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Protein

Homeobox protein Hox-C5

Gene

HOXC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi155 – 214HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BRENDAi2.7.11.21 2681

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C5
Alternative name(s):
Homeobox protein CP11
Homeobox protein Hox-3D
Gene namesi
Name:HOXC5
Synonyms:HOX3D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000172789.3
HGNCiHGNC:5127 HOXC5
MIMi142973 gene
neXtProtiNX_Q00444

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3222
OpenTargetsiENSG00000172789
PharmGKBiPA29402

Polymorphism and mutation databases

DMDMi232262

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001691 – 222Homeobox protein Hox-C5Add BLAST222

Proteomic databases

MaxQBiQ00444
PaxDbiQ00444
PeptideAtlasiQ00444
PRIDEiQ00444

PTM databases

iPTMnetiQ00444
PhosphoSitePlusiQ00444

Expressioni

Gene expression databases

BgeeiENSG00000172789
GenevisibleiQ00444 HS

Organism-specific databases

HPAiHPA026794

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ00444, 8 interactors
STRINGi9606.ENSP00000309336

Structurei

3D structure databases

ProteinModelPortaliQ00444
SMRiQ00444
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi140 – 145Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231178
HOVERGENiHBG016849
InParanoidiQ00444
KOiK09305
OMAiCYSGLDL
OrthoDBiEOG091G09XD
PhylomeDBiQ00444
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q00444-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP
60 70 80 90 100
PPAPSNSLHG VDMAANPRAH PDRPACSAAA APGHAPGRDE AAPLNPGMYS
110 120 130 140 150
QKAARPALEE RAKSSGEIKE EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS
160 170 180 190 200
HETDGKRSRT SYTRYQTLEL EKEFHFNRYL TRRRRIEIAN NLCLNERQIK
210 220
IWFQNRRMKW KKDSKMKSKE AL
Length:222
Mass (Da):24,976
Last modified:April 1, 1993 - v1
Checksum:i9ABA38D35E4E61AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61755 Genomic DNA Translation: CAA43894.1
CCDSiCCDS8872.1
PIRiS20029
RefSeqiNP_061826.1, NM_018953.3
UniGeneiHs.549040

Genome annotation databases

EnsembliENST00000312492; ENSP00000309336; ENSG00000172789
GeneIDi3222
KEGGihsa:3222
UCSCiuc001sew.4 human

Similar proteinsi

Entry informationi

Entry nameiHXC5_HUMAN
AccessioniPrimary (citable) accession number: Q00444
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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