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Q00502

- COX1_PARVE

UniProt

Q00502 - COX1_PARVE

Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Paracoccus versutus (Thiobacillus versutus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Subunit I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Binds 1 copper B ion per subunit.
    Binds 2 heme groups per subunit.

    Pathwayi

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 1
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:ctaD
    Synonyms:coxI
    OrganismiParacoccus versutus (Thiobacillus versutus)
    Taxonomic identifieri34007 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›25›25Cytochrome c oxidase subunit 1PRO_0000183457Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane

    Sequencei

    Sequence statusi: Fragment.

    Q00502-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADAAVHGHG DHHDTRGFFT RWFMS                              25
    Length:25
    Mass (Da):2,887
    Last modified:November 1, 1996 - v1
    Checksum:i81CBFABB2C72937C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei25 – 251

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62808 Genomic DNA. Translation: CAA44628.1.
    PIRiS23631.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62808 Genomic DNA. Translation: CAA44628.1 .
    PIRi S23631.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Cytochrome c550 from Thiobacillus versutus: cloning, expression in Escherichia coli, and purification of the heterologous holoprotein."
      Ubbink M., van Beeumen J., Canters G.W.
      J. Bacteriol. 174:3707-3714(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 25364 / DSM 582 / JCM 20754 / NBRC 14567 / VKM B-2163.

    Entry informationi

    Entry nameiCOX1_PARVE
    AccessioniPrimary (citable) accession number: Q00502
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3