Reviewed,
UniProtKB/Swiss-Prot Q00404 (VHCA_METVO)
Last modified
June 16, 2009.
Version 41.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: F420-non-reducing hydrogenase vhc subunit A EC=1.12.99.- | ||
| Gene names |
| ||
| Organism | Methanococcus voltae | ||
| Taxonomic identifier | 2188 [NCBI] | ||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanococcus |
Protein attributes
| Sequence length | 474 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Cofactor | Nickel Potential. |
| Subunit structure | The F420-non-reducing hydrogenase vhc is composed of three subunits; vhcA, vhcD and vhcG By similarity. |
| Induction | By selenium deprivation. |
| Sequence similarities | Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Nickel |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ferredoxin hydrogenase activity Inferred from electronic annotation. Source: InterPro nickel ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 474 | 474 | F420-non-reducing hydrogenase vhc subunit A | PRO_0000199729 | |||||
Sites | |||||||||
| Metal binding | 61 | 1 | Nickel Potential | ||||||
| Metal binding | 64 | 1 | Nickel Potential | ||||||
| Metal binding | 445 | 1 | Nickel Potential | ||||||
| Metal binding | 448 | 1 | Nickel Potential | ||||||
Sequences
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References
| [1] | "Methanococcus voltae harbors four gene clusters potentially encoding two [NiFe] and two [NiFeSe] hydrogenases, each of the cofactor F420-reducing or F420-non-reducing types." Halboth S., Klein A. Mol. Gen. Genet. 233:217-224(1992) [PubMed: 1603063] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: DSM 1537 / PS. |
| [2] | "Selenium is involved in the negative regulation of the expression of selenium-free [NiFe] hydrogenases in Methanococcus voltae." Berghoefer Y., Agha-Amiri K., Klein A. Mol. Gen. Genet. 242:369-373(1994) [PubMed: 8121392] [Abstract] Cited for: TRANSCRIPTIONAL REGULATION. Strain: DSM 1537 / PS. |
Cross-references
Sequence databases | |
|---|---|
| X61203 Genomic DNA. Translation: CAA43506.1. | |
| PIR | S16727. |
3D structure databases | |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR001501. Ni-dep_hyd_lsu. IPR018194. Ni-dep_hyd_lsu_Ni_BS. [Graphical view] |
| Pfam | PF00374. NiFeSe_Hases. 2 hits. [Graphical view] |
| PROSITE | PS00507. NI_HGENASE_L_1. 1 hit. PS00508. NI_HGENASE_L_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | VHCA_METVO | ||||||||
| Accession | Primary (citable) accession number: Q00404 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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