Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclin-dependent kinase-like 1

Gene

CDKL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34ATPPROSITE-ProRule annotation1
Active sitei127Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 19ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 2681
SignaLinkiQ00532

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 1 (EC:2.7.11.22)
Alternative name(s):
Protein kinase p42 KKIALRE
Serine/threonine-protein kinase KKIALRE
Gene namesi
Name:CDKL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100490.9
HGNCiHGNC:1781 CDKL1
MIMi603441 gene
neXtProtiNX_Q00532

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8814
PharmGKBiPA26317

Chemistry databases

ChEMBLiCHEMBL5789
GuidetoPHARMACOLOGYi1982

Polymorphism and mutation databases

BioMutaiCDKL1
DMDMi229463050

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858101 – 358Cyclin-dependent kinase-like 1Add BLAST358

Proteomic databases

EPDiQ00532
MaxQBiQ00532
PaxDbiQ00532
PeptideAtlasiQ00532
PRIDEiQ00532

PTM databases

iPTMnetiQ00532
PhosphoSitePlusiQ00532

Expressioni

Tissue specificityi

Highly expressed in kidney, and to a lower extent in ovary.1 Publication

Gene expression databases

BgeeiENSG00000100490
CleanExiHS_CDKL1
ExpressionAtlasiQ00532 baseline and differential
GenevisibleiQ00532 HS

Organism-specific databases

HPAiHPA059605
HPA065919

Interactioni

Protein-protein interaction databases

BioGridi114341, 13 interactors
IntActiQ00532, 6 interactors
MINTiQ00532
STRINGi9606.ENSP00000379176

Chemistry databases

BindingDBiQ00532

Structurei

Secondary structure

1358
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 12Combined sources9
Beta strandi14 – 23Combined sources10
Turni24 – 26Combined sources3
Beta strandi29 – 35Combined sources7
Helixi42 – 57Combined sources16
Beta strandi66 – 72Combined sources7
Beta strandi75 – 81Combined sources7
Beta strandi84 – 86Combined sources3
Helixi87 – 93Combined sources7
Helixi100 – 119Combined sources20
Helixi129 – 131Combined sources3
Beta strandi132 – 134Combined sources3
Beta strandi140 – 142Combined sources3
Helixi165 – 167Combined sources3
Helixi170 – 174Combined sources5
Helixi182 – 197Combined sources16
Helixi207 – 218Combined sources12
Helixi223 – 230Combined sources8
Helixi233 – 235Combined sources3
Helixi249 – 252Combined sources4
Helixi258 – 267Combined sources10
Turni272 – 274Combined sources3
Helixi278 – 282Combined sources5
Helixi285 – 287Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AGUX-ray2.40A/B/C1-300[»]
ProteinModelPortaliQ00532
SMRiQ00532
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 288Protein kinasePROSITE-ProRule annotationAdd BLAST284

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 52[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0593 Eukaryota
ENOG410XNSW LUCA
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ00532
KOiK08824
OrthoDBiEOG091G0BZP
PhylomeDBiQ00532
TreeFamiTF101031

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q00532-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEKYEKIGK IGEGSYGVVF KCRNRDTGQI VAIKKFLESE DDPVIKKIAL
60 70 80 90 100
REIRMLKQLK HPNLVNLLEV FRRKRRLHLV FEYCDHTVLH ELDRYQRGVP
110 120 130 140 150
EHLVKSITWQ TLQAVNFCHK HNCIHRDVKP ENILITKHSV IKLCDFGFAR
160 170 180 190 200
LLAGPSDYYT DYVATRWYRS PELLVGDTQY GPPVDVWAIG CVFAELLSGV
210 220 230 240 250
PLWPGKSDVD QLYLIRKTLG DLIPRHQQVF STNQYFSGVK IPDPEDMEPL
260 270 280 290 300
ELKFPNISYP ALGLLKGCLH MDPTQRLTCE QLLHHPYFEN IREIEDLAKE
310 320 330 340 350
HNKPTRKTLR KSRKHHCFTE TSKLQYLPQL TGSSILPALD NKKYYCDTKK

LNYRFPNI
Length:358
Mass (Da):41,803
Last modified:March 28, 2018 - v6
Checksum:i83C14DC5935B0DBC
GO
Isoform 2 (identifier: Q00532-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-2: M → MELSTDTGWN...HFKKIYSSMM
     57-57: K → KAPSPYAAEP...RGGSAAQEPT
     99-122: VPEHLVKSITWQTLQAVNFCHKHN → ICNIFVCTGR...ELTSSDSPQR
     248-358: EPLELKFPNI...KKLNYRFPNI → SLCLSVTLTE...EQEKYLSYGA

Show »
Length:994
Mass (Da):109,062
Checksum:i018765BE4BFEF3D2
GO
Isoform 3 (identifier: Q00532-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-276: CLHMDPTQR → RVPIASRTE
     277-358: Missing.

Show »
Length:276
Mass (Da):31,902
Checksum:iB5C7297C59EE847C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153A → T in CAA47002 (PubMed:1639063).Curated1
Sequence conflicti153A → T in AAL58838 (Ref. 2) Curated1
Sequence conflicti153A → T in AAS00095 (Ref. 3) Curated1
Sequence conflicti153A → T in AAI04978 (PubMed:15489334).Curated1
Sequence conflicti153A → T in AK308732 (PubMed:14702039).Curated1
Sequence conflicti302N → D in CAA47002 (PubMed:1639063).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02057667L → P1 PublicationCorresponds to variant dbSNP:rs11570814Ensembl.1
Natural variantiVAR_020577275Q → E3 PublicationsCorresponds to variant dbSNP:rs7161563Ensembl.1
Natural variantiVAR_020578330L → V2 PublicationsCorresponds to variant dbSNP:rs9323183Ensembl.1
Natural variantiVAR_020579342K → N1 PublicationCorresponds to variant dbSNP:rs11570886Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0412392M → MELSTDTGWNQKSNFPPCDS RVSKEEAQLPFPTPSSYGAD SSNQTYAHKSQSEREQHKEV RAVLNHCSGLDGGEESGLCG TSTRIDAGTGNGTDDKVTDQ HRHRRCLQGTKGNNRGSEVW GLLLQGNVDRSGGAPSAGVL LRRRGYSCALHGLRKFANLA GLLSRQQDSARGVSHHSRLK IHFKKIYSSMM in isoform 2. 1 Publication1
Alternative sequenceiVSP_04124057K → KAPSPYAAEPSLCGMKMVRR GKKEFLPAVAEKVDAPSGVG GQGQDSVTVGSLGRRSTYGR KQEKQVRQREGIIYCYVAVL LRIYYFDQGCVAREEEQFQE LVFGPFCHIGSYFTGHRTNV RPYILLLSRPSPFKTAAGTY EAGLVILECSYFLAEQEPYC PTQALQQPHPIIGPWALEGG GVESKEDRHPPPKEAPASCE GFLRSAVPKQAYTPFKTSPD KRLSDCVATPPWAPPTPLII SSGVLVAICSMIDPVPEFHS EGLLAKATSGSAGILVWIFL CNDAFIYGKYILRSGVLWVR GLPGFKSEAAALCHKCYSSA DPKREQQQDLLQRVKEQSFH SVNGAQARHKGSPSPHQTQE PSWPHPVDPTPGHRWSCLPV PCRAPALLSPWVVDGTGCCG AGGGSDRGGSAAQEPT in isoform 2. 1 Publication1
Alternative sequenceiVSP_04124199 – 122VPEHL…CHKHN → ICNIFVCTGRRLGEHTEALS KKKKKGGGGPFLKLRAASCR ITLFKNVGCGLETTGDLSLN SGGGAASRGVAAALRALVCG TELTSSDSPQR in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_041242248 – 358EPLEL…RFPNI → SLCLSVTLTEGGLLASGAVK RSQMGSSVSQATSWPHPDIV AETAELDDIAMARQTPVMLR FNRQKEQEKYLSYGA in isoform 2. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_059391268 – 276CLHMDPTQR → RVPIASRTE in isoform 3. 9
Alternative sequenceiVSP_059392277 – 358Missing in isoform 3. Add BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66358, X66359 mRNA Translation: CAA47002.1
AF390028 mRNA Translation: AAL58838.1
AY525548 Genomic DNA Translation: AAS00095.1
AL118556 Genomic DNA No translation available.
AL359397 Genomic DNA No translation available.
AK308732 mRNA No translation available.
BC104977 mRNA Translation: AAI04978.1
PIRiS22745
S23383
RefSeqiNP_004187.2, NM_004196.4
XP_005268214.1, XM_005268157.2
XP_016877218.1, XM_017021729.1
UniGeneiHs.280881
Hs.679430

Genome annotation databases

EnsembliENST00000395834; ENSP00000379176; ENSG00000100490
GeneIDi8814
KEGGihsa:8814
UCSCiuc001wxz.5 human [Q00532-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCDKL1_HUMAN
AccessioniPrimary (citable) accession number: Q00532
Secondary accession number(s): J3KMW1
, Q2M3A4, Q6QUA0, Q8WXQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: March 28, 2018
Last modified: April 25, 2018
This is version 168 of the entry and version 6 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health