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Reviewed, UniProtKB/Swiss-Prot Q00415 (HPPD_COCPO)

Last modified November 25, 2008. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    4-hydroxyphenylpyruvate dioxygenase
      Short name=HPPDase
      Short name=4HPPD
      Short name=HPD
    EC=1.13.11.27
Alternative name(s):
    T-cell reactive protein
Gene names
Name: TCRP
OrganismCoccidioides posadasii
Taxonomic identifier199306 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2).

Cofactor

Binds 1 iron ion per subunit By similarity.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 3/6.

Sequence similarities

Belongs to the 4HPPD family.

Sequence caution

The sequence BAE20309.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAE20310.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAE20311.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAE20312.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAE20313.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAE20314.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAE20315.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAE20318.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAE20321.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAE20322.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAE20324.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAE20325.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAE20326.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAE20327.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3993994-hydroxyphenylpyruvate dioxygenase
PRO_0000088403

Sites

Metal binding2001Iron By similarity
Metal binding2831Iron By similarity
Metal binding3661Iron By similarity

Natural variations

Natural variant2501N → S in strain: IFM 45817.

Experimental info

Sequence conflict2971N → T in AAC60567. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q00415-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 342DEFF33091C3C2

FASTA39945,262
        10         20         30         40         50         60 
MAPAADSPTL QPAQPSDLNQ YRGYDHVHWY VGNAKQAATY YVTRMGFERV AYRGLETGSK 

        70         80         90        100        110        120 
AVASHVVRNG NITFILTSPL RSVEQASRFP EDEALLKEIH AHLERHGDGV KDVAFEVDCV 

       130        140        150        160        170        180 
ESVFSAAVRN GAEVVSDVRT VEDEDGQIKM ATIRTYGETT HTLIERSGYR GGFMPGYRME 

       190        200        210        220        230        240 
SNADATSKFL PKVVLERIDH CVGNQDWDEM ERVCDYYEKI LGFHRFWSVD DKDICTEFSA 

       250        260        270        280        290        300 
LKSIVMASPN DIVKMPINEP AKGKKQSQIE EYVDFYNGAG VQHIALRTNN IIDAITNLKA 

       310        320        330        340        350        360 
RGTEFIKVPE TYYEDMKIRL KRQGLVLDED FETLKSLDIL IDFDENGYLL QLFTKHLMDR 

       370        380        390 
PTVFIEIIQR NNFSGFGAGN FRALFEAIER EQALRGTLI 

« Hide

References

[1]"Cloning and expression of a gene encoding a T-cell reactive protein from Coccidioides immitis: homology to 4-hydroxyphenylpyruvate dioxygenase and the mammalian F antigen."
Wyckoff E.E., Pishko E.J., Kirkland T.N., Cole G.T.
Gene 161:107-111(1995) [PubMed: 7642122] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C735.
[2]"Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitis."
Koufopanou V., Burt A., Taylor J.W.
Proc. Natl. Acad. Sci. U.S.A. 94:5478-5482(1997) [PubMed: 9144263] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 233-362.
Strain: RMSCC 757 / Silveira.
[3]Erratum
Koufopanou V., Burt A., Taylor J.W.
Proc. Natl. Acad. Sci. U.S.A. 95:8414-8414(1998)
[4]"Reexamination of Coccidioides spp. reserved in the Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, based on a multiple gene analysis."
Sano A., Miyaji M., Kamei K., Mikami Y., Nishimura K.
Nippon Ishinkin Gakkai Zasshi 47:113-117(2006) [PubMed: 16699492] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 237-383, VARIANT SER-250.
Strain: IFM 45809, IFM 45810, IFM 45811, IFM 45812, IFM 45813, IFM 45817, IFM 4935, IFM 4945, IFM 50993, IFM 50994, IFM 51112, IFM 54194, IFM 54195 and IFM 54196.
[5]"Coccidioides immitis fractions which are antigenic for immune T lymphocytes."
Kirkland T.N., Zhu S., Kruse D., Hsu L., Seshan K.R., Cole G.T.
Infect. Immun. 59:3952-3961(1991) [PubMed: 1840578] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 237-305.
Strain: C634 and C735.

Cross-references

Sequence databases

L38493 Genomic DNA. Translation: AAA82574.1.
AJ291968 Genomic DNA. Translation: CAC35132.1.
AB232864 Genomic DNA. Translation: BAE20309.1. Sequence problems.
AB232865 Genomic DNA. Translation: BAE20310.1. Sequence problems.
AB232866 Genomic DNA. Translation: BAE20311.1. Sequence problems.
AB232867 Genomic DNA. Translation: BAE20312.1. Sequence problems.
AB232868 Genomic DNA. Translation: BAE20313.1. Sequence problems.
AB232869 Genomic DNA. Translation: BAE20314.1. Sequence problems.
AB232870 Genomic DNA. Translation: BAE20315.1. Sequence problems.
AB232873 Genomic DNA. Translation: BAE20318.1. Sequence problems.
AB232876 Genomic DNA. Translation: BAE20321.1. Sequence problems.
AB232877 Genomic DNA. Translation: BAE20322.1. Sequence problems.
AB232879 Genomic DNA. Translation: BAE20324.1. Sequence problems.
AB232880 Genomic DNA. Translation: BAE20325.1. Sequence problems.
AB232881 Genomic DNA. Translation: BAE20326.1. Sequence problems.
AB232882 Genomic DNA. Translation: BAE20327.1. Sequence problems.
S69110 mRNA. Translation: AAC60567.2.

3D structure databases

HSSPHSSP built from PDB template 1CJX based on UniProtKB P80064.
ModBaseSearch...

Family and domain databases

InterProIPR005956. 4OHPhenylPyrv_dOase.
IPR004360. Glyas_bleo-R_dOase.
[Graphical view]
PANTHERPTHR11959. HPP_dOase. 1 hit.
PfamPF00903. Glyoxalase. 1 hit.
[Graphical view]
PIRSFPIRSF009283. HPP_dOase. 1 hit.
TIGRFAMsTIGR01263. 4HPPD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHPPD_COCPO
AccessionPrimary (citable) accession number: Q00415
Secondary accession number(s): Q02288 expand/collapse secondary AC list , Q400Q0, Q400Q8, Q9C0M8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 25, 2008
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents