ID PHE3_RHDS2 Reviewed; 128 AA. AC Q00433; O82050; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 27-MAY-2002, sequence version 2. DT 22-FEB-2023, entry version 111. DE RecName: Full=Phycoerythrin alpha-3 chain, chloroplastic; DE Flags: Precursor; GN Name=cpeA3; OS Rhodomonas sp. (strain CS 24) (Chroomonas sp. (strain CS24)). OC Eukaryota; Cryptophyceae; Pyrenomonadales; Pyrenomonadaceae; Rhodomonas. OX NCBI_TaxID=79257; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=2226853; DOI=10.1016/0014-5793(90)81082-y; RA Jenkins J., Hiller R.G., Speirs J., Godovac-Zimmermann J.; RT "A genomic clone encoding a cryptophyte phycoerythrin alpha-subunit. RT Evidence for three alpha-subunits and an N-terminal membrane transit RT sequence."; RL FEBS Lett. 273:191-194(1990). RN [2] RP ERRATUM OF PUBMED:2226853. RX PubMed=2004659; DOI=10.1016/0014-5793(91)80187-8; RA Jenkins J., Hiller R.G., Speirs J., Godovac-Zimmermann J.; RL FEBS Lett. 279:361-361(1991). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION TO 62. RA Hiller R.G., Howe C.E.; RT "Nuclear-encoded genes of phycoerythrin alpha subunits."; RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases. RN [4] RP X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 53-128 IN COMPLEX WITH CPEA2; RP CPEB AND 15,16-DIHYDROBILIVERDIN, SUBUNIT, AND HYDROXYLATION AT LYS-56. RX PubMed=10430868; DOI=10.1073/pnas.96.16.8901; RA Wilk K.E., Harrop S.J., Jankova L., Edler D., Keenan G., Sharples F., RA Hiller R.G., Curmi P.M.; RT "Evolution of a light-harvesting protein by addition of new subunits and RT rearrangement of conserved elements: crystal structure of a cryptophyte RT phycoerythrin at 1.63-A resolution."; RL Proc. Natl. Acad. Sci. U.S.A. 96:8901-8906(1999). RN [5] RP X-RAY CRYSTALLOGRAPHY (0.97 ANGSTROMS) OF 53-128 IN COMPLEX WITH CPEA2; RP CPEB AND 15,16-DIHYDROBILIVERDIN, SUBUNIT, AND HYDROXYLATION AT LYS-56. RX PubMed=15504407; DOI=10.1016/j.jmb.2004.09.044; RA Doust A.B., Marai C.N., Harrop S.J., Wilk K.E., Curmi P.M., Scholes G.D.; RT "Developing a structure-function model for the cryptophyte phycoerythrin RT 545 using ultrahigh resolution crystallography and ultrafast laser RT spectroscopy."; RL J. Mol. Biol. 344:135-153(2004). CC -!- FUNCTION: Light-harvesting photosynthetic tetrapyrrole chromophore- CC protein from the phycobiliprotein complex. CC -!- SUBUNIT: Heterotetramer of 2 different alpha chains and 2 identical CC beta chains. The subunit composition could comprise of any combination CC of 2 out of 4 different alpha units with an invariant beta unit. CC {ECO:0000269|PubMed:10430868, ECO:0000269|PubMed:15504407}. CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane; CC Peripheral membrane protein; Lumenal side. CC -!- PTM: Contains one covalently linked 15,16-dihydrobiliverdin CC chromophore. CC -!- MISCELLANEOUS: The light-harvesting system in Cryptophytes contains CC phycobiliprotein complexes. Unusually they are composed of either CC phycoerythrin (CPE) or phycocyanin (CPC) but never allophycocyanin CC (APC), with only one type of biliprotein being present in any one CC species. Unlike cyanobacteria or red algae these proteins are not CC arranged into higher-order phycobilisome complexes, and they are found CC in the thylakoid lumen. CC -!- SIMILARITY: Belongs to the phycoerythrin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ006994; CAA07415.2; -; Genomic_DNA. DR PIR; S12900; S12900. DR PDB; 1QGW; X-ray; 1.63 A; A=53-128. DR PDB; 1XF6; X-ray; 1.10 A; A=53-128. DR PDB; 1XG0; X-ray; 0.97 A; A=53-128. DR PDBsum; 1QGW; -. DR PDBsum; 1XF6; -. DR PDBsum; 1XG0; -. DR AlphaFoldDB; Q00433; -. DR SMR; Q00433; -. DR EvolutionaryTrace; Q00433; -. DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030089; C:phycobilisome; IEA:InterPro. DR GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW. DR Gene3D; 3.90.510.10; Phycoerythrin alpha chain; 1. DR InterPro; IPR011070; Globular_prot_asu/bsu. DR InterPro; IPR037011; Phycoerythr-like_a_sf. DR InterPro; IPR004228; Phycoerythr_a. DR InterPro; IPR006311; TAT_signal. DR Pfam; PF02972; Phycoerythr_ab; 1. DR SUPFAM; SSF56568; Non-globular alpha+beta subunits of globular proteins; 1. DR PROSITE; PS51318; TAT; 1. PE 1: Evidence at protein level; KW 3D-structure; Bile pigment; Chloroplast; Chromophore; Electron transport; KW Hydroxylation; Membrane; Photosynthesis; Plastid; Thylakoid; KW Transit peptide; Transport. FT TRANSIT 1..52 FT /note="Chloroplast" FT CHAIN 53..128 FT /note="Phycoerythrin alpha-3 chain, chloroplastic" FT /id="PRO_0000002828" FT REGION 70..89 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 71 FT /ligand="15,16-dihydrobiliverdin" FT /ligand_id="ChEBI:CHEBI:57899" FT /note="covalent" FT /evidence="ECO:0000269|PubMed:10430868, FT ECO:0000269|PubMed:15504407" FT BINDING 73 FT /ligand="15,16-dihydrobiliverdin" FT /ligand_id="ChEBI:CHEBI:57899" FT /evidence="ECO:0000269|PubMed:10430868, FT ECO:0000269|PubMed:15504407" FT BINDING 77..78 FT /ligand="15,16-dihydrobiliverdin" FT /ligand_id="ChEBI:CHEBI:57899" FT BINDING 93 FT /ligand="15,16-dihydrobiliverdin" FT /ligand_id="ChEBI:CHEBI:57899" FT /evidence="ECO:0000269|PubMed:10430868, FT ECO:0000269|PubMed:15504407" FT MOD_RES 56 FT /note="5-hydroxylysine" FT /evidence="ECO:0000269|PubMed:10430868, FT ECO:0000269|PubMed:15504407" FT STRAND 59..67 FT /evidence="ECO:0007829|PDB:1XG0" FT HELIX 86..89 FT /evidence="ECO:0007829|PDB:1XG0" FT STRAND 90..98 FT /evidence="ECO:0007829|PDB:1XG0" FT HELIX 103..113 FT /evidence="ECO:0007829|PDB:1XG0" FT STRAND 120..122 FT /evidence="ECO:0007829|PDB:1XG0" SQ SEQUENCE 128 AA; 13175 MW; 44B1ECFD62C12732 CRC64; MFAKTLASLA VIGSAAAYVP MMSMDMGRRE VVQAGAAAAA VTPFLSGAPA GAAMDKSAKA PQITIFDHRG CSRAPKESTG GKAGGQDDEM MVKVASTKVT VSESDAAKKL QEFITFEKGI DGPFTSKN //