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Protein

Homeobox protein Hox-C5

Gene

HOXC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi155 – 21460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. embryonic skeletal system development Source: Ensembl
  3. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C5
Alternative name(s):
Homeobox protein CP11
Homeobox protein Hox-3D
Gene namesi
Name:HOXC5
Synonyms:HOX3D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:5127. HOXC5.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: HPA
  2. nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29402.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Homeobox protein Hox-C5PRO_0000200169Add
BLAST

Proteomic databases

MaxQBiQ00444.
PaxDbiQ00444.
PRIDEiQ00444.

PTM databases

PhosphoSiteiQ00444.

Expressioni

Gene expression databases

BgeeiQ00444.
GenevestigatoriQ00444.

Organism-specific databases

HPAiHPA026794.

Interactioni

Protein-protein interaction databases

BioGridi109462. 1 interaction.
STRINGi9606.ENSP00000309336.

Structurei

3D structure databases

ProteinModelPortaliQ00444.
SMRiQ00444. Positions 159-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi140 – 1456Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG286013.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiQ00444.
KOiK09305.
OMAiCYSGLDL.
OrthoDBiEOG780RP4.
PhylomeDBiQ00444.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00444-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP
60 70 80 90 100
PPAPSNSLHG VDMAANPRAH PDRPACSAAA APGHAPGRDE AAPLNPGMYS
110 120 130 140 150
QKAARPALEE RAKSSGEIKE EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS
160 170 180 190 200
HETDGKRSRT SYTRYQTLEL EKEFHFNRYL TRRRRIEIAN NLCLNERQIK
210 220
IWFQNRRMKW KKDSKMKSKE AL
Length:222
Mass (Da):24,976
Last modified:April 1, 1993 - v1
Checksum:i9ABA38D35E4E61AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61755 Genomic DNA. Translation: CAA43894.1.
CCDSiCCDS8872.1.
PIRiS20029.
RefSeqiNP_061826.1. NM_018953.3.
UniGeneiHs.549040.

Genome annotation databases

EnsembliENST00000312492; ENSP00000309336; ENSG00000172789.
GeneIDi3222.
KEGGihsa:3222.
UCSCiuc001sew.3. human.

Polymorphism databases

DMDMi232262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61755 Genomic DNA. Translation: CAA43894.1.
CCDSiCCDS8872.1.
PIRiS20029.
RefSeqiNP_061826.1. NM_018953.3.
UniGeneiHs.549040.

3D structure databases

ProteinModelPortaliQ00444.
SMRiQ00444. Positions 159-214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109462. 1 interaction.
STRINGi9606.ENSP00000309336.

PTM databases

PhosphoSiteiQ00444.

Polymorphism databases

DMDMi232262.

Proteomic databases

MaxQBiQ00444.
PaxDbiQ00444.
PRIDEiQ00444.

Protocols and materials databases

DNASUi3222.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312492; ENSP00000309336; ENSG00000172789.
GeneIDi3222.
KEGGihsa:3222.
UCSCiuc001sew.3. human.

Organism-specific databases

CTDi3222.
GeneCardsiGC12P054471.
HGNCiHGNC:5127. HOXC5.
HPAiHPA026794.
MIMi142973. gene.
neXtProtiNX_Q00444.
PharmGKBiPA29402.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG286013.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiQ00444.
KOiK09305.
OMAiCYSGLDL.
OrthoDBiEOG780RP4.
PhylomeDBiQ00444.
TreeFamiTF316310.

Miscellaneous databases

GeneWikiiHOXC5.
GenomeRNAii3222.
NextBioi12820.
PROiQ00444.
SOURCEiSearch...

Gene expression databases

BgeeiQ00444.
GenevestigatoriQ00444.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins."
    Arcioni L., Simeone A., Guazzi S., Zappavigna V., Boncinelli E., Mavilio F.
    EMBO J. 11:265-277(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 155-220.

Entry informationi

Entry nameiHXC5_HUMAN
AccessioniPrimary (citable) accession number: Q00444
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: February 4, 2015
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.