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Q00403

- TF2B_HUMAN

UniProt

Q00403 - TF2B_HUMAN

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Protein
Transcription initiation factor IIB
Gene
GTF2B, TF2B, TFIIB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.

Cofactori

Binds 1 zinc ion per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi15 – 151Zinc
Metal bindingi18 – 181Zinc
Metal bindingi34 – 341Zinc
Metal bindingi37 – 371Zinc

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri11 – 4232TFIIB-type
Add
BLAST

GO - Molecular functioni

  1. core promoter binding Source: Ensembl
  2. protein binding Source: UniProtKB
  3. thyroid hormone receptor binding Source: UniProtKB
  4. transcription factor binding Source: UniProtKB
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. gene expression Source: Reactome
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription elongation from RNA polymerase II promoter Source: Reactome
  4. transcription from RNA polymerase II promoter Source: Reactome
  5. transcription initiation from RNA polymerase II promoter Source: Reactome
  6. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_1851. RNA Polymerase II Transcription Initiation.
REACT_2089. RNA Polymerase II Promoter Escape.
REACT_22107. RNA Polymerase II Pre-transcription Events.
REACT_6233. Transcription of the HIV genome.
REACT_6253. RNA Polymerase II HIV Promoter Escape.
REACT_6332. HIV Transcription Initiation.
REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIB
Alternative name(s):
General transcription factor TFIIB
S300-II
Gene namesi
Name:GTF2B
Synonyms:TF2B, TFIIB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:4648. GTF2B.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi51 – 566EWRTFS → AWRTFA: Partial loss of HIV-1 Vpr binding.
Mutagenesisi52 – 521W → A: Partial loss of HIV-1 Vpr binding.
Mutagenesisi53 – 542RT → AA: Partial loss of HIV-1 Vpr binding.
Mutagenesisi55 – 551F → A: Partial loss of HIV-1 Vpr binding.

Organism-specific databases

PharmGKBiPA29035.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Transcription initiation factor IIB
PRO_0000119293Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ00403.
PaxDbiQ00403.
PeptideAtlasiQ00403.
PRIDEiQ00403.

PTM databases

PhosphoSiteiQ00403.

Miscellaneous databases

PMAP-CutDBQ00403.

Expressioni

Gene expression databases

ArrayExpressiQ00403.
BgeeiQ00403.
CleanExiHS_GTF2B.
GenevestigatoriQ00403.

Organism-specific databases

HPAiHPA061626.

Interactioni

Subunit structurei

Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1 By similarity. Interacts with Epstein-Barr virus EBNA2.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EP300Q094722EBI-389564,EBI-447295
GRF4P460772EBI-389564,EBI-637479From a different organism.
VdrP482812EBI-389564,EBI-346797From a different organism.

Protein-protein interaction databases

BioGridi109214. 64 interactions.
DIPiDIP-1077N.
IntActiQ00403. 25 interactions.
MINTiMINT-156550.
STRINGi9606.ENSP00000359531.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 63
Beta strandi18 – 214
Beta strandi24 – 263
Beta strandi27 – 293
Turni35 – 373
Helixi111 – 1133
Helixi114 – 12714
Helixi132 – 14817
Beta strandi152 – 1543
Helixi156 – 17015
Helixi177 – 1826
Beta strandi184 – 1863
Helixi188 – 20114
Helixi212 – 22110
Helixi226 – 24116
Helixi250 – 26314
Beta strandi265 – 2673
Helixi271 – 2788
Helixi282 – 29211
Helixi293 – 2953
Helixi296 – 2994
Helixi310 – 3123

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1C9BX-ray2.65A/E/I/M/Q110-316[»]
1DL6NMR-A2-59[»]
1RLYNMR-A1-60[»]
1RO4NMR-A1-60[»]
1TFBNMR-A112-316[»]
1VOLX-ray2.70A113-316[»]
2PHGNMR-A112-316[»]
ProteinModelPortaliQ00403.
SMRiQ00403. Positions 2-316.

Miscellaneous databases

EvolutionaryTraceiQ00403.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati124 – 200771
Add
BLAST
Repeati218 – 294772
Add
BLAST

Sequence similaritiesi

Belongs to the TFIIB family.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG1405.
HOGENOMiHOG000108634.
HOVERGENiHBG017914.
InParanoidiQ00403.
KOiK03124.
OMAiYMASHIR.
OrthoDBiEOG78WKS2.
PhylomeDBiQ00403.
TreeFamiTF105953.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view]
PANTHERiPTHR11618. PTHR11618. 1 hit.
PfamiPF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view]
PRINTSiPR00685. TIFACTORIIB.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q00403-1 [UniParc]FASTAAdd to Basket

« Hide

MASTSRLDAL PRVTCPNHPD AILVEDYRAG DMICPECGLV VGDRVIDVGS    50
EWRTFSNDKA TKDPSRVGDS QNPLLSDGDL STMIGKGTGA ASFDEFGNSK 100
YQNRRTMSSS DRAMMNAFKE ITTMADRINL PRNIVDRTNN LFKQVYEQKS 150
LKGRANDAIA SACLYIACRQ EGVPRTFKEI CAVSRISKKE IGRCFKLILK 200
ALETSVDLIT TGDFMSRFCS NLCLPKQVQM AATHIARKAV ELDLVPGRSP 250
ISVAAAAIYM ASQASAEKRT QKEIGDIAGV ADVTIRQSYR LIYPRAPDLF 300
PTDFKFDTPV DKLPQL 316
Length:316
Mass (Da):34,833
Last modified:December 1, 1992 - v1
Checksum:i9CC7E102526C2722
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191P → S.
Corresponds to variant rs1804499 [ dbSNP | Ensembl ].
VAR_011977
Natural varianti132 – 1321R → Q in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035722

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59268 mRNA. Translation: CAA41958.1.
M76766 mRNA. Translation: AAA61149.1.
AK289822 mRNA. Translation: BAF82511.1.
AB451296 mRNA. Translation: BAG70110.1.
AL445991 Genomic DNA. Translation: CAI41341.1.
BC020597 mRNA. Translation: AAH20597.1.
S44184 mRNA. Translation: AAB23144.1.
CCDSiCCDS715.1.
PIRiS17654. TWHU2B.
RefSeqiNP_001505.1. NM_001514.5.
UniGeneiHs.481852.

Genome annotation databases

EnsembliENST00000370500; ENSP00000359531; ENSG00000137947.
GeneIDi2959.
KEGGihsa:2959.
UCSCiuc001dmo.4. human.

Polymorphism databases

DMDMi135629.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59268 mRNA. Translation: CAA41958.1 .
M76766 mRNA. Translation: AAA61149.1 .
AK289822 mRNA. Translation: BAF82511.1 .
AB451296 mRNA. Translation: BAG70110.1 .
AL445991 Genomic DNA. Translation: CAI41341.1 .
BC020597 mRNA. Translation: AAH20597.1 .
S44184 mRNA. Translation: AAB23144.1 .
CCDSi CCDS715.1.
PIRi S17654. TWHU2B.
RefSeqi NP_001505.1. NM_001514.5.
UniGenei Hs.481852.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1C9B X-ray 2.65 A/E/I/M/Q 110-316 [» ]
1DL6 NMR - A 2-59 [» ]
1RLY NMR - A 1-60 [» ]
1RO4 NMR - A 1-60 [» ]
1TFB NMR - A 112-316 [» ]
1VOL X-ray 2.70 A 113-316 [» ]
2PHG NMR - A 112-316 [» ]
ProteinModelPortali Q00403.
SMRi Q00403. Positions 2-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109214. 64 interactions.
DIPi DIP-1077N.
IntActi Q00403. 25 interactions.
MINTi MINT-156550.
STRINGi 9606.ENSP00000359531.

PTM databases

PhosphoSitei Q00403.

Polymorphism databases

DMDMi 135629.

Proteomic databases

MaxQBi Q00403.
PaxDbi Q00403.
PeptideAtlasi Q00403.
PRIDEi Q00403.

Protocols and materials databases

DNASUi 2959.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370500 ; ENSP00000359531 ; ENSG00000137947 .
GeneIDi 2959.
KEGGi hsa:2959.
UCSCi uc001dmo.4. human.

Organism-specific databases

CTDi 2959.
GeneCardsi GC01M089318.
HGNCi HGNC:4648. GTF2B.
HPAi HPA061626.
MIMi 189963. gene.
neXtProti NX_Q00403.
PharmGKBi PA29035.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1405.
HOGENOMi HOG000108634.
HOVERGENi HBG017914.
InParanoidi Q00403.
KOi K03124.
OMAi YMASHIR.
OrthoDBi EOG78WKS2.
PhylomeDBi Q00403.
TreeFami TF105953.

Enzyme and pathway databases

Reactomei REACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_1851. RNA Polymerase II Transcription Initiation.
REACT_2089. RNA Polymerase II Promoter Escape.
REACT_22107. RNA Polymerase II Pre-transcription Events.
REACT_6233. Transcription of the HIV genome.
REACT_6253. RNA Polymerase II HIV Promoter Escape.
REACT_6332. HIV Transcription Initiation.
REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

ChiTaRSi GTF2B. human.
EvolutionaryTracei Q00403.
GeneWikii Transcription_factor_II_B.
GenomeRNAii 2959.
NextBioi 11730.
PMAP-CutDB Q00403.
PROi Q00403.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q00403.
Bgeei Q00403.
CleanExi HS_GTF2B.
Genevestigatori Q00403.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR000812. TFIIB.
IPR023486. TFIIB_CS.
IPR013150. TFIIB_cyclin.
IPR013137. Znf_TFIIB.
[Graphical view ]
PANTHERi PTHR11618. PTHR11618. 1 hit.
Pfami PF08271. TF_Zn_Ribbon. 1 hit.
PF00382. TFIIB. 2 hits.
[Graphical view ]
PRINTSi PR00685. TIFACTORIIB.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00782. TFIIB. 2 hits.
PS51134. ZF_TFIIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a human gene encoding the general transcription initiation factor IIB."
    Ha I., Lane W.S., Reinberg D.
    Nature 352:689-695(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sequence of general transcription factor TFIIB and relationships to other initiation factors."
    Malik S., Hisatake K., Sumimoto H., Horikoshi M., Roeder R.G.
    Proc. Natl. Acad. Sci. U.S.A. 88:9553-9557(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
    Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
    , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
    Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  7. "Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II)."
    Ing N.H., Beekman J.M., Tsai S.Y., Tsai M.J., O'Malley B.W.
    J. Biol. Chem. 267:17617-17623(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-316.
  8. "Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II."
    Umehara T., Kida S., Yamamoto T., Horikoshi M.
    Gene 167:297-302(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TCEA2.
  9. "The Epstein-Barr virus nuclear protein 2 acidic domain can interact with TFIIB, TAF40, and RPA70 but not with TATA-binding protein."
    Tong X., Wang F., Thut C.J., Kieff E.
    J. Virol. 69:585-588(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EBV EBNA2.
  10. "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB."
    Agostini I., Navarro J.-M., Rey F., Bouhamdan M., Spire B., Vigne R., Sire J.
    J. Mol. Biol. 261:599-606(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HIV-1 VPR.
  11. "The HIV-1 Vpr co-activator induces a conformational change in TFIIB."
    Agostini I., Navarro J.M., Bouhamdan M., Willetts K., Rey F., Spire B., Vigne R., Pomerantz R., Sire J.
    FEBS Lett. 450:235-239(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF 52-GLU--SER-56.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein."
    Bagby S., Kim S., Maldonado E., Tong K.I., Reinberg D., Ikura M.
    Cell 82:857-867(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 111-316.
  16. "Crystal structure of a TFIIB-TBP-TATA-element ternary complex."
    Nikolov D.B., Chen H., Halay E.D., Usheva A.A., Hisatake K., Lee D.K., Roeder R.G., Burley S.K.
    Nature 377:119-128(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 112-316.
  17. "Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription."
    Chen H.T., Legault P., Glushka J., Omichinski J.G., Scott R.A.
    Protein Sci. 9:1743-1752(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 2-59.
  18. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-132.

Entry informationi

Entry nameiTF2B_HUMAN
AccessioniPrimary (citable) accession number: Q00403
Secondary accession number(s): A8K1A7, Q5JS30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 3, 2014
This is version 161 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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