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Reviewed, UniProtKB/Swiss-Prot Q00495 (CSF1R_RAT)

Last modified February 9, 2010. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Macrophage colony-stimulating factor 1 receptor
      Short name=CSF-1-R
    EC=2.7.10.1
Alternative name(s):
    Proto-oncogene fms
    c-fms
    CD_antigen=CD115
Gene names
Name: Csf1r
Synonyms: Csfmr, Fms
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length978 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34 By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Interacts with INPPL1/SHIP2 and THOC5 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 protein kinase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 978959Macrophage colony-stimulating factor 1 receptor
PRO_0000016767

Regions

Topological domain20 – 511492Extracellular Potential
Transmembrane512 – 53625 Potential
Topological domain537 – 978442Cytoplasmic Potential
Domain24 – 10481Ig-like C2-type 1
Domain107 – 19791Ig-like C2-type 2
Domain204 – 29895Ig-like C2-type 3
Domain299 – 39799Ig-like C2-type 4
Domain398 – 503106Ig-like C2-type 5
Domain580 – 914335Protein kinase
Nucleotide binding586 – 5949ATP By similarity

Sites

Active site7761Proton acceptor By similarity
Binding site6141ATP By similarity

Amino acid modifications

Modified residue5541Phosphotyrosine By similarity
Modified residue5601Phosphothreonine By similarity
Modified residue5651Phosphothreonine By similarity
Modified residue6971Phosphotyrosine; by autocatalysis By similarity
Modified residue7061Phosphotyrosine; by autocatalysis By similarity
Modified residue7111Phosphoserine By similarity
Modified residue7141Phosphoserine By similarity
Modified residue8071Phosphotyrosine; by autocatalysis By similarity
Glycosylation451N-linked (GlcNAc...) Potential
Glycosylation731N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3351N-linked (GlcNAc...) Potential
Glycosylation3891N-linked (GlcNAc...) Potential
Glycosylation4101N-linked (GlcNAc...) Potential
Glycosylation4491N-linked (GlcNAc...) Potential
Glycosylation4781N-linked (GlcNAc...) Potential
Glycosylation4911N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 84 Potential
Disulfide bond127 ↔ 177 Potential
Disulfide bond224 ↔ 278 Potential
Disulfide bond417 ↔ 483 Potential

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Sequences

Sequence LengthMass (Da)Tools
Q00495-1 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 0A68456EF56BC7E3

FASTA978109,264
        10         20         30         40         50         60 
MELGPPLVLL LATVWHGQGA PVIEPSGPEL VVEPGETVTL RCVSNGSVEW DGPISPYWTL 

        70         80         90        100        110        120 
DPESPGSTLT TRNATFKNTG TYRCTELEDP MAGSTTIHLY VKDPAHSWNL LAQEVTVVEG 

       130        140        150        160        170        180 
QEAVLPCLIT DPALKDSVSL MREGGRQVLR KTVYFFSAWR GFIIRKAKVL DSNTYVCKTM 

       190        200        210        220        230        240 
VNGRESTSTG IWLKVNRVHP EPPQIKLEPS KLVRIRGEAA QIVCSATNAE VGFNVILKRG 

       250        260        270        280        290        300 
DTKLEIPLNS DFQDNYYKKV RALSLNAVDF QDAGIYSCVA SNDVGTRTAT MNFQVVESAY 

       310        320        330        340        350        360 
LNLTSEQSLL QEVSVGDSLI LTVHADAYPS IQHYNWTYLG PFFEDQRKLE FITQRAIYRY 

       370        380        390        400        410        420 
TFKLFLNRVK ASEAGQYFLM AQNKAGWNNL TFELTLRYPP EVSVTWMPVN GSDVLFCDVS 

       430        440        450        460        470        480 
GYPQPSVTWM ECRGHTDRCD EAQALQVWND THPEVLSQKP FDKVIIQSQL PIGTLKHNMT 

       490        500        510        520        530        540 
YFCKTHNSVG NSSQYFRAVS LGQSKQLPDE SLFTPVVVAC MSVMSLLVLL LLLLLYKYKQ 

       550        560        570        580        590        600 
KPKYQVRWKI IERYEGNSYT FIDPTQLPYN EKWEFPRNNL QFGKTLGAGA FGKVVEATAF 

       610        620        630        640        650        660 
GLGKEDAVLK VAVKMLKSTA HADEKEALMS ELKIMSHLGQ HENIVNLLGA CTHGGPVLVI 

       670        680        690        700        710        720 
TEYCCYGDLL NFLRRKAEAM LGPSLSPGQD SEGDSSYKNI HLEKKYVRRD SGFSSQGVDT 

       730        740        750        760        770        780 
YVEMRPVSTS SSDSFFKQDL DKEPSRPLEL WDLLHFSSQV AQGMAFLASK NCIHRDVAAR 

       790        800        810        820        830        840 
NVLLTSGHVA KIGDFGLARD IMNDSNYVVK GNARLPVKWM APESILYCVY TVQSDVWSYG 

       850        860        870        880        890        900 
ILLWEIFSLG LNPYPGILVN NKFYKLVKDG YQMAQPVFAP KNIYSIMQSC WDLEPTRRPT 

       910        920        930        940        950        960 
FQQICFLLQE QARLERRDQD YANLPSSGGS SGSDSGGGSS GGSSSEPEEE SSSEHLACCE 

       970 
PGDIAQPLLQ PNNYQFAC

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References

[1]"Molecular cloning of CSF-1 receptor from rat myoblasts. Sequence analysis and regulation during myogenesis."
Borycki A.G., Guillier M., Leibovitch M.P., Leibovitch S.A.
Growth Factors 6:209-218(1992) [PubMed: 1389227] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Skeletal muscle.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X61479 mRNA. Translation: CAA43706.1.
IPIIPI00199372.
PIRS16385. I60321.
UniGeneRn.72599

3D structure databases

SMRQ00495. Positions 19-497, 541-916.
ModBaseSearch...

Proteomic databases

PRIDEQ00495.

Organism-specific databases

RGD2425. Csf1r.

Phylogenomic databases

HOVERGENQ00495.

Enzyme and pathway databases

BRENDA2.7.10.1. 248.

Gene expression databases

GenevestigatorQ00495.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR020635. Tyr_Pkinase_cat_dom.
IPR020685. Tyr_prot_kinase.
IPR008266. Tyr_prot_kinase_AS.
IPR016243. Tyr_prot_kinase_CSF1/PDGF_rcpt.
IPR020729. Tyr_prot_kinase_MCSF1_rcpt.
IPR001824. Tyr_prot_kinase_rcpt_3_CS.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 3 hits.
PANTHERPTHR23256. Tyr_prot_kinase. 1 hit.
PTHR23256:SF237. Tyr_prot_kinase_MCSF1_rcpt. 1 hit.
PIRSFPIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTSM00409. IG. 3 hits.
SM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 4 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCSF1R_RAT
AccessionPrimary (citable) accession number: Q00495
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 9, 2010
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents