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Protein

Homeobox protein Hox-C5

Gene

HOXC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi155 – 214HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BRENDAi2.7.11.21. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C5
Alternative name(s):
Homeobox protein CP11
Homeobox protein Hox-3D
Gene namesi
Name:HOXC5
Synonyms:HOX3D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:5127. HOXC5.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3222.
OpenTargetsiENSG00000172789.
PharmGKBiPA29402.

Polymorphism and mutation databases

DMDMi232262.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001691 – 222Homeobox protein Hox-C5Add BLAST222

Proteomic databases

MaxQBiQ00444.
PaxDbiQ00444.
PeptideAtlasiQ00444.
PRIDEiQ00444.

PTM databases

iPTMnetiQ00444.
PhosphoSitePlusiQ00444.

Expressioni

Gene expression databases

BgeeiENSG00000172789.
GenevisibleiQ00444. HS.

Organism-specific databases

HPAiHPA026794.

Interactioni

Protein-protein interaction databases

IntActiQ00444. 8 interactors.
STRINGi9606.ENSP00000309336.

Structurei

3D structure databases

ProteinModelPortaliQ00444.
SMRiQ00444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi140 – 145Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiQ00444.
KOiK09305.
OMAiCYSGLDL.
OrthoDBiEOG091G09XD.
PhylomeDBiQ00444.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q00444-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP
60 70 80 90 100
PPAPSNSLHG VDMAANPRAH PDRPACSAAA APGHAPGRDE AAPLNPGMYS
110 120 130 140 150
QKAARPALEE RAKSSGEIKE EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS
160 170 180 190 200
HETDGKRSRT SYTRYQTLEL EKEFHFNRYL TRRRRIEIAN NLCLNERQIK
210 220
IWFQNRRMKW KKDSKMKSKE AL
Length:222
Mass (Da):24,976
Last modified:April 1, 1993 - v1
Checksum:i9ABA38D35E4E61AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61755 Genomic DNA. Translation: CAA43894.1.
CCDSiCCDS8872.1.
PIRiS20029.
RefSeqiNP_061826.1. NM_018953.3.
UniGeneiHs.549040.

Genome annotation databases

EnsembliENST00000312492; ENSP00000309336; ENSG00000172789.
GeneIDi3222.
KEGGihsa:3222.
UCSCiuc001sew.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61755 Genomic DNA. Translation: CAA43894.1.
CCDSiCCDS8872.1.
PIRiS20029.
RefSeqiNP_061826.1. NM_018953.3.
UniGeneiHs.549040.

3D structure databases

ProteinModelPortaliQ00444.
SMRiQ00444.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ00444. 8 interactors.
STRINGi9606.ENSP00000309336.

PTM databases

iPTMnetiQ00444.
PhosphoSitePlusiQ00444.

Polymorphism and mutation databases

DMDMi232262.

Proteomic databases

MaxQBiQ00444.
PaxDbiQ00444.
PeptideAtlasiQ00444.
PRIDEiQ00444.

Protocols and materials databases

DNASUi3222.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312492; ENSP00000309336; ENSG00000172789.
GeneIDi3222.
KEGGihsa:3222.
UCSCiuc001sew.4. human.

Organism-specific databases

CTDi3222.
DisGeNETi3222.
GeneCardsiHOXC5.
HGNCiHGNC:5127. HOXC5.
HPAiHPA026794.
MIMi142973. gene.
neXtProtiNX_Q00444.
OpenTargetsiENSG00000172789.
PharmGKBiPA29402.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118945.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiQ00444.
KOiK09305.
OMAiCYSGLDL.
OrthoDBiEOG091G09XD.
PhylomeDBiQ00444.
TreeFamiTF316310.

Enzyme and pathway databases

BRENDAi2.7.11.21. 2681.

Miscellaneous databases

GeneWikiiHOXC5.
GenomeRNAii3222.
PROiQ00444.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172789.
GenevisibleiQ00444. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHXC5_HUMAN
AccessioniPrimary (citable) accession number: Q00444
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: March 15, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.