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Q00526

- CDK3_HUMAN

UniProt

Q00526 - CDK3_HUMAN

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Protein

Cyclin-dependent kinase 3

Gene
CDK3, CDKN3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.3 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarity
Active sitei127 – 1271Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: ProtInc

GO - Biological processi

  1. cell proliferation Source: UniProtKB
  2. G0 to G1 transition Source: UniProtKB
  3. G1/S transition of mitotic cell cycle Source: UniProtKB
  4. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 2681.
SignaLinkiQ00526.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 3 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 3
Gene namesi
Name:CDK3
Synonyms:CDKN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:1772. CDK3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26309.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Cyclin-dependent kinase 3PRO_0000085776Add
BLAST

Proteomic databases

PaxDbiQ00526.
PRIDEiQ00526.

PTM databases

PhosphoSiteiQ00526.

Expressioni

Tissue specificityi

Expressed in cancer cell lines and glioblastoma tissue.1 Publication

Gene expression databases

BgeeiQ00526.
CleanExiHS_CDK3.
GenevestigatoriQ00526.

Organism-specific databases

HPAiHPA007420.

Interactioni

Subunit structurei

Interacts with CABLES1 and CABLES2 By similarity. Interacts with ATF1. Binding to CCNC/cyclin-C promotes RB1 phosphorylation.2 Publications

Protein-protein interaction databases

BioGridi107453. 32 interactions.
DIPiDIP-686N.
IntActiQ00526. 23 interactions.
MINTiMINT-1509509.
STRINGi9606.ENSP00000400088.

Structurei

Secondary structure

1
305
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 129
Beta strandi14 – 2310
Turni24 – 263
Beta strandi29 – 368
Beta strandi39 – 424
Helixi46 – 5712
Beta strandi66 – 716
Beta strandi73 – 819
Beta strandi84 – 863
Helixi87 – 937
Turni95 – 973
Helixi101 – 12020
Helixi130 – 1323
Beta strandi133 – 1353
Beta strandi141 – 1433
Beta strandi154 – 1574
Turni159 – 1613
Helixi171 – 1755
Helixi183 – 19816
Helixi208 – 21912
Turni224 – 2263
Helixi230 – 2323
Helixi248 – 2514
Helixi257 – 26610
Turni271 – 2733
Helixi277 – 2826
Helixi284 – 2863

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LFNmodel-A1-305[»]
ProteinModelPortaliQ00526.
SMRiQ00526. Positions 1-286.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 286283Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ00526.
KOiK02088.
OMAiMVIRRAL.
OrthoDBiEOG7966H8.
PhylomeDBiQ00526.
TreeFamiTF101021.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00526-1 [UniParc]FASTAAdd to Basket

« Hide

MDMFQKVEKI GEGTYGVVYK AKNRETGQLV ALKKIRLDLE MEGVPSTAIR    50
EISLLKELKH PNIVRLLDVV HNERKLYLVF EFLSQDLKKY MDSTPGSELP 100
LHLIKSYLFQ LLQGVSFCHS HRVIHRDLKP QNLLINELGA IKLADFGLAR 150
AFGVPLRTYT HEVVTLWYRA PEILLGSKFY TTAVDIWSIG CIFAEMVTRK 200
ALFPGDSEID QLFRIFRMLG TPSEDTWPGV TQLPDYKGSF PKWTRKGLEE 250
IVPNLEPEGR DLLMQLLQYD PSQRITAKTA LAHPYFSSPE PSPAARQYVL 300
QRFRH 305
Length:305
Mass (Da):35,046
Last modified:April 1, 1993 - v1
Checksum:i1128BE0096EA262A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061S → N in a glioblastoma multiforme sample; somatic mutation. 1 Publication
VAR_041973
Natural varianti124 – 1241I → T.1 Publication
Corresponds to variant rs34918446 [ dbSNP | Ensembl ].
VAR_041974
Natural varianti214 – 2141R → H.1 Publication
Corresponds to variant rs34670267 [ dbSNP | Ensembl ].
VAR_041975
Natural varianti226 – 2261T → I.1 Publication
Corresponds to variant rs2069532 [ dbSNP | Ensembl ].
VAR_021101
Natural varianti264 – 2641M → T.2 Publications
Corresponds to variant rs17884251 [ dbSNP | Ensembl ].
VAR_021102

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66357 mRNA. Translation: CAA47001.1.
AY789470 Genomic DNA. Translation: AAV40830.1.
CCDSiCCDS11736.1.
PIRiS23382.
RefSeqiNP_001249.1. NM_001258.2.
UniGeneiHs.706766.

Genome annotation databases

EnsembliENST00000425876; ENSP00000410561; ENSG00000250506.
ENST00000448471; ENSP00000400088; ENSG00000250506.
GeneIDi1018.
KEGGihsa:1018.
UCSCiuc010dgt.3. human.

Polymorphism databases

DMDMi231726.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66357 mRNA. Translation: CAA47001.1 .
AY789470 Genomic DNA. Translation: AAV40830.1 .
CCDSi CCDS11736.1.
PIRi S23382.
RefSeqi NP_001249.1. NM_001258.2.
UniGenei Hs.706766.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LFN model - A 1-305 [» ]
ProteinModelPortali Q00526.
SMRi Q00526. Positions 1-286.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107453. 32 interactions.
DIPi DIP-686N.
IntActi Q00526. 23 interactions.
MINTi MINT-1509509.
STRINGi 9606.ENSP00000400088.

Chemistry

BindingDBi Q00526.
ChEMBLi CHEMBL2111444.
GuidetoPHARMACOLOGYi 1975.

PTM databases

PhosphoSitei Q00526.

Polymorphism databases

DMDMi 231726.

Proteomic databases

PaxDbi Q00526.
PRIDEi Q00526.

Protocols and materials databases

DNASUi 1018.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000425876 ; ENSP00000410561 ; ENSG00000250506 .
ENST00000448471 ; ENSP00000400088 ; ENSG00000250506 .
GeneIDi 1018.
KEGGi hsa:1018.
UCSCi uc010dgt.3. human.

Organism-specific databases

CTDi 1018.
GeneCardsi GC17P073996.
HGNCi HGNC:1772. CDK3.
HPAi HPA007420.
MIMi 123828. gene.
neXtProti NX_Q00526.
PharmGKBi PA26309.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
HOVERGENi HBG014652.
InParanoidi Q00526.
KOi K02088.
OMAi MVIRRAL.
OrthoDBi EOG7966H8.
PhylomeDBi Q00526.
TreeFami TF101021.

Enzyme and pathway databases

BRENDAi 2.7.11.22. 2681.
SignaLinki Q00526.

Miscellaneous databases

GeneWikii Cyclin-dependent_kinase_3.
GenomeRNAii 1018.
NextBioi 4279.
PROi Q00526.
SOURCEi Search...

Gene expression databases

Bgeei Q00526.
CleanExi HS_CDK3.
Genevestigatori Q00526.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A family of human cdc2-related protein kinases."
    Meyerson M., Enders G.H., Wu C.-L., Su L.-K., Gorka C., Nelson C., Harlow E., Tsai L.-H.
    EMBO J. 11:2909-2917(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  2. NIEHS SNPs program
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-226 AND THR-264.
  3. "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit."
    Hofmann F., Livingston D.M.
    Genes Dev. 10:851-861(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN G1-S TRANSITION.
  4. "Cyclin C/cdk3 promotes Rb-dependent G0 exit."
    Ren S., Rollins B.J.
    Cell 117:239-251(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS RB1 KINASE, FUNCTION IN G0-G1 TRANSITION, INTERACTION WITH CCNC.
  5. "Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation."
    Zheng D., Cho Y.-Y., Lau A.T.Y., Zhang J., Ma W.-Y., Bode A.M., Dong Z.
    Cancer Res. 68:7650-7660(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS ATF1 KINASE, TISSUE SPECIFICITY, INTERACTION WITH ATF1.
  6. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-106; THR-124; HIS-214 AND THR-264.

Entry informationi

Entry nameiCDK3_HUMAN
AccessioniPrimary (citable) accession number: Q00526
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 3, 2014
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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