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Q00444

- HXC5_HUMAN

UniProt

Q00444 - HXC5_HUMAN

Protein

Homeobox protein Hox-C5

Gene

HOXC5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi155 – 21460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. embryonic skeletal system development Source: Ensembl
    3. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C5
    Alternative name(s):
    Homeobox protein CP11
    Homeobox protein Hox-3D
    Gene namesi
    Name:HOXC5
    Synonyms:HOX3D
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:5127. HOXC5.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29402.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 222222Homeobox protein Hox-C5PRO_0000200169Add
    BLAST

    Proteomic databases

    MaxQBiQ00444.
    PaxDbiQ00444.
    PRIDEiQ00444.

    PTM databases

    PhosphoSiteiQ00444.

    Expressioni

    Gene expression databases

    BgeeiQ00444.
    GenevestigatoriQ00444.

    Organism-specific databases

    HPAiHPA026794.

    Interactioni

    Protein-protein interaction databases

    BioGridi109462. 1 interaction.
    STRINGi9606.ENSP00000309336.

    Structurei

    3D structure databases

    ProteinModelPortaliQ00444.
    SMRiQ00444. Positions 159-214.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi140 – 1456Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG286013.
    HOGENOMiHOG000231178.
    HOVERGENiHBG016849.
    InParanoidiQ00444.
    KOiK09305.
    OMAiCYSGLDL.
    OrthoDBiEOG780RP4.
    PhylomeDBiQ00444.
    TreeFamiTF316310.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q00444-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP    50
    PPAPSNSLHG VDMAANPRAH PDRPACSAAA APGHAPGRDE AAPLNPGMYS 100
    QKAARPALEE RAKSSGEIKE EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS 150
    HETDGKRSRT SYTRYQTLEL EKEFHFNRYL TRRRRIEIAN NLCLNERQIK 200
    IWFQNRRMKW KKDSKMKSKE AL 222
    Length:222
    Mass (Da):24,976
    Last modified:April 1, 1993 - v1
    Checksum:i9ABA38D35E4E61AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61755 Genomic DNA. Translation: CAA43894.1.
    CCDSiCCDS8872.1.
    PIRiS20029.
    RefSeqiNP_061826.1. NM_018953.3.
    UniGeneiHs.549040.

    Genome annotation databases

    EnsembliENST00000312492; ENSP00000309336; ENSG00000172789.
    GeneIDi3222.
    KEGGihsa:3222.
    UCSCiuc001sew.3. human.

    Polymorphism databases

    DMDMi232262.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61755 Genomic DNA. Translation: CAA43894.1 .
    CCDSi CCDS8872.1.
    PIRi S20029.
    RefSeqi NP_061826.1. NM_018953.3.
    UniGenei Hs.549040.

    3D structure databases

    ProteinModelPortali Q00444.
    SMRi Q00444. Positions 159-214.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109462. 1 interaction.
    STRINGi 9606.ENSP00000309336.

    PTM databases

    PhosphoSitei Q00444.

    Polymorphism databases

    DMDMi 232262.

    Proteomic databases

    MaxQBi Q00444.
    PaxDbi Q00444.
    PRIDEi Q00444.

    Protocols and materials databases

    DNASUi 3222.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312492 ; ENSP00000309336 ; ENSG00000172789 .
    GeneIDi 3222.
    KEGGi hsa:3222.
    UCSCi uc001sew.3. human.

    Organism-specific databases

    CTDi 3222.
    GeneCardsi GC12P054379.
    HGNCi HGNC:5127. HOXC5.
    HPAi HPA026794.
    MIMi 142973. gene.
    neXtProti NX_Q00444.
    PharmGKBi PA29402.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG286013.
    HOGENOMi HOG000231178.
    HOVERGENi HBG016849.
    InParanoidi Q00444.
    KOi K09305.
    OMAi CYSGLDL.
    OrthoDBi EOG780RP4.
    PhylomeDBi Q00444.
    TreeFami TF316310.

    Miscellaneous databases

    GeneWikii HOXC5.
    GenomeRNAii 3222.
    NextBioi 12820.
    PROi Q00444.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q00444.
    Genevestigatori Q00444.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins."
      Arcioni L., Simeone A., Guazzi S., Zappavigna V., Boncinelli E., Mavilio F.
      EMBO J. 11:265-277(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Organization of human class I homeobox genes."
      Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
      Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 155-220.

    Entry informationi

    Entry nameiHXC5_HUMAN
    AccessioniPrimary (citable) accession number: Q00444
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3