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Q00502

- COX1_PARVE

UniProt

Q00502 - COX1_PARVE

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Protein
Cytochrome c oxidase subunit 1
Gene
ctaD, coxI
Organism
Paracoccus versutus (Thiobacillus versutus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunit I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B ion per subunit.
Binds 2 heme groups per subunit.

Pathwayi

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Synonyms:coxI
OrganismiParacoccus versutus (Thiobacillus versutus)
Taxonomic identifieri34007 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›25›25Cytochrome c oxidase subunit 1
PRO_0000183457Add
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane

Sequencei

Sequence statusi: Fragment.

Q00502-1 [UniParc]FASTAAdd to Basket

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MADAAVHGHG DHHDTRGFFT RWFMS                              25
Length:25
Mass (Da):2,887
Last modified:November 1, 1996 - v1
Checksum:i81CBFABB2C72937C
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei25 – 251

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62808 Genomic DNA. Translation: CAA44628.1.
PIRiS23631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62808 Genomic DNA. Translation: CAA44628.1 .
PIRi S23631.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Cytochrome c550 from Thiobacillus versutus: cloning, expression in Escherichia coli, and purification of the heterologous holoprotein."
    Ubbink M., van Beeumen J., Canters G.W.
    J. Bacteriol. 174:3707-3714(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 25364 / DSM 582 / JCM 20754 / NBRC 14567 / VKM B-2163.

Entry informationi

Entry nameiCOX1_PARVE
AccessioniPrimary (citable) accession number: Q00502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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