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Q00422

- GABPA_MOUSE

UniProt

Q00422 - GABPA_MOUSE

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Protein

GA-binding protein alpha chain

Gene

Gabpa

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor capable of interacting with purine rich repeats (GA repeats).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi320 – 40081ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. protein heterodimerization activity Source: MGI
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  6. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
  7. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. in utero embryonic development Source: MGI
  2. negative regulation of megakaryocyte differentiation Source: MGI
  3. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  5. regulation of transcription from RNA polymerase II promoter Source: MGI
  6. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_205251. Transcriptional activation of mitochondrial biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
GA-binding protein alpha chain
Short name:
GABP subunit alpha
Gene namesi
Name:Gabpa
Synonyms:E4tf1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:95610. Gabpa.

Subcellular locationi

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454GA-binding protein alpha chainPRO_0000204128Add
BLAST

Proteomic databases

MaxQBiQ00422.
PaxDbiQ00422.
PRIDEiQ00422.

PTM databases

PhosphoSiteiQ00422.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ00422.
CleanExiMM_GABPA.
ExpressionAtlasiQ00422. baseline and differential.
GenevestigatoriQ00422.

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.

Protein-protein interaction databases

DIPiDIP-156N.
IntActiQ00422. 1 interaction.
MINTiMINT-1531786.

Structurei

Secondary structure

1
454
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi36 – 4712Combined sources
Helixi48 – 503Combined sources
Helixi51 – 544Combined sources
Helixi56 – 594Combined sources
Beta strandi67 – 704Combined sources
Turni81 – 833Combined sources
Beta strandi90 – 9910Combined sources
Beta strandi107 – 1159Combined sources
Helixi168 – 17710Combined sources
Turni178 – 1803Combined sources
Helixi186 – 1883Combined sources
Helixi191 – 20414Combined sources
Helixi213 – 2153Combined sources
Helixi219 – 2246Combined sources
Helixi227 – 2337Combined sources
Helixi238 – 24912Combined sources
Turni250 – 2523Combined sources
Helixi322 – 3309Combined sources
Turni333 – 3386Combined sources
Beta strandi339 – 3413Combined sources
Beta strandi343 – 3497Combined sources
Helixi353 – 36412Combined sources
Helixi371 – 3799Combined sources
Helixi380 – 3834Combined sources
Beta strandi384 – 3896Combined sources
Beta strandi396 – 3994Combined sources
Helixi403 – 4064Combined sources
Helixi411 – 42818Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AWCX-ray2.15A320-429[»]
1SXDNMR-A168-254[»]
2JUONMR-A35-121[»]
ProteinModelPortaliQ00422.
SMRiQ00422. Positions 35-121, 168-254, 320-429.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ00422.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 25184PNTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG252121.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000285952.
HOVERGENiHBG051687.
InParanoidiQ00422.
KOiK09441.
OMAiGIPYDPV.
OrthoDBiEOG7TXKGT.
TreeFamiTF350537.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR024668. GABP_asu_N.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016312. TF_GA-bd_asu.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF11620. GABP-alpha. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PIRSFiPIRSF001703. GABP_alpha. 1 hit.
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00422-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYTPAECVSQ AIDINEPIGN
60 70 80 90 100
LKKLLEPRLQ CSLDAHEICL QDIQLDPDRS LFDQGVKTDG TVQLSVQVIS
110 120 130 140 150
YQGMEPKLNI LEIVKTAETV EVVIDPDAHH AEAEAHLVEE AQVITLDGTK
160 170 180 190 200
HITTISDETS EQVTRWAAAL EGYRKEQERL GIPYDPIHWS TDQVLHWVVW
210 220 230 240 250
VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL WSHLELLRKY
260 270 280 290 300
VLASQEQQMN EIVTIDQPVQ IIPASVPPAT PTTIKVINSS AKAAKVQRSP
310 320 330 340 350
RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL
360 370 380 390 400
NQPELVAQKW GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV
410 420 430 440 450
CDLKTLIGYS AAELNRLVIE CEQKKLARMQ LHGIAQPVTA VALAATSLQA

DKEI
Length:454
Mass (Da):51,344
Last modified:July 27, 2011 - v2
Checksum:i2CBC40B895563685
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 1881H → R in AAA53030. (PubMed:1876836)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74515 mRNA. Translation: AAA53030.1.
AK139916 mRNA. Translation: BAE24181.1.
AK145446 mRNA. Translation: BAE26442.1.
AK145838 mRNA. Translation: BAE26687.1.
AK148087 mRNA. Translation: BAE28337.1.
AK150455 mRNA. Translation: BAE29575.1.
CH466521 Genomic DNA. Translation: EDK98317.1.
BC052448 mRNA. Translation: AAH52448.1.
CCDSiCCDS28284.1.
PIRiA40858.
RefSeqiNP_032091.2. NM_008065.2.
XP_006522970.1. XM_006522907.1.
UniGeneiMm.18974.

Genome annotation databases

EnsembliENSMUST00000009120; ENSMUSP00000009120; ENSMUSG00000008976.
ENSMUST00000114184; ENSMUSP00000109822; ENSMUSG00000008976.
GeneIDi14390.
KEGGimmu:14390.
UCSCiuc007ztj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74515 mRNA. Translation: AAA53030.1 .
AK139916 mRNA. Translation: BAE24181.1 .
AK145446 mRNA. Translation: BAE26442.1 .
AK145838 mRNA. Translation: BAE26687.1 .
AK148087 mRNA. Translation: BAE28337.1 .
AK150455 mRNA. Translation: BAE29575.1 .
CH466521 Genomic DNA. Translation: EDK98317.1 .
BC052448 mRNA. Translation: AAH52448.1 .
CCDSi CCDS28284.1.
PIRi A40858.
RefSeqi NP_032091.2. NM_008065.2.
XP_006522970.1. XM_006522907.1.
UniGenei Mm.18974.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AWC X-ray 2.15 A 320-429 [» ]
1SXD NMR - A 168-254 [» ]
2JUO NMR - A 35-121 [» ]
ProteinModelPortali Q00422.
SMRi Q00422. Positions 35-121, 168-254, 320-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-156N.
IntActi Q00422. 1 interaction.
MINTi MINT-1531786.

PTM databases

PhosphoSitei Q00422.

Proteomic databases

MaxQBi Q00422.
PaxDbi Q00422.
PRIDEi Q00422.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000009120 ; ENSMUSP00000009120 ; ENSMUSG00000008976 .
ENSMUST00000114184 ; ENSMUSP00000109822 ; ENSMUSG00000008976 .
GeneIDi 14390.
KEGGi mmu:14390.
UCSCi uc007ztj.1. mouse.

Organism-specific databases

CTDi 2551.
MGIi MGI:95610. Gabpa.

Phylogenomic databases

eggNOGi NOG252121.
GeneTreei ENSGT00760000118907.
HOGENOMi HOG000285952.
HOVERGENi HBG051687.
InParanoidi Q00422.
KOi K09441.
OMAi GIPYDPV.
OrthoDBi EOG7TXKGT.
TreeFami TF350537.

Enzyme and pathway databases

Reactomei REACT_205251. Transcriptional activation of mitochondrial biogenesis.

Miscellaneous databases

EvolutionaryTracei Q00422.
NextBioi 285913.
PROi Q00422.
SOURCEi Search...

Gene expression databases

Bgeei Q00422.
CleanExi MM_GABPA.
ExpressionAtlasi Q00422. baseline and differential.
Genevestigatori Q00422.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProi IPR000418. Ets_dom.
IPR024668. GABP_asu_N.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR016312. TF_GA-bd_asu.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
PF11620. GABP-alpha. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view ]
PIRSFi PIRSF001703. GABP_alpha. 1 hit.
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Ets- and notch-related subunits in GA binding protein."
    Lamarco K., Thompson C.C., Byers B.P., Walton E.M., McKnight S.L.
    Science 253:789-792(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Egg and Liver.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  5. "The structure of GABPalpha/beta: an ETS domain-ankyrin repeat heterodimer bound to DNA."
    Batchelor A.H., Piper D.E., de la Brousse F.C., McKnight S.L., Wolberger C.
    Science 279:1037-1041(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 320-320.

Entry informationi

Entry nameiGABPA_MOUSE
AccessioniPrimary (citable) accession number: Q00422
Secondary accession number(s): Q7TT22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3