Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GA-binding protein alpha chain

Gene

Gabpa

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor capable of interacting with purine rich repeats (GA repeats).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi320 – 400ETSPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

  • cellular response to dopamine Source: MGI
  • in utero embryonic development Source: MGI
  • negative regulation of megakaryocyte differentiation Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2151201 Transcriptional activation of mitochondrial biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
GA-binding protein alpha chain
Short name:
GABP subunit alpha
Gene namesi
Name:Gabpa
Synonyms:E4tf1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:95610 Gabpa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041281 – 454GA-binding protein alpha chainAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei303PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ00422
MaxQBiQ00422
PaxDbiQ00422
PeptideAtlasiQ00422
PRIDEiQ00422

PTM databases

iPTMnetiQ00422
PhosphoSitePlusiQ00422

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000008976
CleanExiMM_GABPA
GenevisibleiQ00422 MM

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199795, 1 interactor
DIPiDIP-156N
IntActiQ00422, 2 interactors
MINTiQ00422
STRINGi10090.ENSMUSP00000009120

Structurei

Secondary structure

1454
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 47Combined sources12
Helixi48 – 50Combined sources3
Helixi51 – 54Combined sources4
Helixi56 – 59Combined sources4
Beta strandi67 – 70Combined sources4
Turni81 – 83Combined sources3
Beta strandi90 – 99Combined sources10
Beta strandi107 – 115Combined sources9
Helixi168 – 177Combined sources10
Turni178 – 180Combined sources3
Helixi186 – 188Combined sources3
Helixi191 – 204Combined sources14
Helixi213 – 215Combined sources3
Helixi219 – 224Combined sources6
Helixi227 – 233Combined sources7
Helixi238 – 249Combined sources12
Turni250 – 252Combined sources3
Helixi322 – 330Combined sources9
Turni333 – 338Combined sources6
Beta strandi339 – 341Combined sources3
Beta strandi343 – 349Combined sources7
Helixi353 – 364Combined sources12
Helixi371 – 379Combined sources9
Helixi380 – 383Combined sources4
Beta strandi384 – 389Combined sources6
Beta strandi396 – 399Combined sources4
Helixi403 – 406Combined sources4
Helixi411 – 428Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AWCX-ray2.15A320-429[»]
1SXDNMR-A168-254[»]
2JUONMR-A35-121[»]
ProteinModelPortaliQ00422
SMRiQ00422
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00422

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 251PNTPROSITE-ProRule annotationAdd BLAST84

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00760000118907
HOGENOMiHOG000285952
HOVERGENiHBG051687
InParanoidiQ00422
KOiK09441
OMAiNVFWTHL
OrthoDBiEOG091G0EXE
TreeFamiTF350537

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR024668 GABP_asu_N
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR016312 TF_GA-bd_asu
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF11620 GABP-alpha, 1 hit
PF02198 SAM_PNT, 1 hit
PIRSFiPIRSF001703 GABP_alpha, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequencei

Sequence statusi: Complete.

Q00422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYTPAECVSQ AIDINEPIGN
60 70 80 90 100
LKKLLEPRLQ CSLDAHEICL QDIQLDPDRS LFDQGVKTDG TVQLSVQVIS
110 120 130 140 150
YQGMEPKLNI LEIVKTAETV EVVIDPDAHH AEAEAHLVEE AQVITLDGTK
160 170 180 190 200
HITTISDETS EQVTRWAAAL EGYRKEQERL GIPYDPIHWS TDQVLHWVVW
210 220 230 240 250
VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL WSHLELLRKY
260 270 280 290 300
VLASQEQQMN EIVTIDQPVQ IIPASVPPAT PTTIKVINSS AKAAKVQRSP
310 320 330 340 350
RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL
360 370 380 390 400
NQPELVAQKW GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV
410 420 430 440 450
CDLKTLIGYS AAELNRLVIE CEQKKLARMQ LHGIAQPVTA VALAATSLQA

DKEI
Length:454
Mass (Da):51,344
Last modified:July 27, 2011 - v2
Checksum:i2CBC40B895563685
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188H → R in AAA53030 (PubMed:1876836).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74515 mRNA Translation: AAA53030.1
AK139916 mRNA Translation: BAE24181.1
AK145446 mRNA Translation: BAE26442.1
AK145838 mRNA Translation: BAE26687.1
AK148087 mRNA Translation: BAE28337.1
AK150455 mRNA Translation: BAE29575.1
CH466521 Genomic DNA Translation: EDK98317.1
BC052448 mRNA Translation: AAH52448.1
CCDSiCCDS28284.1
PIRiA40858
RefSeqiNP_032091.2, NM_008065.2
XP_006522970.1, XM_006522907.2
UniGeneiMm.18974

Genome annotation databases

EnsembliENSMUST00000009120; ENSMUSP00000009120; ENSMUSG00000008976
ENSMUST00000114184; ENSMUSP00000109822; ENSMUSG00000008976
GeneIDi14390
KEGGimmu:14390
UCSCiuc007ztj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGABPA_MOUSE
AccessioniPrimary (citable) accession number: Q00422
Secondary accession number(s): Q7TT22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health