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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-3885-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
70 kDa antigen
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Ordered Locus Names:MAP_3840
OrganismiMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
Taxonomic identifieri262316 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
Proteomesi
  • UP000000580 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 623622Chaperone protein DnaKPRO_0000078494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

By stress conditions e.g. heat shock (By similarity).By similarity

Interactioni

Protein-protein interaction databases

STRINGi262316.MAP3840.

Structurei

3D structure databases

ProteinModelPortaliQ00488.
SMRiQ00488. Positions 1-509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
KOiK04043.
OMAiEKMAPPQ.
OrthoDBiPOG091H01UE.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q00488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAVGIDLG TTNSVVAVLE GGDPVVVANS EGSRTTPSIV AFARNGEVLV
60 70 80 90 100
GQPAKNQAVT NVDRTIRSVK RHMGTDWSIE IDGKKYTAQE ISARVLMKLK
110 120 130 140 150
RDAEAYLGED ITDAVITVPA YFNDAQRQAT KEAGQIAGLN VLRIVNEPTA
160 170 180 190 200
AALAYGLDKG EKEQTILVFD LGGGTFDVSL LEIGEGVVEV RATSGDNQLG
210 220 230 240 250
GDDWDDRIVN WLVDKFKGTS GIDLTKDKMA MQRLREAAEK AKIELSSSQS
260 270 280 290 300
TSINLPYITV DADKNPLFLD EQLTRAEFQR ITQDLLDRTR QPFKSVIADA
310 320 330 340 350
GISVSDIDHV VLVGGSTRMP AVTDLVKELT GGKEPNKGVN PDEVVAVGAA
360 370 380 390 400
LQAGVLKGEV KDVLLLDVTP LSLGIETKGG VMTKLIERNT TIPTKRSETF
410 420 430 440 450
TTADDNQPSV QIQVYQGERE IAAHNKLLGS FELTGIPPAP RGVPQIEVTF
460 470 480 490 500
DIDANGIVHV TAKDKGTGKE NTIKIQEGSG LSKEEIDRMI KDAEAHAEED
510 520 530 540 550
RKRREEADVR NQAESLVYQT EKFVKDQREA EGGSKVPEET LSKVDAAIAD
560 570 580 590 600
AKTALGGTDI TAIKSAMEKL GQESQALGQA IYEATQAESA QAGGPDGAAA
610 620
GGGSGSADDV VDAEVVDDDR ESK
Length:623
Mass (Da):66,518
Last modified:January 23, 2007 - v4
Checksum:i02EB979BD413AAF6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 92DL → RY in CAA42063 (PubMed:1886778).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59437 Genomic DNA. Translation: CAA42063.1.
AF254578 Genomic DNA. Translation: AAF65842.1.
AE016958 Genomic DNA. Translation: AAS06390.1.
PIRiS34440.
RefSeqiWP_003879232.1. NC_002944.2.

Genome annotation databases

EnsemblBacteriaiAAS06390; AAS06390; MAP_3840.
GeneIDi2719889.
KEGGimpa:MAP_3840.
PATRICi18000562. VBIMycAvi108102_4087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59437 Genomic DNA. Translation: CAA42063.1.
AF254578 Genomic DNA. Translation: AAF65842.1.
AE016958 Genomic DNA. Translation: AAS06390.1.
PIRiS34440.
RefSeqiWP_003879232.1. NC_002944.2.

3D structure databases

ProteinModelPortaliQ00488.
SMRiQ00488. Positions 1-509.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262316.MAP3840.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS06390; AAS06390; MAP_3840.
GeneIDi2719889.
KEGGimpa:MAP_3840.
PATRICi18000562. VBIMycAvi108102_4087.

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
KOiK04043.
OMAiEKMAPPQ.
OrthoDBiPOG091H01UE.

Enzyme and pathway databases

BioCyciMAVI262316:GCQR-3885-MONOMER.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_MYCPA
AccessioniPrimary (citable) accession number: Q00488
Secondary accession number(s): Q9L589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 116 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.