Q00444 (HXC5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-C5

Alternative name(s):
Homeobox protein CP11
Homeobox protein Hox-3D

Gene names

Name:	HOXC5
Synonyms:	HOX3D

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara embryonic skeletal system development Inferred from electronic annotation. Source: Compara regulation of transcription from RNA polymerase II promoter Traceable author statement Ref.1. Source: ProtInc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cell junction Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Homeobox protein Hox-C5		PRO_0000200169
Regions
	DNA binding	155 – 214	60	Homeobox
	Motif	140 – 145	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	Q00444 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 9ABA38D35E4E61AB	FASTA	222	24,976
	10 20 30 40 50 60 MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP PPAPSNSLHG 70 80 90 100 110 120 VDMAANPRAH PDRPACSAAA APGHAPGRDE AAPLNPGMYS QKAARPALEE RAKSSGEIKE 130 140 150 160 170 180 EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS HETDGKRSRT SYTRYQTLEL EKEFHFNRYL 190 200 210 220 TRRRRIEIAN NLCLNERQIK IWFQNRRMKW KKDSKMKSKE AL

References

[1]	"The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins." Arcioni L., Simeone A., Guazzi S., Zappavigna V., Boncinelli E., Mavilio F. EMBO J. 11:265-277(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Organization of human class I homeobox genes." Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A. Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 155-220.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X61755 Genomic DNA. Translation: CAA43894.1.
IPI	IPI00022893.
PIR	S20029.
RefSeq	NP_061826.1. NM_018953.2.
UniGene	Hs.549040.
3D structure databases
ProteinModelPortal	Q00444.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000309336.
PTM databases
PhosphoSite	Q00444.
Polymorphism databases
DMDM	232262.
Proteomic databases
PaxDb	Q00444.
PRIDE	Q00444.
Protocols and materials databases
DNASU	3222.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000312492; ENSP00000309336; ENSG00000172789.
GeneID	3222.
KEGG	hsa:3222.
UCSC	uc001sew.3. human.
Organism-specific databases
CTD	3222.
GeneCards	GC12P054379.
HGNC	HGNC:5127. HOXC5.
HPA	HPA026794.
MIM	142973. gene.
neXtProt	NX_Q00444.
PharmGKB	PA29402.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG286013.
HOGENOM	HOG000231178.
HOVERGEN	HBG016849.
InParanoid	Q00444.
KO	K09305.
OMA	CYSGLDL.
OrthoDB	EOG4CRM16.
PhylomeDB	Q00444.
Gene expression databases
Bgee	Q00444.
Genevestigator	Q00444.
GermOnline	ENSG00000172789. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3222.
NextBio	12820.
SOURCE	Search...

Entry information

Entry name

HXC5_HUMAN

Accession

Primary (citable) accession number: Q00444

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	May 1, 2013
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.