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Q00403

- TF2B_HUMAN

UniProt

Q00403 - TF2B_HUMAN

Protein

Transcription initiation factor IIB

Gene

GTF2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 162 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.

    Cofactori

    Binds 1 zinc ion per subunit.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi15 – 151Zinc
    Metal bindingi18 – 181Zinc
    Metal bindingi34 – 341Zinc
    Metal bindingi37 – 371Zinc

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri11 – 4232TFIIB-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. core promoter binding Source: Ensembl
    2. protein binding Source: UniProtKB
    3. thyroid hormone receptor binding Source: UniProtKB
    4. transcription factor binding Source: UniProtKB
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. gene expression Source: Reactome
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription elongation from RNA polymerase II promoter Source: Reactome
    4. transcription from RNA polymerase II promoter Source: Reactome
    5. transcription initiation from RNA polymerase II promoter Source: Reactome
    6. viral process Source: Reactome

    Keywords - Biological processi

    Host-virus interaction, Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
    REACT_1851. RNA Polymerase II Transcription Initiation.
    REACT_2089. RNA Polymerase II Promoter Escape.
    REACT_22107. RNA Polymerase II Pre-transcription Events.
    REACT_6233. Transcription of the HIV genome.
    REACT_6253. RNA Polymerase II HIV Promoter Escape.
    REACT_6332. HIV Transcription Initiation.
    REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription initiation factor IIB
    Alternative name(s):
    General transcription factor TFIIB
    S300-II
    Gene namesi
    Name:GTF2B
    Synonyms:TF2B, TFIIB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:4648. GTF2B.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi51 – 566EWRTFS → AWRTFA: Partial loss of HIV-1 Vpr binding. 1 Publication
    Mutagenesisi52 – 521W → A: Partial loss of HIV-1 Vpr binding. 1 Publication
    Mutagenesisi53 – 542RT → AA: Partial loss of HIV-1 Vpr binding. 1 Publication
    Mutagenesisi55 – 551F → A: Partial loss of HIV-1 Vpr binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA29035.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Transcription initiation factor IIBPRO_0000119293Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei76 – 761Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ00403.
    PaxDbiQ00403.
    PeptideAtlasiQ00403.
    PRIDEiQ00403.

    PTM databases

    PhosphoSiteiQ00403.

    Miscellaneous databases

    PMAP-CutDBQ00403.

    Expressioni

    Gene expression databases

    ArrayExpressiQ00403.
    BgeeiQ00403.
    CleanExiHS_GTF2B.
    GenevestigatoriQ00403.

    Organism-specific databases

    HPAiHPA061626.

    Interactioni

    Subunit structurei

    Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1 By similarity. Interacts with Epstein-Barr virus EBNA2.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EP300Q094722EBI-389564,EBI-447295
    GRF4P460772EBI-389564,EBI-637479From a different organism.
    VdrP482812EBI-389564,EBI-346797From a different organism.

    Protein-protein interaction databases

    BioGridi109214. 64 interactions.
    DIPiDIP-1077N.
    IntActiQ00403. 25 interactions.
    MINTiMINT-156550.
    STRINGi9606.ENSP00000359531.

    Structurei

    Secondary structure

    1
    316
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 63
    Beta strandi18 – 214
    Beta strandi24 – 263
    Beta strandi27 – 293
    Turni35 – 373
    Helixi111 – 1133
    Helixi114 – 12714
    Helixi132 – 14817
    Beta strandi152 – 1543
    Helixi156 – 17015
    Helixi177 – 1826
    Beta strandi184 – 1863
    Helixi188 – 20114
    Helixi212 – 22110
    Helixi226 – 24116
    Helixi250 – 26314
    Beta strandi265 – 2673
    Helixi271 – 2788
    Helixi282 – 29211
    Helixi293 – 2953
    Helixi296 – 2994
    Helixi310 – 3123

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1C9BX-ray2.65A/E/I/M/Q110-316[»]
    1DL6NMR-A2-59[»]
    1RLYNMR-A1-60[»]
    1RO4NMR-A1-60[»]
    1TFBNMR-A112-316[»]
    1VOLX-ray2.70A113-316[»]
    2PHGNMR-A112-316[»]
    ProteinModelPortaliQ00403.
    SMRiQ00403. Positions 2-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ00403.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati124 – 200771Add
    BLAST
    Repeati218 – 294772Add
    BLAST

    Sequence similaritiesi

    Belongs to the TFIIB family.Curated
    Contains 1 TFIIB-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri11 – 4232TFIIB-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1405.
    HOGENOMiHOG000108634.
    HOVERGENiHBG017914.
    InParanoidiQ00403.
    KOiK03124.
    OMAiYMASHIR.
    OrthoDBiEOG78WKS2.
    PhylomeDBiQ00403.
    TreeFamiTF105953.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR023486. TFIIB_CS.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view]
    PANTHERiPTHR11618. PTHR11618. 1 hit.
    PfamiPF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view]
    PRINTSiPR00685. TIFACTORIIB.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00782. TFIIB. 2 hits.
    PS51134. ZF_TFIIB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q00403-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASTSRLDAL PRVTCPNHPD AILVEDYRAG DMICPECGLV VGDRVIDVGS    50
    EWRTFSNDKA TKDPSRVGDS QNPLLSDGDL STMIGKGTGA ASFDEFGNSK 100
    YQNRRTMSSS DRAMMNAFKE ITTMADRINL PRNIVDRTNN LFKQVYEQKS 150
    LKGRANDAIA SACLYIACRQ EGVPRTFKEI CAVSRISKKE IGRCFKLILK 200
    ALETSVDLIT TGDFMSRFCS NLCLPKQVQM AATHIARKAV ELDLVPGRSP 250
    ISVAAAAIYM ASQASAEKRT QKEIGDIAGV ADVTIRQSYR LIYPRAPDLF 300
    PTDFKFDTPV DKLPQL 316
    Length:316
    Mass (Da):34,833
    Last modified:December 1, 1992 - v1
    Checksum:i9CC7E102526C2722
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191P → S.
    Corresponds to variant rs1804499 [ dbSNP | Ensembl ].
    VAR_011977
    Natural varianti132 – 1321R → Q in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035722

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59268 mRNA. Translation: CAA41958.1.
    M76766 mRNA. Translation: AAA61149.1.
    AK289822 mRNA. Translation: BAF82511.1.
    AB451296 mRNA. Translation: BAG70110.1.
    AL445991 Genomic DNA. Translation: CAI41341.1.
    BC020597 mRNA. Translation: AAH20597.1.
    S44184 mRNA. Translation: AAB23144.1.
    CCDSiCCDS715.1.
    PIRiS17654. TWHU2B.
    RefSeqiNP_001505.1. NM_001514.5.
    UniGeneiHs.481852.

    Genome annotation databases

    EnsembliENST00000370500; ENSP00000359531; ENSG00000137947.
    GeneIDi2959.
    KEGGihsa:2959.
    UCSCiuc001dmo.4. human.

    Polymorphism databases

    DMDMi135629.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59268 mRNA. Translation: CAA41958.1 .
    M76766 mRNA. Translation: AAA61149.1 .
    AK289822 mRNA. Translation: BAF82511.1 .
    AB451296 mRNA. Translation: BAG70110.1 .
    AL445991 Genomic DNA. Translation: CAI41341.1 .
    BC020597 mRNA. Translation: AAH20597.1 .
    S44184 mRNA. Translation: AAB23144.1 .
    CCDSi CCDS715.1.
    PIRi S17654. TWHU2B.
    RefSeqi NP_001505.1. NM_001514.5.
    UniGenei Hs.481852.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1C9B X-ray 2.65 A/E/I/M/Q 110-316 [» ]
    1DL6 NMR - A 2-59 [» ]
    1RLY NMR - A 1-60 [» ]
    1RO4 NMR - A 1-60 [» ]
    1TFB NMR - A 112-316 [» ]
    1VOL X-ray 2.70 A 113-316 [» ]
    2PHG NMR - A 112-316 [» ]
    ProteinModelPortali Q00403.
    SMRi Q00403. Positions 2-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109214. 64 interactions.
    DIPi DIP-1077N.
    IntActi Q00403. 25 interactions.
    MINTi MINT-156550.
    STRINGi 9606.ENSP00000359531.

    PTM databases

    PhosphoSitei Q00403.

    Polymorphism databases

    DMDMi 135629.

    Proteomic databases

    MaxQBi Q00403.
    PaxDbi Q00403.
    PeptideAtlasi Q00403.
    PRIDEi Q00403.

    Protocols and materials databases

    DNASUi 2959.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370500 ; ENSP00000359531 ; ENSG00000137947 .
    GeneIDi 2959.
    KEGGi hsa:2959.
    UCSCi uc001dmo.4. human.

    Organism-specific databases

    CTDi 2959.
    GeneCardsi GC01M089318.
    HGNCi HGNC:4648. GTF2B.
    HPAi HPA061626.
    MIMi 189963. gene.
    neXtProti NX_Q00403.
    PharmGKBi PA29035.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1405.
    HOGENOMi HOG000108634.
    HOVERGENi HBG017914.
    InParanoidi Q00403.
    KOi K03124.
    OMAi YMASHIR.
    OrthoDBi EOG78WKS2.
    PhylomeDBi Q00403.
    TreeFami TF105953.

    Enzyme and pathway databases

    Reactomei REACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
    REACT_1851. RNA Polymerase II Transcription Initiation.
    REACT_2089. RNA Polymerase II Promoter Escape.
    REACT_22107. RNA Polymerase II Pre-transcription Events.
    REACT_6233. Transcription of the HIV genome.
    REACT_6253. RNA Polymerase II HIV Promoter Escape.
    REACT_6332. HIV Transcription Initiation.
    REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.

    Miscellaneous databases

    ChiTaRSi GTF2B. human.
    EvolutionaryTracei Q00403.
    GeneWikii Transcription_factor_II_B.
    GenomeRNAii 2959.
    NextBioi 11730.
    PMAP-CutDB Q00403.
    PROi Q00403.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q00403.
    Bgeei Q00403.
    CleanExi HS_GTF2B.
    Genevestigatori Q00403.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR000812. TFIIB.
    IPR023486. TFIIB_CS.
    IPR013150. TFIIB_cyclin.
    IPR013137. Znf_TFIIB.
    [Graphical view ]
    PANTHERi PTHR11618. PTHR11618. 1 hit.
    Pfami PF08271. TF_Zn_Ribbon. 1 hit.
    PF00382. TFIIB. 2 hits.
    [Graphical view ]
    PRINTSi PR00685. TIFACTORIIB.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00782. TFIIB. 2 hits.
    PS51134. ZF_TFIIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a human gene encoding the general transcription initiation factor IIB."
      Ha I., Lane W.S., Reinberg D.
      Nature 352:689-695(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Sequence of general transcription factor TFIIB and relationships to other initiation factors."
      Malik S., Hisatake K., Sumimoto H., Horikoshi M., Roeder R.G.
      Proc. Natl. Acad. Sci. U.S.A. 88:9553-9557(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
      Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
      , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
      Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    7. "Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II)."
      Ing N.H., Beekman J.M., Tsai S.Y., Tsai M.J., O'Malley B.W.
      J. Biol. Chem. 267:17617-17623(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-316.
    8. "Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II."
      Umehara T., Kida S., Yamamoto T., Horikoshi M.
      Gene 167:297-302(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TCEA2.
    9. "The Epstein-Barr virus nuclear protein 2 acidic domain can interact with TFIIB, TAF40, and RPA70 but not with TATA-binding protein."
      Tong X., Wang F., Thut C.J., Kieff E.
      J. Virol. 69:585-588(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EBV EBNA2.
    10. "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB."
      Agostini I., Navarro J.-M., Rey F., Bouhamdan M., Spire B., Vigne R., Sire J.
      J. Mol. Biol. 261:599-606(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HIV-1 VPR.
    11. "The HIV-1 Vpr co-activator induces a conformational change in TFIIB."
      Agostini I., Navarro J.M., Bouhamdan M., Willetts K., Rey F., Spire B., Vigne R., Pomerantz R., Sire J.
      FEBS Lett. 450:235-239(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF 52-GLU--SER-56.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein."
      Bagby S., Kim S., Maldonado E., Tong K.I., Reinberg D., Ikura M.
      Cell 82:857-867(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 111-316.
    16. "Crystal structure of a TFIIB-TBP-TATA-element ternary complex."
      Nikolov D.B., Chen H., Halay E.D., Usheva A.A., Hisatake K., Lee D.K., Roeder R.G., Burley S.K.
      Nature 377:119-128(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 112-316.
    17. "Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription."
      Chen H.T., Legault P., Glushka J., Omichinski J.G., Scott R.A.
      Protein Sci. 9:1743-1752(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 2-59.
    18. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-132.

    Entry informationi

    Entry nameiTF2B_HUMAN
    AccessioniPrimary (citable) accession number: Q00403
    Secondary accession number(s): A8K1A7, Q5JS30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 162 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3