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Q00502 (COX1_PARVE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene names
Name:ctaD
Synonyms:coxI
OrganismParacoccus versutus (Thiobacillus versutus)
Taxonomic identifier34007 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Protein attributes

Sequence length25 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunit I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Binds 1 copper B ion per subunit.

Binds 2 heme groups per subunit.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Cell inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›25›25Cytochrome c oxidase subunit 1
PRO_0000183457

Experimental info

Non-terminal residue251

Sequences

Sequence LengthMass (Da)Tools
Q00502 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 81CBFABB2C72937C

FASTA252,887
        10         20 
MADAAVHGHG DHHDTRGFFT RWFMS 

« Hide

References

[1]"Cytochrome c550 from Thiobacillus versutus: cloning, expression in Escherichia coli, and purification of the heterologous holoprotein."
Ubbink M., van Beeumen J., Canters G.W.
J. Bacteriol. 174:3707-3714(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 25364 / DSM 582 / JCM 20754 / NBRC 14567 / VKM B-2163.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62808 Genomic DNA. Translation: CAA44628.1.
PIRS23631.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameCOX1_PARVE
AccessionPrimary (citable) accession number: Q00502
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways