ID URIC_ASPFL Reviewed; 302 AA. AC Q00511; DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 3. DT 27-MAR-2024, entry version 142. DE RecName: Full=Uricase {ECO:0000303|PubMed:1339455}; DE EC=1.7.3.3 {ECO:0000269|PubMed:1339455, ECO:0000269|PubMed:25314114}; DE AltName: Full=Rasburicase {ECO:0000303|PubMed:28272834}; DE AltName: Full=Urate oxidase {ECO:0000303|PubMed:1339455}; GN Name=uaZ {ECO:0000303|PubMed:1339455}; GN Synonyms=Uox {ECO:0000303|PubMed:17020862}; OS Aspergillus flavus. OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus; OC Aspergillus subgen. Circumdati. OX NCBI_TaxID=5059; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], PARTIAL PROTEIN SEQUENCE, RP ACETYLATION AT SER-2, FUNCTION, CATALYTIC ACTIVITY, AND PATHWAY. RC STRAIN=ATCC 20047; RX PubMed=1339455; DOI=10.1016/s0021-9258(18)42480-5; RA Legoux R., Delpech B., Dumont X., Guillemot J.-C., Ramond P., Shire D., RA Caput D., Ferrara P., Loison G.; RT "Cloning and expression in Escherichia coli of the gene encoding RT Aspergillus flavus urate oxidase."; RL J. Biol. Chem. 267:8565-8570(1992). RN [2] RP FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, AND ACTIVITY RP REGULATION. RX PubMed=17020862; DOI=10.1016/0301-4622(94)00150-i; RA Bayol A., Dupin P., Boe J.F., Claudy P., Letoffe J.M.; RT "Study of pH and temperature-induced transitions in urate oxidase (Uox- RT EC1.7.3.3) by microcalorimetry (DSC), size exclusion chromatography (SEC) RT and enzymatic activity experiments."; RL Biophys. Chem. 54:229-235(1995). RN [3] RP FUNCTION, CATALYTIC ACTIVITY, AND BIOPHYSICOCHEMICAL PROPERTIES. RX DOI=10.1021/ja970375t; RA Kahn K., Serfozo P., Tipton P.A.; RT "Identification of the true product of the urate oxidase reaction."; RL J. Am. Chem. Soc. 119:5435-5442(1997). RN [4] RP FUNCTION, AND BIOTECHNOLOGY. RX PubMed=28272834; DOI=10.1002/14651858.cd006945.pub4; RA Cheuk D.K., Chiang A.K., Chan G.C., Ha S.Y.; RT "Urate oxidase for the prevention and treatment of tumour lysis syndrome in RT children with cancer."; RL Cochrane Database Syst. Rev. 3:CD006945-CD006945(2017). RN [5] RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH INHIBITOR RP 8-AZAXANTHINE, AND SUBUNIT. RX PubMed=9360612; DOI=10.1038/nsb1197-947; RA Colloc'h N., el Hajji M., Bachet B., L'Hermite G., Schiltz M., Prange T., RA Castro B., Mornon J.-P.; RT "Crystal structure of the protein drug urate oxidase-inhibitor complex at RT 2.05-A resolution."; RL Nat. Struct. Biol. 4:947-952(1997). RN [6] {ECO:0007744|PDB:1R4S, ECO:0007744|PDB:1R4U, ECO:0007744|PDB:1R51, ECO:0007744|PDB:1R56} RP X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 2-302. RX PubMed=14993669; DOI=10.1107/s0907444903029718; RA Retailleau P., Colloc'h N., Vivares D., Bonnete F., Castro B., El-Hajji M., RA Mornon J.P., Monard G., Prange T.; RT "Complexed and ligand-free high-resolution structures of urate oxidase RT (Uox) from Aspergillus flavus: a reassignment of the active-site binding RT mode."; RL Acta Crystallogr. D 60:453-462(2004). RN [7] {ECO:0007744|PDB:1WRR, ECO:0007744|PDB:1WS2, ECO:0007744|PDB:1WS3, ECO:0007744|PDB:1XT4, ECO:0007744|PDB:1XXJ, ECO:0007744|PDB:1XY3} RP X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS) OF 2-302 IN COMPLEX WITH GUANINE. RX PubMed=15735331; DOI=10.1107/s0907444904031531; RA Retailleau P., Colloc'h N., Vivares D., Bonnete F., Castro B., El Hajji M., RA Prange T.; RT "Urate oxidase from Aspergillus flavus: new crystal-packing contacts in RT relation to the content of the active site."; RL Acta Crystallogr. D 61:218-229(2005). RN [8] {ECO:0007744|PDB:2FUB} RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 2-302, AND SUBUNIT. RX PubMed=16478683; DOI=10.1016/j.bbapap.2006.01.006; RA Colloc'h N., Girard E., Dhaussy A.C., Kahn R., Ascone I., Mezouar M., RA Fourme R.; RT "High pressure macromolecular crystallography: the 140-MPa crystal RT structure at 2.3 A resolution of urate oxidase, a 135-kDa tetrameric RT assembly."; RL Biochim. Biophys. Acta 1764:391-397(2006). RN [9] {ECO:0007744|PDB:2FXL} RP X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 2-302. RX PubMed=16545381; DOI=10.1016/j.febslet.2006.03.007; RA Gabison L., Chiadmi M., Colloc'h N., Castro B., El Hajji M., Prange T.; RT "Recapture of [S]-allantoin, the product of the two-step degradation of RT uric acid, by urate oxidase."; RL FEBS Lett. 580:2087-2091(2006). RN [10] {ECO:0007744|PDB:2IBA, ECO:0007744|PDB:2IC0, ECO:0007744|PDB:2ICQ} RP X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 2-302. RX PubMed=17028130; DOI=10.1529/biophysj.106.093807; RA Colloc'h N., Sopkova-de Oliveira Santos J., Retailleau P., Vivares D., RA Bonnete F., Langlois d'Estainto B., Gallois B., Brisson A., Risso J.J., RA Lemaire M., Prange T., Abraini J.H.; RT "Protein crystallography under xenon and nitrous oxide pressure: comparison RT with in vivo pharmacology studies and implications for the mechanism of RT inhaled anesthetic action."; RL Biophys. J. 92:217-224(2007). RN [11] {ECO:0007744|PDB:3BJP, ECO:0007744|PDB:3BK8} RP X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 2-302. RX PubMed=18638417; DOI=10.1186/1472-6807-8-32; RA Gabison L., Prange T., Colloc'h N., El Hajji M., Castro B., Chiadmi M.; RT "Structural analysis of urate oxidase in complex with its natural substrate RT inhibited by cyanide: mechanistic implications."; RL BMC Struct. Biol. 8:32-32(2008). RN [12] {ECO:0007744|PDB:2ZKA, ECO:0007744|PDB:2ZKB, ECO:0007744|PDB:3CKS, ECO:0007744|PDB:3CKU} RP X-RAY CRYSTALLOGRAPHY (1.61 ANGSTROMS) OF 2-302. RX PubMed=18375516; DOI=10.1529/biophysj.107.122184; RA Colloc'h N., Gabison L., Monard G., Altarsha M., Chiadmi M., Marassio G., RA Sopkova-de Oliveira Santos J., El Hajji M., Castro B., Abraini J.H., RA Prange T.; RT "Oxygen pressurized X-ray crystallography: probing the dioxygen binding RT site in cofactorless urate oxidase and implications for its catalytic RT mechanism."; RL Biophys. J. 95:2415-2422(2008). RN [13] {ECO:0007744|PDB:3GKO} RP X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 2-302. RX DOI=10.1021/cg900473n; RA Giffard M., Delfosse V., Sciara G., Mayer C., Cambillau C., El Hajji M., RA Castro B., Bonnete F.; RT "Surfactant poloxamer 188 as a new crystallizing agent for urate oxidase."; RL Cryst. Growth Des. 9:4199-4206(2009). RN [14] {ECO:0007744|PDB:3L8W, ECO:0007744|PDB:3L9G, ECO:0007744|PDB:3LBG, ECO:0007744|PDB:3LD4} RP X-RAY CRYSTALLOGRAPHY (1.00 ANGSTROMS) OF 2-296 IN COMPLEX WITH XANTHINE. RX PubMed=20516624; DOI=10.1107/s090744491001142x; RA Gabison L., Chiadmi M., El Hajji M., Castro B., Colloc'h N., Prange T.; RT "Near-atomic resolution structures of urate oxidase complexed with its RT substrate and analogues: the protonation state of the ligand."; RL Acta Crystallogr. D 66:714-724(2010). RN [15] {ECO:0007744|PDB:2PES} RP X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 2-296. RX PubMed=20606256; DOI=10.1107/s0907444910010954; RA Pompidor G., Maury O., Vicat J., Kahn R.; RT "A dipicolinate lanthanide complex for solving protein structures using RT anomalous diffraction."; RL Acta Crystallogr. D 66:762-769(2010). RN [16] {ECO:0007744|PDB:3F2M} RP X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 2-302. RX PubMed=20483346; DOI=10.1016/j.bpj.2010.01.058; RA Girard E., Marchal S., Perez J., Finet S., Kahn R., Fourme R., Marassio G., RA Dhaussy A.C., Prange T., Giffard M., Dulin F., Bonnete F., Lange R., RA Abraini J.H., Mezouar M., Colloc'h N.; RT "Structure-function perturbation and dissociation of tetrameric urate RT oxidase by high hydrostatic pressure."; RL Biophys. J. 98:2365-2373(2010). RN [17] {ECO:0007744|PDB:3P9F} RP X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 2-302. RA Gabison L., Colloc'h N., El Hajji M., Castro B., Chiadmi M., Prange T.; RT "Azide and cyanide have different inhibition modes of urate oxidase."; RL Submitted (OCT-2010) to the PDB data bank. RN [18] {ECO:0007744|PDB:3P9O} RP X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 2-302. RA Gabison L., Colloc'h N., El Hajji M., Castro B., Chiadmi M., Prange T.; RT "Azide and cyanide show different inhibition modes to urate oxidase."; RL Submitted (OCT-2010) to the PDB data bank. RN [19] {ECO:0007744|PDB:3PJK, ECO:0007744|PDB:3PK3, ECO:0007744|PDB:3PK4, ECO:0007744|PDB:3PK5, ECO:0007744|PDB:3PK6, ECO:0007744|PDB:3PK8, ECO:0007744|PDB:3PKF, ECO:0007744|PDB:3PKG} RP X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 2-302. RX PubMed=21421845; DOI=10.1096/fj.11-183046; RA Marassio G., Prange T., David H.N., Santos J.S., Gabison L., Delcroix N., RA Abraini J.H., Colloc'h N.; RT "Pressure-response analysis of anesthetic gases xenon and nitrous oxide on RT urate oxidase: a crystallographic study."; RL FASEB J. 25:2266-2275(2011). RN [20] {ECO:0007744|PDB:3OBP} RP X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 2-302. RX PubMed=21491497; DOI=10.1002/prot.23022; RA Gabison L., Chopard C., Colloc'h N., Peyrot F., Castro B., El Hajji M., RA Altarsha M., Monard G., Chiadmi M., Prange T.; RT "X-ray, ESR, and quantum mechanics studies unravel a spin well in the RT cofactor-less urate oxidase."; RL Proteins 79:1964-1976(2011). RN [21] {ECO:0007744|PDB:4FSK} RP X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 2-302. RA Gabison L., Colloc'h N., El Hajji M., Castro B., Chiadmi M., Prange T.; RT "Azide and cyanide have different inhibition modes of urate oxidase."; RL Submitted (JUN-2012) to the PDB data bank. RN [22] {ECO:0007744|PDB:4OQC, ECO:0007744|PDB:4POE, ECO:0007744|PDB:4PR8, ECO:0007744|PDB:4PUV} RP X-RAY CRYSTALLOGRAPHY (1.07 ANGSTROMS) OF 2-302, AND ACTIVITY REGULATION. RX PubMed=25005084; DOI=10.1107/s2053230x14011753; RA Gabison L., Colloc'h N., Prange T.; RT "Azide inhibition of urate oxidase."; RL Acta Crystallogr. F Struct. Biol. Commun. 70:896-902(2014). RN [23] {ECO:0007744|PDB:4CW0, ECO:0007744|PDB:4CW2, ECO:0007744|PDB:4CW3, ECO:0007744|PDB:4CW6, ECO:0007744|PDB:4D12, ECO:0007744|PDB:4D13, ECO:0007744|PDB:4D17, ECO:0007744|PDB:4D19} RP X-RAY CRYSTALLOGRAPHY (1.28 ANGSTROMS) OF 2-302, AND CATALYTIC ACTIVITY. RX PubMed=25314114; DOI=10.1002/anie.201405485; RA Bui S., von Stetten D., Jambrina P.G., Prange T., Colloc'h N., RA de Sanctis D., Royant A., Rosta E., Steiner R.A.; RT "Direct evidence for a peroxide intermediate and a reactive enzyme- RT substrate-dioxygen configuration in a cofactor-free oxidase."; RL Angew. Chem. Int. Ed. 53:13710-13714(2014). RN [24] {ECO:0007744|PDB:4OP6, ECO:0007744|PDB:4OP9} RP X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 2-302. RX PubMed=24657440; DOI=10.1016/j.febslet.2014.03.017; RA Colloc'h N., Prange T.; RT "Functional relevance of the internal hydrophobic cavity of urate RT oxidase."; RL FEBS Lett. 588:1715-1719(2014). RN [25] {ECO:0007744|PDB:4N3M, ECO:0007744|PDB:4N9M, ECO:0007744|PDB:4N9S, ECO:0007744|PDB:4N9V} RP X-RAY CRYSTALLOGRAPHY (1.06 ANGSTROMS) OF 2-302, AND ACTIVE SITE. RX PubMed=24466188; DOI=10.1371/journal.pone.0086651; RA Oksanen E., Blakeley M.P., El-Hajji M., Ryde U., Budayova-Spano M.; RT "The neutron structure of urate oxidase resolves a long-standing RT mechanistic conundrum and reveals unexpected changes in protonation."; RL PLoS ONE 9:e86651-e86651(2014). RN [26] {ECO:0007744|PDB:5FRC} RP X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS) OF 2-302. RX DOI=10.1107/S1600576716010992; RA Lafumat B., Mueller-Dieckmann C., Colloc'h N., Prange T., Royant A., RA van der Linden P., Carpentier P.; RT "Gas-sensitive biological crystals processed in pressurized oxygen and RT krypton atmospheres: deciphering gas channels in proteins using a novel RT `soak-and-freeze' methodology."; RL J. Appl. Crystallogr. 49:1478-1487(2016). RN [27] {ECO:0007744|PDB:6RGT} RP X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS). RA Bui S., Lowden S.R.J., Steiner R.A.; RT "Crystal structure of the cofactor-free Aspergillus flavus urate oxidase RT T57A variant anaerobically complexed with 9-methyl uric acid."; RL Submitted (APR-2019) to the PDB data bank. RN [28] {ECO:0007744|PDB:7A0L} RP STRUCTURE (1.33 ANGSTROMS). RX PubMed=33520242; DOI=10.1107/s2052252520013615; RA McGregor L., Foeldes T., Bui S., Moulin M., Coquelle N., Blakeley M.P., RA Rosta E., Steiner R.A.; RT "Joint neutron/X-ray crystal structure of a mechanistically relevant RT complex of perdeuterated urate oxidase and simulations provide insight into RT the hydration step of catalysis."; RL IUCrJ 8:46-59(2021). RN [29] {ECO:0007744|PDB:6I9X, ECO:0007744|PDB:6I9Z, ECO:0007744|PDB:6IA1, ECO:0007744|PDB:6IA3, ECO:0007744|PDB:6IA9, ECO:0007744|PDB:6IC1, ECO:0007744|PDB:6RGM, ECO:0007744|PDB:7P0C} RP X-RAY CRYSTALLOGRAPHY (1.10 ANGSTROMS) OF 2-302. RA Prange T., Carpentier P., Dhaussy A.C., Girard E., Colloc'h N.; RT "Comparative study of the effects of high hydrostatic pressure per se and RT high argon pressure on urate oxidase ligand stabilization."; RL Submitted (OCT-2021) to the PDB data bank. CC -!- FUNCTION: Urate oxidase is a cofactorless enzyme involved in the CC metabolism of purines (PubMed:1339455, PubMed:17020862, Ref.3, CC PubMed:28272834). Catalyzes, in the presence of molecular oxygen, the CC hydroxylation of uric acid to metastable 5-hydroxyisourate (5-HIU) CC which is further degraded to allantoin (PubMed:1339455, CC PubMed:17020862, PubMed:28272834). {ECO:0000269|PubMed:1339455, CC ECO:0000269|PubMed:17020862, ECO:0000269|PubMed:28272834, CC ECO:0000269|Ref.3}. CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + O2 + urate = 5-hydroxyisourate + H2O2; CC Xref=Rhea:RHEA:21368, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, CC ChEBI:CHEBI:16240, ChEBI:CHEBI:17775, ChEBI:CHEBI:18072; EC=1.7.3.3; CC Evidence={ECO:0000269|PubMed:1339455, ECO:0000269|PubMed:17020862, CC ECO:0000269|PubMed:25314114, ECO:0000269|Ref.3}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21369; CC Evidence={ECO:0000269|PubMed:1339455, ECO:0000269|PubMed:17020862, CC ECO:0000269|Ref.3}; CC -!- ACTIVITY REGULATION: 8-Azaxanthine is one of the most potent CC competitive inhibitors of uricase activity (PubMed:17020862). CC Hypoxanthine has only a small inhibitor effect, and caffeine has no CC effect at all (PubMed:17020862). Azide not only competes with dioxygen CC but also competes with the substrate for its enzymatic site CC (PubMed:25005084). {ECO:0000269|PubMed:17020862, CC ECO:0000269|PubMed:25005084}. CC -!- BIOPHYSICOCHEMICAL PROPERTIES: CC pH dependence: CC Optimum pH is 8.0. {ECO:0000269|PubMed:17020862}; CC Temperature dependence: CC Optimum temperature is 30 degrees Celsius. CC {ECO:0000269|PubMed:17020862}; CC -!- PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from CC urate: step 1/3. {ECO:0000269|PubMed:1339455}. CC -!- SUBUNIT: Homotetramer. {ECO:0000269|PubMed:16478683, CC ECO:0000269|PubMed:9360612}. CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000305|PubMed:1339455}. CC -!- BIOTECHNOLOGY: Recombnant urate oxidase might be effective in reducing CC serum uric acid, and thus could be used to prevent and treat tumor CC lysis syndrome (TLS), a serious complication of malignancies that can CC result in renal failure or death in children with cancer. CC {ECO:0000269|PubMed:28272834}. CC -!- SIMILARITY: Belongs to the uricase family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X61766; CAA43896.1; -; mRNA. DR EMBL; X61765; CAA43895.1; -; Genomic_DNA. DR PIR; A38097; A38097. DR PDB; 1R4S; X-ray; 1.80 A; A=2-302. DR PDB; 1R4U; X-ray; 1.65 A; A=2-302. DR PDB; 1R51; X-ray; 1.75 A; A=2-302. DR PDB; 1R56; X-ray; 2.30 A; A/B/C/D/E/F/G/H=2-302. DR PDB; 1WRR; X-ray; 1.64 A; A=2-302. DR PDB; 1WS2; X-ray; 2.70 A; A/B/C/D=2-302. DR PDB; 1WS3; X-ray; 3.20 A; A/B/C/D=2-302. DR PDB; 1XT4; X-ray; 2.01 A; A=2-302. DR PDB; 1XXJ; X-ray; 2.80 A; A/B/C/D=2-302. DR PDB; 1XY3; X-ray; 3.20 A; A/B/C/D/E/F/G/H=2-302. DR PDB; 2FUB; X-ray; 2.30 A; A=2-302. DR PDB; 2FXL; X-ray; 1.76 A; A=2-302. DR PDB; 2IBA; X-ray; 1.50 A; A=2-302. DR PDB; 2IC0; X-ray; 1.78 A; A=2-302. DR PDB; 2ICQ; X-ray; 1.75 A; A=2-302. DR PDB; 2PES; X-ray; 1.60 A; A=2-296. DR PDB; 2ZKA; X-ray; 1.61 A; A=2-302. DR PDB; 2ZKB; X-ray; 1.61 A; A=2-302. DR PDB; 3BJP; X-ray; 1.80 A; A=2-302. DR PDB; 3BK8; X-ray; 1.60 A; A=2-302. DR PDB; 3CKS; X-ray; 1.70 A; A=2-302. DR PDB; 3CKU; X-ray; 1.70 A; A=2-302. DR PDB; 3F2M; X-ray; 1.80 A; A=2-302. DR PDB; 3GKO; X-ray; 1.60 A; A=2-302. DR PDB; 3L8W; X-ray; 1.00 A; A=2-296. DR PDB; 3L9G; X-ray; 1.75 A; A=2-296. DR PDB; 3LBG; X-ray; 1.50 A; A=2-296. DR PDB; 3LD4; X-ray; 1.35 A; A=2-296. DR PDB; 3OBP; X-ray; 1.50 A; A=2-302. DR PDB; 3P9F; X-ray; 1.70 A; A=2-302. DR PDB; 3P9O; X-ray; 1.45 A; A=2-302. DR PDB; 3PJK; X-ray; 1.70 A; A=2-302. DR PDB; 3PK3; X-ray; 1.65 A; A=2-302. DR PDB; 3PK4; X-ray; 1.85 A; A=2-302. DR PDB; 3PK5; X-ray; 1.75 A; A=2-302. DR PDB; 3PK6; X-ray; 1.80 A; A=2-302. DR PDB; 3PK8; X-ray; 1.65 A; A=2-302. DR PDB; 3PKF; X-ray; 1.65 A; A=2-302. DR PDB; 3PKG; X-ray; 1.60 A; A=2-302. DR PDB; 3PKH; X-ray; 1.71 A; A=2-302. DR PDB; 3PKK; X-ray; 1.73 A; A=2-302. DR PDB; 3PKL; X-ray; 1.75 A; A=2-302. DR PDB; 3PKS; X-ray; 1.75 A; A=2-302. DR PDB; 3PKT; X-ray; 1.75 A; A=2-302. DR PDB; 3PKU; X-ray; 1.75 A; A=2-302. DR PDB; 3PLE; X-ray; 1.60 A; A=2-302. DR PDB; 3PLG; X-ray; 1.60 A; A=2-302. DR PDB; 3PLH; X-ray; 1.80 A; A=2-302. DR PDB; 3PLI; X-ray; 1.68 A; A=2-302. DR PDB; 3PLJ; X-ray; 1.73 A; A=2-302. DR PDB; 3PLM; X-ray; 1.62 A; A=2-302. DR PDB; 4CW0; X-ray; 1.50 A; A=2-302. DR PDB; 4CW2; X-ray; 1.32 A; A=2-302. DR PDB; 4CW3; X-ray; 1.34 A; A=2-302. DR PDB; 4CW6; X-ray; 1.28 A; A=2-302. DR PDB; 4D12; X-ray; 1.40 A; A=1-302. DR PDB; 4D13; X-ray; 1.30 A; A=1-302. DR PDB; 4D17; X-ray; 1.30 A; A=1-302. DR PDB; 4D19; X-ray; 1.35 A; A=1-302. DR PDB; 4FSK; X-ray; 1.98 A; A=2-302. DR PDB; 4N3M; Other; 1.90 A; A=2-302. DR PDB; 4N9M; Other; 2.30 A; A=2-302. DR PDB; 4N9S; X-ray; 1.06 A; A=2-302. DR PDB; 4N9V; X-ray; 1.10 A; A=2-302. DR PDB; 4OP6; X-ray; 1.65 A; A=2-302. DR PDB; 4OP9; X-ray; 1.58 A; A=2-302. DR PDB; 4OQC; X-ray; 1.30 A; A=2-302. DR PDB; 4POE; X-ray; 1.07 A; A=2-302. DR PDB; 4PR8; X-ray; 1.16 A; A=2-296. DR PDB; 4PUV; X-ray; 1.30 A; A=2-302. DR PDB; 5FRC; X-ray; 1.44 A; A=2-302. DR PDB; 6I9X; X-ray; 1.60 A; A=2-302. DR PDB; 6I9Z; X-ray; 1.60 A; A=2-302. DR PDB; 6IA1; X-ray; 2.36 A; A=2-302. DR PDB; 6IA3; X-ray; 1.69 A; A=2-302. DR PDB; 6IA9; X-ray; 1.80 A; A/B=2-302. DR PDB; 6IC1; X-ray; 1.10 A; A=2-302. DR PDB; 6RGM; X-ray; 1.50 A; A=2-302. DR PDB; 6RGT; X-ray; 1.60 A; A=1-302. DR PDB; 7A0L; Other; 1.33 A; A=1-302. DR PDB; 7P0C; X-ray; 2.15 A; A=2-302. DR PDB; 7P0D; X-ray; 2.40 A; A=2-302. DR PDB; 7P0G; X-ray; 1.90 A; A=2-302. DR PDB; 7PUF; X-ray; 1.86 A; A/B=2-296. DR PDB; 7PWN; X-ray; 1.64 A; A/B=2-296. DR PDB; 7Q09; X-ray; 2.19 A; A/B=2-296. DR PDB; 7QAR; X-ray; 2.30 A; AAA=1-302. DR PDBsum; 1R4S; -. DR PDBsum; 1R4U; -. DR PDBsum; 1R51; -. DR PDBsum; 1R56; -. DR PDBsum; 1WRR; -. DR PDBsum; 1WS2; -. DR PDBsum; 1WS3; -. DR PDBsum; 1XT4; -. DR PDBsum; 1XXJ; -. DR PDBsum; 1XY3; -. DR PDBsum; 2FUB; -. DR PDBsum; 2FXL; -. DR PDBsum; 2IBA; -. DR PDBsum; 2IC0; -. DR PDBsum; 2ICQ; -. DR PDBsum; 2PES; -. DR PDBsum; 2ZKA; -. DR PDBsum; 2ZKB; -. DR PDBsum; 3BJP; -. DR PDBsum; 3BK8; -. DR PDBsum; 3CKS; -. DR PDBsum; 3CKU; -. DR PDBsum; 3F2M; -. DR PDBsum; 3GKO; -. DR PDBsum; 3L8W; -. DR PDBsum; 3L9G; -. DR PDBsum; 3LBG; -. DR PDBsum; 3LD4; -. DR PDBsum; 3OBP; -. DR PDBsum; 3P9F; -. DR PDBsum; 3P9O; -. DR PDBsum; 3PJK; -. DR PDBsum; 3PK3; -. DR PDBsum; 3PK4; -. DR PDBsum; 3PK5; -. DR PDBsum; 3PK6; -. DR PDBsum; 3PK8; -. DR PDBsum; 3PKF; -. DR PDBsum; 3PKG; -. DR PDBsum; 3PKH; -. DR PDBsum; 3PKK; -. DR PDBsum; 3PKL; -. DR PDBsum; 3PKS; -. DR PDBsum; 3PKT; -. DR PDBsum; 3PKU; -. DR PDBsum; 3PLE; -. DR PDBsum; 3PLG; -. DR PDBsum; 3PLH; -. DR PDBsum; 3PLI; -. DR PDBsum; 3PLJ; -. DR PDBsum; 3PLM; -. DR PDBsum; 4CW0; -. DR PDBsum; 4CW2; -. DR PDBsum; 4CW3; -. DR PDBsum; 4CW6; -. DR PDBsum; 4D12; -. DR PDBsum; 4D13; -. DR PDBsum; 4D17; -. DR PDBsum; 4D19; -. DR PDBsum; 4FSK; -. DR PDBsum; 4N3M; -. DR PDBsum; 4N9M; -. DR PDBsum; 4N9S; -. DR PDBsum; 4N9V; -. DR PDBsum; 4OP6; -. DR PDBsum; 4OP9; -. DR PDBsum; 4OQC; -. DR PDBsum; 4POE; -. DR PDBsum; 4PR8; -. DR PDBsum; 4PUV; -. DR PDBsum; 5FRC; -. DR PDBsum; 6I9X; -. DR PDBsum; 6I9Z; -. DR PDBsum; 6IA1; -. DR PDBsum; 6IA3; -. DR PDBsum; 6IA9; -. DR PDBsum; 6IC1; -. DR PDBsum; 6RGM; -. DR PDBsum; 6RGT; -. DR PDBsum; 7A0L; -. DR PDBsum; 7P0C; -. DR PDBsum; 7P0D; -. DR PDBsum; 7P0G; -. DR PDBsum; 7PUF; -. DR PDBsum; 7PWN; -. DR PDBsum; 7Q09; -. DR PDBsum; 7QAR; -. DR AlphaFoldDB; Q00511; -. DR SASBDB; Q00511; -. DR SMR; Q00511; -. DR iPTMnet; Q00511; -. DR EnsemblFungi; EED52707; EED52707; AFLA_044090. DR VEuPathDB; FungiDB:AFLA_007981; -. DR VEuPathDB; FungiDB:F9C07_2229599; -. DR OMA; ATMYKMS; -. DR BRENDA; 1.7.3.3; 506. DR UniPathway; UPA00394; UER00650. DR EvolutionaryTrace; Q00511; -. DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell. DR GO; GO:0004846; F:urate oxidase activity; IEA:UniProtKB-EC. DR GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW. DR GO; GO:0019628; P:urate catabolic process; IEA:UniProtKB-UniPathway. DR CDD; cd00445; Uricase; 1. DR Gene3D; 3.10.270.10; Urate Oxidase; 1. DR InterPro; IPR002042; Uricase. DR InterPro; IPR019842; Uricase_CS. DR NCBIfam; TIGR03383; urate_oxi; 1. DR PANTHER; PTHR42874; URICASE; 1. DR PANTHER; PTHR42874:SF1; URICASE; 1. DR Pfam; PF01014; Uricase; 2. DR PIRSF; PIRSF000241; Urate_oxidase; 1. DR PRINTS; PR00093; URICASE. DR SUPFAM; SSF55620; Tetrahydrobiopterin biosynthesis enzymes-like; 2. DR PROSITE; PS00366; URICASE; 1. PE 1: Evidence at protein level; KW 3D-structure; Acetylation; Direct protein sequencing; Oxidoreductase; KW Peroxisome; Purine metabolism. FT INIT_MET 1 FT /note="Removed" FT CHAIN 2..302 FT /note="Uricase" FT /id="PRO_0000165995" FT MOTIF 300..302 FT /note="Microbody targeting signal" FT /evidence="ECO:0000255" FT ACT_SITE 11 FT /note="Charge relay system" FT /evidence="ECO:0000269|PubMed:24466188, FT ECO:0007744|PDB:4N3M, ECO:0007744|PDB:4N9M, FT ECO:0007744|PDB:4N9S, ECO:0007744|PDB:4N9V" FT ACT_SITE 58 FT /note="Charge relay system" FT /evidence="ECO:0000269|PubMed:24466188, FT ECO:0007744|PDB:4N3M, ECO:0007744|PDB:4N9M, FT ECO:0007744|PDB:4N9S, ECO:0007744|PDB:4N9V" FT ACT_SITE 257 FT /note="Charge relay system" FT /evidence="ECO:0000269|PubMed:24466188, FT ECO:0007744|PDB:4N3M, ECO:0007744|PDB:4N9M, FT ECO:0007744|PDB:4N9S, ECO:0007744|PDB:4N9V" FT BINDING 58 FT /ligand="5-hydroxyisourate" FT /ligand_id="ChEBI:CHEBI:18072" FT /evidence="ECO:0000305|PubMed:25314114, FT ECO:0007744|PDB:1R4U, ECO:0007744|PDB:3BJP, FT ECO:0007744|PDB:3L8W, ECO:0007744|PDB:3L9G, FT ECO:0007744|PDB:3OBP, ECO:0007744|PDB:4D12, FT ECO:0007744|PDB:4D13, ECO:0007744|PDB:4D17, FT ECO:0007744|PDB:4D19, ECO:0007744|PDB:4PR8" FT BINDING 58 FT /ligand="O2" FT /ligand_id="ChEBI:CHEBI:15379" FT /evidence="ECO:0007744|PDB:2ZKA, ECO:0007744|PDB:2ZKB, FT ECO:0007744|PDB:3CKS, ECO:0007744|PDB:4CW3, FT ECO:0007744|PDB:4CW6, ECO:0007744|PDB:4D17, FT ECO:0007744|PDB:4D19, ECO:0007744|PDB:4OP6, FT ECO:0007744|PDB:5FRC" FT BINDING 58 FT /ligand="urate" FT /ligand_id="ChEBI:CHEBI:17775" FT /evidence="ECO:0000305|PubMed:9360612, FT ECO:0007744|PDB:1R4S, ECO:0007744|PDB:1R51, FT ECO:0007744|PDB:1WS2, ECO:0007744|PDB:2FUB, FT ECO:0007744|PDB:2FXL, ECO:0007744|PDB:2IBA, FT ECO:0007744|PDB:2IC0, ECO:0007744|PDB:2ICQ, FT ECO:0007744|PDB:2PES, ECO:0007744|PDB:2ZKA, FT ECO:0007744|PDB:2ZKB, ECO:0007744|PDB:3BK8, FT ECO:0007744|PDB:3CKS, ECO:0007744|PDB:3CKU, FT ECO:0007744|PDB:3F2M, ECO:0007744|PDB:3GKO, FT ECO:0007744|PDB:3LBG, ECO:0007744|PDB:3LD4, FT ECO:0007744|PDB:3P9F, ECO:0007744|PDB:3PJK, FT ECO:0007744|PDB:3PK3, ECO:0007744|PDB:3PK4, FT ECO:0007744|PDB:3PK5, ECO:0007744|PDB:3PK6, FT ECO:0007744|PDB:3PK8, ECO:0007744|PDB:3PKF, FT ECO:0007744|PDB:3PKG, ECO:0007744|PDB:3PKH, FT ECO:0007744|PDB:3PKK, ECO:0007744|PDB:3PKL, FT ECO:0007744|PDB:3PKS, ECO:0007744|PDB:3PKT, FT ECO:0007744|PDB:3PKU, ECO:0007744|PDB:3PLE, FT ECO:0007744|PDB:3PLG, ECO:0007744|PDB:3PLH, FT ECO:0007744|PDB:3PLI, ECO:0007744|PDB:3PLJ, FT ECO:0007744|PDB:3PLM, ECO:0007744|PDB:4CW0, FT ECO:0007744|PDB:4CW2, ECO:0007744|PDB:4CW3, FT ECO:0007744|PDB:4CW6, ECO:0007744|PDB:4N9S, FT ECO:0007744|PDB:4N9V, ECO:0007744|PDB:4OP6, FT ECO:0007744|PDB:4OP9, ECO:0007744|PDB:5FRC" FT BINDING 59 FT /ligand="5-hydroxyisourate" FT /ligand_id="ChEBI:CHEBI:18072" FT /evidence="ECO:0000305|PubMed:25314114, FT ECO:0007744|PDB:1R4U, ECO:0007744|PDB:3BJP, FT ECO:0007744|PDB:3L9G, ECO:0007744|PDB:3OBP, FT ECO:0007744|PDB:4D12, ECO:0007744|PDB:4D13, FT ECO:0007744|PDB:4D17, ECO:0007744|PDB:4D19, FT ECO:0007744|PDB:4PR8" FT BINDING 59 FT /ligand="urate" FT /ligand_id="ChEBI:CHEBI:17775" FT /evidence="ECO:0000305|PubMed:9360612, FT ECO:0007744|PDB:1R4S, ECO:0007744|PDB:3LBG, FT ECO:0007744|PDB:3LD4, ECO:0007744|PDB:4CW0, FT ECO:0007744|PDB:4CW2, ECO:0007744|PDB:4CW3, FT ECO:0007744|PDB:4CW6, ECO:0007744|PDB:4N9S" FT BINDING 160 FT /ligand="5-hydroxyisourate" FT /ligand_id="ChEBI:CHEBI:18072" FT /evidence="ECO:0000305|PubMed:25314114, FT ECO:0007744|PDB:1R4U, ECO:0007744|PDB:2FXL, FT ECO:0007744|PDB:3BJP, ECO:0007744|PDB:3L9G, FT ECO:0007744|PDB:3LBG, ECO:0007744|PDB:3LD4, FT ECO:0007744|PDB:3OBP, ECO:0007744|PDB:4D12, FT ECO:0007744|PDB:4D13, ECO:0007744|PDB:4D17, FT ECO:0007744|PDB:4D19, ECO:0007744|PDB:4N9S, FT ECO:0007744|PDB:4PR8" FT BINDING 160 FT /ligand="urate" FT /ligand_id="ChEBI:CHEBI:17775" FT /evidence="ECO:0000305|PubMed:9360612, FT ECO:0007744|PDB:1R4S, ECO:0007744|PDB:1R51, FT ECO:0007744|PDB:1WS3, ECO:0007744|PDB:1XT4, FT ECO:0007744|PDB:1XY3, ECO:0007744|PDB:2FUB, FT ECO:0007744|PDB:2IBA, ECO:0007744|PDB:2IC0, FT ECO:0007744|PDB:2ICQ, ECO:0007744|PDB:2PES, FT ECO:0007744|PDB:2ZKA, ECO:0007744|PDB:2ZKB, FT ECO:0007744|PDB:3BK8, ECO:0007744|PDB:3CKS, FT ECO:0007744|PDB:3CKU, ECO:0007744|PDB:3F2M, FT ECO:0007744|PDB:3GKO, ECO:0007744|PDB:3L8W, FT ECO:0007744|PDB:3P9F, ECO:0007744|PDB:3PJK, FT ECO:0007744|PDB:3PK3, ECO:0007744|PDB:3PK4, FT ECO:0007744|PDB:3PK5, ECO:0007744|PDB:3PK6, FT ECO:0007744|PDB:3PK8, ECO:0007744|PDB:3PKF, FT ECO:0007744|PDB:3PKG, ECO:0007744|PDB:3PKH, FT ECO:0007744|PDB:3PKK, ECO:0007744|PDB:3PKL, FT ECO:0007744|PDB:3PKS, ECO:0007744|PDB:3PKT, FT ECO:0007744|PDB:3PKU, ECO:0007744|PDB:3PLE, FT ECO:0007744|PDB:3PLG, ECO:0007744|PDB:3PLH, FT ECO:0007744|PDB:3PLI, ECO:0007744|PDB:3PLJ, FT ECO:0007744|PDB:3PLM, ECO:0007744|PDB:4CW0, FT ECO:0007744|PDB:4CW2, ECO:0007744|PDB:4CW3, FT ECO:0007744|PDB:4CW6, ECO:0007744|PDB:4N9V, FT ECO:0007744|PDB:4OP6, ECO:0007744|PDB:4OP9, FT ECO:0007744|PDB:5FRC" FT BINDING 177 FT /ligand="5-hydroxyisourate" FT /ligand_id="ChEBI:CHEBI:18072" FT /evidence="ECO:0000305|PubMed:25314114, FT ECO:0007744|PDB:1R4U, ECO:0007744|PDB:2FXL, FT ECO:0007744|PDB:3LD4, ECO:0007744|PDB:4D13, FT ECO:0007744|PDB:4D17, ECO:0007744|PDB:4D19, FT ECO:0007744|PDB:4N9S" FT BINDING 177 FT /ligand="urate" FT /ligand_id="ChEBI:CHEBI:17775" FT /evidence="ECO:0000305|PubMed:9360612, FT ECO:0007744|PDB:1R4S, ECO:0007744|PDB:1R51, FT ECO:0007744|PDB:1WRR, ECO:0007744|PDB:1WS2, FT ECO:0007744|PDB:1WS3, ECO:0007744|PDB:1XT4, FT ECO:0007744|PDB:1XXJ, ECO:0007744|PDB:1XY3, FT ECO:0007744|PDB:2FUB, ECO:0007744|PDB:2IBA, FT ECO:0007744|PDB:2IC0, ECO:0007744|PDB:2ICQ, FT ECO:0007744|PDB:2PES, ECO:0007744|PDB:2ZKA, FT ECO:0007744|PDB:2ZKB, ECO:0007744|PDB:3BK8, FT ECO:0007744|PDB:3CKS, ECO:0007744|PDB:3CKU, FT ECO:0007744|PDB:3F2M, ECO:0007744|PDB:3GKO, FT ECO:0007744|PDB:3L8W, ECO:0007744|PDB:3LBG, FT ECO:0007744|PDB:3P9F, ECO:0007744|PDB:3PJK, FT ECO:0007744|PDB:3PK3, ECO:0007744|PDB:3PK4, FT ECO:0007744|PDB:3PK5, ECO:0007744|PDB:3PK6, FT ECO:0007744|PDB:3PK8, ECO:0007744|PDB:3PKF, FT ECO:0007744|PDB:3PKG, ECO:0007744|PDB:3PKH, FT ECO:0007744|PDB:3PKK, ECO:0007744|PDB:3PKL, FT ECO:0007744|PDB:3PKS, ECO:0007744|PDB:3PKT, FT ECO:0007744|PDB:3PKU, ECO:0007744|PDB:3PLE, FT ECO:0007744|PDB:3PLG, ECO:0007744|PDB:3PLH, FT ECO:0007744|PDB:3PLI, ECO:0007744|PDB:3PLJ, FT ECO:0007744|PDB:3PLM, ECO:0007744|PDB:4CW0, FT ECO:0007744|PDB:4CW2, ECO:0007744|PDB:4CW3, FT ECO:0007744|PDB:4CW6, ECO:0007744|PDB:4N9V, FT ECO:0007744|PDB:4OP6, ECO:0007744|PDB:4OP9, FT ECO:0007744|PDB:5FRC" FT BINDING 228 FT /ligand="5-hydroxyisourate" FT /ligand_id="ChEBI:CHEBI:18072" FT /evidence="ECO:0000305|PubMed:25314114, FT ECO:0007744|PDB:1R4U, ECO:0007744|PDB:3BJP, FT ECO:0007744|PDB:3L9G, ECO:0007744|PDB:3OBP, FT ECO:0007744|PDB:4D12, ECO:0007744|PDB:4D13, FT ECO:0007744|PDB:4D17, ECO:0007744|PDB:4D19, FT ECO:0007744|PDB:4PR8" FT BINDING 228 FT /ligand="urate" FT /ligand_id="ChEBI:CHEBI:17775" FT /evidence="ECO:0000305|PubMed:9360612, FT ECO:0007744|PDB:1R4S, ECO:0007744|PDB:1R51, FT ECO:0007744|PDB:1WRR, ECO:0007744|PDB:1XT4, FT ECO:0007744|PDB:1XXJ, ECO:0007744|PDB:1XY3, FT ECO:0007744|PDB:2FUB, ECO:0007744|PDB:2IBA, FT ECO:0007744|PDB:2IC0, ECO:0007744|PDB:2ICQ, FT ECO:0007744|PDB:2PES, ECO:0007744|PDB:2ZKA, FT ECO:0007744|PDB:2ZKB, ECO:0007744|PDB:3BK8, FT ECO:0007744|PDB:3CKS, ECO:0007744|PDB:3CKU, FT ECO:0007744|PDB:3F2M, ECO:0007744|PDB:3GKO, FT ECO:0007744|PDB:3L8W, ECO:0007744|PDB:3P9F, FT ECO:0007744|PDB:3PJK, ECO:0007744|PDB:3PK3, FT ECO:0007744|PDB:3PK4, ECO:0007744|PDB:3PK5, FT ECO:0007744|PDB:3PK6, ECO:0007744|PDB:3PK8, FT ECO:0007744|PDB:3PKF, ECO:0007744|PDB:3PKG, FT ECO:0007744|PDB:3PKH, ECO:0007744|PDB:3PKK, FT ECO:0007744|PDB:3PKL, ECO:0007744|PDB:3PKS, FT ECO:0007744|PDB:3PKT, ECO:0007744|PDB:3PKU, FT ECO:0007744|PDB:3PLE, ECO:0007744|PDB:3PLG, FT ECO:0007744|PDB:3PLH, ECO:0007744|PDB:3PLI, FT ECO:0007744|PDB:3PLJ, ECO:0007744|PDB:3PLM, FT ECO:0007744|PDB:4CW0, ECO:0007744|PDB:4CW2, FT ECO:0007744|PDB:4CW3, ECO:0007744|PDB:4CW6, FT ECO:0007744|PDB:4N9V, ECO:0007744|PDB:4OP6, FT ECO:0007744|PDB:4OP9, ECO:0007744|PDB:5FRC" FT BINDING 229 FT /ligand="5-hydroxyisourate" FT /ligand_id="ChEBI:CHEBI:18072" FT /evidence="ECO:0000305|PubMed:25314114, FT ECO:0007744|PDB:1R4U, ECO:0007744|PDB:3BJP, FT ECO:0007744|PDB:3L9G, ECO:0007744|PDB:4D13, FT ECO:0007744|PDB:4D17, ECO:0007744|PDB:4D19" FT BINDING 229 FT /ligand="urate" FT /ligand_id="ChEBI:CHEBI:17775" FT /evidence="ECO:0000305|PubMed:9360612, FT ECO:0007744|PDB:1R4S, ECO:0007744|PDB:1R51, FT ECO:0007744|PDB:1WRR, ECO:0007744|PDB:1WS2, FT ECO:0007744|PDB:1XT4, ECO:0007744|PDB:1XXJ, FT ECO:0007744|PDB:1XY3, ECO:0007744|PDB:2FUB, FT ECO:0007744|PDB:2IBA, ECO:0007744|PDB:2IC0, FT ECO:0007744|PDB:2ICQ, ECO:0007744|PDB:2PES, FT ECO:0007744|PDB:2ZKA, ECO:0007744|PDB:2ZKB, FT ECO:0007744|PDB:3BK8, ECO:0007744|PDB:3CKS, FT ECO:0007744|PDB:3CKU, ECO:0007744|PDB:3F2M, FT ECO:0007744|PDB:3GKO, ECO:0007744|PDB:3L8W, FT ECO:0007744|PDB:3LBG, ECO:0007744|PDB:3LD4, FT ECO:0007744|PDB:3P9F, ECO:0007744|PDB:3PJK, FT ECO:0007744|PDB:3PK3, ECO:0007744|PDB:3PK4, FT ECO:0007744|PDB:3PK5, ECO:0007744|PDB:3PK6, FT ECO:0007744|PDB:3PK8, ECO:0007744|PDB:3PKF, FT ECO:0007744|PDB:3PKG, ECO:0007744|PDB:3PKH, FT ECO:0007744|PDB:3PKK, ECO:0007744|PDB:3PKL, FT ECO:0007744|PDB:3PKS, ECO:0007744|PDB:3PKT, FT ECO:0007744|PDB:3PKU, ECO:0007744|PDB:3PLE, FT ECO:0007744|PDB:3PLG, ECO:0007744|PDB:3PLH, FT ECO:0007744|PDB:3PLI, ECO:0007744|PDB:3PLJ, FT ECO:0007744|PDB:3PLM, ECO:0007744|PDB:4CW0, FT ECO:0007744|PDB:4CW2, ECO:0007744|PDB:4CW3, FT ECO:0007744|PDB:4CW6, ECO:0007744|PDB:4N9S, FT ECO:0007744|PDB:4N9V, ECO:0007744|PDB:4OP6, FT ECO:0007744|PDB:4OP9, ECO:0007744|PDB:5FRC" FT BINDING 255 FT /ligand="5-hydroxyisourate" FT /ligand_id="ChEBI:CHEBI:18072" FT /evidence="ECO:0000305|PubMed:25314114, FT ECO:0007744|PDB:2FXL, ECO:0007744|PDB:4D13, FT ECO:0007744|PDB:4D17, ECO:0007744|PDB:4D19" FT BINDING 255 FT /ligand="O2" FT /ligand_id="ChEBI:CHEBI:15379" FT /evidence="ECO:0007744|PDB:2ZKA, ECO:0007744|PDB:2ZKB, FT ECO:0007744|PDB:3CKS, ECO:0007744|PDB:4CW3, FT ECO:0007744|PDB:4CW6, ECO:0007744|PDB:4D17, FT ECO:0007744|PDB:4D19, ECO:0007744|PDB:4OP6, FT ECO:0007744|PDB:5FRC" FT BINDING 255 FT /ligand="urate" FT /ligand_id="ChEBI:CHEBI:17775" FT /evidence="ECO:0007744|PDB:4CW2, ECO:0007744|PDB:4CW3, FT ECO:0007744|PDB:4CW6" FT MOD_RES 2 FT /note="N-acetylserine" FT /evidence="ECO:0000305|PubMed:1339455, FT ECO:0007744|PDB:1R4S, ECO:0007744|PDB:1R4U, FT ECO:0007744|PDB:1R51, ECO:0007744|PDB:1R56, FT ECO:0007744|PDB:1WRR, ECO:0007744|PDB:1WS2, FT ECO:0007744|PDB:1WS3, ECO:0007744|PDB:1XT4, FT ECO:0007744|PDB:1XXJ, ECO:0007744|PDB:1XY3, FT ECO:0007744|PDB:2FXL, ECO:0007744|PDB:3BJP, FT ECO:0007744|PDB:4FSK" FT STRAND 9..21 FT /evidence="ECO:0007829|PDB:3L8W" FT TURN 23..25 FT /evidence="ECO:0007829|PDB:3L8W" FT STRAND 28..42 FT /evidence="ECO:0007829|PDB:3L8W" FT HELIX 44..48 FT /evidence="ECO:0007829|PDB:3L8W" FT HELIX 52..54 FT /evidence="ECO:0007829|PDB:3L8W" FT HELIX 58..71 FT /evidence="ECO:0007829|PDB:3L8W" FT HELIX 77..91 FT /evidence="ECO:0007829|PDB:3L8W" FT STRAND 95..105 FT /evidence="ECO:0007829|PDB:3L8W" FT STRAND 108..112 FT /evidence="ECO:0007829|PDB:3L8W" FT STRAND 115..122 FT /evidence="ECO:0007829|PDB:3L8W" FT STRAND 128..136 FT /evidence="ECO:0007829|PDB:3L8W" FT TURN 137..139 FT /evidence="ECO:0007829|PDB:3L8W" FT STRAND 140..158 FT /evidence="ECO:0007829|PDB:3L8W" FT STRAND 174..176 FT /evidence="ECO:0007829|PDB:3L8W" FT STRAND 179..189 FT /evidence="ECO:0007829|PDB:3L8W" FT STRAND 192..194 FT /evidence="ECO:0007829|PDB:3L8W" FT HELIX 195..200 FT /evidence="ECO:0007829|PDB:3L8W" FT HELIX 202..222 FT /evidence="ECO:0007829|PDB:3L8W" FT HELIX 228..242 FT /evidence="ECO:0007829|PDB:3L8W" FT STRAND 246..255 FT /evidence="ECO:0007829|PDB:3L8W" FT STRAND 258..260 FT /evidence="ECO:0007829|PDB:3L8W" FT TURN 264..268 FT /evidence="ECO:0007829|PDB:3L8W" FT HELIX 273..275 FT /evidence="ECO:0007829|PDB:3L8W" FT STRAND 279..281 FT /evidence="ECO:0007829|PDB:3L8W" FT STRAND 287..294 FT /evidence="ECO:0007829|PDB:3L8W" SQ SEQUENCE 302 AA; 34241 MW; B4FAD4ED4EC121AE CRC64; MSAVKAARYG KDNVRVYKVH KDEKTGVQTV YEMTVCVLLE GEIETSYTKA DNSVIVATDS IKNTIYITAK QNPVTPPELF GSILGTHFIE KYNHIHAAHV NIVCHRWTRM DIDGKPHPHS FIRDSEEKRN VQVDVVEGKG IDIKSSLSGL TVLKSTNSQF WGFLRDEYTT LKETWDRILS TDVDATWQWK NFSGLQEVRS HVPKFDATWA TAREVTLKTF AEDNSASVQA TMYKMAEQIL ARQQLIETVE YSLPNKHYFE IDLSWHKGLQ NTGKNAEVFA PQSDPNGLIK CTVGRSSLKS KL //