fu W.Y., Chen Y., Sahin M., Zhao X.S., Shi L., Bikoff J.B., Lai K.O., Yung W.H., Fu A.K., Greenberg M.E., Ip N.Y.
      Nat. Neurosci. 10:67-76(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-15 BY EPHA4.
    22. "Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes."
      Asada A., Yamamoto N., Gohda M., Saito T., Hayashi N., Hisanaga S.
      J. Neurochem. 106:1325-1336(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    23. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    24. Cited for: FUNCTION AS HDAC REGULATOR.
    25. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    26. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    27. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-56, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    28. "Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis."
      Liebl J., Weitensteiner S.B., Vereb G., Takacs L., Fuerst R., Vollmar A.M., Zahler S.
      J. Biol. Chem. 285:35932-35943(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ANGIOGENESIS.
    29. "CDK5 phosphorylates eNOS at Ser-113 and regulates NO production."
      Lee C.-H., Wei Y.-W., Huang Y.-T., Lin Y.-T., Lee Y.-C., Lee K.-H., Lu P.-J.
      J. Cell. Biochem. 110:112-117(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS NOS3 KINASE.
    30. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    31. "Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25."
      Jain P., Flaherty P.T., Yi S., Chopra I., Bleasdell G., Lipay J., Ferandin Y., Meijer L., Madura J.D.
      Bioorg. Med. Chem. 19:359-373(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INHIBITORS.
    32. "Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75)."
      Pan Q., Qiao F., Gao C., Norman B., Optican L., Zelenka P.S.
      Cell. Mol. Life Sci. 68:3425-3436(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS SRC KINASE.
    33. "Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils."
      Lee K.Y., Liu L., Jin Y., Fu S.B., Rosales J.L.
      J. Cell. Physiol. 227:739-750(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS VIM KINASE, SUBCELLULAR LOCATION.
    34. "Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity."
      Sun K.H., Chang K.H., Clawson S., Ghosh S., Mirzaei H., Regnier F., Shah K.
      J. Neurochem. 118:902-914(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, INTERACTION WITH GSTP1.
    35. "High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization."
      Gallazzini M., Heussler G.E., Kunin M., Izumi Y., Burg M.B., Ferraris J.D.
      Mol. Biol. Cell 22:703-714(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS TONEBP/NFAT5 KINASE.
    36. "Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease."
      Wong A.S., Lee R.H., Cheung A.Y., Yeung P.K., Chung S.K., Cheung Z.H., Ip N.Y.
      Nat. Cell Biol. 13:568-579(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS SH3GLB1 KINASE.
    37. "Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control."
      Arif A., Jia J., Moodt R.A., DiCorleto P.E., Fox P.L.
      Proc. Natl. Acad. Sci. U.S.A. 108:1415-1420(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS EPRS KINASE.
    38. Cited for: REVIEW.
    39. "Cell cycle, CDKs and cancer: a changing paradigm."
      Malumbres M., Barbacid M.
      Nat. Rev. Cancer 9:153-166(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON INHIBITORS, GENE FAMILY.
    40. "Making a neuron: Cdk5 in embryonic and adult neurogenesis."
      Jessberger S., Gage F.H., Eisch A.J., Lagace D.C.
      Trends Neurosci. 32:575-582(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON NEURONAL PHYSIOLOGY.
    41. Cited for: FUNCTION.
    42. "Regulation and role of cyclin-dependent kinase activity in neuronal survival and death."
      Hisanaga S., Endo R.
      J. Neurochem. 115:1309-1321(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON REGULATION.
    43. "Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons."
      Zhang J., Herrup K.
      Cell Cycle 10:1208-1214(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON NEURON DEVELOPMENT.
    44. "Cdk5: Mediator of neuronal development, death and the response to DNA damage."
      Zhu J., Li W., Mao Z.
      Mech. Ageing Dev. 132:389-394(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON NEURON DEVELOPMENT.
    45. "Cdk5: multitasking between physiological and pathological conditions."
      Lopes J.P., Agostinho P.
      Prog. Neurobiol. 94:49-63(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON NEURONS.
    46. "Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation."
      Kwak Y., Jeong J., Lee S., Park Y.U., Lee S.A., Han D.H., Kim J.H., Ohshima T., Mikoshiba K., Suh Y.H., Cho S., Park S.K.
      J. Biol. Chem. 288:36878-36889(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CLOCK.
    47. "Structure and regulation of the CDK5-p25(nck5a) complex."
      Tarricone C., Dhavan R., Peng J., Areces L.B., Tsai L.-H., Musacchio A.
      Mol. Cell 8:657-669(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) IN COMPLEX WITH P25, MUTAGENESIS OF SER-159.
    48. "Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation."
      Ahn J.S., Radhakrishnan M.L., Mapelli M., Choi S., Tidor B., Cuny G.D., Musacchio A., Yeh L.A., Kosik K.S.
      Chem. Biol. 12:811-823(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).
    49. Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH INHIBITORS AND P25, PHOSPHORYLATION AT TYR-15.
    50. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-225.

    Entry informationi

    Entry nameiCDK5_HUMAN
    AccessioniPrimary (citable) accession number: Q00535
    Secondary accession number(s): A1XKG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: December 15, 1998
    Last modified: October 1, 2014
    This is version 164 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Dysregulation of CDK5 is associated with neurodegenerative disorders such as Alzheimer, Parkinson, and Niemann-Pick type C diseases, ischemia, and amyotrophic lateral sclerosis.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3