Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Multidrug resistance protein homolog 49

Gene

Mdr49

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi437 – 444ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1094 – 1101ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • drug transmembrane transport Source: UniProtKB
  • germ cell migration Source: FlyBase
  • renal tubular secretion Source: FlyBase
  • response to hypoxia Source: FlyBase
  • response to toxic substance Source: FlyBase
  • xenobiotic transport Source: FlyBase

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-159418. Recycling of bile acids and salts.
R-DME-193368. Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
R-DME-382556. ABC-family proteins mediated transport.

Protein family/group databases

TCDBi3.A.1.201.24. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein homolog 49 (EC:3.6.3.44)
Alternative name(s):
P-glycoprotein 49
Gene namesi
Name:Mdr49
ORF Names:CG3879
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0004512. Mdr49.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46CytoplasmicSequence analysisAdd BLAST46
Transmembranei47 – 67HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei117 – 145HelicalPROSITE-ProRule annotationAdd BLAST29
Transmembranei193 – 213HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei221 – 240HelicalPROSITE-ProRule annotationAdd BLAST20
Transmembranei301 – 322HelicalPROSITE-ProRule annotationAdd BLAST22
Transmembranei340 – 360HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini361 – 734CytoplasmicSequence analysisAdd BLAST374
Transmembranei735 – 756HelicalPROSITE-ProRule annotationAdd BLAST22
Transmembranei780 – 801HelicalPROSITE-ProRule annotationAdd BLAST22
Transmembranei856 – 876HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei878 – 897HelicalPROSITE-ProRule annotationAdd BLAST20
Transmembranei960 – 980HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei997 – 1017HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1018 – 1302CytoplasmicSequence analysisAdd BLAST285

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933471 – 1302Multidrug resistance protein homolog 49Add BLAST1302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ00449.
PRIDEiQ00449.

Expressioni

Gene expression databases

BgeeiFBgn0004512.
ExpressionAtlasiQ00449. differential.
GenevisibleiQ00449. DM.

Interactioni

Protein-protein interaction databases

BioGridi62198. 6 interactors.
IntActiQ00449. 9 interactors.
MINTiMINT-938897.
STRINGi7227.FBpp0086914.

Structurei

3D structure databases

ProteinModelPortaliQ00449.
SMRiQ00449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 367ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST322
Domaini402 – 638ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini735 – 1023ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST289
Domaini1059 – 1297ABC transporter 2PROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00530000062896.
InParanoidiQ00449.
KOiK05658.
OMAiMQTRGNE.
OrthoDBiEOG091G0HVA.
PhylomeDBiQ00449.

Family and domain databases

Gene3Di1.20.1560.10. 2 hits.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q00449-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKKEESRLP QAGDFQLKEG SVVDATRKYS YFDLFRYSTR CERFLLVVSL
60 70 80 90 100
LVATAASAFI PYFMIIYGEF TSLLVDRTVG VGTSSPAFAL PMFGGGQQLT
110 120 130 140 150
NASKEENNQA IIDDATAFGI GSLVGSVAMF LLITLAIDLA NRIALNQIDR
160 170 180 190 200
IRKLFLEAML RQDIAWYDTS SGSNFASKMT EDLDKLKEGI GEKIVIVVFL
210 220 230 240 250
IMTFVIGIVS AFVYGWKLTL VVLSCVPFII AATSVVARLQ GSLAEKELKS
260 270 280 290 300
YSDAANVVEE VFSGIRTVFA FSGQEKEKER FGKLLIPAEN TGRKKGLYSG
310 320 330 340 350
MGNALSWLII YLCMALAIWY GVTLILDERD LPDRVYTPAV LVIVLFAVIM
360 370 380 390 400
GAQNLGFASP HVEAIAVATA AGQTLFNIID RPSQVDPMDE KGNRPENTAG
410 420 430 440 450
HIRFEGIRFR YPARPDVEIL KGLTVDVLPG QTVAFVGASG CGKSTLIQLM
460 470 480 490 500
QRFYDPEAGS VKLDGRDLRT LNVGWLRSQI GVVGQEPVLF ATTIGENIRY
510 520 530 540 550
GRPSATQADI EKAARAANCH DFITRLPKGY DTQVGEKGAQ ISGGQKQRIA
560 570 580 590 600
IARALVRQPQ VLLLDEATSA LDPTSEKRVQ SALELASQGP TTLVVAHRLS
610 620 630 640 650
TITNADKIVF LKDGVVAEQG THEELMERRG LYCELVSITQ RKEATEADEG
660 670 680 690 700
AVAGRPLQKS QNLSDEETDD DEEDEEEDEE PELQTSGSSR DSGFRASTRR
710 720 730 740 750
KRRSQRRKKK KDKEVVSKVS FTQLMKLNSP EWRFIVVGGI ASVMHGATFP
760 770 780 790 800
LWGLFFGDFF GILSDGDDDV VRAEVLKISM IFVGIGLMAG LGNMLQTYMF
810 820 830 840 850
TTAGVKMTTR LRKRAFGTII GQDIAYFDDE RNSVGALCSR LASDCSNVQG
860 870 880 890 900
ATGARVGTML QAVATLVVGM VVGFVFSWQQ TLLTLVTLPL VCLSVYLEGR
910 920 930 940 950
FIMKSAQKAK ASIEEASQVA VEAITNIRTV NGLCLERQVL DQYVQQIDRV
960 970 980 990 1000
DIACRRKVRF RGLVFALGQA APFLAYGISM YYGGILVAEE RMNYEDIIKV
1010 1020 1030 1040 1050
AEALIFGSWM LGQALAYAPN VNDAILSAGR LMDLFKRTST QPNPPQSPYN
1060 1070 1080 1090 1100
TVEKSEGDIV YENVGFEYPT RKGTPILQGL NLTIKKSTTV ALVGPSGSGK
1110 1120 1130 1140 1150
STCVQLLLRY YDPVSGSVNL SGVPSTEFPL DTLRSKLGLV SQEPVLFDRT
1160 1170 1180 1190 1200
IAENIAYGNN FRDDVSMQEI IEAAKKSNIH NFISALPQGY DTRLGKTSQL
1210 1220 1230 1240 1250
SGGQKQRIAI ARALVRNPKI LILDEATSAL DLESEKVVQQ ALDEARSGRT
1260 1270 1280 1290 1300
CLTIAHRLTT VRNADLICVL KRGVVVEHGT HDELMALNKI YANLYLMQQV

SG
Length:1,302
Mass (Da):142,739
Last modified:May 18, 2010 - v2
Checksum:i4FA14DC62B2D661A
GO

Sequence cautioni

Q00449: The sequence ACO25636 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti952I → V in AAA28679 (PubMed:2072901).Curated1
Sequence conflicti952I → V in AAL14020 (PubMed:12537569).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti697S → N1 Publication1
Natural varianti712D → N1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59076 mRNA. Translation: AAA28679.1.
AE013599 Genomic DNA. Translation: AAF58437.2.
AY058791 mRNA. Translation: AAL14020.1.
BT044206 mRNA. Translation: ACH92271.1.
BT081353 mRNA. Translation: ACO25636.1. Sequence problems.
PIRiA41249.
RefSeqiNP_001163132.1. NM_001169661.1.
NP_523724.2. NM_079000.4.
UniGeneiDm.2580.

Genome annotation databases

EnsemblMetazoaiFBtr0087801; FBpp0086914; FBgn0004512.
GeneIDi36428.
KEGGidme:Dmel_CG3879.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMDR49_DROME
AccessioniPrimary (citable) accession number: Q00449
Secondary accession number(s): B5RIT2, C1C3C4, Q9V6I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: May 18, 2010
Last modified: October 25, 2017
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families