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Q00535

- CDK5_HUMAN

UniProt

Q00535 - CDK5_HUMAN

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Protein

Cyclin-dependent-like kinase 5

Gene

CDK5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.21 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Inhibited by 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine), 1-isopropyl-4-aminobenzyl-6-ether-linked benzimidazoles, resveratrol, AT-7519 and olomoucine. Activated by CDK5R1 (p35) and CDK5R2 (p39) during the development of the nervous system; degradation of CDK5R1 (p35) and CDK5R2 (p39) by proteasome result in down regulation of kinase activity, during this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation. Kinase activity is mainly determined by the amount of p35 available and subcellular location; reversible association to plasma membrane inhibits activity. Long-term inactivation as well as CDK5R1 (p25)-mediated hyperactivation of CDK5 triggers cell death. The pro-death activity of hyperactivated CDK5 is suppressed by membrane association of CDK5, via myristoylation of p35. Brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor (NGF), retinoic acid, laminin and neuregulin promote activity. Neurotoxicity enhances nuclear activity, thus leading to MEF2 phosphorylation and inhibition prior to apoptosis of cortical neurons. Repression by GSTP1 via p25/p35 translocation prevents neurodegeneration.5 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. acetylcholine receptor activator activity Source: UniProtKB
  2. ATP binding Source: UniProtKB-KW
  3. cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  4. ErbB-2 class receptor binding Source: UniProtKB
  5. ErbB-3 class receptor binding Source: UniProtKB
  6. kinase activity Source: UniProtKB
  7. protein kinase activity Source: ProtInc
  8. protein serine/threonine kinase activity Source: UniProtKB
  9. tau-protein kinase activity Source: UniProtKB

GO - Biological processi

  1. axon extension Source: UniProtKB
  2. axon guidance Source: Reactome
  3. behavioral response to cocaine Source: Ensembl
  4. blood coagulation Source: Reactome
  5. calcium ion import Source: Ensembl
  6. cell cycle Source: UniProtKB-KW
  7. cell division Source: UniProtKB-KW
  8. cell-matrix adhesion Source: Ensembl
  9. cell proliferation Source: ProtInc
  10. central nervous system neuron development Source: Ensembl
  11. cerebellar cortex formation Source: Ensembl
  12. corpus callosum development Source: Ensembl
  13. cortical actin cytoskeleton organization Source: Ensembl
  14. dendrite morphogenesis Source: Ensembl
  15. embryo development Source: UniProtKB
  16. hippocampus development Source: Ensembl
  17. intracellular protein transport Source: Ensembl
  18. layer formation in cerebral cortex Source: Ensembl
  19. motor neuron axon guidance Source: Ensembl
  20. negative regulation of axon extension Source: Ensembl
  21. negative regulation of cell cycle Source: Ensembl
  22. negative regulation of neuron death Source: ParkinsonsUK-UCL
  23. negative regulation of protein export from nucleus Source: Ensembl
  24. negative regulation of protein ubiquitination Source: Ensembl
  25. negative regulation of proteolysis Source: ParkinsonsUK-UCL
  26. negative regulation of synaptic plasticity Source: Ensembl
  27. negative regulation of transcription, DNA-templated Source: DFLAT
  28. neuron apoptotic process Source: UniProtKB
  29. neuron differentiation Source: UniProtKB
  30. neuron migration Source: UniProtKB
  31. neuron projection development Source: UniProtKB
  32. nucleocytoplasmic transport Source: Ensembl
  33. oligodendrocyte differentiation Source: UniProtKB
  34. peptidyl-serine phosphorylation Source: UniProtKB
  35. peptidyl-threonine phosphorylation Source: Ensembl
  36. phosphorylation Source: DFLAT
  37. positive regulation of actin cytoskeleton reorganization Source: UniProtKB
  38. positive regulation of calcium ion-dependent exocytosis Source: Ensembl
  39. positive regulation of neuron apoptotic process Source: UniProtKB
  40. positive regulation of protein binding Source: Ensembl
  41. positive regulation of protein kinase activity Source: Ensembl
  42. positive regulation of protein targeting to membrane Source: Ensembl
  43. protein autophosphorylation Source: Ensembl
  44. protein localization to synapse Source: Ensembl
  45. receptor catabolic process Source: Ensembl
  46. receptor clustering Source: Ensembl
  47. regulated secretory pathway Source: Ensembl
  48. regulation of apoptotic process Source: UniProtKB
  49. regulation of cell cycle arrest Source: UniProtKB
  50. regulation of cell migration Source: Ensembl
  51. regulation of dendritic spine morphogenesis Source: UniProtKB
  52. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  53. regulation of synaptic plasticity Source: UniProtKB
  54. rhythmic process Source: UniProtKB-KW
  55. Schwann cell development Source: Ensembl
  56. sensory perception of pain Source: Ensembl
  57. serine phosphorylation of STAT3 protein Source: Ensembl
  58. skeletal muscle tissue development Source: Ensembl
  59. synapse assembly Source: UniProtKB
  60. synaptic transmission Source: UniProtKB
  61. synaptic transmission, dopaminergic Source: Ensembl
  62. synaptic transmission, glutamatergic Source: Ensembl
  63. synaptic vesicle endocytosis Source: UniProtKB
  64. synaptic vesicle exocytosis Source: UniProtKB
  65. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis, Biological rhythms, Cell cycle, Cell division, Neurogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 2681.
ReactomeiREACT_15334. DARPP-32 events.
REACT_19199. CRMPs in Sema3A signaling.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
SignaLinkiQ00535.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent-like kinase 5 (EC:2.7.11.1)
Alternative name(s):
Cell division protein kinase 5
Serine/threonine-protein kinase PSSALRE
Tau protein kinase II catalytic subunit
Short name:
TPKII catalytic subunit
Gene namesi
Name:CDK5
Synonyms:CDKN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:1774. CDK5.

Subcellular locationi

Isoform 1 : Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projectionlamellipodium By similarity. Cell projectiongrowth cone By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity
Note: In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5.By similarity

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. cell junction Source: UniProtKB-KW
  3. cyclin-dependent protein kinase 5 holoenzyme complex Source: Ensembl
  4. cytoplasm Source: UniProtKB
  5. cytosol Source: Reactome
  6. dendrite Source: UniProtKB
  7. filopodium Source: Ensembl
  8. growth cone Source: UniProtKB
  9. lamellipodium Source: Ensembl
  10. membrane Source: UniProtKB
  11. neuromuscular junction Source: UniProtKB
  12. neuronal cell body Source: UniProtKB
  13. nucleus Source: UniProtKB
  14. postsynaptic density Source: UniProtKB
  15. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi159 – 1591S → A: No phenotype. 1 Publication
Mutagenesisi159 – 1591S → T: Impaired p35/p25 (CDK5R1) binding. 1 Publication

Keywords - Diseasei

Neurodegeneration

Organism-specific databases

PharmGKBiPA26310.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Cyclin-dependent-like kinase 5PRO_0000085784Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151Phosphotyrosine; by ABL1, EPHA4 and FYN2 Publications
Modified residuei56 – 561N6-acetyllysine1 Publication
Modified residuei72 – 721Phosphoserine2 Publications
Modified residuei159 – 1591Phosphoserine1 Publication

Post-translational modificationi

Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By contrast, phosphorylation at Thr-14 inhibits activity.3 Publications
Phosphorylation at Ser-159 is essential for maximal catalytic activity.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ00535.
PaxDbiQ00535.
PRIDEiQ00535.

PTM databases

PhosphoSiteiQ00535.

Expressioni

Tissue specificityi

Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level). Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary.2 Publications

Gene expression databases

BgeeiQ00535.
CleanExiHS_CDK5.
GenevestigatoriQ00535.

Organism-specific databases

HPAiCAB008909.
HPA018977.

Interactioni

Subunit structurei

Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate p25 that hyperactivates CDK5, that becomes functionally disabled and often toxic. Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 and CABLES2 (By similarity). Interacts with AATK and GSTP1. Binds to HDAC1 when in complex with p25. Interaction with myristoylation p35 promotes CDK5 association with membranes. Both isoforms 1 and 2 interacts with beta-catenin/CTNNB1. Interacts with delta-catenin/CTNND2 and APEX1. Interacts with P53/TP53 in neurons. Interacts with EPHA4; may mediate the activation of NGEF by EPHA4. Interacts with PTK2/FAK1 (By similarity). The complex p35/CDK5 interacts with CLOCK.By similarity9 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CABLES1Q8TDN44EBI-1041567,EBI-604615
CDK5R1Q150786EBI-1041567,EBI-746189
CDKN1AP389364EBI-1041567,EBI-375077
CDKN1BP465276EBI-1041567,EBI-519280
PPARGP37231-22EBI-1041567,EBI-781416

Protein-protein interaction databases

BioGridi107455. 80 interactions.
DIPiDIP-24221N.
IntActiQ00535. 43 interactions.
MINTiMINT-1037488.
STRINGi9606.ENSP00000297518.

Structurei

Secondary structure

1
292
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 129Combined sources
Beta strandi14 – 2310Combined sources
Turni24 – 263Combined sources
Beta strandi29 – 357Combined sources
Beta strandi40 – 423Combined sources
Helixi46 – 5510Combined sources
Beta strandi66 – 705Combined sources
Beta strandi76 – 816Combined sources
Beta strandi84 – 863Combined sources
Helixi87 – 948Combined sources
Helixi100 – 11920Combined sources
Helixi129 – 1313Combined sources
Beta strandi132 – 1343Combined sources
Beta strandi140 – 1423Combined sources
Helixi145 – 1473Combined sources
Helixi165 – 1673Combined sources
Helixi170 – 1734Combined sources
Helixi182 – 19615Combined sources
Turni197 – 1993Combined sources
Helixi208 – 21912Combined sources
Turni224 – 2263Combined sources
Helixi228 – 2325Combined sources
Helixi248 – 2503Combined sources
Helixi257 – 26610Combined sources
Helixi271 – 2733Combined sources
Helixi277 – 2815Combined sources
Helixi284 – 2863Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1H4LX-ray2.65A/B1-292[»]
1LFRmodel-A1-292[»]
1UNGX-ray2.30A/B1-292[»]
1UNHX-ray2.35A/B1-292[»]
1UNLX-ray2.20A/B1-292[»]
3O0GX-ray1.95A/B1-292[»]
4AU8X-ray1.90A/B2-292[»]
ProteinModelPortaliQ00535.
SMRiQ00535. Positions 1-292.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00535.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 286283Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119154.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ00535.
KOiK02090.
OMAiTMTKLPD.
OrthoDBiEOG7966H8.
PhylomeDBiQ00535.
TreeFamiTF101023.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q00535-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR
60 70 80 90 100
EICLLKELKH KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP
110 120 130 140 150
EIVKSFLFQL LKGLGFCHSR NVLHRDLKPQ NLLINRNGEL KLADFGLARA
160 170 180 190 200
FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS TSIDMWSAGC IFAELANAGR
210 220 230 240 250
PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP MYPATTSLVN
260 270 280 290
VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP
Length:292
Mass (Da):33,304
Last modified:December 15, 1998 - v3
Checksum:i54D10495F017D527
GO
Isoform 2 (identifier: Q00535-2) [UniParc]FASTAAdd to Basket

Also known as: CDK5-SV

The sequence of this isoform differs from the canonical sequence as follows:
     105-136: Missing.

Show »
Length:260
Mass (Da):29,544
Checksum:i808E46028B657622
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti225 – 2251E → D.1 Publication
Corresponds to variant rs35186917 [ dbSNP | Ensembl ].
VAR_041977

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei105 – 13632Missing in isoform 2. 1 PublicationVSP_041948Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66364 mRNA. Translation: CAA47007.1.
DQ411039 mRNA. Translation: ABD66016.1.
AY049778 mRNA. Translation: AAL15435.1.
BT006680 mRNA. Translation: AAP35326.1.
AC010973 Genomic DNA. No translation available.
BC005115 mRNA. Translation: AAH05115.1.
CCDSiCCDS47748.1. [Q00535-1]
CCDS55184.1. [Q00535-2]
PIRiS23386.
RefSeqiNP_001157882.1. NM_001164410.1. [Q00535-2]
NP_004926.1. NM_004935.3. [Q00535-1]
UniGeneiHs.647078.

Genome annotation databases

EnsembliENST00000297518; ENSP00000297518; ENSG00000164885. [Q00535-2]
ENST00000485972; ENSP00000419782; ENSG00000164885. [Q00535-1]
ENST00000618146; ENSP00000481070; ENSG00000164885. [Q00535-1]
GeneIDi1020.
KEGGihsa:1020.
UCSCiuc003wir.2. human. [Q00535-1]
uc003wis.2. human. [Q00535-2]

Polymorphism databases

DMDMi4033704.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66364 mRNA. Translation: CAA47007.1 .
DQ411039 mRNA. Translation: ABD66016.1 .
AY049778 mRNA. Translation: AAL15435.1 .
BT006680 mRNA. Translation: AAP35326.1 .
AC010973 Genomic DNA. No translation available.
BC005115 mRNA. Translation: AAH05115.1 .
CCDSi CCDS47748.1. [Q00535-1 ]
CCDS55184.1. [Q00535-2 ]
PIRi S23386.
RefSeqi NP_001157882.1. NM_001164410.1. [Q00535-2 ]
NP_004926.1. NM_004935.3. [Q00535-1 ]
UniGenei Hs.647078.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1H4L X-ray 2.65 A/B 1-292 [» ]
1LFR model - A 1-292 [» ]
1UNG X-ray 2.30 A/B 1-292 [» ]
1UNH X-ray 2.35 A/B 1-292 [» ]
1UNL X-ray 2.20 A/B 1-292 [» ]
3O0G X-ray 1.95 A/B 1-292 [» ]
4AU8 X-ray 1.90 A/B 2-292 [» ]
ProteinModelPortali Q00535.
SMRi Q00535. Positions 1-292.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107455. 80 interactions.
DIPi DIP-24221N.
IntActi Q00535. 43 interactions.
MINTi MINT-1037488.
STRINGi 9606.ENSP00000297518.

Chemistry

BindingDBi Q00535.
ChEMBLi CHEMBL1907600.
GuidetoPHARMACOLOGYi 1977.

PTM databases

PhosphoSitei Q00535.

Polymorphism databases

DMDMi 4033704.

Proteomic databases

MaxQBi Q00535.
PaxDbi Q00535.
PRIDEi Q00535.

Protocols and materials databases

DNASUi 1020.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297518 ; ENSP00000297518 ; ENSG00000164885 . [Q00535-2 ]
ENST00000485972 ; ENSP00000419782 ; ENSG00000164885 . [Q00535-1 ]
ENST00000618146 ; ENSP00000481070 ; ENSG00000164885 . [Q00535-1 ]
GeneIDi 1020.
KEGGi hsa:1020.
UCSCi uc003wir.2. human. [Q00535-1 ]
uc003wis.2. human. [Q00535-2 ]

Organism-specific databases

CTDi 1020.
GeneCardsi GC07M150750.
HGNCi HGNC:1774. CDK5.
HPAi CAB008909.
HPA018977.
MIMi 123831. gene.
neXtProti NX_Q00535.
PharmGKBi PA26310.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119154.
HOGENOMi HOG000233024.
HOVERGENi HBG014652.
InParanoidi Q00535.
KOi K02090.
OMAi TMTKLPD.
OrthoDBi EOG7966H8.
PhylomeDBi Q00535.
TreeFami TF101023.

Enzyme and pathway databases

BRENDAi 2.7.11.22. 2681.
Reactomei REACT_15334. DARPP-32 events.
REACT_19199. CRMPs in Sema3A signaling.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
SignaLinki Q00535.

Miscellaneous databases

ChiTaRSi CDK5. human.
EvolutionaryTracei Q00535.
GeneWikii Cyclin-dependent_kinase_5.
GenomeRNAii 1020.
NextBioi 4287.
PROi Q00535.
SOURCEi Search...

Gene expression databases

Bgeei Q00535.
CleanExi HS_CDK5.
Genevestigatori Q00535.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A family of human cdc2-related protein kinases."
    Meyerson M., Enders G.H., Wu C.-L., Su L.-K., Gorka C., Nelson C., Harlow E., Tsai L.-H.
    EMBO J. 11:2909-2917(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. Meyerson M.
    Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling."
    Li Q., Liu X., Zhang M., Ye G., Qiao Q., Ling Y., Wu Y., Zhang Y., Yu L.
    Mol. Biol. Rep. 37:2415-2421(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH CTNNB1, FUNCTION IN WNT/B-CATENIN SIGNALING PATHWAY.
    Tissue: Testis.
  4. Hu X., Xu Y., Zhang B., Peng X., Yuan J., Qiang B.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  8. "Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5."
    Meijer L., Borgne A., Mulner O., Chong J.P.J., Blow J.J., Inagaki N., Inagaki M., Delcros J.-G., Moulinoux J.-P.
    Eur. J. Biochem. 243:527-536(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION BY ROSCOVITINE AND OLOMOUCINE.
  9. "Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth."
    Paglini G., Pigino G., Kunda P., Morfini G., Maccioni R., Quiroga S., Ferreira A., Caceres A.
    J. Neurosci. 18:9858-9869(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN AXON GROWTH.
  10. "Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation."
    Sharma P., Sharma M., Amin N.D., Albers R.W., Pant H.C.
    Proc. Natl. Acad. Sci. U.S.A. 96:11156-11160(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-159.
  11. "Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35."
    Kerokoski P., Suuronen T., Salminen A., Soininen H., Pirttilae T.
    Brain Res. Mol. Brain Res. 106:50-56(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS P35/CDK5R1 KINASE.
  12. Cited for: INTERACTION WITH AATK.
  13. "Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis."
    Gong X., Tang X., Wiedmann M., Wang X., Peng J., Zheng D., Blair L.A.C., Marshall J., Mao Z.
    Neuron 38:33-46(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS MEF2A KINASE, ENZYME REGULATION, SUBCELLULAR LOCATION.
  14. "Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation."
    Zhu Y.-S., Saito T., Asada A., Maekawa S., Hisanaga S.
    J. Neurochem. 94:1535-1545(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS P35 KINASE, SUBCELLULAR LOCATION, ENZYME REGULATION.
  15. "Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation."
    Kamei H., Saito T., Ozawa M., Fujita Y., Asada A., Bibb J.A., Saido T.C., Sorimachi H., Hisanaga S.
    J. Biol. Chem. 282:1687-1694(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS P35/CDK5R KINASE.
  16. "cdk5 modulates beta- and delta-catenin/Pin1 interactions in neuronal cells."
    Munoz J.P., Huichalaf C.H., Orellana D., Maccioni R.B.
    J. Cell. Biochem. 100:738-749(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS CTNNB1 AND CTNND2 KINASE, INTERACTION WITH CTNNB1 AND CTNND2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  17. "Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death."
    Lee J.-H., Kim H.-S., Lee S.-J., Kim K.-T.
    J. Cell Sci. 120:2259-2271(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS P53/TP53 KINASE, INTERACTION WITH P53/TP53, SUBCELLULAR LOCATION.
  18. "Cdk5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin."
    Miyamoto Y., Yamauchi J., Chan J.R., Okada A., Tomooka Y., Hisanaga S., Tanoue A.
    J. Cell Sci. 120:4355-4366(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS PXN KINASE.
  19. "Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons."
    Anne S.L., Saudou F., Humbert S.
    J. Neurosci. 27:7318-7328(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS HUNTINGTIN KINASE, ENZYME REGULATION BY ROSCOVITINE.
  20. "Regulation of membrane association and kinase activity of Cdk5-p35 by phosphorylation of p35."
    Sato K., Zhu Y.-S., Saito T., Yotsumoto K., Asada A., Hasegawa M., Hisanaga S.
    J. Neurosci. Res. 85:3071-3078(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS P35/CDK5R KINASE, INTERACTION WITH P35/CDK5R, SUBCELLULAR LOCATION.
  21. "Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism."
    Fu W.Y., Chen Y., Sahin M., Zhao X.S., Shi L., Bikoff J.B., Lai K.O., Yung W.H., Fu A.K., Greenberg M.E., Ip N.Y.
    Nat. Neurosci. 10:67-76(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-15 BY EPHA4.
  22. "Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear localization of active cyclin-dependent kinase 5 complexes."
    Asada A., Yamamoto N., Gohda M., Saito T., Hayashi N., Hisanaga S.
    J. Neurochem. 106:1325-1336(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  23. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  24. Cited for: FUNCTION AS HDAC REGULATOR.
  25. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  26. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  27. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-56, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  28. "Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis."
    Liebl J., Weitensteiner S.B., Vereb G., Takacs L., Fuerst R., Vollmar A.M., Zahler S.
    J. Biol. Chem. 285:35932-35943(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ANGIOGENESIS.
  29. "CDK5 phosphorylates eNOS at Ser-113 and regulates NO production."
    Lee C.-H., Wei Y.-W., Huang Y.-T., Lin Y.-T., Lee Y.-C., Lee K.-H., Lu P.-J.
    J. Cell. Biochem. 110:112-117(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS NOS3 KINASE.
  30. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  31. "Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25."
    Jain P., Flaherty P.T., Yi S., Chopra I., Bleasdell G., Lipay J., Ferandin Y., Meijer L., Madura J.D.
    Bioorg. Med. Chem. 19:359-373(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INHIBITORS.
  32. "Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75)."
    Pan Q., Qiao F., Gao C., Norman B., Optican L., Zelenka P.S.
    Cell. Mol. Life Sci. 68:3425-3436(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS SRC KINASE.
  33. "Cdk5 mediates vimentin Ser56 phosphorylation during GTP-induced secretion by neutrophils."
    Lee K.Y., Liu L., Jin Y., Fu S.B., Rosales J.L.
    J. Cell. Physiol. 227:739-750(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS VIM KINASE, SUBCELLULAR LOCATION.
  34. "Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity."
    Sun K.H., Chang K.H., Clawson S., Ghosh S., Mirzaei H., Regnier F., Shah K.
    J. Neurochem. 118:902-914(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION, INTERACTION WITH GSTP1.
  35. "High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization."
    Gallazzini M., Heussler G.E., Kunin M., Izumi Y., Burg M.B., Ferraris J.D.
    Mol. Biol. Cell 22:703-714(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS TONEBP/NFAT5 KINASE.
  36. "Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease."
    Wong A.S., Lee R.H., Cheung A.Y., Yeung P.K., Chung S.K., Cheung Z.H., Ip N.Y.
    Nat. Cell Biol. 13:568-579(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS SH3GLB1 KINASE.
  37. "Phosphorylation of glutamyl-prolyl tRNA synthetase by cyclin-dependent kinase 5 dictates transcript-selective translational control."
    Arif A., Jia J., Moodt R.A., DiCorleto P.E., Fox P.L.
    Proc. Natl. Acad. Sci. U.S.A. 108:1415-1420(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS EPRS KINASE.
  38. Cited for: REVIEW.
  39. "Cell cycle, CDKs and cancer: a changing paradigm."
    Malumbres M., Barbacid M.
    Nat. Rev. Cancer 9:153-166(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON INHIBITORS, GENE FAMILY.
  40. "Making a neuron: Cdk5 in embryonic and adult neurogenesis."
    Jessberger S., Gage F.H., Eisch A.J., Lagace D.C.
    Trends Neurosci. 32:575-582(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON NEURONAL PHYSIOLOGY.
  41. Cited for: FUNCTION.
  42. "Regulation and role of cyclin-dependent kinase activity in neuronal survival and death."
    Hisanaga S., Endo R.
    J. Neurochem. 115:1309-1321(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON REGULATION.
  43. "Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons."
    Zhang J., Herrup K.
    Cell Cycle 10:1208-1214(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON NEURON DEVELOPMENT.
  44. "Cdk5: Mediator of neuronal development, death and the response to DNA damage."
    Zhu J., Li W., Mao Z.
    Mech. Ageing Dev. 132:389-394(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON NEURON DEVELOPMENT.
  45. "Cdk5: multitasking between physiological and pathological conditions."
    Lopes J.P., Agostinho P.
    Prog. Neurobiol. 94:49-63(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON NEURONS.
  46. "Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation."
    Kwak Y., Jeong J., Lee S., Park Y.U., Lee S.A., Han D.H., Kim J.H., Ohshima T., Mikoshiba K., Suh Y.H., Cho S., Park S.K.
    J. Biol. Chem. 288:36878-36889(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CLOCK.
  47. "Structure and regulation of the CDK5-p25(nck5a) complex."
    Tarricone C., Dhavan R., Peng J., Areces L.B., Tsai L.-H., Musacchio A.
    Mol. Cell 8:657-669(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) IN COMPLEX WITH P25, MUTAGENESIS OF SER-159.
  48. "Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation."
    Ahn J.S., Radhakrishnan M.L., Mapelli M., Choi S., Tidor B., Cuny G.D., Musacchio A., Yeh L.A., Kosik K.S.
    Chem. Biol. 12:811-823(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).
  49. Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH INHIBITORS AND P25, PHOSPHORYLATION AT TYR-15.
  50. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-225.

Entry informationi

Entry nameiCDK5_HUMAN
AccessioniPrimary (citable) accession number: Q00535
Secondary accession number(s): A1XKG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 15, 1998
Last modified: November 26, 2014
This is version 166 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Dysregulation of CDK5 is associated with neurodegenerative disorders such as Alzheimer, Parkinson, and Niemann-Pick type C diseases, ischemia, and amyotrophic lateral sclerosis.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

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