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Q00444 (HXC5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-C5
Alternative name(s):
Homeobox protein CP11
Homeobox protein Hox-3D
Gene names
Name:HOXC5
Synonyms:HOX3D
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 222222Homeobox protein Hox-C5
PRO_0000200169

Regions

DNA binding155 – 21460Homeobox
Motif140 – 1456Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
Q00444 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 9ABA38D35E4E61AB

FASTA22224,976
        10         20         30         40         50         60 
MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP PPAPSNSLHG 

        70         80         90        100        110        120 
VDMAANPRAH PDRPACSAAA APGHAPGRDE AAPLNPGMYS QKAARPALEE RAKSSGEIKE 

       130        140        150        160        170        180 
EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS HETDGKRSRT SYTRYQTLEL EKEFHFNRYL 

       190        200        210        220 
TRRRRIEIAN NLCLNERQIK IWFQNRRMKW KKDSKMKSKE AL 

« Hide

References

[1]"The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins."
Arcioni L., Simeone A., Guazzi S., Zappavigna V., Boncinelli E., Mavilio F.
EMBO J. 11:265-277(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Organization of human class I homeobox genes."
Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 155-220.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X61755 Genomic DNA. Translation: CAA43894.1.
PIRS20029.
RefSeqNP_061826.1. NM_018953.3.
UniGeneHs.549040.

3D structure databases

ProteinModelPortalQ00444.
SMRQ00444. Positions 159-214.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109462. 1 interaction.
STRING9606.ENSP00000309336.

PTM databases

PhosphoSiteQ00444.

Polymorphism databases

DMDM232262.

Proteomic databases

PaxDbQ00444.
PRIDEQ00444.

Protocols and materials databases

DNASU3222.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312492; ENSP00000309336; ENSG00000172789.
GeneID3222.
KEGGhsa:3222.
UCSCuc001sew.3. human.

Organism-specific databases

CTD3222.
GeneCardsGC12P054379.
HGNCHGNC:5127. HOXC5.
HPAHPA026794.
MIM142973. gene.
neXtProtNX_Q00444.
PharmGKBPA29402.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG286013.
HOGENOMHOG000231178.
HOVERGENHBG016849.
InParanoidQ00444.
KOK09305.
OMACYSGLDL.
OrthoDBEOG780RP4.
PhylomeDBQ00444.
TreeFamTF316310.

Gene expression databases

BgeeQ00444.
GenevestigatorQ00444.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHOXC5.
GenomeRNAi3222.
NextBio12820.
PROQ00444.
SOURCESearch...

Entry information

Entry nameHXC5_HUMAN
AccessionPrimary (citable) accession number: Q00444
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 19, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries