ID   ACOX2_CANMA             Reviewed;         724 AA.
AC   Q00468;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   RecName: Full=Acyl-coenzyme A oxidase 2;
DE            Short=AOX 2;
DE            Short=Acyl-CoA oxidase 2;
DE            EC=1.3.3.6;
GN   Name=POX2;
OS   Candida maltosa (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=5479;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 28140 / CBS 5611 / IAM 12247 / JCM 1504 / NBRC 1977;
RX   PubMed=8566769; DOI=10.1016/0378-1119(95)00655-9;
RA   Masuda Y., Park S.M., Ohta A., Takagi M.;
RT   "Cloning and characterization of the POX2 gene in Candida maltosa.";
RL   Gene 167:157-161(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2;
CC         Xref=Rhea:RHEA:38959, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:58856, ChEBI:CHEBI:65111; EC=1.3.3.6;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC   -!- PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation.
CC   -!- SUBCELLULAR LOCATION: Peroxisome.
CC   -!- SIMILARITY: Belongs to the acyl-CoA oxidase family. {ECO:0000305}.
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DR   EMBL; D21228; BAA04761.1; -; Genomic_DNA.
DR   PIR; JC4563; JC4563.
DR   AlphaFoldDB; Q00468; -.
DR   SMR; Q00468; -.
DR   UniPathway; UPA00661; -.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0003997; F:acyl-CoA oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0033540; P:fatty acid beta-oxidation using acyl-CoA oxidase; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.540.10; Acyl-CoA dehydrogenase/oxidase, N-terminal domain; 1.
DR   Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 1.
DR   Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 2.
DR   InterPro; IPR029320; Acyl-CoA_ox_N.
DR   InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR   InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR   InterPro; IPR012258; Acyl-CoA_oxidase.
DR   InterPro; IPR002655; Acyl-CoA_oxidase_C.
DR   InterPro; IPR036250; AcylCo_DH-like_C.
DR   InterPro; IPR037069; AcylCoA_DH/ox_N_sf.
DR   InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR   PANTHER; PTHR10909; ELECTRON TRANSPORT OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR10909:SF352; PEROXISOMAL ACYL-COENZYME A OXIDASE 3; 1.
DR   Pfam; PF01756; ACOX; 1.
DR   Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR   Pfam; PF14749; Acyl-CoA_ox_N; 1.
DR   PIRSF; PIRSF000168; Acyl-CoA_oxidase; 1.
DR   SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 1.
PE   3: Inferred from homology;
KW   FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Oxidoreductase;
KW   Peroxisome.
FT   CHAIN           1..724
FT                   /note="Acyl-coenzyme A oxidase 2"
FT                   /id="PRO_0000204693"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   724 AA;  82274 MW;  6081C636926CEFC1 CRC64;
     MALISNLKDE YDHPTKTDPD TNPKIVADII SSKEPPQPSQ DVAEERSRTD WDLKEMHEFL
     EGDEAKSEEI LRLYQSIERD PILQTRPEQF DYTKNEERES VALRINQMSK YLETEPYEKF
     RRRLQLMTVN DPSLGIRMLV NIGLFLNCIR GNGTQKQYDF WAKTKEAGKV KQLLRLFRYD
     ELGHGFNVAG CEIFATFDEK TDQFIIDTPH IGATKWWIGG AAHSATHTVC YARLIVKDID
     YGVKTFVVPL RDSTHNLLPG VAIGDIGPKL GRQGVDNGWI QFTEVRIPRF FMLQRWCKVD
     RQGNVTLPPL EQLSYISLLE GRVGMATDSY RIGARYTTIA LRYAVARRQF SKGDGQPETK
     LIDYTLHQRR LLPYLALTYL AALGTDKLER QHDQLLKNLD KALATNNKLL LKNTIQSTKS
     MFVDSGSLKS TLTWLASDLI NEARQSCGGH GYSAYNGFGK TYGDWAVQCT WEGDNNVLGM
     SAGKTIIKTV QQVLNGKQLK DSTLEFLNDA PALSSAKKAV IRIKSHVDDT DRVLKAIAGL
     ISKYAKDLIP VSYQSWDSIG PQRVVLSKFR CHYYLLETFN ERLNDRIKAK SPARPHLENI
     IKLYYVTNVL GPFIDEFLRF GVISPSVAKY ITTEYPQKLC AAIRPYVIGL TDSFQQPDNF
     INSLIGRYDG NVYTNYLTNV TNVNDPTNYK APYSEALEAM LNRASLEERE RFEKSKAVAA
     KLSQ
//